Dr Derek Gilchrist
- Honorary Clinical Senior Lecturer (School of Infection & Immunity)
email:
Derek.Gilchrist@glasgow.ac.uk
Causeway Therapeutics, ICE Building, Landlands Drive, Glasgow, G51 4TF
Publications
2023
Nyirenda, M. H., Nijjar, J. S., Frleta-Gilchrist, M., Gilchrist, D. S., Porter, D., Siebert, S. , Goodyear, C. S. and McInnes, I. B. (2023) JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation. RMD Open, 9(1), e002671. (doi: 10.1136/rmdopen-2022-002671) (PMID:36599629) (PMCID:PMC9815080)
2018
Kara, E. E. et al. (2018) Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), pp. 801-813. (doi: 10.1084/jem.20171067) (PMID:29386231)
2017
Watts, A. E. et al. (2017) MicroRNA29a treatment improves early tendon injury. Molecular Therapy, 25(10), pp. 2415-2426. (doi: 10.1016/j.ymthe.2017.07.015) (PMID:28822690)
Akbar, M. et al. (2017) Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis. RMD Open, 3(2), e000456. (doi: 10.1136/rmdopen-2017-000456) (PMID:28879051) (PMCID:PMC5574425)
Kurow, O. et al. (2017) Full length interleukin 33 aggravates radiation-induced skin reaction. Frontiers in Immunology, 8, 722. (doi: 10.3389/fimmu.2017.00722) (PMID:28702024) (PMCID:PMC5487387)
Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)
2016
Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)
2015
Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)
2014
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)
2013
Frleta, M., Rainey, A.-A., Gilchrist, D.S., Crawford, L., Baxter, D., Kurowska-Stolarska, M. and McInnes, I.B. (2013) Mir-27b as Biomarker and Regulator of IL-6R Pathway in Resistant Rheumatoid Arthritis Monocyte. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S1035.
Millar, N.L. , Gilchrist, D.S., Kurowska-Stolarska, M. , Murrell, G.A.C. and McInnes, I. B. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: EULAR 2013: Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June 2013, p. 140.
Millar, N. L. , Gilchrist, D. S., Kurowska-Stolarska, M. , Murrell, G. A.C. and McInnes, I. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S405.
Miller, A. M., Gilchrist, D. S., Nijjar, J., Araldi, E., Ramirez, C. M., Lavery, C. A., Fernández-Hernando, C., McInnes, I. B. and Kurowska-Stolarska, M. (2013) MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE, 8(8), e72324. (doi: 10.1371/journal.pone.0072324) (PMID:23991091) (PMCID:PMC3749101)
Rainey, A.-A., Gilchrist, D. S., Tange, C. E., Frleta, M., Crawford, L., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-125a: A novel regulator of IL-6 and TLR driven pathways in RA pathogenesis. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S404.
Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.
2012
Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)
Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)
Frleta, M., King, V., Reilly, J.H., Gilchrist, D.S., Tornehave, D., Lundsgaard, D., Miller, A.M. and McInnes, I.B. (2012) Expression of IL-21 receptor in synovial tissue and blood of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71(Sup. 1), A83. (doi: 10.1136/annrheumdis-2011-201238.25)
Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)
Kurowska-Stolarska, M. , Hasoo, M., Gilchrist, D. G., Ruzicska, E., Asquith, D., Welsh, D., Crawford, L., Hirani, N., McInnes, I. B. and McSharry, C. (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)
2011
Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi: 10.1182/blood-2011-03-344044)
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Komai-Koma, M., Gilchrist, D. S., McKenzie, A. N. J., Goodyear, C. S. , Xu, D. and Liew, F. Y. (2011) IL-33 activates B1 cells and exacerbates contact sensitivity. Journal of Immunology, 186(4), pp. 2584-2591. (doi: 10.4049/jimmunol.1002103)
Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.
2009
Komai-Koma, M., Gilchrist, D. S. and Xu, D. (2009) Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. European Journal of Immunology, 39(6), pp. 1564-1572. (doi: 10.1002/eji.200838866)
Jiang, H., Gilchrist, D., Popoff, J., Jamieson, S., Truscott, M., White, J. and Blackwell, J. (2009) Influence of Slc11a1 (formerly Nramp1) on DSS-induced colitis in mice. Journal of Leukocyte Biology, 85(4), pp. 703-710.
2008
Li, Y., Komai-Koma, M., Gilchrist, D.S., Hsu, D.K., Liu, F.-T., Spingall, T. and Xu, D. (2008) Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. Journal of Immunology, 181(4), pp. 2781-2789.
2007
Nibbs, R. J.B. , Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D. and Graham, G. J. (2007) The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. Journal of Clinical Investigation, 117(7), pp. 1884-1892. (doi: 10.1172/JCI30068)
Articles
Nyirenda, M. H., Nijjar, J. S., Frleta-Gilchrist, M., Gilchrist, D. S., Porter, D., Siebert, S. , Goodyear, C. S. and McInnes, I. B. (2023) JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation. RMD Open, 9(1), e002671. (doi: 10.1136/rmdopen-2022-002671) (PMID:36599629) (PMCID:PMC9815080)
Kara, E. E. et al. (2018) Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), pp. 801-813. (doi: 10.1084/jem.20171067) (PMID:29386231)
Watts, A. E. et al. (2017) MicroRNA29a treatment improves early tendon injury. Molecular Therapy, 25(10), pp. 2415-2426. (doi: 10.1016/j.ymthe.2017.07.015) (PMID:28822690)
Akbar, M. et al. (2017) Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis. RMD Open, 3(2), e000456. (doi: 10.1136/rmdopen-2017-000456) (PMID:28879051) (PMCID:PMC5574425)
Kurow, O. et al. (2017) Full length interleukin 33 aggravates radiation-induced skin reaction. Frontiers in Immunology, 8, 722. (doi: 10.3389/fimmu.2017.00722) (PMID:28702024) (PMCID:PMC5487387)
Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)
Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)
Millar, N. L. , Gilchrist, D., Akbar, M., Reilly, J. H., Kerr, S. C., Campbell, A. L., Murrell, G. A.C., Liew, F. Y., Kurowska-Stolarska, M. and McInnes, I. B. (2015) MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nature Communications, 6, 6774. (doi: 10.1038/ncomms7774) (PMID:25857925) (PMCID:PMC4403384)
Miller, A. M., Gilchrist, D. S., Nijjar, J., Araldi, E., Ramirez, C. M., Lavery, C. A., Fernández-Hernando, C., McInnes, I. B. and Kurowska-Stolarska, M. (2013) MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE, 8(8), e72324. (doi: 10.1371/journal.pone.0072324) (PMID:23991091) (PMCID:PMC3749101)
Frleta, M., King, V., Reilly, J.H., Gilchrist, D.S., Tornehave, D., Lundsgaard, D., Miller, A.M. and McInnes, I.B. (2012) Expression of IL-21 receptor in synovial tissue and blood of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71(Sup. 1), A83. (doi: 10.1136/annrheumdis-2011-201238.25)
Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)
Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi: 10.1182/blood-2011-03-344044)
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Komai-Koma, M., Gilchrist, D. S., McKenzie, A. N. J., Goodyear, C. S. , Xu, D. and Liew, F. Y. (2011) IL-33 activates B1 cells and exacerbates contact sensitivity. Journal of Immunology, 186(4), pp. 2584-2591. (doi: 10.4049/jimmunol.1002103)
Komai-Koma, M., Gilchrist, D. S. and Xu, D. (2009) Direct recognition of LPS by human but not murine CD8+ T cells via TLR4 complex. European Journal of Immunology, 39(6), pp. 1564-1572. (doi: 10.1002/eji.200838866)
Jiang, H., Gilchrist, D., Popoff, J., Jamieson, S., Truscott, M., White, J. and Blackwell, J. (2009) Influence of Slc11a1 (formerly Nramp1) on DSS-induced colitis in mice. Journal of Leukocyte Biology, 85(4), pp. 703-710.
Li, Y., Komai-Koma, M., Gilchrist, D.S., Hsu, D.K., Liu, F.-T., Spingall, T. and Xu, D. (2008) Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. Journal of Immunology, 181(4), pp. 2781-2789.
Nibbs, R. J.B. , Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D. and Graham, G. J. (2007) The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. Journal of Clinical Investigation, 117(7), pp. 1884-1892. (doi: 10.1172/JCI30068)
Conference or Workshop Item
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)
Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)
Conference Proceedings
Frleta, M., Rainey, A.-A., Gilchrist, D.S., Crawford, L., Baxter, D., Kurowska-Stolarska, M. and McInnes, I.B. (2013) Mir-27b as Biomarker and Regulator of IL-6R Pathway in Resistant Rheumatoid Arthritis Monocyte. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S1035.
Millar, N.L. , Gilchrist, D.S., Kurowska-Stolarska, M. , Murrell, G.A.C. and McInnes, I. B. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: EULAR 2013: Annual European Congress of Rheumatology, Madrid, Spain, 12-15 June 2013, p. 140.
Millar, N. L. , Gilchrist, D. S., Kurowska-Stolarska, M. , Murrell, G. A.C. and McInnes, I. (2013) The Interleukin 33/miR29 Axis Regulates Differential Collagen Production in Tendinopathy. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S405.
Rainey, A.-A., Gilchrist, D. S., Tange, C. E., Frleta, M., Crawford, L., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-125a: A novel regulator of IL-6 and TLR driven pathways in RA pathogenesis. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S404.
Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.
Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. , McInnes, I. and Kurowska-Stolarska, M. (2012) The role of miR-155 in monocyte migration in Rheumatoid arthritis. In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012, pp. 588-589. (doi: 10.1111/imm.12002)
Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D. , McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi: 10.1002/art.37735)
Kurowska-Stolarska, M. , Hasoo, M., Gilchrist, D. G., Ruzicska, E., Asquith, D., Welsh, D., Crawford, L., Hirani, N., McInnes, I. B. and McSharry, C. (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)
Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.