New paper “Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP” from Dr Yuan Yan (Angie) Sin and Prof George Baillie published in FEBS Letters.
Published: 9 July 2024
Dr Yuan Yan (Angie) Sin and Prof George Baillie published in FEBS Letters.
One of Dr Sin's micrographs from the article has been selected for the cover of the July issue of FEBS Letters.
Cover illustration
Proximity ligation assay with red puncta represent direct interaction between PDE4 and β-amyloid in SH-SY5Y cells counterstained with wheat germ agglutinin (green).
Credit: Dr Yuan Yan Sin and Glasgow Imaging Facility.
Prof Baillie and Dr Sin's work is the first to show that beta-amyloid can directly associate with the PDE4D, suggesting a novel mechanism by which beta-amyloid can depress cAMP signalling, a factor associated with loss of synaptic plasticity.
First published: 9 July 2024