Dr Phil Whitfield
- College Head of Facilities (MVLS Research Facilities)
https://orcid.org/0000-0002-0814-4119Publications
2024
Mezincescu, A. M. et al. (2024) Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes. Nature Communications, 15(1), 3690. (doi: 10.1038/s41467-024-47843-y) (PMID:38750012) (PMCID:PMC11096352)
2023
Crozier, L. et al. (2023) CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Molecular Cell, 83(22), 4062-4077.e5. (doi: 10.1016/j.molcel.2023.10.016) (PMID:37977118)
Suchacki, K. J. et al. (2023) The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent. eLife, 12, e88080. (doi: 10.7554/elife.88080) (PMID:37096321) (PMCID:PMC10171869)
Thompson, D., Mahmood, S., Morrice, N., Kamli-Salino, S., Dekeryte, R., Hoffmann, P. A., Doherty, M. K., Whitfield, P. D. , Delibegović, M. and Mody, N. (2023) Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR −/− mice. Scientific Reports, 13, 3937. (doi: 10.1038/s41598-023-30759-w) (PMID:36894641) (PMCID:PMC9998859)
Aye, C.-C. et al. (2023) CBL/CAP is essential for mitochondria respiration complex I assembly and bioenergetics efficiency in muscle cells. International Journal of Molecular Sciences, 24(4), 3399. (doi: 10.3390/ijms24043399) (PMID:36834818) (PMCID:PMC9964740)
2022
Kurzawa‐Akanbi, M. et al. (2022) Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina. Journal of Extracellular Vesicles, 11(12), 12295. (doi: 10.1002/jev2.12295) (PMID:36544284) (PMCID:PMC9772497)
Raposo de Magalhães, C., Farinha, A. P., Blackburn, G., Whitfield, P. D. , Carrilho, R., Schrama, D., Cerqueira, M. and Rodrigues, P. M. (2022) Gilthead seabream liver integrative proteomics and metabolomics analysis reveals regulation by different prosurvival pathways in the metabolic adaptation to stress. International Journal of Molecular Sciences, 23(23), 15395. (doi: 10.3390/ijms232315395) (PMID:36499720) (PMCID:PMC9741202)
O'Brien, Á. C. et al. (2022) Using organic contaminants to constrain the terrestrial journey of the martian meteorite Lafayette. Astrobiology, 22(11), pp. 1351-1362. (doi: 10.1089/ast.2021.0180) (PMID:36264546) (PMCID:PMC9618387)
Bedi, P., Ziegler, K., Whitfield, P. D. , Davidson, D., Rossi, A. G. and Hill, A. T. (2022) Dysregulation of prostaglandins, leukotrienes and lipoxin A4 in bronchiectasis. Thorax, 77(10), pp. 960-967. (doi: 10.1136/thoraxjnl-2020-216475) (PMID:34789559) (PMCID:PMC9510413)
Gurke, R. et al. (2022) Omics and multi-omics analysis for the early identification and improved outcome of patients with psoriatic arthritis. Biomedicines, 10(10), 2387. (doi: 10.3390/biomedicines10102387) (PMID:36289648) (PMCID:PMC9598654)
Alpizar-Sosa, E. A., Kumordzi, Y., Wei, W., Whitfield, P. D. , Barrett, M. P. and Denny, P. W. (2022) Genome deletions to overcome the directed loss of gene function in Leishmania. Frontiers in Cellular and Infection Microbiology, 12, 988688. (doi: 10.3389/fcimb.2022.988688) (PMID:36211960) (PMCID:PMC9539739)
Brace, N., Megson, I. L., Rossi, A. G., Doherty, M. K. and Whitfield, P. D. (2022) SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages. Journal of Inflammation, 19, 12. (doi: 10.1186/s12950-022-00309-8) (PMID:36050729) (PMCID:PMC9438320)
2021
McCreath, G., Whitfield, P. D. , Roe, A. J. , Watson, M. J. and Sim, M. A.B. (2021) A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol. BMC Infectious Diseases, 21, 1204. (doi: 10.1186/s12879-021-06832-y)
Kurzawa-Akanbi, M. et al. (2021) Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders. Acta Neuropathologica, 142(6), pp. 961-984. (doi: 10.1007/s00401-021-02367-3) (PMID:34514546)
Morro, B. et al. (2021) Endoplasmic reticulum stress as a key mechanism in stunted growth of seawater rainbow trout (Oncorhynchus mykiss). BMC Genomics, 22, 824. (doi: 10.1186/s12864-021-08153-5) (PMCID:PMC8594166)
2020
Martin, S. F., Doherty, M. K., Chirnside, E., Tammireddy, S. R., Liu, J., LeBihan, T. and Whitfield, P. D. (2020) Surviving starvation: proteomic and lipidomic profiling of nutrient deprivation in the smallest known free-living eukaryote. Metabolites, 10(7), 273. (doi: 10.3390/metabo10070273) (PMID:32635273)
2019
Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Have, S. T., Whitfield, P. D. , Lamond, A. I. and Brown, S. J. (2019) Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model. Wellcome Open Research, 4, 134. (doi: 10.12688/wellcomeopenres.15405.2) (PMID:31641698) (PMCID:PMC6790913)
2011
Eckersall, P. D. and Whitfield, P. D. (Eds.) (2011) Methods in Animal Proteomics. Wiley-Blackwell: Chichester. ISBN 9780813817910
Articles
Mezincescu, A. M. et al. (2024) Comparison of intramyocellular lipid metabolism in patients with diabetes and male athletes. Nature Communications, 15(1), 3690. (doi: 10.1038/s41467-024-47843-y) (PMID:38750012) (PMCID:PMC11096352)
Crozier, L. et al. (2023) CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence. Molecular Cell, 83(22), 4062-4077.e5. (doi: 10.1016/j.molcel.2023.10.016) (PMID:37977118)
Suchacki, K. J. et al. (2023) The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent. eLife, 12, e88080. (doi: 10.7554/elife.88080) (PMID:37096321) (PMCID:PMC10171869)
Thompson, D., Mahmood, S., Morrice, N., Kamli-Salino, S., Dekeryte, R., Hoffmann, P. A., Doherty, M. K., Whitfield, P. D. , Delibegović, M. and Mody, N. (2023) Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR −/− mice. Scientific Reports, 13, 3937. (doi: 10.1038/s41598-023-30759-w) (PMID:36894641) (PMCID:PMC9998859)
Aye, C.-C. et al. (2023) CBL/CAP is essential for mitochondria respiration complex I assembly and bioenergetics efficiency in muscle cells. International Journal of Molecular Sciences, 24(4), 3399. (doi: 10.3390/ijms24043399) (PMID:36834818) (PMCID:PMC9964740)
Kurzawa‐Akanbi, M. et al. (2022) Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina. Journal of Extracellular Vesicles, 11(12), 12295. (doi: 10.1002/jev2.12295) (PMID:36544284) (PMCID:PMC9772497)
Raposo de Magalhães, C., Farinha, A. P., Blackburn, G., Whitfield, P. D. , Carrilho, R., Schrama, D., Cerqueira, M. and Rodrigues, P. M. (2022) Gilthead seabream liver integrative proteomics and metabolomics analysis reveals regulation by different prosurvival pathways in the metabolic adaptation to stress. International Journal of Molecular Sciences, 23(23), 15395. (doi: 10.3390/ijms232315395) (PMID:36499720) (PMCID:PMC9741202)
O'Brien, Á. C. et al. (2022) Using organic contaminants to constrain the terrestrial journey of the martian meteorite Lafayette. Astrobiology, 22(11), pp. 1351-1362. (doi: 10.1089/ast.2021.0180) (PMID:36264546) (PMCID:PMC9618387)
Bedi, P., Ziegler, K., Whitfield, P. D. , Davidson, D., Rossi, A. G. and Hill, A. T. (2022) Dysregulation of prostaglandins, leukotrienes and lipoxin A4 in bronchiectasis. Thorax, 77(10), pp. 960-967. (doi: 10.1136/thoraxjnl-2020-216475) (PMID:34789559) (PMCID:PMC9510413)
Gurke, R. et al. (2022) Omics and multi-omics analysis for the early identification and improved outcome of patients with psoriatic arthritis. Biomedicines, 10(10), 2387. (doi: 10.3390/biomedicines10102387) (PMID:36289648) (PMCID:PMC9598654)
Alpizar-Sosa, E. A., Kumordzi, Y., Wei, W., Whitfield, P. D. , Barrett, M. P. and Denny, P. W. (2022) Genome deletions to overcome the directed loss of gene function in Leishmania. Frontiers in Cellular and Infection Microbiology, 12, 988688. (doi: 10.3389/fcimb.2022.988688) (PMID:36211960) (PMCID:PMC9539739)
Brace, N., Megson, I. L., Rossi, A. G., Doherty, M. K. and Whitfield, P. D. (2022) SILAC-based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages. Journal of Inflammation, 19, 12. (doi: 10.1186/s12950-022-00309-8) (PMID:36050729) (PMCID:PMC9438320)
McCreath, G., Whitfield, P. D. , Roe, A. J. , Watson, M. J. and Sim, M. A.B. (2021) A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol. BMC Infectious Diseases, 21, 1204. (doi: 10.1186/s12879-021-06832-y)
Kurzawa-Akanbi, M. et al. (2021) Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders. Acta Neuropathologica, 142(6), pp. 961-984. (doi: 10.1007/s00401-021-02367-3) (PMID:34514546)
Morro, B. et al. (2021) Endoplasmic reticulum stress as a key mechanism in stunted growth of seawater rainbow trout (Oncorhynchus mykiss). BMC Genomics, 22, 824. (doi: 10.1186/s12864-021-08153-5) (PMCID:PMC8594166)
Martin, S. F., Doherty, M. K., Chirnside, E., Tammireddy, S. R., Liu, J., LeBihan, T. and Whitfield, P. D. (2020) Surviving starvation: proteomic and lipidomic profiling of nutrient deprivation in the smallest known free-living eukaryote. Metabolites, 10(7), 273. (doi: 10.3390/metabo10070273) (PMID:32635273)
Elias, M. S., Wright, S. C., Nicholson, W. V., Morrison, K. D., Prescott, A. R., Have, S. T., Whitfield, P. D. , Lamond, A. I. and Brown, S. J. (2019) Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model. Wellcome Open Research, 4, 134. (doi: 10.12688/wellcomeopenres.15405.2) (PMID:31641698) (PMCID:PMC6790913)
Edited Books
Eckersall, P. D. and Whitfield, P. D. (Eds.) (2011) Methods in Animal Proteomics. Wiley-Blackwell: Chichester. ISBN 9780813817910