Professor Alan Crozier
- Honorary Senior Research Fellow (School of Medicine, Dentistry & Nursing)
email:
Alan.Crozier@glasgow.ac.uk
School of Medicine, Dentistry and Nursing, University of Glasgow, G12 8QQ
Publications
2024
Cáceres-Jiménez, S., Pereira-Caro, G., Dobani, S., Pourshahidi, K., Gill, C. I.R., Moreno-Rojas, J. M., Ordoñez-Díaz, J. L., Almutairi, T. M., Clifford, M. N. and Crozier, A. (2024) Bioavailability of mango (poly)phenols: an evaluation of the impact of the colon, and phenylalanine and tyrosine on the production of phenolic catabolites. Free Radical Biology and Medicine, 225, pp. 605-616. (doi: 10.1016/j.freeradbiomed.2024.10.289) (PMID:39426756)
Pereira-Caro, G. et al. (2024) Colon-available mango (poly)phenols exhibit mitigating effects on the intestinal barrier function in human intestinal cell monolayers under inflammatory conditions. Food and Function, 15(9), pp. 5118-5131. (doi: 10.1039/d4fo00451e) (PMID:38682277)
Clifford, M. N. et al. (2024) Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines. Redox Biology, 71, 103068. (doi: 10.1016/j.redox.2024.103068) (PMID:38377790) (PMCID:PMC10891336)
Agulló, V., Favari, C., Pilla, N., Bresciani, L., Tomás-Barberán, F. A., Crozier, A., Del Rio, D. and Mena, P. (2024) Using targeted metabolomics to unravel phenolic metabolites of plant origin in animal milk. International Journal of Molecular Sciences, 25(8), 4536. (doi: 10.3390/ijms25084536) (PMID:38674121) (PMCID:PMC11050474)
Di Pede, G. et al. (2024) A systematic review and comprehensive evaluation of human intervention studies to unravel the bioavailability of hydroxycinnamic acids. Antioxidants and Redox Signaling, 40(7-9), pp. 510-541. (doi: 10.1089/ars.2023.0254) (PMID:37382416) (PMCID:PMC10960166)
2023
Cáceres-Jiménez, S., Rodríguez-Solana, R., Dobani, S., Pourshahidi, K., Gill, C., Moreno-Rojas, J. M., Almutairi, T. M., Crozier, A. and Pereira-Caro, G. (2023) UHPLC-HRMS spectrometric analysis: method validation and plasma and urinary metabolite identification after mango pulp intake. Journal of Agricultural and Food Chemistry, 71(30), pp. 11520-11533. (doi: 10.1021/acs.jafc.3c03846) (PMID:37471325)
Pereira-Caro, G. et al. (2023) Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids. International Journal of Food Sciences and Nutrition, 74(4), pp. 532-543. (doi: 10.1080/09637486.2023.2226369) (PMID:37369137)
Pereira-Caro, G., Almutairi, T. M., Cáceres-Jiménez, S., Moreno-Rojas, J. M., Malkova, D. , Garcia, A. L. and Crozier, A. (2023) Bioavailability of orange juice (poly)phenols: β-glucan-rich oat bran decreases urinary excretion of flavanone phase II metabolites and enhances excretion of microbiota-derived phenolic catabolites. Free Radical Biology and Medicine, 199, pp. 34-43. (doi: 10.1016/j.freeradbiomed.2023.02.002) (PMID:36764628)
Di Pede, G., Mena, P., Bresciani, L., Almutairi, T. M., Del Rio, D., Clifford, M. N. and Crozier, A. (2023) Human colonic catabolism of dietary flavan-3-ol bioactives. Molecular Aspects of Medicine, 89, 101107. (doi: 10.1016/j.mam.2022.101107) (PMID:35931563)
Di Pede, G. et al. (2023) Revisiting the bioavailability of flavan-3-ols in humans: a systematic review and comprehensive data analysis. Molecular Aspects of Medicine, 89, 101146. (doi: 10.1016/j.mam.2022.101146) (PMID:36207170)
2022
Di Pede, G., Bresciani, L., Brighenti, F., Clifford, M. N., Crozier, A., Del Rio, D. and Mena, P. (2022) In vitro faecal fermentation of monomeric and oligomeric flavan‐3‐ols: catabolic pathways and stoichiometry. Molecular Nutrition and Food Research, 66(21), 2101090. (doi: 10.1002/mnfr.202101090) (PMID:35107868)
Pereira-Caro, G., Almutairi, T. M., Crozier, A., Ordoñez-Díaz, J. L., Moreno-Rojas, J. M., Ortiz-Somovilla, V., Morillo-Santander, G., Lazarova, S., Malkova, D. and Garcia, A. L. (2022) Acute effect of oat β-glucan on the bioavailability of orange juice flavanones. International Journal of Food Sciences and Nutrition, 73(4), pp. 531-537. (doi: 10.1080/09637486.2021.2015572) (PMID:34933644)
2020
Pereira-Caro, G., Clifford, M. N., Polyviou, T., Ludwig, I. A., Alfheeaid, H. , Morena-Rojas, J. M., Garcia, A. L. , Malkova, D. and Crozier, A. (2020) Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men. Free Radical Biology and Medicine, 160, pp. 784-795. (doi: 10.1016/j.freeradbiomed.2020.09.007) (PMID:32927016)
Kay, C. D. et al. (2020) Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites. American Journal of Clinical Nutrition, 112(4), pp. 1051-1068. (doi: 10.1093/ajcn/nqaa204) (PMID:32936878) (PMCID:PMC7528558)
Pereira-Caro, G., Gaillet, S., Ordóñez, J. L., Mena, P., Bresciani, L., Bindon, K. A., Del Rio, D., Rouanet, J.-M., Moreno-Rojas, J. M. and Crozier, A. (2020) Bioavailability of red wine and grape seed proanthocyanidins in rats. Food and Function, 11(5), pp. 3986-4001. (doi: 10.1039/D0FO00350F) (PMID:32347279)
2019
Mena, P. et al. (2019) Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity. Natural Product Reports, 36(5), pp. 714-752. (doi: 10.1039/C8NP00062J) (PMID:30468210)
2018
Williamson, G., Kay, C. D. and Crozier, A. (2018) The bioavailability, transport, and bioactivity of dietary flavonoids: a review from a historical perspective. Comprehensive Reviews in Food Science and Food Safety, 17(5), pp. 1054-1112. (doi: 10.1111/1541-4337.12351)
2017
Pereira-Caro, G., Polyviou, T., Ludwig, I. A., Natase, A.-M., Moreno-Rojas, M., Garcia, A. L. , Malkova, D. and Crozier, A. (2017) Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes. American Journal of Clinical Nutrition, 106(3), pp. 791-800. (doi: 10.3945/ajcn.116.149898) (PMID:28747329)
2016
Borges, G., van der Hooft, J. J.J. and Crozier, A. (2016) A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats. Free Radical Biology and Medicine, 99, pp. 128-138. (doi: 10.1016/j.freeradbiomed.2016.08.001)
Pereira-Caro, G., Ludwig, I. A., Polyviou, T., Malkova, D. , Garcia, A. , Moreno-Rojas, J. M. and Crozier, A. (2016) Identification of plasma and urinary metabolites and catabolites derived from orange juice (poly)phenols: analysis by high-performance liquid chromatography–high-resolution mass spectrometry. Journal of Agricultural and Food Chemistry, 64(28), pp. 5724-5735. (doi: 10.1021/acs.jafc.6b02088) (PMID:27339035)
2015
Ludwig, I. A., Mena, P., Calani, L., Borges, G., Pereira-Caro, G., Bresciani, L., Del Rio, D., Lean, M. E. J. and Crozier, A. (2015) New insights into the bioavailability of red raspberry anthocyanins and ellagitannins. Free Radical Biology and Medicine, 89, pp. 758-769. (doi: 10.1016/j.freeradbiomed.2015.10.400) (PMID:26475039)
Ashihara, H., Ludwig, I. A., Katahira, R., Yokota, T., Fujimura, T. and Crozier, A. (2015) Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health. Phytochemistry Reviews, 14(5), pp. 765-798. (doi: 10.1007/s11101-014-9375-z)
Monente, C., Ludwig, I. A., Stalmach, A. , Paz de Peña, M., Cid, C. and Crozier, A. (2015) In vitro studies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds. International Journal of Food Sciences and Nutrition, 66(6), pp. 657-664. (PMID:26203817)
2014
Brown, E. M., Nitecki, S., Pereira-Caro, G., McDougall, G. J., Stewart, D., Rowland, I., Crozier, A. and Gill, C. I.R. (2014) Comparison ofin vivoandin vitrodigestion on polyphenol composition in lingonberries: potential impact on colonic health. BioFactors, 40(6), pp. 611-623. (doi: 10.1002/biof.1173)
Ruotolo, R., Calani, L., Brighenti, F., Crozier, A., Ottonello, S. and Del Rio, D. (2014) Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell model systems. Archives of Biochemistry and Biophysics, 559, pp. 62-67. (doi: 10.1016/j.abb.2014.03.003)
Ludwig, I. A., Clifford, M. N., Lean, M. E.J. , Ashihara, H. and Crozier, A. (2014) Coffee: biochemistry and potential impact on health. Food and Function, 5(8), pp. 1695-1717. (doi: 10.1039/c4fo00042k)
Ludwig, I. A., Mena, P., Cid, C., Del Rio, D., Lean, M. and Crozier, A. (2014) Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food and Function, 5(8), pp. 1718-1726. (doi: 10.1039/c4fo00290c)
Brown, E. M., Latimer, C., Allsopp, P., Ternan, N. G., McMullan, G., McDougall, G. J., Stewart, D., Crozier, A., Rowland, I. and Gill, C. I. R. (2014) In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries. Journal of Agricultural and Food Chemistry, 62(18), pp. 3852-3866. (doi: 10.1021/jf4050759)
Rodriguez-Mateos, A., Heiss, C., Borges, G. and Crozier, A. (2014) Berry (poly)phenols and cardiovascular health. Journal of Agricultural and Food Chemistry, 62(18), pp. 3842-3851. (doi: 10.1021/jf403757g)
Ky, I., Lorrain, B., Kolbas, N., Crozier, A. and Teissedre, P.-L. (2014) Wine by-products: phenolic characterization and antioxidant activity evaluation of grapes and grape Pomaces from six different french grape varieties. Molecules, 19(1), pp. 482-506. (doi: 10.3390/molecules19010482)
Calani, L. et al. (2014) Bioavailability and metabolism of hydroxycinnamates in rats fed with durum wheat aleurone fractions. Food and Function, 5(8), pp. 1738-1746. (doi: 10.1039/c4fo00328d)
Escudero-López, B., Calani, L., Fernández-Pachón, M.-S., Ortega, Á., Brighenti, F., Crozier, A. and Del Rio, D. (2014) Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats. BioFactors, 40(3), pp. 327-335. (doi: 10.1002/biof.1152)
McDougall, G. J. et al. (2014) Tracking (Poly)phenol components from raspberries in ileal fluid. Journal of Agricultural and Food Chemistry, 62(30), pp. 7631-7641. (doi: 10.1021/jf502259j)
Peluso, I., Villano, D.V., Roberts, S.A., Cesqui, E., Raguzzini, A., Borges, G., Crozier, A., Catasta, G., Toti, E. and Serafini, M. (2014) Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects. Current Pharmaceutical Design, 20(6), pp. 1020-1024. (doi: 10.2174/138161282006140220144802)
Pereira-Caro, G., Borges, G., Van Der Hooft, J. , Clifford, M. N., Del Rio, D., Lean, M. E.J. , Roberts, S. A., Kellerhals, M. B. and Crozier, A. (2014) Orange juice (poly)phenols are highly bioavailable in humans. American Journal of Clinical Nutrition, 100(5), pp. 1378-1384. (doi: 10.3945/ajcn.114.090282)
Stalmach, A., Williamson, G. and Crozier, A. (2014) Impact of dose on the bioavailability of coffee chlorogenic acids in humans. Food and Function, 5(8), pp. 1727-1737. (doi: 10.1039/c4fo00316k)
2013
Pereira-Caro, G., Watanabe, S., Crozier, A., Fujimura, T., Yokota, T. and Ashihara, H. (2013) Phytochemical profile of a Japanese black–purple rice. Food Chemistry, 141(3), pp. 2821-2827. (doi: 10.1016/j.foodchem.2013.05.100)
Clifford, M.N., Van Der Hooft, J.J. and Crozier, A. (2013) Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols. American Journal of Clinical Nutrition, 98(6), 1619S-1630S. (doi: 10.3945/ajcn.113.058958)
Ludwig, I.A., Paz de Peña, M., Concepción, C. and Crozier, A. (2013) Catabolism of coffee chlorogenic acids by human colonic microbiota. BioFactors, 39(6), pp. 623-632. (doi: 10.1002/biof.1124)
Ruotolo, R., Calani, L., Fietta, E., Brighenti, F., Crozier, A., Meda, C., Maggi, A., Ottonello, S. and Del Rio, D. (2013) Anti-estrogenic activity of a human resveratrol metabolite. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), pp. 1086-1092. (doi: 10.1016/j.numecd.2013.01.002)
Crozier, A. (2013) Absorption, metabolism, and excretion of (-)-epicatechin in humans: an evaluation of recent findings. American Journal of Clinical Nutrition, 98(4), pp. 861-862. (doi: 10.3945/ajcn.113.072009)
Pereira-Caro, G., Borges, G., Nagai, C., Jackson, M.C., Yokota, T., Crozier, A. and Ashihara, H. (2013) Profiles of phenolic compounds and purine alkaloids during the development of seeds of theobroma cacaocv. Trinitario. Journal of Agricultural and Food Chemistry, 61(2), pp. 427-434. (doi: 10.1021/jf304397m)
Ashihara, H., Yokota, T. and Crozier, A. (2013) Biosynthesis and catabolism of purine alkaloids. Advances in Botanical Research, 68, pp. 111-138. (doi: 10.1016/B978-0-12-408061-4.00004-3)
Ashihara, H., Yokota, T. and Crozier, A. (2013) Biosynthesis of alkaloids in plants. In: Giglioli-Guivarc'h, N. (ed.) Advances in Botanical Research. Academic Press: London, UK, pp. 111-138. ISBN 9780124080614
Ashihara, H., Yokota, T. and Crozier, A. (2013) Purine alkaloids, cytokinins and purine-like neurotoxin alkaloids. In: Ramawat, K.G. and Mérillon, J.M. (eds.) Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Springer: Berlin, Germany, pp. 953-975. ISBN 9783642221439
Borges, G. and Crozier, A. (2013) HPLC–PDA–MS fingerprinting to assess the authenticity of pomegranate beverages. Food Chemistry, 135(3), pp. 1863-1867. (doi: 10.1016/j.foodchem.2012.05.108)
Borges, G., Lean, M.E.J. , Roberts, S.A. and Crozier, A. (2013) Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine. Food and Function, 2013(4), pp. 754-762. (doi: 10.1039/c3fo60024f)
Del Rio, D., Rodriguez-Mateo, A., Spencer, J.P.E., Tognolini, M., Borges, G. and Crozier, A. (2013) Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidants and Redox Signaling, 18(14), pp. 1818-1892. (doi: 10.1089/ars.2012.4581)
Pereira-Caro, G., Cros, G., Yokota, T. and Crozier, A. (2013) Phytochemical profiles of black, red, brown, and white rice from the camargue region of France. Journal of Agricultural and Food Chemistry, 61(33), pp. 7976-7986. (doi: 10.1021/jf401937b)
Stalmach, A. , Edwards, C.A. , Wightman, J.D. and Crozier, A. (2013) Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice. Food and Function, 4(1), p. 52. (doi: 10.1039/C2FO30151B)
2012
Yin, Y., Borges, G., Sakuta, M., Crozier, A. and Ashihara, H. (2012) Effect of phosphate deficiency on the content and biosynthesis of anthocyanins and the expression of related genes in suspension-cultured grape (Vitis sp.) cells. Plant Physiology and Biochemistry, 55, pp. 77-84. (doi: 10.1016/j.plaphy.2012.03.009)
Bahorun, T., Luximon-Ramma, A., Neergheen-Bhujun, V.S., Gunness, T.K., Googoolye, K., Auger, C., Crozier, A. and Aruoma, O.I. (2012) The effect of black tea on risk factors of cardiovascular disease in a normal population. Preventive Medicine, 54(Suppl.), S98-S102. (doi: 10.1016/j.ypmed.2011.12.009)
Stalmach, A. , Edwards, C.A. , Wightman, J.D. and Crozier, A. (2012) Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans. Molecular Nutrition and Food Research, 56(3), pp. 497-509. (doi: 10.1002/mnfr.201100566)
Spencer, J.P.E. and Crozier, A. (Eds.) (2012) Bioavailability and Function of Flavonoids. Series: Oxidative Stress and Disease. CRC Press: Boca Raton, FL, USA, pp. 45-78. ISBN 9781439848265
Brown, E.M., McDougall, G.J., Stewart, D., Pereira-Caro, G., González-Barrio, R., Allsopp, P., Magee, P., Crozier, A., Rowland, I. and Gill, C.I.R. (2012) Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation. PLoS ONE, 7(11), e49740. (doi: 10.1371/journal.pone.0049740) (PMID:23185422) (PMCID:PMC3504104)
Clifford, M.C. and Crozier, A. (2012) Phytochemicals in teas and tisanes and their bioavailability. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 45-98. ISBN 9781444334418
Crozier, A., Clifford, M.N. and Del Rio, D. (2012) Bioavailability of dietary monomeric and polymeric flavan-3-ols. In: Spencer, J.P.E. and Crozier, A. (eds.) Bioavailability and Function of Flavonoids. Series: Oxidative Stress and Disease, 29. CRC Press: Boca Raton, FL, USA, pp. 45-78. ISBN 9781439848265
Crozier, T.W.M., Stalmach, A. , Lean, M.E.J. and Crozier, A. (2012) Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food and Function, 3(1), pp. 30-33. (doi: 10.1039/C1FO10240K)
Derlindati, E., Dall'Asta, M., Ardigò, D., Brighenti, F., Zavaroni, I., Crozier, A. and Del Rio, D. (2012) Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects. Food and Function, 3(11), p. 1144. (doi: 10.1039/c2fo30127j)
Lean, M. and Crozier, A. (2012) Coffee, caffeine and health: What's in your cup? Maturitas, 72(3), pp. 171-172. (doi: 10.1016/j.maturitas.2012.04.005)
Lean, M.E.J. , Ashihara, H., Clifford, M. and Crozier, A. (2012) Teas, cocoa and coffee. In: Crozier, A., Ashihara, H. and Tomas-Barberan, F. (eds.) Teas, Cocoa and Coffee: Plant secondary metabolites and health. Blackwell Publishing Ltd: UK, pp. 25-44. ISBN 9781444334418
Lean, M.E.J. , Ashihara, H., Clifford, M.N. and Crozier, A. (2012) Purine alkaloids: a focus on caffeine and related compounds in beverages. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 25-44. ISBN 9781444334418
Mena, P., Calani, L., Dall'Asta, C., Galaverna, G., García-Viguera, C., Bruni, R., Crozier, A. and Del Rio, D. (2012) Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (punica granatum L.) juice by UHPLC-MSn. Molecules, 17(12), pp. 14821-14840. (doi: 10.3390/molecules171214821)
Omar, M.H., Mullen, W. , Stalmach, A. , Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)
Stalmach, A. , Clifford, M.N., Crozier, A. and Williamson, G. (2012) Phytochemicals in coffee and the bioavailability of chlorogenic acids. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 143-168. ISBN 9781444334418
Tognolini, M. et al. (2012) Perturbation of the EphA2–EphrinA1 system in human prostate cancer cells by colonic (poly)phenol catabolites. Journal of Agricultural and Food Chemistry, 60(36), pp. 8877-8884. (doi: 10.1021/jf205305m)
Tomás-Barbéran, F., Borges, G. and Crozier, A. (2012) Phytochemicals in cocoa and the bioavailability of flavan-3-ols. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 193-217. ISBN 9781444334418
2011
Stalmach, A. , Edwards, C.A. , Wightman, J.D. and Crozier, A. (2011) Identification of (Poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. Journal of Agricultural and Food Chemistry, 59(17), pp. 9512-22. (doi: 10.1021/jf2015039)
Gonzalez-Barrio, R., Edwards, C. and Crozier, A. (2011) Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies. Drug Metabolism and Disposition, 39(9), pp. 1680-1688. (doi: 10.1124/dmd.111.039651)
Broekhuizen, L.N., van Wijk, D.F., Vink, H., Stalmach, A. , Crozier, A., Hutten, B.A., Kastelein, J.J.P., Hugenholtz, P.G., Koenig, W. and Stroes, E.S.G. (2011) Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors. British Journal of Nutrition, pp. 1-7. (doi: 10.1017/S0007114511002431)
AlGamdi, N., Mullen, W. and Crozier, A. (2011) Tea prepared from Anastatica hirerochuntica seeds contains a diversity of antioxidant flavonoids, chlorogenic acids and phenolic compounds. Phytochemistry, 72(2-3), pp. 248-254. (doi: 10.1016/j.phytochem.2010.11.017)
Combet, E. , Lean, M.E.J. , Boyle, J., Crozier, A. and Davidson, D.F. (2011) Dietary flavonols contribute to false-positive elevation of homovanillic acid, a marker of catecholamine-secreting tumours. Clinica Chimica Acta, 412(1-2), pp. 165-169. (doi: 10.1016/j.cca.2010.09.037)
Ashihara, H., Crozier, A. and Komamine, A. (Eds.) (2011) Plant Metabolism and Biotechnology. Wiley: Cambridge, UK. ISBN 9780470747032
Albalat, A., Gornik, S.G., Mullen, W. , Crozier, A., Atkinson, R.J.A., Coombs, G.H. and Neil, D.M. (2011) Quality changes in chilled Norway lobster (Nephrops norvegicus) tail meat and the effects of delayed icing. International Journal of Food Science and Technology, 46(7), pp. 1413-1421. (doi: 10.1111/j.1365-2621.2011.02650.x)
Ashihara, H., Kato, M. and Crozier, A. (2011) Distribution, biosynthesis and catabolism of methylxanthines in plants. In: Fedholm, B. (ed.) Methylxanthines. Series: Handbook of Experimental Pharmacology, 200. Springer-Verlag: Heidelberg, Germany, pp. 11-31. ISBN 9783642134425
Ashihara, H., Ogita, S. and Crozier, A. (2011) Purine alkaloid metabolism. In: Ashihara, H., Crozier, A. and Komamine, A. (eds.) Plant Metabolism and Biotechnology. Wiley: Cambridge, UK, pp. 155-181. ISBN 9780470747032
Jaganath, I.B. and Crozier, A. (2011) Flavonoid metabolism. In: Ashihara, H., Crozier, A. and Komamine, A. (eds.) Plant Metabolism and Biotechnology. Wiley: Cambridge, UK, pp. 285-312. ISBN 9780470747032
Lotito, S.B., Zhang, W.-J., Yang, C.S., Crozier, A. and Frei, B. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radical Biology and Medicine, 51(2), pp. 454-463. (doi: 10.1016/j.freeradbiomed.2011.04.032)
Omar, M.H., Mullen, W. and Crozier, A. (2011) Identification of proanthocyanidin dimers and trimers, FlavoneC-Glycosides, and antioxidants in Ficus deltoidea, a Malaysian herbal tea. Journal of Agricultural and Food Chemistry, 59(4), pp. 1363-1369. (doi: 10.1021/jf1032729)
Roowi, S. and Crozier, A. (2011) Flavonoids in tropical citrus species. Journal of Agricultural and Food Chemistry, 59(22), pp. 12217-12225. (doi: 10.1021/jf203022f)
Suh, J.-H., Romain, C., González-Barrio, R., Cristol, J.-P., Teissèdre, P.-L., Crozier, A. and Rouanet, J.-M. (2011) Raspberry juice consumption, oxidative stress and reduction of atherosclerosis risk factors in hypercholesterolemic golden Syrian hamsters. Food and Function, 2(7), pp. 400-405. (doi: 10.1039/C1FO10047E)
Verzelloni, E. et al. (2011) Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites. Molecular Nutrition and Food Research, 55(S1), S35-S43. (doi: 10.1002/mnfr.201000525)
2010
Wong, C.C., Meinl, W., Glatt, H.-R., Barron, D., Stalmach, A. , Steiling, H., Crozier, A. and Williamson, G. (2010) In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans. Journal of Nutritional Biochemistry, 21(11), pp. 1060-1068. (doi: 10.1016/j.jnutbio.2009.09.001)
Borges, G., Mullen, W. and Crozier, A. (2010) Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices. Food and Function, 1(1), pp. 73-83. (doi: 10.1039/c0fo00008f)
Borges, G., Mullen, W. , Mullan, A., Lean, M. , Roberts, S. and Crozier, A. (2010) Bioavailability of multiple components following acute ingestion of a polyphenol-rich juice drink. Molecular Nutrition and Food Research, 54(S2), S268-S277. (doi: 10.1002/mnfr.200900611)
Chapman, M.H., Kajihara, M., Borges, G., O'Beirne, J., Patch, D., Dhillon, A.P., Crozier, A. and Morgan, M.Y. (2010) Severe, acute liver injury and khat leaves. New England Journal of Medicine, 362(17), pp. 1642-1644. (doi: 10.1056/NEJMc0908038)
Borges, G., Degeneve, A., Mullen, W. and Crozier, A. (2010) Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries. Journal of Agricultural and Food Chemistry, 58(7), pp. 3901-3909. (doi: 10.1021/jf902263n)
Ashihara, H., Deng, W.-W., Mullen, W. and Crozier, A. (2010) Distribution and biosynthesis of flavan-3-ols in Camellia sinensis seedlings and expression of genes encoding biosynthetic enzymes. Phytochemistry, 71(5-6), pp. 559-566. (doi: 10.1016/j.phytochem.2010.01.010)
Combet, E., Elmesmari, A., Preston, T., Crozier, A. and McColl, K.E.L. (2010) Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids. Free Radical Biology and Medicine, 48(6), pp. 763-771. (doi: 10.1016/j.freeradbiomed.2009.12.011)
Stalmach, A. , Mullen, W., Steiling, H., Williamson, G., Lean, M.E.J. and Crozier, A. (2010) Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Molecular Nutrition and Food Research, 54(3), pp. 323-334. (doi: 10.1002/mnfr.200900194)
Rouanet, J.-M., Décordé, K., Del Rio, D., Auger, C., Borges, G., Cristol, J.-P., Lean, M.E.J. and Crozier, A. (2010) Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters. Food Chemistry, 118(2), pp. 266-271. (doi: 10.1016/j.foodchem.2009.04.116)
Del Rio, D., Costa, L.G., Lean, M.E.J. and Crozier, A. (2010) Polyphenols and health: what compounds are involved? Nutrition, Metabolism and Cardiovascular Diseases, 20(1), pp. 1-6. (doi: 10.1016/j.numecd.2009.05.015)
Bahorun, T., Luximon-Ramma, A., Gunness, T.K., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A. and Aruoma, O.I. (2010) Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases. Toxicology, 278(1), pp. 68-74. (doi: 10.1016/j.tox.2009.11.024)
Crozier, A., Del Rio, D. and Clifford, M. N. (2010) Bioavailability of dietary flavonoids and phenolic compounds. Molecular Aspects of Medicine, 31(6), pp. 446-467. (doi: 10.1016/j.mam.2010.09.007)
Del Rio, D., Borges, G. and Crozier, A. (2010) Berry flavonoids and phenolics: bioavailability and evidence of protective effects. British Journal of Nutrition, 104(S3), S67-S90. (doi: 10.1017/S0007114510003958)
Del Rio, D., Costa, L.G., Lean, M.E.J. and Crozier, A. (2010) Polyphenols and health: What compounds are involved? Nutrition, Metabolism and Cardiovascular Diseases, 20(1), pp. 1-6. (doi: 10.1016/j.numecd.2009.05.015)
Del Rio, D., Stalmach, A. , Calani, L. and Crozier, A. (2010) Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols. Nutrients, 2(8), pp. 820-833. (doi: 10.3390/nu2080820)
Fumeaux, R., Menozzi-Smarrito, C., Stalmach, A. , Munari, C., Kraehenbuehl, K., Steiling, H., Crozier, A., Williamson, G. and Barron, D. (2010) First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption. Organic and Biomolecular Chemistry, 8(22), pp. 5199-5277. (doi: 10.1039/c0ob00137f)
Gonzalez-Barrio, R., Borges, G., Mullen, W. and Crozier, A. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry, 58(7), pp. 3933-3939. (doi: 10.1021/jf100315d)
González-Barrio, R., Borges, G., Mullen, W. and Crozier, A. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy†. Journal of Agricultural and Food Chemistry, 58(7), pp. 3933-3939. (doi: 10.1021/jf100315d)
Mullen, W., Borges, G., Lean, M.E.J., Roberts, S.A. and Crozier, A. (2010) Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink. Journal of Agricultural and Food Chemistry, 58(4), pp. 2586-2595. (doi: 10.1021/jf904096v)
Mullen, W. , Larcombe, S., Arnold, K., Welchman, H. and Crozier, A. (2010) Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues. Journal of Agricultural and Food Chemistry, 58(7), pp. 3910-3915. (doi: 10.1021/jf902267v)
Roowi, S., Stalmach, A., Mullen, W., Lean, M., Edwards, C.A. and Crozier, A. (2010) Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. Journal of Agricultural and Food Chemistry, 58(2), pp. 1296-1304. (doi: 10.1021/jf9032975)
Rouanet, J.-M., Décordé, K., Rio, D.D., Auger, C., Borges, G., Cristol, J.P., Lean, M.E.J. and Crozier, A. (2010) Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters. Food Chemistry, 118(2), pp. 266-271. (doi: 10.1016/j.foodchem.2009.04.116)
Stalmach, A. , Steiling, H., Williamson, G. and Crozier, A. (2010) Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Archives of Biochemistry and Biophysics, 501(1), pp. 98-105. (doi: 10.1016/j.abb.2010.03.005)
Troufflard, S., Mullen, W. , Larson, T. R., Graham, I. A., Crozier, A., Amtmann, A. and Armengaud, P. (2010) Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana. BMC Plant Biology, 10(1), p. 172. (doi: 10.1186/1471-2229-10-172)
Villaño, D., Pecorari, M., Testa, M. F., Raguzzini, A., Stalmach, A. , Crozier, A., Tubili, C. and Serafini, M. (2010) Unfermented and fermented rooibos teas (Aspalathus linearis) increase plasma total antioxidant capacity in healthy humans. Food Chemistry, 123(3), pp. 679-683. (doi: 10.1016/j.foodchem.2010.05.032)
Wright, B., Moraes, L.A., Kemp, C.F., Mullen, W. , Crozier, A., Lovegrove, J.A. and Gibbins, J.M. (2010) A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British Journal of Pharmacology, 159(6), pp. 1312-1325. (doi: 10.1111/j.1476-5381.2009.00632.x)
2009
Jaganath, I.B., Mullen, W., Lean, M., Edwards, C.A. and Crozier, A. (2009) In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites. Free Radical Biology and Medicine, 47(8), pp. 1180-1189. (doi: 10.1016/j.freeradbiomed.2009.07.031)
Stalmach, A. , Mullen, W. , Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G. and Crozier, A. (2009) Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metabolism and Disposition, 37(8), pp. 1749-1758. (doi: 10.1124/dmd.109.028019)
Mullen, W. , Borges, G.,, Donovan, J.L., Edwards, C.A. , Serafini, M., Lean, M.E.J. and Crozier, A. (2009) Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. American Journal of Clinical Nutrition, 89(6), pp. 1784-1791. (doi: 10.3945/ajcn.2008.27339) (PMID:19403635)
Stalmach, A. , Troufflard, S., Serafini, M. and Crozier, A. (2009) Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Molecular Nutrition and Food Research, 53(S1), pp. 44-53. (doi: 10.1002/mnfr.200800169)
Crozier, A., Jaganath, I.B. and Clifford, M.N. (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports, 26(8), pp. 1001-1043. (doi: 10.1039/b802662a)
Jaganath, I.B. and Crozier, A. (2009) Overview of health promoting compounds in fruits and vegetables. In: Fraga, C. (ed.) Phenolic Compounds of Plant Origin and Health: The Biochemistry behind their Nutritional and Pharmacological Value. Wiley-Blackwell: Oxford, UK, pp. 1-48. ISBN 9780470287217
Marks, S.C., Mullen, W. , Borges, G. and Crozier, A. (2009) Absorption, Metabolism, and Excretion of Cider Dihydrochalcones in Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry, 57(5), pp. 2009-2015. (doi: 10.1021/jf802757x)
Renouf, M. et al. (2009) Metabolism of chlorogenic acids after coffee ingestion in ileostomy and healthy subjects. In: 22nd International Conference on Coffee Science, ASIC 2008, Campinas, Brazil, 14-19 September 2008, pp. 110-117.
Roowi, S., Mullen, W. , Edwards, C.A. and Crozier, A. (2009) Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Molecular Nutrition and Food Research, 53(Suppl), S68-S75. (doi: 10.1002/mnfr.200800287)
Stalmach, A. , Mullen, W., Pecorari, M., Serafini, M. and Crozier, A. (2009) Bioavailability of c-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. Journal of Agricultural and Food Chemistry, 57(15), pp. 7104-7111. (doi: 10.1021/jf9011642)
Yokoyama, A., Sakakibara, H., Crozier, A., Kawai, Y., Matsui, A., Terao, J., Kumazawa, S. and Shimoi, K. (2009) Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free Radical Research, 43(10), pp. 913-921. (doi: 10.1080/10715760903137010)
2008
Jordão, A.M., Ricardo-Da-Silva, J.M., Laureano, O., Mullen, W. and Crozier, A. (2008) Effect of ellagitannins, ellagic acid and volatile compounds from oak wood on the (+)-catechin, procyanidin B1 and malvidin-3-glucoside content of model wines. Australian Journal of Grape and Wine Research, 14(3), pp. 260-270.
Auger, C., Mullen, W. , Hara, Y. and Crozier, A. (2008) Bioavailability of polyphenon E flavan-3-ols in humans with an lleostomy. Journal of Nutrition, 138(8), 1535S-1542S.
Ashihara, H., Sano, H. and Crozier, A. (2008) Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. Phytochemistry, 69(4), pp. 841-856. (doi: 10.1016/j.phytochem.2007.10.029)
Gauliard, B., Grieve, D., Wilson, R., Crozier, A., Jenkins, C., Mullen, W. and Lean, M. (2008) The effects of dietary phenolic compounds on cytokine and antioxidant production by a549 cells. Journal of Medicinal Food, 11(2), pp. 382-384. (doi: 10.1089/jmf.2007.593)
Jaganath, I.B. and Crozier, A. (2008) Overview of health promoting compounds in fruits and vegetables. In: Tomás Barberán, F. and Gil, M.I. (eds.) Improving the Health-Promoting Compounds of Fruits and Vegetables. Series: Woodhead Publishing series in food science, technology and nutrition (157). Woodhead Publishing Ltd: Cambridge, UK, pp. 3-37. ISBN 9781845691844
Mullen, W. , Archeveque, M.-A., Edwards, C.A. , Matsumoto, H. and Crozier, A. (2008) Bioavailability and Metabolism of Orange Juice Flavanones in Humans: Impact of a Full-Fat Yogurt. Journal of Agricultural and Food Chemistry, 56(23), pp. 11157-11164. (doi: 10.1021/jf801974v)
Mullen, W. , Edwards, C.A., Serafini, M. and Crozier, A. (2008) Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. Journal of Agricultural and Food Chemistry, 56(3), pp. 713-719. (doi: 10.1021/jf072000p)
Mullen, W. , Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)
2007
Marks, S.C., Mullen, W. and Crozier, A. (2007) Flavonoid and hydroxycinnamate profiles of English apple ciders. Journal of Agricultural and Food Chemistry, 55, pp. 8723-8730. (doi: 10.1021/jf071155u)
Borges, G., Crozier, A., Duthie, G., Lean, M., Roowi, S. and Rouanet, J. (2007) The bioavallability of raspberry anthocyanins and ellagitannins in rats. Molecular Nutrition and Food Research, 51, pp. 714-725. (doi: 10.1002/mnfr.200700024)
Marks, S., Mullen, W. and Crozier, A. (2007) Flavonoid and chlorogenic acid profiles of English cider apples. Journal of the Science of Food and Agriculture, 87, pp. 719-728. (doi: 10.1002/jsfa.2778)
Marks, S., Mullen, W. and Crozier, A. (2007) Flavonoid and hydroxycinnamate profiles of English apple ciders. Journal of Agricultural and Food Chemistry, 55, pp. 8723-8730. (doi: 10.1021/jf071155u)
Mullen, W., Marks, S. and Crozier, A. (2007) Evaluation of phenolic compounds in commercial fruit juices and fruit drinks. Journal of Agricultural and Food Chemistry, 55, pp. 3148-3157. (doi: 10.1021/jf062970x)
2006
Crozier, A., Clifford, M.N. and Ashihara, H. (Eds.) (2006) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Publishing. ISBN 9781405125093
Brighenti, F. et al. (2006) Do flavan-3-ols from green tea reach the human brain? Nutritional Neuroscience, 9, pp. 57-61. (doi: 10.1080/10284150600637739)
Corder, R., Mullen, W., Khan, N., Marks, S., Wood, E., Carrier, M. and Crozier, A. (2006) Red wine procyanidins and vascular health. Nature, 444, p. 566. (doi: 10.1038/444566a)
Crozier, A., Edwards, C., Jaganath, I. and Mullen, W. (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radical Research, 40, pp. 1035-1046. (doi: 10.1080/10715760600771400)
Crozier, A., Edwards, C. and Mullen, W. (2006) Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. British Journal of Nutrition, 96, pp. 107-116. (doi: 10.1079/BJN20061809)
Crozier, A., Jaganath, I.B. and Clifford, M.N. (2006) Phenols, polyphenols and tannins: an overview. In: Crozier, A., Clifford, M.N. and Ashihara, H. (eds.) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Publishing, pp. 1-24. ISBN 1405125098
Crozier, A., Yokota, T., Jaganath, I.B., Marks, S., Saltmarsh, M. and Clifford, M.N. (2006) Secondary metabolites as dietary components in plant-based foods and beverages. In: Crozier, A., Clifford, M.N. and Ashihara, H. (eds.) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Publishing, pp. 208-302. ISBN 9781405125093
Duthie, S., Jenkinson, A., Crozier, A., Mullen, W., Pirie, L., Kyle, J., Yap, L., Christen, P. and Duthie, G. (2006) The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. European Journal of Nutrition, 45, pp. 113-122. (doi: 10.1007/s00394-005-0572-9)
Luximon-Ramma, A., Neergheen, V.S., Bahorun, T., Crozier, A., Zbarsky, V., Datla, K.P., Dexter, D.T. and Aruoma, O.I. (2006) Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions. BioFactors, 27, pp. 79-91. (doi: 10.1002/biof.5520270108) (PMID:17012766)
Stalmach, A. , Mullen, W. , Nagai, A. and Crozier, A. (2006) On-line HPLC analysis of the antioxidant activity of phenolic compounds in brewed, paper-filtered coffee. Brazilian Journal of Plant Physiology, 18(1), pp. 253-262. (doi: 10.1590/S1677-04202006000100018)
2005
Crozier, A. (2005) Potential health benefits of berries. Current Nutrition and Food Science, 1(1), pp. 71-86.
Crozier, A., Duthie, G., Duthie, S., Higgins, S., Howie, M., Lean, M., Mullen, W. and Tsang, C. (2005) The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers. British Journal of Nutrition, 93, pp. 233-240. (doi: 10.1079/BJN20041311)
Luximon-Ramma, A., Bahorun, T., Crozier, A., Zbarsky, V., Datla, K., Dexter, D. and Aruoma, O. (2005) Characterization of the antioxidant functions of flavonoids and proanthocyanidins in Mauritian black teas. Food Research International, 38, pp. 357-367. (doi: 10.1016/j.foodres.2004.10.005)
Stewart, A., Mullen, W. and Crozier, A. (2005) On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea. Molecular Nutrition and Food Research, 49, pp. 52-60.
Tsang, C., Auger, C., Mullen, W., Bornet, A., Rouanet, J., Crozier, A. and Teissedre, P. (2005) The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. British Journal of Nutrition, 94, pp. 170-181. (doi: 10.1079/BJN20051480)
2004
Kroon, P. A., Clifford, M. N., Crozier, A., Day, A. J., Donovan, J. L., Manach, C. and Williamson, G. (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? American Journal of Clinical Nutrition, 80(1), pp. 15-21. (doi: 10.1093/ajcn/80.1.15) (PMID:15213022)
Bahorun, T., Luximon-Ramma, A., Crozier, A. and Aruoma, O. (2004) Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables. Journal of the Science of Food and Agriculture, 84, pp. 1553-1561. (doi: 10.1002/jsfa.1820)
Brighenti, F., Burns, J., Crozier, A., Del, R., Lean, M., Mullen, W. and Stewart, A. (2004) HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. Journal of Agricultural and Food Chemistry, 52, pp. 2807-2815. (doi: 10.1021/jf0354848)
Crozier, A., Huxley, R., John, J., Lean, M. and Neil, H. (2004) Effect of dietary advice to increase fruit and vegetable consumption on plasma flavonol concentrations: results from a randomised controlled intervention trial. Journal of Epidemiology and Community Health, 58, pp. 288-289. (doi: 10.1136/jech.2003.014274)
Crozier, A., Borges, G. and Stewart, A.J. (2004) Absorption, metabolism and potential bioavailability of dietary flavonols and anthocyanins. Agro Food Industry Hi-Tech, 15, pp. 16-19.
Mullen, W., Boitier, A., Stewart, A. and Crozier, A. (2004) Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection. Journal of Chromatography A, 1058, pp. 163-168. (doi: 10.1016/j.chroma.2004.08117)
2003
Keya, C. A., Crozier, A. and Ashihara, H. (2003) Inhibition of caffeine biosynthesis in tea (Camellia sinensis) and coffee (Coffea arabica) plants by ribavirin. FEBS Letters, 554(3), pp. 473-477. (doi: 10.1016/S0014-5793(03)01213-4)
Serafini, M., Bugianesi, R., Maiani, G., Valtuena, S., De Santis, S. and Crozier, A. (2003) Plasma antioxidants from chocolate. Nature, 424(6952), p. 1013. (doi: 10.1038/4241013a)
Crozier, A. (2003) Methods in polyphenol analysis. Phytochemistry, 64(6), pp. 1172-1173. (doi: 10.1016/S0031-9422(03)00513-2)
Crozier, A., Lean, M., Mullen, W. and Yokota, T. (2003) Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MSn. Phytochemistry, 64, pp. 617-624. (doi: 10.1016/S0031-9422(03)00281-4)
Duthie, G.G. and Crozier, A. (2003) Beverages. In: Goldberg, G. (ed.) Plants: Diet and Health. Blackwell Publishing on behalf of The British Nutrition Foundation, pp. 147-182. ISBN 9780632059621
Luximon-Ramma, A., Bahorun, T. and Crozier, A. (2003) Antioxidant actions and phenolic and vitamin C contents of common Mauritian exotic fruits. Journal of the Science of Food and Agriculture, 83, pp. 496-502. (doi: 10.1002/jsfa.1365)
Saltmarsh, M., Crozier, A. and Radcliffe, B. (2003) Fruit and vegetables. In: Goldberg, G. (ed.) Plants: Diet and Health. Blackwell Publishing on behalf of The British Nutrition Foundation, pp. 107-133. ISBN 9780632059621
2002
Ashihara, H., Burns, J., Crozier, A., Lean, M. and Yokota, T. (2002) Plant foods and herbal sources of resveratrol. Journal of Agricultural and Food Chemistry, 50, pp. 3337-3340. (doi: 10.1021/jf0112973)
Burns, J., Crozier, A., Landrault, N., Lean, M., Mullen, W. and Teissedre, P. (2002) Variations in the profile and content of anthocyanins in wines made from Cabernet Sauvignon and hybrid grapes. Journal of Agricultural and Food Chemistry, 50, pp. 4096-4102. (doi: 10.1021/jf011233s)
Crozier, A., Duthie, G., Gardner, P., Lean, M., Mullen, W. and Stewart, A. (2002) Effect of freezing and storage on the phenolics, ellagitannins, flavonoids, and antioxidant capacity of red raspberries. Journal of Agricultural and Food Chemistry, 50, pp. 5197-5201. (doi: 10.1021/jf020141f)
Crozier, A., Lean, M. and Mullen, W. (2002) Rapid characterization of anthocyanins in red raspberry fruit by high-performance liquid chromatography coupled to single quadrupole mass spectrometry. Journal of Chromatography A, 966, pp. 63-70.
Crozier, A., Duthie, G.G., Gardner, P., Lean, M.E.J., MacLean, M.R., McGinn, J., Mullen, W. and Yokota, T. (2002) Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. Journal of Agricultural and Food Chemistry, 50, pp. 5191-5196. (doi: 10.1021/jf020140n)
Zheng, X., Ye, C., Kato, M., Crozier, A. and Ashihara, H. (2002) Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha). Phytochemistry, 60, pp. 129-134.
2001
Koshiishi, C., Kato, A., Yama, S., Crozier, A. and Ashihara, H. (2001) A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle. FEBS Letters, 499(1-2), pp. 50-54. (doi: 10.1016/S0014-5793(01)02512-1)
Ashihara, H. and Crozier, A. (2001) Caffeine: a well known but little mentioned compound in plant science. Trends in Plant Science, 6, pp. 407-413.
Burns, J., Crozier, A., Duthie, G., Gardner, P., Lean, M. and Matthews, D. (2001) Extraction of phenolics and changes in antioxidant activity of red wines during vinification. Journal of Agricultural and Food Chemistry, 49, pp. 5797-5808. (doi: 10.1021/jf010682p)
Burns, J., Crozier, A. and Lean, M.E.J. (2001) Alcohol consumption and mortality: Is wine different from other alcoholic beverages? Nutrition, Metabolism and Cardiovascular Diseases, 11, pp. 249-258.
Koshiishi, C., Crozier, A. and Ashihara, H. (2001) Profiles of purine and pyrimidine nucleotides in fresh and manufactured tea leaves. Journal of Agricultural and Food Chemistry, 49, pp. 4378-4382. (doi: 10.1021/jf0104679)
2000
Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)
Kato, M., Mizuno, K., Crozier, A., Fujimura, T. and Ashihara, H. (2000) Caffeine synthase gene from tea leaves. Nature, 406(6799), pp. 956-957. (doi: 10.1038/35023072)
1999
Young, J. F., Nielsen, S. E., Haraldsdóttir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandström, B. and Dragsted, L. O. (1999) Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. American Journal of Clinical Nutrition, 69(1), pp. 87-94. (doi: 10.1093/ajcn/69.1.87) (PMID:9925128)
Articles
Cáceres-Jiménez, S., Pereira-Caro, G., Dobani, S., Pourshahidi, K., Gill, C. I.R., Moreno-Rojas, J. M., Ordoñez-Díaz, J. L., Almutairi, T. M., Clifford, M. N. and Crozier, A. (2024) Bioavailability of mango (poly)phenols: an evaluation of the impact of the colon, and phenylalanine and tyrosine on the production of phenolic catabolites. Free Radical Biology and Medicine, 225, pp. 605-616. (doi: 10.1016/j.freeradbiomed.2024.10.289) (PMID:39426756)
Pereira-Caro, G. et al. (2024) Colon-available mango (poly)phenols exhibit mitigating effects on the intestinal barrier function in human intestinal cell monolayers under inflammatory conditions. Food and Function, 15(9), pp. 5118-5131. (doi: 10.1039/d4fo00451e) (PMID:38682277)
Clifford, M. N. et al. (2024) Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines. Redox Biology, 71, 103068. (doi: 10.1016/j.redox.2024.103068) (PMID:38377790) (PMCID:PMC10891336)
Agulló, V., Favari, C., Pilla, N., Bresciani, L., Tomás-Barberán, F. A., Crozier, A., Del Rio, D. and Mena, P. (2024) Using targeted metabolomics to unravel phenolic metabolites of plant origin in animal milk. International Journal of Molecular Sciences, 25(8), 4536. (doi: 10.3390/ijms25084536) (PMID:38674121) (PMCID:PMC11050474)
Di Pede, G. et al. (2024) A systematic review and comprehensive evaluation of human intervention studies to unravel the bioavailability of hydroxycinnamic acids. Antioxidants and Redox Signaling, 40(7-9), pp. 510-541. (doi: 10.1089/ars.2023.0254) (PMID:37382416) (PMCID:PMC10960166)
Cáceres-Jiménez, S., Rodríguez-Solana, R., Dobani, S., Pourshahidi, K., Gill, C., Moreno-Rojas, J. M., Almutairi, T. M., Crozier, A. and Pereira-Caro, G. (2023) UHPLC-HRMS spectrometric analysis: method validation and plasma and urinary metabolite identification after mango pulp intake. Journal of Agricultural and Food Chemistry, 71(30), pp. 11520-11533. (doi: 10.1021/acs.jafc.3c03846) (PMID:37471325)
Pereira-Caro, G. et al. (2023) Excretion by subjects on a low (poly)phenol diet of phenolic gut microbiota catabolites sequestered in tissues or associated with catecholamines and surplus amino acids. International Journal of Food Sciences and Nutrition, 74(4), pp. 532-543. (doi: 10.1080/09637486.2023.2226369) (PMID:37369137)
Pereira-Caro, G., Almutairi, T. M., Cáceres-Jiménez, S., Moreno-Rojas, J. M., Malkova, D. , Garcia, A. L. and Crozier, A. (2023) Bioavailability of orange juice (poly)phenols: β-glucan-rich oat bran decreases urinary excretion of flavanone phase II metabolites and enhances excretion of microbiota-derived phenolic catabolites. Free Radical Biology and Medicine, 199, pp. 34-43. (doi: 10.1016/j.freeradbiomed.2023.02.002) (PMID:36764628)
Di Pede, G., Mena, P., Bresciani, L., Almutairi, T. M., Del Rio, D., Clifford, M. N. and Crozier, A. (2023) Human colonic catabolism of dietary flavan-3-ol bioactives. Molecular Aspects of Medicine, 89, 101107. (doi: 10.1016/j.mam.2022.101107) (PMID:35931563)
Di Pede, G. et al. (2023) Revisiting the bioavailability of flavan-3-ols in humans: a systematic review and comprehensive data analysis. Molecular Aspects of Medicine, 89, 101146. (doi: 10.1016/j.mam.2022.101146) (PMID:36207170)
Di Pede, G., Bresciani, L., Brighenti, F., Clifford, M. N., Crozier, A., Del Rio, D. and Mena, P. (2022) In vitro faecal fermentation of monomeric and oligomeric flavan‐3‐ols: catabolic pathways and stoichiometry. Molecular Nutrition and Food Research, 66(21), 2101090. (doi: 10.1002/mnfr.202101090) (PMID:35107868)
Pereira-Caro, G., Almutairi, T. M., Crozier, A., Ordoñez-Díaz, J. L., Moreno-Rojas, J. M., Ortiz-Somovilla, V., Morillo-Santander, G., Lazarova, S., Malkova, D. and Garcia, A. L. (2022) Acute effect of oat β-glucan on the bioavailability of orange juice flavanones. International Journal of Food Sciences and Nutrition, 73(4), pp. 531-537. (doi: 10.1080/09637486.2021.2015572) (PMID:34933644)
Pereira-Caro, G., Clifford, M. N., Polyviou, T., Ludwig, I. A., Alfheeaid, H. , Morena-Rojas, J. M., Garcia, A. L. , Malkova, D. and Crozier, A. (2020) Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men. Free Radical Biology and Medicine, 160, pp. 784-795. (doi: 10.1016/j.freeradbiomed.2020.09.007) (PMID:32927016)
Kay, C. D. et al. (2020) Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites. American Journal of Clinical Nutrition, 112(4), pp. 1051-1068. (doi: 10.1093/ajcn/nqaa204) (PMID:32936878) (PMCID:PMC7528558)
Pereira-Caro, G., Gaillet, S., Ordóñez, J. L., Mena, P., Bresciani, L., Bindon, K. A., Del Rio, D., Rouanet, J.-M., Moreno-Rojas, J. M. and Crozier, A. (2020) Bioavailability of red wine and grape seed proanthocyanidins in rats. Food and Function, 11(5), pp. 3986-4001. (doi: 10.1039/D0FO00350F) (PMID:32347279)
Mena, P. et al. (2019) Phenyl-γ-valerolactones and phenylvaleric acids, the main colonic metabolites of flavan-3-ols: synthesis, analysis, bioavailability, and bioactivity. Natural Product Reports, 36(5), pp. 714-752. (doi: 10.1039/C8NP00062J) (PMID:30468210)
Williamson, G., Kay, C. D. and Crozier, A. (2018) The bioavailability, transport, and bioactivity of dietary flavonoids: a review from a historical perspective. Comprehensive Reviews in Food Science and Food Safety, 17(5), pp. 1054-1112. (doi: 10.1111/1541-4337.12351)
Pereira-Caro, G., Polyviou, T., Ludwig, I. A., Natase, A.-M., Moreno-Rojas, M., Garcia, A. L. , Malkova, D. and Crozier, A. (2017) Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes. American Journal of Clinical Nutrition, 106(3), pp. 791-800. (doi: 10.3945/ajcn.116.149898) (PMID:28747329)
Borges, G., van der Hooft, J. J.J. and Crozier, A. (2016) A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats. Free Radical Biology and Medicine, 99, pp. 128-138. (doi: 10.1016/j.freeradbiomed.2016.08.001)
Pereira-Caro, G., Ludwig, I. A., Polyviou, T., Malkova, D. , Garcia, A. , Moreno-Rojas, J. M. and Crozier, A. (2016) Identification of plasma and urinary metabolites and catabolites derived from orange juice (poly)phenols: analysis by high-performance liquid chromatography–high-resolution mass spectrometry. Journal of Agricultural and Food Chemistry, 64(28), pp. 5724-5735. (doi: 10.1021/acs.jafc.6b02088) (PMID:27339035)
Ludwig, I. A., Mena, P., Calani, L., Borges, G., Pereira-Caro, G., Bresciani, L., Del Rio, D., Lean, M. E. J. and Crozier, A. (2015) New insights into the bioavailability of red raspberry anthocyanins and ellagitannins. Free Radical Biology and Medicine, 89, pp. 758-769. (doi: 10.1016/j.freeradbiomed.2015.10.400) (PMID:26475039)
Ashihara, H., Ludwig, I. A., Katahira, R., Yokota, T., Fujimura, T. and Crozier, A. (2015) Trigonelline and related nicotinic acid metabolites: occurrence, biosynthesis, taxonomic considerations, and their roles in planta and in human health. Phytochemistry Reviews, 14(5), pp. 765-798. (doi: 10.1007/s11101-014-9375-z)
Monente, C., Ludwig, I. A., Stalmach, A. , Paz de Peña, M., Cid, C. and Crozier, A. (2015) In vitro studies on the stability in the proximal gastrointestinal tract and bioaccessibility in Caco-2 cells of chlorogenic acids from spent coffee grounds. International Journal of Food Sciences and Nutrition, 66(6), pp. 657-664. (PMID:26203817)
Brown, E. M., Nitecki, S., Pereira-Caro, G., McDougall, G. J., Stewart, D., Rowland, I., Crozier, A. and Gill, C. I.R. (2014) Comparison ofin vivoandin vitrodigestion on polyphenol composition in lingonberries: potential impact on colonic health. BioFactors, 40(6), pp. 611-623. (doi: 10.1002/biof.1173)
Ruotolo, R., Calani, L., Brighenti, F., Crozier, A., Ottonello, S. and Del Rio, D. (2014) Glucuronidation does not suppress the estrogenic activity of quercetin in yeast and human breast cancer cell model systems. Archives of Biochemistry and Biophysics, 559, pp. 62-67. (doi: 10.1016/j.abb.2014.03.003)
Ludwig, I. A., Clifford, M. N., Lean, M. E.J. , Ashihara, H. and Crozier, A. (2014) Coffee: biochemistry and potential impact on health. Food and Function, 5(8), pp. 1695-1717. (doi: 10.1039/c4fo00042k)
Ludwig, I. A., Mena, P., Cid, C., Del Rio, D., Lean, M. and Crozier, A. (2014) Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food and Function, 5(8), pp. 1718-1726. (doi: 10.1039/c4fo00290c)
Brown, E. M., Latimer, C., Allsopp, P., Ternan, N. G., McMullan, G., McDougall, G. J., Stewart, D., Crozier, A., Rowland, I. and Gill, C. I. R. (2014) In vitro and in vivo models of colorectal cancer: antigenotoxic activity of berries. Journal of Agricultural and Food Chemistry, 62(18), pp. 3852-3866. (doi: 10.1021/jf4050759)
Rodriguez-Mateos, A., Heiss, C., Borges, G. and Crozier, A. (2014) Berry (poly)phenols and cardiovascular health. Journal of Agricultural and Food Chemistry, 62(18), pp. 3842-3851. (doi: 10.1021/jf403757g)
Ky, I., Lorrain, B., Kolbas, N., Crozier, A. and Teissedre, P.-L. (2014) Wine by-products: phenolic characterization and antioxidant activity evaluation of grapes and grape Pomaces from six different french grape varieties. Molecules, 19(1), pp. 482-506. (doi: 10.3390/molecules19010482)
Calani, L. et al. (2014) Bioavailability and metabolism of hydroxycinnamates in rats fed with durum wheat aleurone fractions. Food and Function, 5(8), pp. 1738-1746. (doi: 10.1039/c4fo00328d)
Escudero-López, B., Calani, L., Fernández-Pachón, M.-S., Ortega, Á., Brighenti, F., Crozier, A. and Del Rio, D. (2014) Absorption, metabolism, and excretion of fermented orange juice (poly)phenols in rats. BioFactors, 40(3), pp. 327-335. (doi: 10.1002/biof.1152)
McDougall, G. J. et al. (2014) Tracking (Poly)phenol components from raspberries in ileal fluid. Journal of Agricultural and Food Chemistry, 62(30), pp. 7631-7641. (doi: 10.1021/jf502259j)
Peluso, I., Villano, D.V., Roberts, S.A., Cesqui, E., Raguzzini, A., Borges, G., Crozier, A., Catasta, G., Toti, E. and Serafini, M. (2014) Consumption of mixed fruit-juice drink and vitamin C reduces postprandial stress induced by a high fat meal in healthy overweight subjects. Current Pharmaceutical Design, 20(6), pp. 1020-1024. (doi: 10.2174/138161282006140220144802)
Pereira-Caro, G., Borges, G., Van Der Hooft, J. , Clifford, M. N., Del Rio, D., Lean, M. E.J. , Roberts, S. A., Kellerhals, M. B. and Crozier, A. (2014) Orange juice (poly)phenols are highly bioavailable in humans. American Journal of Clinical Nutrition, 100(5), pp. 1378-1384. (doi: 10.3945/ajcn.114.090282)
Stalmach, A., Williamson, G. and Crozier, A. (2014) Impact of dose on the bioavailability of coffee chlorogenic acids in humans. Food and Function, 5(8), pp. 1727-1737. (doi: 10.1039/c4fo00316k)
Pereira-Caro, G., Watanabe, S., Crozier, A., Fujimura, T., Yokota, T. and Ashihara, H. (2013) Phytochemical profile of a Japanese black–purple rice. Food Chemistry, 141(3), pp. 2821-2827. (doi: 10.1016/j.foodchem.2013.05.100)
Clifford, M.N., Van Der Hooft, J.J. and Crozier, A. (2013) Human studies on the absorption, distribution, metabolism, and excretion of tea polyphenols. American Journal of Clinical Nutrition, 98(6), 1619S-1630S. (doi: 10.3945/ajcn.113.058958)
Ludwig, I.A., Paz de Peña, M., Concepción, C. and Crozier, A. (2013) Catabolism of coffee chlorogenic acids by human colonic microbiota. BioFactors, 39(6), pp. 623-632. (doi: 10.1002/biof.1124)
Ruotolo, R., Calani, L., Fietta, E., Brighenti, F., Crozier, A., Meda, C., Maggi, A., Ottonello, S. and Del Rio, D. (2013) Anti-estrogenic activity of a human resveratrol metabolite. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), pp. 1086-1092. (doi: 10.1016/j.numecd.2013.01.002)
Crozier, A. (2013) Absorption, metabolism, and excretion of (-)-epicatechin in humans: an evaluation of recent findings. American Journal of Clinical Nutrition, 98(4), pp. 861-862. (doi: 10.3945/ajcn.113.072009)
Pereira-Caro, G., Borges, G., Nagai, C., Jackson, M.C., Yokota, T., Crozier, A. and Ashihara, H. (2013) Profiles of phenolic compounds and purine alkaloids during the development of seeds of theobroma cacaocv. Trinitario. Journal of Agricultural and Food Chemistry, 61(2), pp. 427-434. (doi: 10.1021/jf304397m)
Ashihara, H., Yokota, T. and Crozier, A. (2013) Biosynthesis and catabolism of purine alkaloids. Advances in Botanical Research, 68, pp. 111-138. (doi: 10.1016/B978-0-12-408061-4.00004-3)
Borges, G. and Crozier, A. (2013) HPLC–PDA–MS fingerprinting to assess the authenticity of pomegranate beverages. Food Chemistry, 135(3), pp. 1863-1867. (doi: 10.1016/j.foodchem.2012.05.108)
Borges, G., Lean, M.E.J. , Roberts, S.A. and Crozier, A. (2013) Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine. Food and Function, 2013(4), pp. 754-762. (doi: 10.1039/c3fo60024f)
Del Rio, D., Rodriguez-Mateo, A., Spencer, J.P.E., Tognolini, M., Borges, G. and Crozier, A. (2013) Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidants and Redox Signaling, 18(14), pp. 1818-1892. (doi: 10.1089/ars.2012.4581)
Pereira-Caro, G., Cros, G., Yokota, T. and Crozier, A. (2013) Phytochemical profiles of black, red, brown, and white rice from the camargue region of France. Journal of Agricultural and Food Chemistry, 61(33), pp. 7976-7986. (doi: 10.1021/jf401937b)
Stalmach, A. , Edwards, C.A. , Wightman, J.D. and Crozier, A. (2013) Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice. Food and Function, 4(1), p. 52. (doi: 10.1039/C2FO30151B)
Yin, Y., Borges, G., Sakuta, M., Crozier, A. and Ashihara, H. (2012) Effect of phosphate deficiency on the content and biosynthesis of anthocyanins and the expression of related genes in suspension-cultured grape (Vitis sp.) cells. Plant Physiology and Biochemistry, 55, pp. 77-84. (doi: 10.1016/j.plaphy.2012.03.009)
Bahorun, T., Luximon-Ramma, A., Neergheen-Bhujun, V.S., Gunness, T.K., Googoolye, K., Auger, C., Crozier, A. and Aruoma, O.I. (2012) The effect of black tea on risk factors of cardiovascular disease in a normal population. Preventive Medicine, 54(Suppl.), S98-S102. (doi: 10.1016/j.ypmed.2011.12.009)
Stalmach, A. , Edwards, C.A. , Wightman, J.D. and Crozier, A. (2012) Gastrointestinal stability and bioavailability of (poly)phenolic compounds following ingestion of Concord grape juice by humans. Molecular Nutrition and Food Research, 56(3), pp. 497-509. (doi: 10.1002/mnfr.201100566)
Brown, E.M., McDougall, G.J., Stewart, D., Pereira-Caro, G., González-Barrio, R., Allsopp, P., Magee, P., Crozier, A., Rowland, I. and Gill, C.I.R. (2012) Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation. PLoS ONE, 7(11), e49740. (doi: 10.1371/journal.pone.0049740) (PMID:23185422) (PMCID:PMC3504104)
Crozier, T.W.M., Stalmach, A. , Lean, M.E.J. and Crozier, A. (2012) Espresso coffees, caffeine and chlorogenic acid intake: potential health implications. Food and Function, 3(1), pp. 30-33. (doi: 10.1039/C1FO10240K)
Derlindati, E., Dall'Asta, M., Ardigò, D., Brighenti, F., Zavaroni, I., Crozier, A. and Del Rio, D. (2012) Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects. Food and Function, 3(11), p. 1144. (doi: 10.1039/c2fo30127j)
Lean, M. and Crozier, A. (2012) Coffee, caffeine and health: What's in your cup? Maturitas, 72(3), pp. 171-172. (doi: 10.1016/j.maturitas.2012.04.005)
Mena, P., Calani, L., Dall'Asta, C., Galaverna, G., García-Viguera, C., Bruni, R., Crozier, A. and Del Rio, D. (2012) Rapid and comprehensive evaluation of (poly)phenolic compounds in pomegranate (punica granatum L.) juice by UHPLC-MSn. Molecules, 17(12), pp. 14821-14840. (doi: 10.3390/molecules171214821)
Omar, M.H., Mullen, W. , Stalmach, A. , Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)
Tognolini, M. et al. (2012) Perturbation of the EphA2–EphrinA1 system in human prostate cancer cells by colonic (poly)phenol catabolites. Journal of Agricultural and Food Chemistry, 60(36), pp. 8877-8884. (doi: 10.1021/jf205305m)
Stalmach, A. , Edwards, C.A. , Wightman, J.D. and Crozier, A. (2011) Identification of (Poly)phenolic compounds in concord grape juice and their metabolites in human plasma and urine after juice consumption. Journal of Agricultural and Food Chemistry, 59(17), pp. 9512-22. (doi: 10.1021/jf2015039)
Gonzalez-Barrio, R., Edwards, C. and Crozier, A. (2011) Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies. Drug Metabolism and Disposition, 39(9), pp. 1680-1688. (doi: 10.1124/dmd.111.039651)
Broekhuizen, L.N., van Wijk, D.F., Vink, H., Stalmach, A. , Crozier, A., Hutten, B.A., Kastelein, J.J.P., Hugenholtz, P.G., Koenig, W. and Stroes, E.S.G. (2011) Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors. British Journal of Nutrition, pp. 1-7. (doi: 10.1017/S0007114511002431)
AlGamdi, N., Mullen, W. and Crozier, A. (2011) Tea prepared from Anastatica hirerochuntica seeds contains a diversity of antioxidant flavonoids, chlorogenic acids and phenolic compounds. Phytochemistry, 72(2-3), pp. 248-254. (doi: 10.1016/j.phytochem.2010.11.017)
Combet, E. , Lean, M.E.J. , Boyle, J., Crozier, A. and Davidson, D.F. (2011) Dietary flavonols contribute to false-positive elevation of homovanillic acid, a marker of catecholamine-secreting tumours. Clinica Chimica Acta, 412(1-2), pp. 165-169. (doi: 10.1016/j.cca.2010.09.037)
Albalat, A., Gornik, S.G., Mullen, W. , Crozier, A., Atkinson, R.J.A., Coombs, G.H. and Neil, D.M. (2011) Quality changes in chilled Norway lobster (Nephrops norvegicus) tail meat and the effects of delayed icing. International Journal of Food Science and Technology, 46(7), pp. 1413-1421. (doi: 10.1111/j.1365-2621.2011.02650.x)
Lotito, S.B., Zhang, W.-J., Yang, C.S., Crozier, A. and Frei, B. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radical Biology and Medicine, 51(2), pp. 454-463. (doi: 10.1016/j.freeradbiomed.2011.04.032)
Omar, M.H., Mullen, W. and Crozier, A. (2011) Identification of proanthocyanidin dimers and trimers, FlavoneC-Glycosides, and antioxidants in Ficus deltoidea, a Malaysian herbal tea. Journal of Agricultural and Food Chemistry, 59(4), pp. 1363-1369. (doi: 10.1021/jf1032729)
Roowi, S. and Crozier, A. (2011) Flavonoids in tropical citrus species. Journal of Agricultural and Food Chemistry, 59(22), pp. 12217-12225. (doi: 10.1021/jf203022f)
Suh, J.-H., Romain, C., González-Barrio, R., Cristol, J.-P., Teissèdre, P.-L., Crozier, A. and Rouanet, J.-M. (2011) Raspberry juice consumption, oxidative stress and reduction of atherosclerosis risk factors in hypercholesterolemic golden Syrian hamsters. Food and Function, 2(7), pp. 400-405. (doi: 10.1039/C1FO10047E)
Verzelloni, E. et al. (2011) Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites. Molecular Nutrition and Food Research, 55(S1), S35-S43. (doi: 10.1002/mnfr.201000525)
Wong, C.C., Meinl, W., Glatt, H.-R., Barron, D., Stalmach, A. , Steiling, H., Crozier, A. and Williamson, G. (2010) In vitro and in vivo conjugation of dietary hydroxycinnamic acids by UDP-glucuronosyltransferases and sulfotransferases in humans. Journal of Nutritional Biochemistry, 21(11), pp. 1060-1068. (doi: 10.1016/j.jnutbio.2009.09.001)
Borges, G., Mullen, W. and Crozier, A. (2010) Comparison of the polyphenolic composition and antioxidant activity of European commercial fruit juices. Food and Function, 1(1), pp. 73-83. (doi: 10.1039/c0fo00008f)
Borges, G., Mullen, W. , Mullan, A., Lean, M. , Roberts, S. and Crozier, A. (2010) Bioavailability of multiple components following acute ingestion of a polyphenol-rich juice drink. Molecular Nutrition and Food Research, 54(S2), S268-S277. (doi: 10.1002/mnfr.200900611)
Chapman, M.H., Kajihara, M., Borges, G., O'Beirne, J., Patch, D., Dhillon, A.P., Crozier, A. and Morgan, M.Y. (2010) Severe, acute liver injury and khat leaves. New England Journal of Medicine, 362(17), pp. 1642-1644. (doi: 10.1056/NEJMc0908038)
Borges, G., Degeneve, A., Mullen, W. and Crozier, A. (2010) Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries. Journal of Agricultural and Food Chemistry, 58(7), pp. 3901-3909. (doi: 10.1021/jf902263n)
Ashihara, H., Deng, W.-W., Mullen, W. and Crozier, A. (2010) Distribution and biosynthesis of flavan-3-ols in Camellia sinensis seedlings and expression of genes encoding biosynthetic enzymes. Phytochemistry, 71(5-6), pp. 559-566. (doi: 10.1016/j.phytochem.2010.01.010)
Combet, E., Elmesmari, A., Preston, T., Crozier, A. and McColl, K.E.L. (2010) Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids. Free Radical Biology and Medicine, 48(6), pp. 763-771. (doi: 10.1016/j.freeradbiomed.2009.12.011)
Stalmach, A. , Mullen, W., Steiling, H., Williamson, G., Lean, M.E.J. and Crozier, A. (2010) Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Molecular Nutrition and Food Research, 54(3), pp. 323-334. (doi: 10.1002/mnfr.200900194)
Rouanet, J.-M., Décordé, K., Del Rio, D., Auger, C., Borges, G., Cristol, J.-P., Lean, M.E.J. and Crozier, A. (2010) Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters. Food Chemistry, 118(2), pp. 266-271. (doi: 10.1016/j.foodchem.2009.04.116)
Del Rio, D., Costa, L.G., Lean, M.E.J. and Crozier, A. (2010) Polyphenols and health: what compounds are involved? Nutrition, Metabolism and Cardiovascular Diseases, 20(1), pp. 1-6. (doi: 10.1016/j.numecd.2009.05.015)
Bahorun, T., Luximon-Ramma, A., Gunness, T.K., Sookar, D., Bhoyroo, S., Jugessur, R., Reebye, D., Googoolye, K., Crozier, A. and Aruoma, O.I. (2010) Black tea reduces uric acid and C-reactive protein levels in humans susceptible to cardiovascular diseases. Toxicology, 278(1), pp. 68-74. (doi: 10.1016/j.tox.2009.11.024)
Crozier, A., Del Rio, D. and Clifford, M. N. (2010) Bioavailability of dietary flavonoids and phenolic compounds. Molecular Aspects of Medicine, 31(6), pp. 446-467. (doi: 10.1016/j.mam.2010.09.007)
Del Rio, D., Borges, G. and Crozier, A. (2010) Berry flavonoids and phenolics: bioavailability and evidence of protective effects. British Journal of Nutrition, 104(S3), S67-S90. (doi: 10.1017/S0007114510003958)
Del Rio, D., Costa, L.G., Lean, M.E.J. and Crozier, A. (2010) Polyphenols and health: What compounds are involved? Nutrition, Metabolism and Cardiovascular Diseases, 20(1), pp. 1-6. (doi: 10.1016/j.numecd.2009.05.015)
Del Rio, D., Stalmach, A. , Calani, L. and Crozier, A. (2010) Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols. Nutrients, 2(8), pp. 820-833. (doi: 10.3390/nu2080820)
Fumeaux, R., Menozzi-Smarrito, C., Stalmach, A. , Munari, C., Kraehenbuehl, K., Steiling, H., Crozier, A., Williamson, G. and Barron, D. (2010) First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption. Organic and Biomolecular Chemistry, 8(22), pp. 5199-5277. (doi: 10.1039/c0ob00137f)
Gonzalez-Barrio, R., Borges, G., Mullen, W. and Crozier, A. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry, 58(7), pp. 3933-3939. (doi: 10.1021/jf100315d)
González-Barrio, R., Borges, G., Mullen, W. and Crozier, A. (2010) Bioavailability of Anthocyanins and Ellagitannins Following Consumption of Raspberries by Healthy Humans and Subjects with an Ileostomy†. Journal of Agricultural and Food Chemistry, 58(7), pp. 3933-3939. (doi: 10.1021/jf100315d)
Mullen, W., Borges, G., Lean, M.E.J., Roberts, S.A. and Crozier, A. (2010) Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink. Journal of Agricultural and Food Chemistry, 58(4), pp. 2586-2595. (doi: 10.1021/jf904096v)
Mullen, W. , Larcombe, S., Arnold, K., Welchman, H. and Crozier, A. (2010) Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues. Journal of Agricultural and Food Chemistry, 58(7), pp. 3910-3915. (doi: 10.1021/jf902267v)
Roowi, S., Stalmach, A., Mullen, W., Lean, M., Edwards, C.A. and Crozier, A. (2010) Green tea flavan-3-ols: colonic degradation and urinary excretion of catabolites by humans. Journal of Agricultural and Food Chemistry, 58(2), pp. 1296-1304. (doi: 10.1021/jf9032975)
Rouanet, J.-M., Décordé, K., Rio, D.D., Auger, C., Borges, G., Cristol, J.P., Lean, M.E.J. and Crozier, A. (2010) Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters. Food Chemistry, 118(2), pp. 266-271. (doi: 10.1016/j.foodchem.2009.04.116)
Stalmach, A. , Steiling, H., Williamson, G. and Crozier, A. (2010) Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Archives of Biochemistry and Biophysics, 501(1), pp. 98-105. (doi: 10.1016/j.abb.2010.03.005)
Troufflard, S., Mullen, W. , Larson, T. R., Graham, I. A., Crozier, A., Amtmann, A. and Armengaud, P. (2010) Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana. BMC Plant Biology, 10(1), p. 172. (doi: 10.1186/1471-2229-10-172)
Villaño, D., Pecorari, M., Testa, M. F., Raguzzini, A., Stalmach, A. , Crozier, A., Tubili, C. and Serafini, M. (2010) Unfermented and fermented rooibos teas (Aspalathus linearis) increase plasma total antioxidant capacity in healthy humans. Food Chemistry, 123(3), pp. 679-683. (doi: 10.1016/j.foodchem.2010.05.032)
Wright, B., Moraes, L.A., Kemp, C.F., Mullen, W. , Crozier, A., Lovegrove, J.A. and Gibbins, J.M. (2010) A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British Journal of Pharmacology, 159(6), pp. 1312-1325. (doi: 10.1111/j.1476-5381.2009.00632.x)
Jaganath, I.B., Mullen, W., Lean, M., Edwards, C.A. and Crozier, A. (2009) In vitro catabolism of rutin by human fecal bacteria and the antioxidant capacity of its catabolites. Free Radical Biology and Medicine, 47(8), pp. 1180-1189. (doi: 10.1016/j.freeradbiomed.2009.07.031)
Stalmach, A. , Mullen, W. , Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G. and Crozier, A. (2009) Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption. Drug Metabolism and Disposition, 37(8), pp. 1749-1758. (doi: 10.1124/dmd.109.028019)
Mullen, W. , Borges, G.,, Donovan, J.L., Edwards, C.A. , Serafini, M., Lean, M.E.J. and Crozier, A. (2009) Milk decreases urinary excretion but not plasma pharmacokinetics of cocoa flavan-3-ol metabolites in humans. American Journal of Clinical Nutrition, 89(6), pp. 1784-1791. (doi: 10.3945/ajcn.2008.27339) (PMID:19403635)
Stalmach, A. , Troufflard, S., Serafini, M. and Crozier, A. (2009) Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Molecular Nutrition and Food Research, 53(S1), pp. 44-53. (doi: 10.1002/mnfr.200800169)
Crozier, A., Jaganath, I.B. and Clifford, M.N. (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Natural Product Reports, 26(8), pp. 1001-1043. (doi: 10.1039/b802662a)
Marks, S.C., Mullen, W. , Borges, G. and Crozier, A. (2009) Absorption, Metabolism, and Excretion of Cider Dihydrochalcones in Healthy Humans and Subjects with an Ileostomy. Journal of Agricultural and Food Chemistry, 57(5), pp. 2009-2015. (doi: 10.1021/jf802757x)
Roowi, S., Mullen, W. , Edwards, C.A. and Crozier, A. (2009) Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Molecular Nutrition and Food Research, 53(Suppl), S68-S75. (doi: 10.1002/mnfr.200800287)
Stalmach, A. , Mullen, W., Pecorari, M., Serafini, M. and Crozier, A. (2009) Bioavailability of c-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas. Journal of Agricultural and Food Chemistry, 57(15), pp. 7104-7111. (doi: 10.1021/jf9011642)
Yokoyama, A., Sakakibara, H., Crozier, A., Kawai, Y., Matsui, A., Terao, J., Kumazawa, S. and Shimoi, K. (2009) Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free Radical Research, 43(10), pp. 913-921. (doi: 10.1080/10715760903137010)
Jordão, A.M., Ricardo-Da-Silva, J.M., Laureano, O., Mullen, W. and Crozier, A. (2008) Effect of ellagitannins, ellagic acid and volatile compounds from oak wood on the (+)-catechin, procyanidin B1 and malvidin-3-glucoside content of model wines. Australian Journal of Grape and Wine Research, 14(3), pp. 260-270.
Auger, C., Mullen, W. , Hara, Y. and Crozier, A. (2008) Bioavailability of polyphenon E flavan-3-ols in humans with an lleostomy. Journal of Nutrition, 138(8), 1535S-1542S.
Ashihara, H., Sano, H. and Crozier, A. (2008) Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. Phytochemistry, 69(4), pp. 841-856. (doi: 10.1016/j.phytochem.2007.10.029)
Gauliard, B., Grieve, D., Wilson, R., Crozier, A., Jenkins, C., Mullen, W. and Lean, M. (2008) The effects of dietary phenolic compounds on cytokine and antioxidant production by a549 cells. Journal of Medicinal Food, 11(2), pp. 382-384. (doi: 10.1089/jmf.2007.593)
Mullen, W. , Archeveque, M.-A., Edwards, C.A. , Matsumoto, H. and Crozier, A. (2008) Bioavailability and Metabolism of Orange Juice Flavanones in Humans: Impact of a Full-Fat Yogurt. Journal of Agricultural and Food Chemistry, 56(23), pp. 11157-11164. (doi: 10.1021/jf801974v)
Mullen, W. , Edwards, C.A., Serafini, M. and Crozier, A. (2008) Bioavailability of pelargonidin-3-O-glucoside and its metabolites in humans following the ingestion of strawberries with and without cream. Journal of Agricultural and Food Chemistry, 56(3), pp. 713-719. (doi: 10.1021/jf072000p)
Mullen, W. , Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)
Marks, S.C., Mullen, W. and Crozier, A. (2007) Flavonoid and hydroxycinnamate profiles of English apple ciders. Journal of Agricultural and Food Chemistry, 55, pp. 8723-8730. (doi: 10.1021/jf071155u)
Borges, G., Crozier, A., Duthie, G., Lean, M., Roowi, S. and Rouanet, J. (2007) The bioavallability of raspberry anthocyanins and ellagitannins in rats. Molecular Nutrition and Food Research, 51, pp. 714-725. (doi: 10.1002/mnfr.200700024)
Marks, S., Mullen, W. and Crozier, A. (2007) Flavonoid and chlorogenic acid profiles of English cider apples. Journal of the Science of Food and Agriculture, 87, pp. 719-728. (doi: 10.1002/jsfa.2778)
Marks, S., Mullen, W. and Crozier, A. (2007) Flavonoid and hydroxycinnamate profiles of English apple ciders. Journal of Agricultural and Food Chemistry, 55, pp. 8723-8730. (doi: 10.1021/jf071155u)
Mullen, W., Marks, S. and Crozier, A. (2007) Evaluation of phenolic compounds in commercial fruit juices and fruit drinks. Journal of Agricultural and Food Chemistry, 55, pp. 3148-3157. (doi: 10.1021/jf062970x)
Brighenti, F. et al. (2006) Do flavan-3-ols from green tea reach the human brain? Nutritional Neuroscience, 9, pp. 57-61. (doi: 10.1080/10284150600637739)
Corder, R., Mullen, W., Khan, N., Marks, S., Wood, E., Carrier, M. and Crozier, A. (2006) Red wine procyanidins and vascular health. Nature, 444, p. 566. (doi: 10.1038/444566a)
Crozier, A., Edwards, C., Jaganath, I. and Mullen, W. (2006) The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radical Research, 40, pp. 1035-1046. (doi: 10.1080/10715760600771400)
Crozier, A., Edwards, C. and Mullen, W. (2006) Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. British Journal of Nutrition, 96, pp. 107-116. (doi: 10.1079/BJN20061809)
Duthie, S., Jenkinson, A., Crozier, A., Mullen, W., Pirie, L., Kyle, J., Yap, L., Christen, P. and Duthie, G. (2006) The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. European Journal of Nutrition, 45, pp. 113-122. (doi: 10.1007/s00394-005-0572-9)
Luximon-Ramma, A., Neergheen, V.S., Bahorun, T., Crozier, A., Zbarsky, V., Datla, K.P., Dexter, D.T. and Aruoma, O.I. (2006) Assessment of the polyphenolic composition of the organic extracts of Mauritian black teas: a potential contributor to their antioxidant functions. BioFactors, 27, pp. 79-91. (doi: 10.1002/biof.5520270108) (PMID:17012766)
Stalmach, A. , Mullen, W. , Nagai, A. and Crozier, A. (2006) On-line HPLC analysis of the antioxidant activity of phenolic compounds in brewed, paper-filtered coffee. Brazilian Journal of Plant Physiology, 18(1), pp. 253-262. (doi: 10.1590/S1677-04202006000100018)
Crozier, A. (2005) Potential health benefits of berries. Current Nutrition and Food Science, 1(1), pp. 71-86.
Crozier, A., Duthie, G., Duthie, S., Higgins, S., Howie, M., Lean, M., Mullen, W. and Tsang, C. (2005) The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers. British Journal of Nutrition, 93, pp. 233-240. (doi: 10.1079/BJN20041311)
Luximon-Ramma, A., Bahorun, T., Crozier, A., Zbarsky, V., Datla, K., Dexter, D. and Aruoma, O. (2005) Characterization of the antioxidant functions of flavonoids and proanthocyanidins in Mauritian black teas. Food Research International, 38, pp. 357-367. (doi: 10.1016/j.foodres.2004.10.005)
Stewart, A., Mullen, W. and Crozier, A. (2005) On-line high-performance liquid chromatography analysis of the antioxidant activity of phenolic compounds in green and black tea. Molecular Nutrition and Food Research, 49, pp. 52-60.
Tsang, C., Auger, C., Mullen, W., Bornet, A., Rouanet, J., Crozier, A. and Teissedre, P. (2005) The absorption, metabolism and excretion of flavan-3-ols and procyanidins following the ingestion of a grape seed extract by rats. British Journal of Nutrition, 94, pp. 170-181. (doi: 10.1079/BJN20051480)
Kroon, P. A., Clifford, M. N., Crozier, A., Day, A. J., Donovan, J. L., Manach, C. and Williamson, G. (2004) How should we assess the effects of exposure to dietary polyphenols in vitro? American Journal of Clinical Nutrition, 80(1), pp. 15-21. (doi: 10.1093/ajcn/80.1.15) (PMID:15213022)
Bahorun, T., Luximon-Ramma, A., Crozier, A. and Aruoma, O. (2004) Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables. Journal of the Science of Food and Agriculture, 84, pp. 1553-1561. (doi: 10.1002/jsfa.1820)
Brighenti, F., Burns, J., Crozier, A., Del, R., Lean, M., Mullen, W. and Stewart, A. (2004) HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. Journal of Agricultural and Food Chemistry, 52, pp. 2807-2815. (doi: 10.1021/jf0354848)
Crozier, A., Huxley, R., John, J., Lean, M. and Neil, H. (2004) Effect of dietary advice to increase fruit and vegetable consumption on plasma flavonol concentrations: results from a randomised controlled intervention trial. Journal of Epidemiology and Community Health, 58, pp. 288-289. (doi: 10.1136/jech.2003.014274)
Crozier, A., Borges, G. and Stewart, A.J. (2004) Absorption, metabolism and potential bioavailability of dietary flavonols and anthocyanins. Agro Food Industry Hi-Tech, 15, pp. 16-19.
Mullen, W., Boitier, A., Stewart, A. and Crozier, A. (2004) Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection. Journal of Chromatography A, 1058, pp. 163-168. (doi: 10.1016/j.chroma.2004.08117)
Keya, C. A., Crozier, A. and Ashihara, H. (2003) Inhibition of caffeine biosynthesis in tea (Camellia sinensis) and coffee (Coffea arabica) plants by ribavirin. FEBS Letters, 554(3), pp. 473-477. (doi: 10.1016/S0014-5793(03)01213-4)
Serafini, M., Bugianesi, R., Maiani, G., Valtuena, S., De Santis, S. and Crozier, A. (2003) Plasma antioxidants from chocolate. Nature, 424(6952), p. 1013. (doi: 10.1038/4241013a)
Crozier, A. (2003) Methods in polyphenol analysis. Phytochemistry, 64(6), pp. 1172-1173. (doi: 10.1016/S0031-9422(03)00513-2)
Crozier, A., Lean, M., Mullen, W. and Yokota, T. (2003) Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC-MSn. Phytochemistry, 64, pp. 617-624. (doi: 10.1016/S0031-9422(03)00281-4)
Luximon-Ramma, A., Bahorun, T. and Crozier, A. (2003) Antioxidant actions and phenolic and vitamin C contents of common Mauritian exotic fruits. Journal of the Science of Food and Agriculture, 83, pp. 496-502. (doi: 10.1002/jsfa.1365)
Ashihara, H., Burns, J., Crozier, A., Lean, M. and Yokota, T. (2002) Plant foods and herbal sources of resveratrol. Journal of Agricultural and Food Chemistry, 50, pp. 3337-3340. (doi: 10.1021/jf0112973)
Burns, J., Crozier, A., Landrault, N., Lean, M., Mullen, W. and Teissedre, P. (2002) Variations in the profile and content of anthocyanins in wines made from Cabernet Sauvignon and hybrid grapes. Journal of Agricultural and Food Chemistry, 50, pp. 4096-4102. (doi: 10.1021/jf011233s)
Crozier, A., Duthie, G., Gardner, P., Lean, M., Mullen, W. and Stewart, A. (2002) Effect of freezing and storage on the phenolics, ellagitannins, flavonoids, and antioxidant capacity of red raspberries. Journal of Agricultural and Food Chemistry, 50, pp. 5197-5201. (doi: 10.1021/jf020141f)
Crozier, A., Lean, M. and Mullen, W. (2002) Rapid characterization of anthocyanins in red raspberry fruit by high-performance liquid chromatography coupled to single quadrupole mass spectrometry. Journal of Chromatography A, 966, pp. 63-70.
Crozier, A., Duthie, G.G., Gardner, P., Lean, M.E.J., MacLean, M.R., McGinn, J., Mullen, W. and Yokota, T. (2002) Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. Journal of Agricultural and Food Chemistry, 50, pp. 5191-5196. (doi: 10.1021/jf020140n)
Zheng, X., Ye, C., Kato, M., Crozier, A. and Ashihara, H. (2002) Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha). Phytochemistry, 60, pp. 129-134.
Koshiishi, C., Kato, A., Yama, S., Crozier, A. and Ashihara, H. (2001) A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle. FEBS Letters, 499(1-2), pp. 50-54. (doi: 10.1016/S0014-5793(01)02512-1)
Ashihara, H. and Crozier, A. (2001) Caffeine: a well known but little mentioned compound in plant science. Trends in Plant Science, 6, pp. 407-413.
Burns, J., Crozier, A., Duthie, G., Gardner, P., Lean, M. and Matthews, D. (2001) Extraction of phenolics and changes in antioxidant activity of red wines during vinification. Journal of Agricultural and Food Chemistry, 49, pp. 5797-5808. (doi: 10.1021/jf010682p)
Burns, J., Crozier, A. and Lean, M.E.J. (2001) Alcohol consumption and mortality: Is wine different from other alcoholic beverages? Nutrition, Metabolism and Cardiovascular Diseases, 11, pp. 249-258.
Koshiishi, C., Crozier, A. and Ashihara, H. (2001) Profiles of purine and pyrimidine nucleotides in fresh and manufactured tea leaves. Journal of Agricultural and Food Chemistry, 49, pp. 4378-4382. (doi: 10.1021/jf0104679)
Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)
Kato, M., Mizuno, K., Crozier, A., Fujimura, T. and Ashihara, H. (2000) Caffeine synthase gene from tea leaves. Nature, 406(6799), pp. 956-957. (doi: 10.1038/35023072)
Young, J. F., Nielsen, S. E., Haraldsdóttir, J., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Crozier, A., Sandström, B. and Dragsted, L. O. (1999) Effect of fruit juice intake on urinary quercetin excretion and biomarkers of antioxidative status. American Journal of Clinical Nutrition, 69(1), pp. 87-94. (doi: 10.1093/ajcn/69.1.87) (PMID:9925128)
Book Sections
Ashihara, H., Yokota, T. and Crozier, A. (2013) Biosynthesis of alkaloids in plants. In: Giglioli-Guivarc'h, N. (ed.) Advances in Botanical Research. Academic Press: London, UK, pp. 111-138. ISBN 9780124080614
Ashihara, H., Yokota, T. and Crozier, A. (2013) Purine alkaloids, cytokinins and purine-like neurotoxin alkaloids. In: Ramawat, K.G. and Mérillon, J.M. (eds.) Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Springer: Berlin, Germany, pp. 953-975. ISBN 9783642221439
Clifford, M.C. and Crozier, A. (2012) Phytochemicals in teas and tisanes and their bioavailability. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 45-98. ISBN 9781444334418
Crozier, A., Clifford, M.N. and Del Rio, D. (2012) Bioavailability of dietary monomeric and polymeric flavan-3-ols. In: Spencer, J.P.E. and Crozier, A. (eds.) Bioavailability and Function of Flavonoids. Series: Oxidative Stress and Disease, 29. CRC Press: Boca Raton, FL, USA, pp. 45-78. ISBN 9781439848265
Lean, M.E.J. , Ashihara, H., Clifford, M. and Crozier, A. (2012) Teas, cocoa and coffee. In: Crozier, A., Ashihara, H. and Tomas-Barberan, F. (eds.) Teas, Cocoa and Coffee: Plant secondary metabolites and health. Blackwell Publishing Ltd: UK, pp. 25-44. ISBN 9781444334418
Lean, M.E.J. , Ashihara, H., Clifford, M.N. and Crozier, A. (2012) Purine alkaloids: a focus on caffeine and related compounds in beverages. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 25-44. ISBN 9781444334418
Stalmach, A. , Clifford, M.N., Crozier, A. and Williamson, G. (2012) Phytochemicals in coffee and the bioavailability of chlorogenic acids. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 143-168. ISBN 9781444334418
Tomás-Barbéran, F., Borges, G. and Crozier, A. (2012) Phytochemicals in cocoa and the bioavailability of flavan-3-ols. In: Crozier, A., Ashihara, H. and Tomás-Barbéran, F. (eds.) Teas, Cocoa and Coffee: Plant Secondary Metabolites and Health. Wiley-Blackwell: Chichester, UK, pp. 193-217. ISBN 9781444334418
Ashihara, H., Kato, M. and Crozier, A. (2011) Distribution, biosynthesis and catabolism of methylxanthines in plants. In: Fedholm, B. (ed.) Methylxanthines. Series: Handbook of Experimental Pharmacology, 200. Springer-Verlag: Heidelberg, Germany, pp. 11-31. ISBN 9783642134425
Ashihara, H., Ogita, S. and Crozier, A. (2011) Purine alkaloid metabolism. In: Ashihara, H., Crozier, A. and Komamine, A. (eds.) Plant Metabolism and Biotechnology. Wiley: Cambridge, UK, pp. 155-181. ISBN 9780470747032
Jaganath, I.B. and Crozier, A. (2011) Flavonoid metabolism. In: Ashihara, H., Crozier, A. and Komamine, A. (eds.) Plant Metabolism and Biotechnology. Wiley: Cambridge, UK, pp. 285-312. ISBN 9780470747032
Jaganath, I.B. and Crozier, A. (2009) Overview of health promoting compounds in fruits and vegetables. In: Fraga, C. (ed.) Phenolic Compounds of Plant Origin and Health: The Biochemistry behind their Nutritional and Pharmacological Value. Wiley-Blackwell: Oxford, UK, pp. 1-48. ISBN 9780470287217
Jaganath, I.B. and Crozier, A. (2008) Overview of health promoting compounds in fruits and vegetables. In: Tomás Barberán, F. and Gil, M.I. (eds.) Improving the Health-Promoting Compounds of Fruits and Vegetables. Series: Woodhead Publishing series in food science, technology and nutrition (157). Woodhead Publishing Ltd: Cambridge, UK, pp. 3-37. ISBN 9781845691844
Crozier, A., Jaganath, I.B. and Clifford, M.N. (2006) Phenols, polyphenols and tannins: an overview. In: Crozier, A., Clifford, M.N. and Ashihara, H. (eds.) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Publishing, pp. 1-24. ISBN 1405125098
Crozier, A., Yokota, T., Jaganath, I.B., Marks, S., Saltmarsh, M. and Clifford, M.N. (2006) Secondary metabolites as dietary components in plant-based foods and beverages. In: Crozier, A., Clifford, M.N. and Ashihara, H. (eds.) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Publishing, pp. 208-302. ISBN 9781405125093
Duthie, G.G. and Crozier, A. (2003) Beverages. In: Goldberg, G. (ed.) Plants: Diet and Health. Blackwell Publishing on behalf of The British Nutrition Foundation, pp. 147-182. ISBN 9780632059621
Saltmarsh, M., Crozier, A. and Radcliffe, B. (2003) Fruit and vegetables. In: Goldberg, G. (ed.) Plants: Diet and Health. Blackwell Publishing on behalf of The British Nutrition Foundation, pp. 107-133. ISBN 9780632059621
Edited Books
Spencer, J.P.E. and Crozier, A. (Eds.) (2012) Bioavailability and Function of Flavonoids. Series: Oxidative Stress and Disease. CRC Press: Boca Raton, FL, USA, pp. 45-78. ISBN 9781439848265
Ashihara, H., Crozier, A. and Komamine, A. (Eds.) (2011) Plant Metabolism and Biotechnology. Wiley: Cambridge, UK. ISBN 9780470747032
Crozier, A., Clifford, M.N. and Ashihara, H. (Eds.) (2006) Plant Secondary Metabolites: Occurrence, Structure and Role in the Human Diet. Blackwell Publishing. ISBN 9781405125093
Conference Proceedings
Renouf, M. et al. (2009) Metabolism of chlorogenic acids after coffee ingestion in ileostomy and healthy subjects. In: 22nd International Conference on Coffee Science, ASIC 2008, Campinas, Brazil, 14-19 September 2008, pp. 110-117.