2024

Lawrence, B. M., O'Donnell, L., Gannon, A.‐L., Smith, S., Curley, M. K., Darbey, A., Mackay, R., O'Shaughnessy, P. J. , Smith, L. B. and Rebourcet, D. (2024) Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes. FASEB Journal, 38(22), e70177. (doi: 10.1096/fj.202402093r) (PMID:39556387)

2020

Lucendo-Villarin, B. et al. (2020) Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells. EXCLI Journal, 19, pp. 1459-1476. (doi: 10.17179/excli2020-2934) (PMID:33312107) (PMCID:PMC7726493)

2019

Rebourcet, D., Monteiro, A., Cruickshanks, L., Jeffery, N., Smith, S., Milne, L., O'Shaughnessy, P. J. and Smith, L. B. (2019) Relationship of transcriptional markers to Leydig cell number in the mouse testis. PLoS ONE, 14(7), e0219524. (doi: 10.1371/journal.pone.0219524) (PMID:31291327) (PMCID:PMC6619764)

O'Shaughnessy, P. J. , Mitchell, R. T., Monteiro, A., O'Hara, L., Cruickshanks, L., Claahsen-van der Grinten, H., Brown, P., Abel, M. and Smith, L. B. (2019) Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis. BMC Developmental Biology, 19, 8. (doi: 10.1186/s12861-019-0189-5) (PMID:30995907) (PMCID:PMC6472051)

Filis, P. et al. (2019) Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males. Environment International, 124, pp. 98-108. (doi: 10.1016/j.envint.2019.01.003) (PMID:30641261)

Walker, N., Filis, P., O'Shaughnessy, P. J. , Bellingham, M. and Fowler, P. A. (2019) Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking. Placenta, 78, pp. 10-17. (doi: 10.1016/j.placenta.2019.02.010) (PMID:PMC6461130) (PMCID:PMC6461130)

O'Shaughnessy, P. J. et al. (2019) Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biology, 17(2), e3000002. (doi: 10.1371/journal.pbio.3000002) (PMID:30763313) (PMCID:PMC6375548)

Bulmer, L., Murray, J.M.D. , Burns, N., Garber, A. , McEwan, N., O'Shaughnessy, P. , Hemmings, A., Ewans, N., Monteiro, A. and Hastie, P.M. (2019) Development of Methods to Investigate the Mechanisms Behind Increased Behavioural Reactivity Associated with an Increased-Starch Diet. Equine Science Symposium, NC, USA, 03-06 Jun 2019.

2018

Dominoni, D. M. , de Jong, M., Bellingham, M. , O'Shaughnessy, P. , van Oers, K., Robinson, J. , Smith, B., Visser, M. E. and Helm, B. (2018) Dose-response effects of light at night on the reproductive physiology of great tits (Parus major): integrating morphological analyses with candidate gene expression. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 329(8-9), pp. 473-487. (doi: 10.1002/jez.2214) (PMID:30058288) (PMCID:PMC6220976)

O'Hara, L., O'Shaughnessy, P. J. , Freeman, T. C. and Smith, L. B. (2018) Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies. BMC Research Notes, 11, 252. (doi: 10.1186/s13104-018-3365-y) (PMID:29690918) (PMCID:PMC5937803)

Johnston, Z. C. et al. (2018) The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. BMC Medicine, 16, 23. (doi: 10.1186/s12916-018-1009-7) (PMID:29429410) (PMCID:PMC5808459)

Rebourcet, D., Darbey, A., Curley, M., O'Shaughnessy, P. and Smith, L. B. (2018) Testicular cell selective ablation using diphtheria toxin receptor transgenic mice. In: Alves, M. G. and Oliveira, P. F. (eds.) Steroli Cells. Series: Methods in molecular biology (1748). Humana Press: New York, NY, pp. 203-228. ISBN 9781493976973 (doi: 10.1007/978-1-4939-7698-0_15)

2017

Soffientini, U., Rebourcet, D., Abel, M.H., Lee, S., Hamilton, G., Fowler, P.A., Smith, L.B. and O'Shaughnessy, P.J. (2017) Identification of Sertoli cell-specific transcripts in the mouse testis and the role of FSH and androgen in the control of Sertoli cell activity. BMC Genomics, 18, 972. (doi: 10.1186/s12864-017-4357-3) (PMID:29246116) (PMCID:PMC5731206)

Lucendo-Villarin, B., Filis, P., Swortwood, M. J., Huestis, M. A., Meseguer-Ripolles, J., Cameron, K., Iredale, J. P., O'Shaughnessy, P. , Fowler, P. A. and Hay, D. C. (2017) Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells. Archives of Toxicology, 91(11), pp. 3633-3643. (doi: 10.1007/s00204-017-1983-0) (PMID:28510779) (PMCID:PMC5696490)

Lucendo-Villarin, B., Filis, P., Swortwood, M. J., Huestis, M. A., Meseguer-Ripolles, J., Cameron, K., Iredale, J. P., O'Shaughnessy, P. J. , Fowler, P. A. and Hay, D. C. (2017) Erratum to: Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells. Archives of Toxicology, 91(11), p. 3645. (doi: 10.1007/s00204-017-2030-x) (PMID:28733887)

Rebourcet, D., Darbey, A., Monteiro, A., Soffientini, U., Tsai, Y. T., Handel, I., Pitetti, J.-L., Nef, S., Smith, L. B. and O'Shaughnessy, P. J. (2017) Sertoli cell number defines, and predicts, germ and Leydig cell population sizes in the adult mouse testis. Endocrinology, 158(9), pp. 2955-2969. (doi: 10.1210/en.2017-00196) (PMID:28911170) (PMCID:PMC5659676)

Capilla-Lasheras, P. , Dominoni, D. M. , Babayan, S. A. , O'Shaughnessy, P. J. , Mladenova, M., Woodford, L., Pollock, C. J., Barr, T., Baldini, F. and Helm, B. (2017) Elevated immune gene expression is associated with poor reproductive success of urban blue tits. Frontiers in Ecology and Evolution, 5, 64. (doi: 10.3389/fevo.2017.00064)

Walker, N., Filis, P., Soffientini, U., Bellingham, M. , O'Shaughnessy, P. J. and Fowler, P. A. (2017) Placental transporter localization and expression in the human: the importance of species, sex and gestational age differences. Biology of Reproduction, 96(4), pp. 733-742. (doi: 10.1093/biolre/iox012) (PMID:28339967)

Murray, J.-A. M. D. , Brown, S., O'Shaughnessy, P. , Monteiro, A., Warren, H. and Hastie, P. M. (2017) Effect of live yeast culture supplementation on fibrolytic and saccharolytic bacterial populations in the feces of horses fed a high-fiber or high-starch diet. Journal of Equine Veterinary Science, 51, pp. 41-45. (doi: 10.1016/j.jevs.2016.12.009)

2016

Huuskonen, P. et al. (2016) The human placental proteome is affected by maternal smoking. Reproductive Toxicology, 63, pp. 22-31. (doi: 10.1016/j.reprotox.2016.05.009) (PMID:27189315) (PMCID:PMC4991937)

Rebourcet, D. et al. (2016) Sertoli cells modulate testicular vascular network development, structure, and function to influence circulating testosterone concentrations in adult male mice. Endocrinology, 157(6), pp. 2479-2488. (doi: 10.1210/en.2016-1156) (PMID:27145015) (PMCID:PMC4891787)

Fowler, P. A., Drake, A. J., O'Shaughnessy, P. J. , Bhattacharya, S., Raab, A., Sinclair, K. D., Feldmann, J. and Meharg, A. A. (2016) Comment on “Effects of arsenite during fetal development on energy metabolism and susceptibility to diet-induced fatty liver diseases in male mice” and “Mechanisms underlying latent disease risk associated with early-life arsenic exposure: current trends and scientific gaps”. Environmental Health Perspectives, 124(6), A99. (doi: 10.1289/ehp.1611345)

Fowler, P. A., Filis, P., Bhattacharya, S., le Bizec, B., Antignac, J.-P., Morvan, M.-L., Drake, A. J., Soffientini, U. and O'Shaughnessy, P. (2016) Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences. Human Reproduction, 31(2), pp. 463-472. (doi: 10.1093/humrep/dev323) (PMID:26732622) (PMCID:PMC4716811)

2015

Smith, L. B., O'Shaughnessy, P. and Rebourcet, D. (2015) Cell-specific ablation in the testis: what have we learned? Andrology, 3(6), pp. 1035-1049. (doi: 10.1111/andr.12107) (PMID:26446427)

O'Shaughnessy, P. and Fowler, P.A. (2015) Aspects of UGT2B15 in the human. Toxicological Sciences, 143(2), p. 230. (doi: 10.1093/toxsci/kfu263) (PMID:25628400)

Drake, A. J. et al. (2015) In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13(18), (doi: 10.1186/s12916-014-0251-x)

Filis, P., Nagrath, N., Fraser, M., Hay, D. C., Iredale, J. P., O'Shaughnessy, P. and Fowler, P. A. (2015) Maternal smoking dysregulates protein expression in second trimester human fetal livers in a sex-specific manner. Journal of Clinical Endocrinology and Metabolism, 100(6), E861-E870. (doi: 10.1210/jc.2014-3941) (PMID:25803269) (PMCID:PMC4533306)

2014

Benato, L., Hastie, P. , O'Shaughnessy, P. , Murray, J.-A. and Meredith, A. (2014) Effects of probioticEnterococcus faeciumandSaccharomyces cerevisiaeon the faecal microflora of pet rabbits. Journal of Small Animal Practice, 55(9), pp. 442-446. (doi: 10.1111/jsap.12242) (PMID:24961954)

Rebourcet, D., O'Shaughnessy, P. J. , Monteiro, A., Milne, L., Cruickshanks, L., Jeffrey, N., Guillou, F., Freeman, T. C., Mitchell, R. T. and Smith, L. B. (2014) Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS ONE, 9(8), e105687. (doi: 10.1371/journal.pone.0105687) (PMID:25144714) (PMCID:PMC4140823)

O'Shaughnessy, P.J. , Monteiro, A., Fowler, P.A. and Morris, I.D. (2014) Identification of Leydig cell-specific mRNA transcripts in the adult rat testis. Reproduction, 147(5), pp. 671-682. (doi: 10.1530/REP-13-0603)

O'Shaughnessy, P. J. (2014) Hormonal control of germ cell development and spermatogenesis. Seminars in Cell and Developmental Biology, 29, pp. 55-65. (doi: 10.1016/j.semcdb.2014.02.010)

O'Shaughnessy, P. J. and Fowler, P. A. (2014) Development of the human fetal testis. Annales d'Endocrinologie, 75(2), pp. 48-53. (doi: 10.1016/j.ando.2014.03.009)

Rebourcet, D. et al. (2014) Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis. Development, 141(10), pp. 2139-2149. (doi: 10.1242/dev.107029) (PMID:24803659) (PMCID:PMC4011090)

Fowler, P. A. et al. (2014) In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. Human Reproduction, 29(7), pp. 1471-1489. (doi: 10.1093/humrep/deu117) (PMID:24847019)

2013

Fowler, P.A. and O'Shaughnessy, P.J. (2013) The Goldilocks principle and developmental androgens in males, what is "just right"? Endocrinology, 154(5), pp. 1669-1671. (doi: 10.1210/en.2013-1279)

Oldknow, K.J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A.A., O'Shaughnessy, P.J. , Gygi, S.P., Schneyer, A.L. and Mukherjee, A. (2013) Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size. Endocrinology, 154(3), pp. 1310-1320. (doi: 10.1210/en.2012-1886)

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S., Fraser, M.J. and Fowler, P.A. (2013) Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. Molecular Human Reproduction, 19(3), pp. 177-187. (doi: 10.1093/molehr/gas059)

2012

Fowler, P. A. et al. (2012) Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Molecular and Cellular Endocrinology, 355(2), pp. 231-239. (doi: 10.1016/j.mce.2011.10.021) (PMID:22061620)

O'Shaughnessy, P.J. , Monteiro, A. and Abel, M. (2012) Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. PLoS ONE, 7(4), e35136. (doi: 10.1371/journal.pone.0035136) (PMID:22514715) (PMCID:PMC3325994)

2011

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S. and Fowler, P.A. (2011) Maternal Smoking and Fetal Sex Significantly Affect Metabolic Enzyme Expression in the Human Fetal Liver. Journal of Clinical Endocrinology and Metabolism, 96(9), pp. 2851-2860. (doi: 10.1210/jc.2011-1437)

Fowler, P.A. et al. (2011) Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary. Journal of Clinical Endocrinology and Metabolism, 96(6), pp. 1754-1762. (doi: 10.1210/jc.2010-2618)

Fowler, P.A., Bhattacharya, S., Flannigan, S., Drake, A.J. and O'Shaughnessy, P.J. (2011) Maternal cigarette smoking and effects on androgen action in male offspring: unexpected effects on second-trimester anogenital distance. Journal of Clinical Endocrinology and Metabolism, 96(9), E1502-E1506. (doi: 10.1210/jc.2011-1100)

O'Shaughnessy, P. J. and Fowler, P. A. (2011) Endocrinology of the mammalian fetal testis. Reproduction, 141(1), pp. 37-46. (doi: 10.1530/REP-10-0365)

O'Shaughnessy, P.J. , Monteiro, A. and Fowler, P.A. (2011) Identification of stable endogenous reference genes for real-time PCR in the human fetal gonad using an external standard technique. Molecular Human Reproduction, 17(10), pp. 620-625. (doi: 10.1093/molehr/gar032)

2010

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

Hu, Z., Dandekar, D., O'Shaughnessy, P.J. , De Gendt, K., Verhoeven, G. and Wilkinson, M.F. (2010) Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes. Molecular Endocrinology, 24(1), pp. 60-75. (doi: 10.1210/me.2009-0303)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

Hu, Z.Y., Dandekar, D., O'Shaughnessy, P.J. , De Gendt, K., Verhoeven, G. and Wilkinson, M. (2010) Androgen-Induced Rhox Homeobox Genes Modulate the Expression of AR-Regulated Genes. Molecular Endocrinology, 24(1), pp. 60-75. (doi: 10.1210/me.2009-0303)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

2009

O'Shaughnessy, P.J. , Morris, I.D., Huhtaniemi, I., Baker, P.J. and Abel, M.H. (2009) Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice. Molecular and Cellular Endocrinology, 306(1-2), pp. 2-8. (doi: 10.1016/j.mce.2008.11.005)

Abel, M.H., Baban, D., Lee, S., Charlton, H.M. and O'Shaughnessy, P.J. (2009) Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse. Journal of Molecular Endocrinology, 42(4), pp. 291-303. (doi: 10.1677/JME-08-0107)

Ayres, J., Rhind, S.M., O'Shaughnessy, P.J. and Fowler, P.A. (2009) PAH exposure. Environmental Health Perspectives, 117(4), A140. (doi: 10.1289/ehp.0800445)

Fowler, P.A., Bhattacharya, S., Gromoll, J., Monteiro, A. and O'Shaughnessy, P.J. (2009) Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis. Journal of Clinical Endocrinology and Metabolism, 94(12), pp. 4688-4695. (doi: 10.1210/jc.2009-0994)

Fowler, P.A. et al. (2009) Gene Expression Analysis of Human Fetal Ovarian Primordial Follicle Formation. Journal of Clinical Endocrinology and Metabolism, 94(4), pp. 1427-1435. (doi: 10.1210/jc.2008-2619)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2009) Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice. Reproductive Biology and Endocrinology, 7, p. 88. (doi: 10.1186/1477-7827-7-88)

O'Shaughnessy, P.J. , Morris, I.D., Huhtaniemi, I., Baker, P.J. and Abel, M.H. (2009) Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: Data from mutant and genetically modified mice. Molecular and Cellular Endocrinology, 306(1-2), pp. 2-8. (doi: 10.1016/j.mce.2008.11.005)

2008

Abel, M.H., Baker, P.J., Charlton, H.M., Monteiro, A., Verhoeven, G., De Gendt, K., Guillou, F. and O'Shaughnessy, P.J. (2008) Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen. Endocrinology, 149(7), pp. 3279-3285. (doi: 10.1210/en.2008-0086)

Fowler, P.A., Cassie, S., Rhind, S.M., Brewer, M.J., Collinson, J.M., Lea, R.G., Baker, P.J., Bhattacharya, S. and O'Shaughnessy, P.J. (2008) Maternal smoking during pregnancy specifically reduces human fetal desert hedgehog gene expression during testis development. Journal of Clinical Endocrinology and Metabolism, 93(2), pp. 619-626. (doi: 10.1210/jc.2007-1860)

Mihm Carmichael, M., Baker, P.J., Fleming, L.M., Monteiro, A.M. and O'Shaughnessy, P.J. (2008) Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes. Reproduction, 135(2), pp. 253-265. (doi: 10.1530/REP-06-0193) (PMID:18239053)

O'Shaughnessy, P. J. , Hu, L. and Baker, P. J. (2008) Effect of germ cell depletion on levels of specific mRNA transcripts in mouse Sertoli cells and Leydig cells. Reproduction, 135(6), pp. 839-850. (doi: 10.1530/REP-08-0012)

O'Shaughnessy, P. J. , Morris, I. D. and Baker, P. J. (2008) Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. Reproduction, 135(6), pp. 851-858. (doi: 10.1530/REP-07-0529)

2007

Hu, L., Monteiro, A., Johnston, H., King, P. and O'Shaughnessy, P.J. (2007) Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Reproduction, 134, pp. 585-591. (doi: 10.1530/REP-07-0133)

Johnston, H., King, P.J. and O'Shaughnessy, P.J. (2007) Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis. Reproduction, 133, pp. 1181-1187. (doi: 10.1530/REP-06-0359)

O'shaughnessy, P. (2007) Developmental Changes in Human Fetal Testicular Cell Numbers and mRNA Levels During the Second Trimester. Journal of Clinical Endocrinology and Metabolism, 92(12), pp. 4792-4801.

O'Shaughnessy, P.J. , Abel, M., Charlton, H.M., Hu, B., Johnston, H. and Baker, P.J. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive Tfm mouse testis. Endocrinology, 148, pp. 2914-2924. (doi: 10.1210/en.2006-1412)

2006

Noon, L.A., Bakmanidis, A., Clark, A.J.L., O'Shaughnessy, P.J. and King, P.J. (2006) Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis. Journal of Molecular Endocrinology, 37, pp. 415-420. (doi: 10.1677/jme.1.02023)

Noon, L.A., Clark, A.J.L., O'Shaughnessy, P.J. and King, P.J. (2006) A CCAAT/enhancer-binding protein site at-87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis. Endocrinology, 147, pp. 6019-6026. (doi: 10.1210/en.2006-0867)

O'Shaughnessy, P.J. , Baker, P.J. and Johnston, H. (2006) The foetal Leydig cell - differentiation, function and regulation. International Journal of Andrology, 29, pp. 90-95. (doi: 10.1111/j.1365-2605.2005.00555.x)

2005

O'Shaughnessy, P.J. , Baker, P.J. and Johnston, H. (2005) Neuroendocrine regulation of Leydig cell development. Testicular Cell Dynamics and Endocrine Signaling, 1061, pp. 109-119. (doi: 10.1196/annals.1336.013)

2004

Johnston, H., Baker, P.J., Abel, M., Charlton, H.M., Jackson, G., Fleming, L., Kumar, T.R. and O'Shaughnessy, P.J. (2004) Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology, 145, pp. 318-329. (doi: 10.1210/en.2003-1055)

2003

Baker, P.J., Johnston, H., Abel, M., Charlton, H.M. and O'Shaughnessy, P.J. (2003) Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice. Reproductive Biology and Endocrinology, 1(4),

Baker, P.J., Pakarinen, P., Huhtaniemi, I.T., Abel, M.H., Charlton, H.M., Kumar, T.R. and O'Shaughnessy, P.J. (2003) Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSH beta-deficient mice: Role for constitutive FSH receptor activity. Endocrinology, 144, pp. 138-145. (doi: 10.1210/en.2002-220637)

O'Shaughnessy, P.J. , Fleming, L., Baker, P.J., Jackson, G. and Johnston, H. (2003) Identification of developmentally regulated genes in the somatic cells of the mouse testis using serial analysis of gene expression. Biology of Reproduction, 69, pp. 797-808. (doi: 10.1095/biolreprod.103.016899)

O'Shaughnessy, P.J. , Fleming, L.M., Jackson, G., Hochgeschwender, U., Reed, P. and Baker, P.J. (2003) Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. Endocrinology, 144, pp. 3279-3284. (doi: 10.1210/en.2003-0277)

Wang, G.M., O'Shaughnessy, P.J. , Chubb, C., Robaire, B. and Hardy, M.P. (2003) Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse Leydig cells. Endocrinology, 144, pp. 5058-5064. (doi: 10.1210/en.2003-0563)

2002

O'Shaughnessy, P.J. , Johnston, H., Willerton, L. and Baker, P.J. (2002) Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. Journal of Cell Science, 115, pp. 3491-3496.

O'Shaughnessy, P.J. , Willerton, L. and Baker, P.J. (2002) Changes in Leydig cell gene expression during development in the mouse. Biology of Reproduction, 66, pp. 966-975.

2001

Baker, P.J. and O'Shaughnessy, P.J. (2001) Expression of prostaglandin D synthetase during development in the mouse testis. Reproduction, 122, pp. 553-559.

Baker, P.J. and O'Shaughnessy, P.J. (2001) Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice. Reproduction, 122, pp. 227-234.

O'shaughnessy, P. (2001) Ovarian function and FSH receptor characteristics during canine anoestrus. Journal of Reproduction and Fertility Supplement, 57(.), pp. 3-10.

Articles

Lawrence, B. M., O'Donnell, L., Gannon, A.‐L., Smith, S., Curley, M. K., Darbey, A., Mackay, R., O'Shaughnessy, P. J. , Smith, L. B. and Rebourcet, D. (2024) Compensatory mechanisms that maintain androgen production in mice lacking key androgen biosynthetic enzymes. FASEB Journal, 38(22), e70177. (doi: 10.1096/fj.202402093r) (PMID:39556387)

Lucendo-Villarin, B. et al. (2020) Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells. EXCLI Journal, 19, pp. 1459-1476. (doi: 10.17179/excli2020-2934) (PMID:33312107) (PMCID:PMC7726493)

Rebourcet, D., Monteiro, A., Cruickshanks, L., Jeffery, N., Smith, S., Milne, L., O'Shaughnessy, P. J. and Smith, L. B. (2019) Relationship of transcriptional markers to Leydig cell number in the mouse testis. PLoS ONE, 14(7), e0219524. (doi: 10.1371/journal.pone.0219524) (PMID:31291327) (PMCID:PMC6619764)

O'Shaughnessy, P. J. , Mitchell, R. T., Monteiro, A., O'Hara, L., Cruickshanks, L., Claahsen-van der Grinten, H., Brown, P., Abel, M. and Smith, L. B. (2019) Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis. BMC Developmental Biology, 19, 8. (doi: 10.1186/s12861-019-0189-5) (PMID:30995907) (PMCID:PMC6472051)

Filis, P. et al. (2019) Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males. Environment International, 124, pp. 98-108. (doi: 10.1016/j.envint.2019.01.003) (PMID:30641261)

Walker, N., Filis, P., O'Shaughnessy, P. J. , Bellingham, M. and Fowler, P. A. (2019) Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking. Placenta, 78, pp. 10-17. (doi: 10.1016/j.placenta.2019.02.010) (PMID:PMC6461130) (PMCID:PMC6461130)

O'Shaughnessy, P. J. et al. (2019) Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biology, 17(2), e3000002. (doi: 10.1371/journal.pbio.3000002) (PMID:30763313) (PMCID:PMC6375548)

Dominoni, D. M. , de Jong, M., Bellingham, M. , O'Shaughnessy, P. , van Oers, K., Robinson, J. , Smith, B., Visser, M. E. and Helm, B. (2018) Dose-response effects of light at night on the reproductive physiology of great tits (Parus major): integrating morphological analyses with candidate gene expression. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology, 329(8-9), pp. 473-487. (doi: 10.1002/jez.2214) (PMID:30058288) (PMCID:PMC6220976)

O'Hara, L., O'Shaughnessy, P. J. , Freeman, T. C. and Smith, L. B. (2018) Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies. BMC Research Notes, 11, 252. (doi: 10.1186/s13104-018-3365-y) (PMID:29690918) (PMCID:PMC5937803)

Johnston, Z. C. et al. (2018) The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester. BMC Medicine, 16, 23. (doi: 10.1186/s12916-018-1009-7) (PMID:29429410) (PMCID:PMC5808459)

Soffientini, U., Rebourcet, D., Abel, M.H., Lee, S., Hamilton, G., Fowler, P.A., Smith, L.B. and O'Shaughnessy, P.J. (2017) Identification of Sertoli cell-specific transcripts in the mouse testis and the role of FSH and androgen in the control of Sertoli cell activity. BMC Genomics, 18, 972. (doi: 10.1186/s12864-017-4357-3) (PMID:29246116) (PMCID:PMC5731206)

Lucendo-Villarin, B., Filis, P., Swortwood, M. J., Huestis, M. A., Meseguer-Ripolles, J., Cameron, K., Iredale, J. P., O'Shaughnessy, P. , Fowler, P. A. and Hay, D. C. (2017) Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells. Archives of Toxicology, 91(11), pp. 3633-3643. (doi: 10.1007/s00204-017-1983-0) (PMID:28510779) (PMCID:PMC5696490)

Lucendo-Villarin, B., Filis, P., Swortwood, M. J., Huestis, M. A., Meseguer-Ripolles, J., Cameron, K., Iredale, J. P., O'Shaughnessy, P. J. , Fowler, P. A. and Hay, D. C. (2017) Erratum to: Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells. Archives of Toxicology, 91(11), p. 3645. (doi: 10.1007/s00204-017-2030-x) (PMID:28733887)

Rebourcet, D., Darbey, A., Monteiro, A., Soffientini, U., Tsai, Y. T., Handel, I., Pitetti, J.-L., Nef, S., Smith, L. B. and O'Shaughnessy, P. J. (2017) Sertoli cell number defines, and predicts, germ and Leydig cell population sizes in the adult mouse testis. Endocrinology, 158(9), pp. 2955-2969. (doi: 10.1210/en.2017-00196) (PMID:28911170) (PMCID:PMC5659676)

Capilla-Lasheras, P. , Dominoni, D. M. , Babayan, S. A. , O'Shaughnessy, P. J. , Mladenova, M., Woodford, L., Pollock, C. J., Barr, T., Baldini, F. and Helm, B. (2017) Elevated immune gene expression is associated with poor reproductive success of urban blue tits. Frontiers in Ecology and Evolution, 5, 64. (doi: 10.3389/fevo.2017.00064)

Walker, N., Filis, P., Soffientini, U., Bellingham, M. , O'Shaughnessy, P. J. and Fowler, P. A. (2017) Placental transporter localization and expression in the human: the importance of species, sex and gestational age differences. Biology of Reproduction, 96(4), pp. 733-742. (doi: 10.1093/biolre/iox012) (PMID:28339967)

Murray, J.-A. M. D. , Brown, S., O'Shaughnessy, P. , Monteiro, A., Warren, H. and Hastie, P. M. (2017) Effect of live yeast culture supplementation on fibrolytic and saccharolytic bacterial populations in the feces of horses fed a high-fiber or high-starch diet. Journal of Equine Veterinary Science, 51, pp. 41-45. (doi: 10.1016/j.jevs.2016.12.009)

Huuskonen, P. et al. (2016) The human placental proteome is affected by maternal smoking. Reproductive Toxicology, 63, pp. 22-31. (doi: 10.1016/j.reprotox.2016.05.009) (PMID:27189315) (PMCID:PMC4991937)

Rebourcet, D. et al. (2016) Sertoli cells modulate testicular vascular network development, structure, and function to influence circulating testosterone concentrations in adult male mice. Endocrinology, 157(6), pp. 2479-2488. (doi: 10.1210/en.2016-1156) (PMID:27145015) (PMCID:PMC4891787)

Fowler, P. A., Drake, A. J., O'Shaughnessy, P. J. , Bhattacharya, S., Raab, A., Sinclair, K. D., Feldmann, J. and Meharg, A. A. (2016) Comment on “Effects of arsenite during fetal development on energy metabolism and susceptibility to diet-induced fatty liver diseases in male mice” and “Mechanisms underlying latent disease risk associated with early-life arsenic exposure: current trends and scientific gaps”. Environmental Health Perspectives, 124(6), A99. (doi: 10.1289/ehp.1611345)

Fowler, P. A., Filis, P., Bhattacharya, S., le Bizec, B., Antignac, J.-P., Morvan, M.-L., Drake, A. J., Soffientini, U. and O'Shaughnessy, P. (2016) Human anogenital distance: an update on fetal smoke-exposure and integration of the perinatal literature on sex differences. Human Reproduction, 31(2), pp. 463-472. (doi: 10.1093/humrep/dev323) (PMID:26732622) (PMCID:PMC4716811)

Smith, L. B., O'Shaughnessy, P. and Rebourcet, D. (2015) Cell-specific ablation in the testis: what have we learned? Andrology, 3(6), pp. 1035-1049. (doi: 10.1111/andr.12107) (PMID:26446427)

O'Shaughnessy, P. and Fowler, P.A. (2015) Aspects of UGT2B15 in the human. Toxicological Sciences, 143(2), p. 230. (doi: 10.1093/toxsci/kfu263) (PMID:25628400)

Drake, A. J. et al. (2015) In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13(18), (doi: 10.1186/s12916-014-0251-x)

Filis, P., Nagrath, N., Fraser, M., Hay, D. C., Iredale, J. P., O'Shaughnessy, P. and Fowler, P. A. (2015) Maternal smoking dysregulates protein expression in second trimester human fetal livers in a sex-specific manner. Journal of Clinical Endocrinology and Metabolism, 100(6), E861-E870. (doi: 10.1210/jc.2014-3941) (PMID:25803269) (PMCID:PMC4533306)

Benato, L., Hastie, P. , O'Shaughnessy, P. , Murray, J.-A. and Meredith, A. (2014) Effects of probioticEnterococcus faeciumandSaccharomyces cerevisiaeon the faecal microflora of pet rabbits. Journal of Small Animal Practice, 55(9), pp. 442-446. (doi: 10.1111/jsap.12242) (PMID:24961954)

Rebourcet, D., O'Shaughnessy, P. J. , Monteiro, A., Milne, L., Cruickshanks, L., Jeffrey, N., Guillou, F., Freeman, T. C., Mitchell, R. T. and Smith, L. B. (2014) Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS ONE, 9(8), e105687. (doi: 10.1371/journal.pone.0105687) (PMID:25144714) (PMCID:PMC4140823)

O'Shaughnessy, P.J. , Monteiro, A., Fowler, P.A. and Morris, I.D. (2014) Identification of Leydig cell-specific mRNA transcripts in the adult rat testis. Reproduction, 147(5), pp. 671-682. (doi: 10.1530/REP-13-0603)

O'Shaughnessy, P. J. (2014) Hormonal control of germ cell development and spermatogenesis. Seminars in Cell and Developmental Biology, 29, pp. 55-65. (doi: 10.1016/j.semcdb.2014.02.010)

O'Shaughnessy, P. J. and Fowler, P. A. (2014) Development of the human fetal testis. Annales d'Endocrinologie, 75(2), pp. 48-53. (doi: 10.1016/j.ando.2014.03.009)

Rebourcet, D. et al. (2014) Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis. Development, 141(10), pp. 2139-2149. (doi: 10.1242/dev.107029) (PMID:24803659) (PMCID:PMC4011090)

Fowler, P. A. et al. (2014) In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. Human Reproduction, 29(7), pp. 1471-1489. (doi: 10.1093/humrep/deu117) (PMID:24847019)

Fowler, P.A. and O'Shaughnessy, P.J. (2013) The Goldilocks principle and developmental androgens in males, what is "just right"? Endocrinology, 154(5), pp. 1669-1671. (doi: 10.1210/en.2013-1279)

Oldknow, K.J., Seebacher, J., Goswami, T., Villen, J., Pitsillides, A.A., O'Shaughnessy, P.J. , Gygi, S.P., Schneyer, A.L. and Mukherjee, A. (2013) Follistatin-like 3 (FSTL3) mediated silencing of transforming growth factor (TGF ) signaling is essential for testicular aging and regulating testis size. Endocrinology, 154(3), pp. 1310-1320. (doi: 10.1210/en.2012-1886)

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S., Fraser, M.J. and Fowler, P.A. (2013) Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. Molecular Human Reproduction, 19(3), pp. 177-187. (doi: 10.1093/molehr/gas059)

Fowler, P. A. et al. (2012) Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Molecular and Cellular Endocrinology, 355(2), pp. 231-239. (doi: 10.1016/j.mce.2011.10.021) (PMID:22061620)

O'Shaughnessy, P.J. , Monteiro, A. and Abel, M. (2012) Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. PLoS ONE, 7(4), e35136. (doi: 10.1371/journal.pone.0035136) (PMID:22514715) (PMCID:PMC3325994)

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S. and Fowler, P.A. (2011) Maternal Smoking and Fetal Sex Significantly Affect Metabolic Enzyme Expression in the Human Fetal Liver. Journal of Clinical Endocrinology and Metabolism, 96(9), pp. 2851-2860. (doi: 10.1210/jc.2011-1437)

Fowler, P.A. et al. (2011) Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary. Journal of Clinical Endocrinology and Metabolism, 96(6), pp. 1754-1762. (doi: 10.1210/jc.2010-2618)

Fowler, P.A., Bhattacharya, S., Flannigan, S., Drake, A.J. and O'Shaughnessy, P.J. (2011) Maternal cigarette smoking and effects on androgen action in male offspring: unexpected effects on second-trimester anogenital distance. Journal of Clinical Endocrinology and Metabolism, 96(9), E1502-E1506. (doi: 10.1210/jc.2011-1100)

O'Shaughnessy, P. J. and Fowler, P. A. (2011) Endocrinology of the mammalian fetal testis. Reproduction, 141(1), pp. 37-46. (doi: 10.1530/REP-10-0365)

O'Shaughnessy, P.J. , Monteiro, A. and Fowler, P.A. (2011) Identification of stable endogenous reference genes for real-time PCR in the human fetal gonad using an external standard technique. Molecular Human Reproduction, 17(10), pp. 620-625. (doi: 10.1093/molehr/gar032)

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

Hu, Z., Dandekar, D., O'Shaughnessy, P.J. , De Gendt, K., Verhoeven, G. and Wilkinson, M.F. (2010) Androgen-induced rhox homeobox genes modulate the expression of AR-regulated genes. Molecular Endocrinology, 24(1), pp. 60-75. (doi: 10.1210/me.2009-0303)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

Hu, Z.Y., Dandekar, D., O'Shaughnessy, P.J. , De Gendt, K., Verhoeven, G. and Wilkinson, M. (2010) Androgen-Induced Rhox Homeobox Genes Modulate the Expression of AR-Regulated Genes. Molecular Endocrinology, 24(1), pp. 60-75. (doi: 10.1210/me.2009-0303)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

O'Shaughnessy, P.J. , Morris, I.D., Huhtaniemi, I., Baker, P.J. and Abel, M.H. (2009) Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice. Molecular and Cellular Endocrinology, 306(1-2), pp. 2-8. (doi: 10.1016/j.mce.2008.11.005)

Abel, M.H., Baban, D., Lee, S., Charlton, H.M. and O'Shaughnessy, P.J. (2009) Effects of FSH on testicular mRNA transcript levels in the hypogonadal mouse. Journal of Molecular Endocrinology, 42(4), pp. 291-303. (doi: 10.1677/JME-08-0107)

Ayres, J., Rhind, S.M., O'Shaughnessy, P.J. and Fowler, P.A. (2009) PAH exposure. Environmental Health Perspectives, 117(4), A140. (doi: 10.1289/ehp.0800445)

Fowler, P.A., Bhattacharya, S., Gromoll, J., Monteiro, A. and O'Shaughnessy, P.J. (2009) Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis. Journal of Clinical Endocrinology and Metabolism, 94(12), pp. 4688-4695. (doi: 10.1210/jc.2009-0994)

Fowler, P.A. et al. (2009) Gene Expression Analysis of Human Fetal Ovarian Primordial Follicle Formation. Journal of Clinical Endocrinology and Metabolism, 94(4), pp. 1427-1435. (doi: 10.1210/jc.2008-2619)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2009) Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice. Reproductive Biology and Endocrinology, 7, p. 88. (doi: 10.1186/1477-7827-7-88)

O'Shaughnessy, P.J. , Morris, I.D., Huhtaniemi, I., Baker, P.J. and Abel, M.H. (2009) Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: Data from mutant and genetically modified mice. Molecular and Cellular Endocrinology, 306(1-2), pp. 2-8. (doi: 10.1016/j.mce.2008.11.005)

Abel, M.H., Baker, P.J., Charlton, H.M., Monteiro, A., Verhoeven, G., De Gendt, K., Guillou, F. and O'Shaughnessy, P.J. (2008) Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen. Endocrinology, 149(7), pp. 3279-3285. (doi: 10.1210/en.2008-0086)

Fowler, P.A., Cassie, S., Rhind, S.M., Brewer, M.J., Collinson, J.M., Lea, R.G., Baker, P.J., Bhattacharya, S. and O'Shaughnessy, P.J. (2008) Maternal smoking during pregnancy specifically reduces human fetal desert hedgehog gene expression during testis development. Journal of Clinical Endocrinology and Metabolism, 93(2), pp. 619-626. (doi: 10.1210/jc.2007-1860)

Mihm Carmichael, M., Baker, P.J., Fleming, L.M., Monteiro, A.M. and O'Shaughnessy, P.J. (2008) Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes. Reproduction, 135(2), pp. 253-265. (doi: 10.1530/REP-06-0193) (PMID:18239053)

O'Shaughnessy, P. J. , Hu, L. and Baker, P. J. (2008) Effect of germ cell depletion on levels of specific mRNA transcripts in mouse Sertoli cells and Leydig cells. Reproduction, 135(6), pp. 839-850. (doi: 10.1530/REP-08-0012)

O'Shaughnessy, P. J. , Morris, I. D. and Baker, P. J. (2008) Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. Reproduction, 135(6), pp. 851-858. (doi: 10.1530/REP-07-0529)

Hu, L., Monteiro, A., Johnston, H., King, P. and O'Shaughnessy, P.J. (2007) Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Reproduction, 134, pp. 585-591. (doi: 10.1530/REP-07-0133)

Johnston, H., King, P.J. and O'Shaughnessy, P.J. (2007) Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis. Reproduction, 133, pp. 1181-1187. (doi: 10.1530/REP-06-0359)

O'shaughnessy, P. (2007) Developmental Changes in Human Fetal Testicular Cell Numbers and mRNA Levels During the Second Trimester. Journal of Clinical Endocrinology and Metabolism, 92(12), pp. 4792-4801.

O'Shaughnessy, P.J. , Abel, M., Charlton, H.M., Hu, B., Johnston, H. and Baker, P.J. (2007) Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive Tfm mouse testis. Endocrinology, 148, pp. 2914-2924. (doi: 10.1210/en.2006-1412)

Noon, L.A., Bakmanidis, A., Clark, A.J.L., O'Shaughnessy, P.J. and King, P.J. (2006) Identification of a novel melanocortin 2 receptor splice variant in murine adipocytes: implications for post-transcriptional control of expression during adipogenesis. Journal of Molecular Endocrinology, 37, pp. 415-420. (doi: 10.1677/jme.1.02023)

Noon, L.A., Clark, A.J.L., O'Shaughnessy, P.J. and King, P.J. (2006) A CCAAT/enhancer-binding protein site at-87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis. Endocrinology, 147, pp. 6019-6026. (doi: 10.1210/en.2006-0867)

O'Shaughnessy, P.J. , Baker, P.J. and Johnston, H. (2006) The foetal Leydig cell - differentiation, function and regulation. International Journal of Andrology, 29, pp. 90-95. (doi: 10.1111/j.1365-2605.2005.00555.x)

O'Shaughnessy, P.J. , Baker, P.J. and Johnston, H. (2005) Neuroendocrine regulation of Leydig cell development. Testicular Cell Dynamics and Endocrine Signaling, 1061, pp. 109-119. (doi: 10.1196/annals.1336.013)

Johnston, H., Baker, P.J., Abel, M., Charlton, H.M., Jackson, G., Fleming, L., Kumar, T.R. and O'Shaughnessy, P.J. (2004) Regulation of Sertoli cell number and activity by follicle-stimulating hormone and androgen during postnatal development in the mouse. Endocrinology, 145, pp. 318-329. (doi: 10.1210/en.2003-1055)

Baker, P.J., Johnston, H., Abel, M., Charlton, H.M. and O'Shaughnessy, P.J. (2003) Differentiation of adult-type Leydig cells occurs in gonadotrophin-deficient mice. Reproductive Biology and Endocrinology, 1(4),

Baker, P.J., Pakarinen, P., Huhtaniemi, I.T., Abel, M.H., Charlton, H.M., Kumar, T.R. and O'Shaughnessy, P.J. (2003) Failure of normal Leydig cell development in follicle-stimulating hormone (FSH) receptor-deficient mice, but not FSH beta-deficient mice: Role for constitutive FSH receptor activity. Endocrinology, 144, pp. 138-145. (doi: 10.1210/en.2002-220637)

O'Shaughnessy, P.J. , Fleming, L., Baker, P.J., Jackson, G. and Johnston, H. (2003) Identification of developmentally regulated genes in the somatic cells of the mouse testis using serial analysis of gene expression. Biology of Reproduction, 69, pp. 797-808. (doi: 10.1095/biolreprod.103.016899)

O'Shaughnessy, P.J. , Fleming, L.M., Jackson, G., Hochgeschwender, U., Reed, P. and Baker, P.J. (2003) Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. Endocrinology, 144, pp. 3279-3284. (doi: 10.1210/en.2003-0277)

Wang, G.M., O'Shaughnessy, P.J. , Chubb, C., Robaire, B. and Hardy, M.P. (2003) Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse Leydig cells. Endocrinology, 144, pp. 5058-5064. (doi: 10.1210/en.2003-0563)

O'Shaughnessy, P.J. , Johnston, H., Willerton, L. and Baker, P.J. (2002) Failure of normal adult Leydig cell development in androgen-receptor-deficient mice. Journal of Cell Science, 115, pp. 3491-3496.

O'Shaughnessy, P.J. , Willerton, L. and Baker, P.J. (2002) Changes in Leydig cell gene expression during development in the mouse. Biology of Reproduction, 66, pp. 966-975.

Baker, P.J. and O'Shaughnessy, P.J. (2001) Expression of prostaglandin D synthetase during development in the mouse testis. Reproduction, 122, pp. 553-559.

Baker, P.J. and O'Shaughnessy, P.J. (2001) Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice. Reproduction, 122, pp. 227-234.

O'shaughnessy, P. (2001) Ovarian function and FSH receptor characteristics during canine anoestrus. Journal of Reproduction and Fertility Supplement, 57(.), pp. 3-10.

Book Sections

Rebourcet, D., Darbey, A., Curley, M., O'Shaughnessy, P. and Smith, L. B. (2018) Testicular cell selective ablation using diphtheria toxin receptor transgenic mice. In: Alves, M. G. and Oliveira, P. F. (eds.) Steroli Cells. Series: Methods in molecular biology (1748). Humana Press: New York, NY, pp. 203-228. ISBN 9781493976973 (doi: 10.1007/978-1-4939-7698-0_15)

Conference or Workshop Item

Bulmer, L., Murray, J.M.D. , Burns, N., Garber, A. , McEwan, N., O'Shaughnessy, P. , Hemmings, A., Ewans, N., Monteiro, A. and Hastie, P.M. (2019) Development of Methods to Investigate the Mechanisms Behind Increased Behavioural Reactivity Associated with an Increased-Starch Diet. Equine Science Symposium, NC, USA, 03-06 Jun 2019.