2023

Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Padmanabhan, V., Lea, R., Sinclair, K. D., Evans, N. P. and Bellingham, M. (2023) Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood. Environmental Toxicology and Pharmacology, 100, 104152. (doi: 10.1016/j.etap.2023.104152) (PMID:37209889)

2022

Elcombe, C. S., Monteiro, A., Elcombe, M. R., Ghasemzadeh-Hasankolaei, M., Sinclair, K. D., Lea, R., Padmanabhan, V., Evans, N. P. and Bellingham, M. (2022) Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs. Environmental Toxicology and Pharmacology, 94, 103913. (doi: 10.1016/j.etap.2022.103913) (PMID:35738462)

2021

Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Evans, N. P. and Bellingham, M. (2021) Morphological and transcriptomic alterations in neonatal lamb testes following developmental exposure to low-level environmental chemical mixture. Environmental Toxicology and Pharmacology, 86, 103670. (doi: 10.1016/j.etap.2021.103670) (PMID:33964400) (PMCID:PMC8316325)

2019

Rebourcet, D., Monteiro, A., Cruickshanks, L., Jeffery, N., Smith, S., Milne, L., O'Shaughnessy, P. J. and Smith, L. B. (2019) Relationship of transcriptional markers to Leydig cell number in the mouse testis. PLoS ONE, 14(7), e0219524. (doi: 10.1371/journal.pone.0219524) (PMID:31291327) (PMCID:PMC6619764)

O'Shaughnessy, P. J. , Mitchell, R. T., Monteiro, A., O'Hara, L., Cruickshanks, L., Claahsen-van der Grinten, H., Brown, P., Abel, M. and Smith, L. B. (2019) Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis. BMC Developmental Biology, 19, 8. (doi: 10.1186/s12861-019-0189-5) (PMID:30995907) (PMCID:PMC6472051)

O'Shaughnessy, P. J. et al. (2019) Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biology, 17(2), e3000002. (doi: 10.1371/journal.pbio.3000002) (PMID:30763313) (PMCID:PMC6375548)

Bulmer, L., Murray, J.M.D. , Burns, N., Garber, A. , McEwan, N., O'Shaughnessy, P. , Hemmings, A., Ewans, N., Monteiro, A. and Hastie, P.M. (2019) Development of Methods to Investigate the Mechanisms Behind Increased Behavioural Reactivity Associated with an Increased-Starch Diet. Equine Science Symposium, NC, USA, 03-06 Jun 2019.

2017

Rebourcet, D., Darbey, A., Monteiro, A., Soffientini, U., Tsai, Y. T., Handel, I., Pitetti, J.-L., Nef, S., Smith, L. B. and O'Shaughnessy, P. J. (2017) Sertoli cell number defines, and predicts, germ and Leydig cell population sizes in the adult mouse testis. Endocrinology, 158(9), pp. 2955-2969. (doi: 10.1210/en.2017-00196) (PMID:28911170) (PMCID:PMC5659676)

Murray, J.-A. M. D. , Brown, S., O'Shaughnessy, P. , Monteiro, A., Warren, H. and Hastie, P. M. (2017) Effect of live yeast culture supplementation on fibrolytic and saccharolytic bacterial populations in the feces of horses fed a high-fiber or high-starch diet. Journal of Equine Veterinary Science, 51, pp. 41-45. (doi: 10.1016/j.jevs.2016.12.009)

2015

Drake, A. J. et al. (2015) In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13(18), (doi: 10.1186/s12916-014-0251-x)

2014

Rebourcet, D., O'Shaughnessy, P. J. , Monteiro, A., Milne, L., Cruickshanks, L., Jeffrey, N., Guillou, F., Freeman, T. C., Mitchell, R. T. and Smith, L. B. (2014) Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS ONE, 9(8), e105687. (doi: 10.1371/journal.pone.0105687) (PMID:25144714) (PMCID:PMC4140823)

O'Shaughnessy, P.J. , Monteiro, A., Fowler, P.A. and Morris, I.D. (2014) Identification of Leydig cell-specific mRNA transcripts in the adult rat testis. Reproduction, 147(5), pp. 671-682. (doi: 10.1530/REP-13-0603)

Rebourcet, D. et al. (2014) Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis. Development, 141(10), pp. 2139-2149. (doi: 10.1242/dev.107029) (PMID:24803659) (PMCID:PMC4011090)

Fowler, P. A. et al. (2014) In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. Human Reproduction, 29(7), pp. 1471-1489. (doi: 10.1093/humrep/deu117) (PMID:24847019)

2013

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S., Fraser, M.J. and Fowler, P.A. (2013) Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. Molecular Human Reproduction, 19(3), pp. 177-187. (doi: 10.1093/molehr/gas059)

2012

Sandercock, D.A., Monteiro, A., Scott, E.M. and Nolan, A.M. (2012) The effect of tail-docking neonate piglets on ATF-3 and NR2B immunoreactivity in coccygeal dorsal root ganglia and spinal cord dorsal horn neurons: preliminary data. Scandinavian Journal of Pain, 3(3), pp. 184-185. (doi: 10.1016/j.sjpain.2012.05.031)

O'Shaughnessy, P.J. , Monteiro, A. and Abel, M. (2012) Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. PLoS ONE, 7(4), e35136. (doi: 10.1371/journal.pone.0035136) (PMID:22514715) (PMCID:PMC3325994)

2011

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S. and Fowler, P.A. (2011) Maternal Smoking and Fetal Sex Significantly Affect Metabolic Enzyme Expression in the Human Fetal Liver. Journal of Clinical Endocrinology and Metabolism, 96(9), pp. 2851-2860. (doi: 10.1210/jc.2011-1437)

Fowler, P.A. et al. (2011) Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary. Journal of Clinical Endocrinology and Metabolism, 96(6), pp. 1754-1762. (doi: 10.1210/jc.2010-2618)

O'Shaughnessy, P.J. , Monteiro, A. and Fowler, P.A. (2011) Identification of stable endogenous reference genes for real-time PCR in the human fetal gonad using an external standard technique. Molecular Human Reproduction, 17(10), pp. 620-625. (doi: 10.1093/molehr/gar032)

2010

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

2009

Fowler, P.A., Bhattacharya, S., Gromoll, J., Monteiro, A. and O'Shaughnessy, P.J. (2009) Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis. Journal of Clinical Endocrinology and Metabolism, 94(12), pp. 4688-4695. (doi: 10.1210/jc.2009-0994)

Fowler, P.A. et al. (2009) Gene Expression Analysis of Human Fetal Ovarian Primordial Follicle Formation. Journal of Clinical Endocrinology and Metabolism, 94(4), pp. 1427-1435. (doi: 10.1210/jc.2008-2619)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2009) Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice. Reproductive Biology and Endocrinology, 7, p. 88. (doi: 10.1186/1477-7827-7-88)

2008

Abel, M.H., Baker, P.J., Charlton, H.M., Monteiro, A., Verhoeven, G., De Gendt, K., Guillou, F. and O'Shaughnessy, P.J. (2008) Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen. Endocrinology, 149(7), pp. 3279-3285. (doi: 10.1210/en.2008-0086)

Mihm Carmichael, M., Baker, P.J., Fleming, L.M., Monteiro, A.M. and O'Shaughnessy, P.J. (2008) Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes. Reproduction, 135(2), pp. 253-265. (doi: 10.1530/REP-06-0193) (PMID:18239053)

2007

Ellis, K.A., Monteiro, A., Innocent, G., Grove-White, D., Cripps, P., McLean, W.G., Howard, C.V. and Mihmz, M. (2007) Investigation of the vitamins A and E and beta-carotene content in milk from UK organic and conventional dairy farms. Journal of Dairy Research, 74(4), pp. 484-491. (doi: 10.1017/S0022029907002816)

O'Shaughnessy, P.J., Baker, P.J., Monteiro, A., Cassie, S., Bhattacharya, S. and Fowler, P.,A., (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. Journal of Clinical Endocrinology and Metabolism, 92(12), pp. 4792-4801. (doi: 10.1210/jc.2007-1690)

2001

Beths, T., Glen, J.B., Reid, J., Monteiro, A.M. and Nolan, A.M. (2001) Evaluation and optimisation of a target-controlled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery. Veterinary Record, 148(7), pp. 198-203. (doi: 10.1136/vr.148.7.198)

Articles

Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Padmanabhan, V., Lea, R., Sinclair, K. D., Evans, N. P. and Bellingham, M. (2023) Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood. Environmental Toxicology and Pharmacology, 100, 104152. (doi: 10.1016/j.etap.2023.104152) (PMID:37209889)

Elcombe, C. S., Monteiro, A., Elcombe, M. R., Ghasemzadeh-Hasankolaei, M., Sinclair, K. D., Lea, R., Padmanabhan, V., Evans, N. P. and Bellingham, M. (2022) Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs. Environmental Toxicology and Pharmacology, 94, 103913. (doi: 10.1016/j.etap.2022.103913) (PMID:35738462)

Elcombe, C. S., Monteiro, A., Ghasemzadeh-Hasankolaei, M., Evans, N. P. and Bellingham, M. (2021) Morphological and transcriptomic alterations in neonatal lamb testes following developmental exposure to low-level environmental chemical mixture. Environmental Toxicology and Pharmacology, 86, 103670. (doi: 10.1016/j.etap.2021.103670) (PMID:33964400) (PMCID:PMC8316325)

Rebourcet, D., Monteiro, A., Cruickshanks, L., Jeffery, N., Smith, S., Milne, L., O'Shaughnessy, P. J. and Smith, L. B. (2019) Relationship of transcriptional markers to Leydig cell number in the mouse testis. PLoS ONE, 14(7), e0219524. (doi: 10.1371/journal.pone.0219524) (PMID:31291327) (PMCID:PMC6619764)

O'Shaughnessy, P. J. , Mitchell, R. T., Monteiro, A., O'Hara, L., Cruickshanks, L., Claahsen-van der Grinten, H., Brown, P., Abel, M. and Smith, L. B. (2019) Androgen receptor expression is required to ensure development of adult Leydig cells and to prevent development of steroidogenic cells with adrenal characteristics in the mouse testis. BMC Developmental Biology, 19, 8. (doi: 10.1186/s12861-019-0189-5) (PMID:30995907) (PMCID:PMC6472051)

O'Shaughnessy, P. J. et al. (2019) Alternative (backdoor) androgen production and masculinization in the human fetus. PLoS Biology, 17(2), e3000002. (doi: 10.1371/journal.pbio.3000002) (PMID:30763313) (PMCID:PMC6375548)

Rebourcet, D., Darbey, A., Monteiro, A., Soffientini, U., Tsai, Y. T., Handel, I., Pitetti, J.-L., Nef, S., Smith, L. B. and O'Shaughnessy, P. J. (2017) Sertoli cell number defines, and predicts, germ and Leydig cell population sizes in the adult mouse testis. Endocrinology, 158(9), pp. 2955-2969. (doi: 10.1210/en.2017-00196) (PMID:28911170) (PMCID:PMC5659676)

Murray, J.-A. M. D. , Brown, S., O'Shaughnessy, P. , Monteiro, A., Warren, H. and Hastie, P. M. (2017) Effect of live yeast culture supplementation on fibrolytic and saccharolytic bacterial populations in the feces of horses fed a high-fiber or high-starch diet. Journal of Equine Veterinary Science, 51, pp. 41-45. (doi: 10.1016/j.jevs.2016.12.009)

Drake, A. J. et al. (2015) In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver. BMC Medicine, 13(18), (doi: 10.1186/s12916-014-0251-x)

Rebourcet, D., O'Shaughnessy, P. J. , Monteiro, A., Milne, L., Cruickshanks, L., Jeffrey, N., Guillou, F., Freeman, T. C., Mitchell, R. T. and Smith, L. B. (2014) Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS ONE, 9(8), e105687. (doi: 10.1371/journal.pone.0105687) (PMID:25144714) (PMCID:PMC4140823)

O'Shaughnessy, P.J. , Monteiro, A., Fowler, P.A. and Morris, I.D. (2014) Identification of Leydig cell-specific mRNA transcripts in the adult rat testis. Reproduction, 147(5), pp. 671-682. (doi: 10.1530/REP-13-0603)

Rebourcet, D. et al. (2014) Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis. Development, 141(10), pp. 2139-2149. (doi: 10.1242/dev.107029) (PMID:24803659) (PMCID:PMC4011090)

Fowler, P. A. et al. (2014) In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling. Human Reproduction, 29(7), pp. 1471-1489. (doi: 10.1093/humrep/deu117) (PMID:24847019)

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S., Fraser, M.J. and Fowler, P.A. (2013) Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy. Molecular Human Reproduction, 19(3), pp. 177-187. (doi: 10.1093/molehr/gas059)

Sandercock, D.A., Monteiro, A., Scott, E.M. and Nolan, A.M. (2012) The effect of tail-docking neonate piglets on ATF-3 and NR2B immunoreactivity in coccygeal dorsal root ganglia and spinal cord dorsal horn neurons: preliminary data. Scandinavian Journal of Pain, 3(3), pp. 184-185. (doi: 10.1016/j.sjpain.2012.05.031)

O'Shaughnessy, P.J. , Monteiro, A. and Abel, M. (2012) Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. PLoS ONE, 7(4), e35136. (doi: 10.1371/journal.pone.0035136) (PMID:22514715) (PMCID:PMC3325994)

O'Shaughnessy, P.J. , Monteiro, A., Bhattacharya, S. and Fowler, P.A. (2011) Maternal Smoking and Fetal Sex Significantly Affect Metabolic Enzyme Expression in the Human Fetal Liver. Journal of Clinical Endocrinology and Metabolism, 96(9), pp. 2851-2860. (doi: 10.1210/jc.2011-1437)

Fowler, P.A. et al. (2011) Development of steroid signaling pathways during primordial follicle formation in the human fetal ovary. Journal of Clinical Endocrinology and Metabolism, 96(6), pp. 1754-1762. (doi: 10.1210/jc.2010-2618)

O'Shaughnessy, P.J. , Monteiro, A. and Fowler, P.A. (2011) Identification of stable endogenous reference genes for real-time PCR in the human fetal gonad using an external standard technique. Molecular Human Reproduction, 17(10), pp. 620-625. (doi: 10.1093/molehr/gar032)

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

O'Shaughnessy, P.J. , Verhoeven, G., De Gendt, K., Monteiro, A. and Abel, M.H. (2010) Direct action through the Sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology, 151(5), pp. 2343-2348. (doi: 10.1210/en.2009-1333)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2010) Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction, 139(1), pp. 177-184. (doi: 10.1530/REP-09-0377)

Fowler, P.A., Bhattacharya, S., Gromoll, J., Monteiro, A. and O'Shaughnessy, P.J. (2009) Maternal Smoking and Developmental Changes in Luteinizing Hormone (LH) and the LH Receptor in the Fetal Testis. Journal of Clinical Endocrinology and Metabolism, 94(12), pp. 4688-4695. (doi: 10.1210/jc.2009-0994)

Fowler, P.A. et al. (2009) Gene Expression Analysis of Human Fetal Ovarian Primordial Follicle Formation. Journal of Clinical Endocrinology and Metabolism, 94(4), pp. 1427-1435. (doi: 10.1210/jc.2008-2619)

O'Shaughnessy, P.J. , Monteiro, A., Verhoeven, G., De Gendt, K. and Abel, M.H. (2009) Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice. Reproductive Biology and Endocrinology, 7, p. 88. (doi: 10.1186/1477-7827-7-88)

Abel, M.H., Baker, P.J., Charlton, H.M., Monteiro, A., Verhoeven, G., De Gendt, K., Guillou, F. and O'Shaughnessy, P.J. (2008) Spermatogenesis and sertoli cell activity in mice lacking Sertoli cell receptors for follicle stimulating hormone and androgen. Endocrinology, 149(7), pp. 3279-3285. (doi: 10.1210/en.2008-0086)

Mihm Carmichael, M., Baker, P.J., Fleming, L.M., Monteiro, A.M. and O'Shaughnessy, P.J. (2008) Differentiation of the bovine dominant follicle from the cohort upregulates mRNA expression for new tissue development genes. Reproduction, 135(2), pp. 253-265. (doi: 10.1530/REP-06-0193) (PMID:18239053)

Ellis, K.A., Monteiro, A., Innocent, G., Grove-White, D., Cripps, P., McLean, W.G., Howard, C.V. and Mihmz, M. (2007) Investigation of the vitamins A and E and beta-carotene content in milk from UK organic and conventional dairy farms. Journal of Dairy Research, 74(4), pp. 484-491. (doi: 10.1017/S0022029907002816)

O'Shaughnessy, P.J., Baker, P.J., Monteiro, A., Cassie, S., Bhattacharya, S. and Fowler, P.,A., (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. Journal of Clinical Endocrinology and Metabolism, 92(12), pp. 4792-4801. (doi: 10.1210/jc.2007-1690)

Beths, T., Glen, J.B., Reid, J., Monteiro, A.M. and Nolan, A.M. (2001) Evaluation and optimisation of a target-controlled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery. Veterinary Record, 148(7), pp. 198-203. (doi: 10.1136/vr.148.7.198)

Conference or Workshop Item

Bulmer, L., Murray, J.M.D. , Burns, N., Garber, A. , McEwan, N., O'Shaughnessy, P. , Hemmings, A., Ewans, N., Monteiro, A. and Hastie, P.M. (2019) Development of Methods to Investigate the Mechanisms Behind Increased Behavioural Reactivity Associated with an Increased-Starch Diet. Equine Science Symposium, NC, USA, 03-06 Jun 2019.