Professor Brenda Gibson
- Honorary Senior Research Fellow (School of Cancer Sciences)
email:
Brenda.Gibson@glasgow.ac.uk
Department of Haematology and Oncology, Royal Hospital for Children, 1345 Govan Road, Glasgow, G51 4TF
Publications
2024
Wilson, A. et al. (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205(6), pp. 2355-2362. (doi: 10.1111/bjh.19791) (PMID:39327775)
Laing, A. et al. (2024) Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism. British Journal of Haematology, (doi: 10.1111/bjh.19884) (Early Online Publication)
2020
Sarrou, E. , Richmond, L. , Carmody, R. J. , Gibson, B. and Keeshan, K. (2020) CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis. International Journal of Molecular Sciences, 21(12), 4266. (doi: 10.3390/ijms21124266) (PMID:32549410) (PMCID:PMC7352880)
2019
Yousafzai, Y. M. et al. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, 10623. (doi: 10.1016/j.leukres.2019.106232) (PMID:31706196)
2018
Chaudhury, S. et al. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, 5280. (doi: 10.1038/s41467-018-07584-1) (PMID:30538250) (PMCID:PMC6290074)
Newcombe, A. A., Gibson, B. E.S. and Keeshan, K. (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi: 10.1016/j.exphem.2018.03.008) (PMID:29608923)
2017
Laing, A. A., Harrison, C. J., Gibson, B. E.S. and Keeshan, K. (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi: 10.1016/j.exphem.2017.06.007) (PMID:28668350)
Sarrou, E. , Gibson, B. and Keeshan, K. (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017. S69. (doi: 10.1016/j.exphem.2017.06.134)
2016
Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Veys, P. et al. (2016) UK experience of unrelated cord blood transplantation in paediatric patients. British Journal of Haematology, 172(3), pp. 482-486. (doi: 10.1111/bjh.13914) (PMID:26728432)
2015
Chaudhury, S. S. , Morison, J. K., Gibson, B. E.S. and Keeshan, K. (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi: 10.1016/j.exphem.2015.05.008) (PMID:26051919)
2014
Marsh, J.C. et al. (2014) Retrospective study of alemtuzumab vs ATG-based conditioning without irradiation for unrelated and matched sibling donor transplants in acquired severe aplastic anemia: a study from the British society for blood and marrow transplantation. Bone Marrow Transplantation, 49(1), pp. 42-48. (doi: 10.1038/bmt.2013.115) (PMID:23912664)
Creutzig, U. et al. (2014) The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01. Haematologica, 99(9), pp. 1472-1478. (doi: 10.3324/haematol.2014.104182) (PMID:24763401)
Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970) (PMID:24700781)
2013
Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.
Roberts, I. et al. (2013) GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Blood, 122(24), pp. 3908-3917. (doi: 10.1182/blood-2013-07-515148)
Kaspers, G.J.L. et al. (2013) Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the international BFM study group. Journal of Clinical Oncology, 31(5), pp. 599-607. (doi: 10.1200/JCO.2012.43.7384)
2012
Geoerger, B. et al. (2012) A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: An Innovative Therapies for Children with Cancer (ITCC) study. European Journal of Cancer, 48(3), pp. 289-296. (doi: 10.1016/j.ejca.2011.10.036)
Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)
Samarasinghe, S. et al. (2012) Excellent outcome of matched unrelated donor transplantation in paediatric aplastic anaemia following failure with immunosuppressive therapy: a United Kingdom multicentre retrospective experience. British Journal of Haematology, 157(3), pp. 339-346. (doi: 10.1111/j.1365-2141.2012.09066.x)
Taylor, G.M., Wade, R., Hussain, A., Thompson, P., Hann, I., Gibson, B., Eden, T. and Richards, S. (2012) HLA-DPβ1 Asp84-Lys69 antigen-binding signature predicts event-free survival in childhood B-cell precursor acute lymphoblastic leukaemia: results from the MRC UKALL XI childhood ALL trial. Blood Cancer Journal, 2(7), e80. (doi: 10.1038/bcj.2012.25)
2011
Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)
Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)
Gibson, B.E.S., Webb, D.K.H., Howman, A.J., De Graaf, S.S.N., Harrison, C.J. and Wheatley, K. (2011) Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial. British Journal of Haematology, 155(3), pp. 366-376. (doi: 10.1111/j.1365-2141.2011.08851.x)
2010
Harrison, C.J. et al. (2010) Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council treatment trials AML 10 and 12. Journal of Clinical Oncology, 28(16), pp. 2674-2681. (doi: 10.1200/JCO.2009.24.8997)
Burnett, A.K., Hills, R.K., Milligan, D.W., Goldstone, A.H., Prentice, A.G., McMullin, M.-F., Duncombe, A., Gibson, B. and Wheatley, K. (2010) Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial. Journal of Clinical Oncology, 28(4), pp. 586-595. (doi: 10.1200/JCO.2009.22.9088)
2007
Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi: 10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)
2006
Gibson, B. E.S. and Halsey, C. (2006) Nonimmune neonatal anemias. In: Arceci, Robert, Hann, Ian M. and Smith, Owen P. (eds.) Pediatric Hematology. Blackwell Publishing: Malden, pp. 130-150. ISBN 9781405134002 (doi: 10.1002/9780470987001.ch7)
2001
Kennedy, H.F., Gemmell, C.G., Bagg, J. , Gibson, B.E.S. and Michie, J.R. (2001) Antimicrobial susceptibility of blood culture isolates of viridans streptococci: relationship to a change in empirical antibiotic therapy in febrile neutropenia. Journal of Antimicrobial Chemotherapy, 47(5), 693 -696. (doi: 10.1093/jac/47.5.693)
Articles
Wilson, A. et al. (2024) Real‐world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies. British Journal of Haematology, 205(6), pp. 2355-2362. (doi: 10.1111/bjh.19791) (PMID:39327775)
Laing, A. et al. (2024) Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism. British Journal of Haematology, (doi: 10.1111/bjh.19884) (Early Online Publication)
Sarrou, E. , Richmond, L. , Carmody, R. J. , Gibson, B. and Keeshan, K. (2020) CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis. International Journal of Molecular Sciences, 21(12), 4266. (doi: 10.3390/ijms21124266) (PMID:32549410) (PMCID:PMC7352880)
Yousafzai, Y. M. et al. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, 10623. (doi: 10.1016/j.leukres.2019.106232) (PMID:31706196)
Chaudhury, S. et al. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, 5280. (doi: 10.1038/s41467-018-07584-1) (PMID:30538250) (PMCID:PMC6290074)
Newcombe, A. A., Gibson, B. E.S. and Keeshan, K. (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi: 10.1016/j.exphem.2018.03.008) (PMID:29608923)
Laing, A. A., Harrison, C. J., Gibson, B. E.S. and Keeshan, K. (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi: 10.1016/j.exphem.2017.06.007) (PMID:28668350)
Veys, P. et al. (2016) UK experience of unrelated cord blood transplantation in paediatric patients. British Journal of Haematology, 172(3), pp. 482-486. (doi: 10.1111/bjh.13914) (PMID:26728432)
Chaudhury, S. S. , Morison, J. K., Gibson, B. E.S. and Keeshan, K. (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi: 10.1016/j.exphem.2015.05.008) (PMID:26051919)
Marsh, J.C. et al. (2014) Retrospective study of alemtuzumab vs ATG-based conditioning without irradiation for unrelated and matched sibling donor transplants in acquired severe aplastic anemia: a study from the British society for blood and marrow transplantation. Bone Marrow Transplantation, 49(1), pp. 42-48. (doi: 10.1038/bmt.2013.115) (PMID:23912664)
Creutzig, U. et al. (2014) The prognostic significance of early treatment response in pediatric relapsed acute myeloid leukemia: results of the international study Relapsed AML 2001/01. Haematologica, 99(9), pp. 1472-1478. (doi: 10.3324/haematol.2014.104182) (PMID:24763401)
Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970) (PMID:24700781)
Roberts, I. et al. (2013) GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Blood, 122(24), pp. 3908-3917. (doi: 10.1182/blood-2013-07-515148)
Kaspers, G.J.L. et al. (2013) Improved outcome in pediatric relapsed acute myeloid leukemia: results of a randomized trial on liposomal daunorubicin by the international BFM study group. Journal of Clinical Oncology, 31(5), pp. 599-607. (doi: 10.1200/JCO.2012.43.7384)
Geoerger, B. et al. (2012) A phase I and pharmacokinetic study of plitidepsin in children with advanced solid tumours: An Innovative Therapies for Children with Cancer (ITCC) study. European Journal of Cancer, 48(3), pp. 289-296. (doi: 10.1016/j.ejca.2011.10.036)
Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)
Samarasinghe, S. et al. (2012) Excellent outcome of matched unrelated donor transplantation in paediatric aplastic anaemia following failure with immunosuppressive therapy: a United Kingdom multicentre retrospective experience. British Journal of Haematology, 157(3), pp. 339-346. (doi: 10.1111/j.1365-2141.2012.09066.x)
Taylor, G.M., Wade, R., Hussain, A., Thompson, P., Hann, I., Gibson, B., Eden, T. and Richards, S. (2012) HLA-DPβ1 Asp84-Lys69 antigen-binding signature predicts event-free survival in childhood B-cell precursor acute lymphoblastic leukaemia: results from the MRC UKALL XI childhood ALL trial. Blood Cancer Journal, 2(7), e80. (doi: 10.1038/bcj.2012.25)
Gibson, B.E.S., Webb, D.K.H., Howman, A.J., De Graaf, S.S.N., Harrison, C.J. and Wheatley, K. (2011) Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial. British Journal of Haematology, 155(3), pp. 366-376. (doi: 10.1111/j.1365-2141.2011.08851.x)
Harrison, C.J. et al. (2010) Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council treatment trials AML 10 and 12. Journal of Clinical Oncology, 28(16), pp. 2674-2681. (doi: 10.1200/JCO.2009.24.8997)
Burnett, A.K., Hills, R.K., Milligan, D.W., Goldstone, A.H., Prentice, A.G., McMullin, M.-F., Duncombe, A., Gibson, B. and Wheatley, K. (2010) Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial. Journal of Clinical Oncology, 28(4), pp. 586-595. (doi: 10.1200/JCO.2009.22.9088)
Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi: 10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)
Kennedy, H.F., Gemmell, C.G., Bagg, J. , Gibson, B.E.S. and Michie, J.R. (2001) Antimicrobial susceptibility of blood culture isolates of viridans streptococci: relationship to a change in empirical antibiotic therapy in febrile neutropenia. Journal of Antimicrobial Chemotherapy, 47(5), 693 -696. (doi: 10.1093/jac/47.5.693)
Book Sections
Gibson, B. E.S. and Halsey, C. (2006) Nonimmune neonatal anemias. In: Arceci, Robert, Hann, Ian M. and Smith, Owen P. (eds.) Pediatric Hematology. Blackwell Publishing: Malden, pp. 130-150. ISBN 9781405134002 (doi: 10.1002/9780470987001.ch7)
Conference or Workshop Item
Sarrou, E. , Gibson, B. and Keeshan, K. (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017. S69. (doi: 10.1016/j.exphem.2017.06.134)
Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.
Conference Proceedings
Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)
Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)