2021

Steketee, P. C., Giordani, F. , Vincent, I. M. , Crouch, K. , Achcar, F. , Dickens, N. J. , Morrison, L. J., MacLeod, A. and Barrett, M. P. (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Nile, D. L., Rae, C. , Walker, D. J. , Canning Waddington, J., Vincent, I. , Burgess, K., Gaze, M. N., Mairs, R. J. and Chalmers, A. J. (2021) Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells. Cancer and Metabolism, 9, 24. (doi: 10.1186/s40170-021-00258-5) (PMID:34011385) (PMCID:PMC8136224)

McLuskey, K., Wandy, J. , Vincent, I. , Van Der Hooft, J. J.J. , Rogers, S. , Burgess, K. and Daly, R. (2021) Ranking metabolite sets by their activity levels. Metabolites, 11(2), 103. (doi: 10.3390/metabo11020103) (PMID:33670102) (PMCID:PMC7916825)

2020

Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)

2019

Lim, A. S. T., Vincent, I. M. , Barrett, M. P. and Gilbert, I. H. (2019) Small polar hits against S. aureus: screening, initial hit optimization, and metabolomic studies. ACS Omega, 4(21), pp. 19199-19215. (doi: 10.1021/acsomega.9b02507) (PMID:31763544) (PMCID:PMC6869403)

2018

Begolo, D. et al. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14(9), e1007315. (doi: 10.1371/journal.ppat.1007315) (PMID:30252911) (PMCID:PMC6173450)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Rattigan, K. M., Pountain, A. W. , Regnault, C., Achcar, F. , Vincent, I. M. , Goodyear, C. S. and Barrett, M. P. (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

Zhang, N. et al. (2018) Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PLoS Pathogens, 14(2), e1006850. (doi: 10.1371/journal.ppat.1006850) (PMID:29425238) (PMCID:PMC5823473)

2017

Fernandez-Prada, C., Vincent, I.M. , Gazanion, E. and Monte-Neto, R.L. (2017) Omics and their impact on the development of chemotherapy against Leishmania. In: Rivas, L. and Gil, C. (eds.) Drug Discovery for Leishmaniasis. Series: Drug discovery series (60). Royal Society of Chemistry: Cambridge, pp. 101-129. ISBN 9781782628897 (doi: 10.1039/9781788010177-00101)

Mwenechanya, R. et al. (2017) Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS Neglected Tropical Diseases, 11(6), e0005649. (doi: 10.1371/journal.pntd.0005649) (PMID:28622334) (PMCID:PMC5498063)

Akram, M. I., Vincent, I. , Siddiqui, A. J. and Musharraf, S. G. (2017) Polymeric hydrophilic interaction liquid chromatography coupled with Orbitrap mass spectrometry and chemometric analysis for untargeted metabolite profiling of natural rice variants. Journal of Cereal Science, 73, pp. 165-173. (doi: 10.1016/j.jcs.2017.01.001)

2016

Vincent, I. M. , Daly, R. , Courtioux, B., Cattanach, A. M., Biéler, S., Ndung’u, J. M., Bisser, S. and Barrett, M. P. (2016) Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis. PLoS Neglected Tropical Diseases, 10(12), e0005140. (doi: 10.1371/journal.pntd.0005140) (PMID:27941966) (PMCID:PMC5152828)

Maes, L., Fernandez-Prada, C., Vincent, I. M. , Brotherton, M.-C., Roberts, M., Roy, G., Rivas, L., Leprohon, P., Smith, T. K. and Ouellette, M. (2016) Different mutations in a p-type ATPase transporter in Leishmania parasites are associated with cross-resistance to two leading drugs by distinct mechanisms. PLoS Neglected Tropical Diseases, 10(12), e0005171. (doi: 10.1371/journal.pntd.0005171) (PMID:27911896) (PMCID:PMC5135041)

2015

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

Vincent, I.M. and Barrett, M.B. (2015) Metabolomic-based strategies for anti-parasite drug discovery. Journal of Biomolecular Screening, 20(1), pp. 44-55. (doi: 10.1177/1087057114551519) (PMID:25281738)

2014

Vincent, I. M. , Weidt, S., Rivas, L., Burgess, K., Smith, T. K. and Ouellette, M. (2014) Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism. International Journal for Parasitology: Drugs and Drug Resistance, 4(1), pp. 20-27. (doi: 10.1016/j.ijpddr.2013.11.002) (PMID:24596665) (PMCID:PMC3940234)

De Paula Lima, C. V., Batista, M., Kugeratski, F. G., Vincent, I. M. , Soares, M. J., Probst, C. M., Krieger, M. A. and Marchini, F. K. (2014) LM14 defined medium enables continuous growth of Trypanosoma cruzi. BMC Microbiology, 14(238), (doi: 10.1186/s12866-014-0238-y)

2013

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi: 10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)

Creek, D.J., Vincent, I.M. and Barrett, M.P. (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi: 10.1002/9783527670383.ch3)

2012

Vincent, I.M. , Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi: 10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)

2011

Barrett, M.P. , Vincent, I.M. , Burchmore, R.J.S. , Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi: 10.2217/fmb.11.88) (PMID:21958143)

2010

Vincent, I.M. , Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi: 10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)

Articles

Steketee, P. C., Giordani, F. , Vincent, I. M. , Crouch, K. , Achcar, F. , Dickens, N. J. , Morrison, L. J., MacLeod, A. and Barrett, M. P. (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)

Nile, D. L., Rae, C. , Walker, D. J. , Canning Waddington, J., Vincent, I. , Burgess, K., Gaze, M. N., Mairs, R. J. and Chalmers, A. J. (2021) Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells. Cancer and Metabolism, 9, 24. (doi: 10.1186/s40170-021-00258-5) (PMID:34011385) (PMCID:PMC8136224)

McLuskey, K., Wandy, J. , Vincent, I. , Van Der Hooft, J. J.J. , Rogers, S. , Burgess, K. and Daly, R. (2021) Ranking metabolite sets by their activity levels. Metabolites, 11(2), 103. (doi: 10.3390/metabo11020103) (PMID:33670102) (PMCID:PMC7916825)

Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)

Lim, A. S. T., Vincent, I. M. , Barrett, M. P. and Gilbert, I. H. (2019) Small polar hits against S. aureus: screening, initial hit optimization, and metabolomic studies. ACS Omega, 4(21), pp. 19199-19215. (doi: 10.1021/acsomega.9b02507) (PMID:31763544) (PMCID:PMC6869403)

Begolo, D. et al. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14(9), e1007315. (doi: 10.1371/journal.ppat.1007315) (PMID:30252911) (PMCID:PMC6173450)

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Rattigan, K. M., Pountain, A. W. , Regnault, C., Achcar, F. , Vincent, I. M. , Goodyear, C. S. and Barrett, M. P. (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)

Zhang, N. et al. (2018) Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PLoS Pathogens, 14(2), e1006850. (doi: 10.1371/journal.ppat.1006850) (PMID:29425238) (PMCID:PMC5823473)

Mwenechanya, R. et al. (2017) Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana. PLoS Neglected Tropical Diseases, 11(6), e0005649. (doi: 10.1371/journal.pntd.0005649) (PMID:28622334) (PMCID:PMC5498063)

Akram, M. I., Vincent, I. , Siddiqui, A. J. and Musharraf, S. G. (2017) Polymeric hydrophilic interaction liquid chromatography coupled with Orbitrap mass spectrometry and chemometric analysis for untargeted metabolite profiling of natural rice variants. Journal of Cereal Science, 73, pp. 165-173. (doi: 10.1016/j.jcs.2017.01.001)

Vincent, I. M. , Daly, R. , Courtioux, B., Cattanach, A. M., Biéler, S., Ndung’u, J. M., Bisser, S. and Barrett, M. P. (2016) Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis. PLoS Neglected Tropical Diseases, 10(12), e0005140. (doi: 10.1371/journal.pntd.0005140) (PMID:27941966) (PMCID:PMC5152828)

Maes, L., Fernandez-Prada, C., Vincent, I. M. , Brotherton, M.-C., Roberts, M., Roy, G., Rivas, L., Leprohon, P., Smith, T. K. and Ouellette, M. (2016) Different mutations in a p-type ATPase transporter in Leishmania parasites are associated with cross-resistance to two leading drugs by distinct mechanisms. PLoS Neglected Tropical Diseases, 10(12), e0005171. (doi: 10.1371/journal.pntd.0005171) (PMID:27911896) (PMCID:PMC5135041)

Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)

Vincent, I.M. and Barrett, M.B. (2015) Metabolomic-based strategies for anti-parasite drug discovery. Journal of Biomolecular Screening, 20(1), pp. 44-55. (doi: 10.1177/1087057114551519) (PMID:25281738)

Vincent, I. M. , Weidt, S., Rivas, L., Burgess, K., Smith, T. K. and Ouellette, M. (2014) Untargeted metabolomic analysis of miltefosine action in Leishmania infantum reveals changes to the internal lipid metabolism. International Journal for Parasitology: Drugs and Drug Resistance, 4(1), pp. 20-27. (doi: 10.1016/j.ijpddr.2013.11.002) (PMID:24596665) (PMCID:PMC3940234)

De Paula Lima, C. V., Batista, M., Kugeratski, F. G., Vincent, I. M. , Soares, M. J., Probst, C. M., Krieger, M. A. and Marchini, F. K. (2014) LM14 defined medium enables continuous growth of Trypanosoma cruzi. BMC Microbiology, 14(238), (doi: 10.1186/s12866-014-0238-y)

Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi: 10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)

Vincent, I.M. , Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi: 10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)

Barrett, M.P. , Vincent, I.M. , Burchmore, R.J.S. , Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi: 10.2217/fmb.11.88) (PMID:21958143)

Vincent, I.M. , Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi: 10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)

Book Sections

Fernandez-Prada, C., Vincent, I.M. , Gazanion, E. and Monte-Neto, R.L. (2017) Omics and their impact on the development of chemotherapy against Leishmania. In: Rivas, L. and Gil, C. (eds.) Drug Discovery for Leishmaniasis. Series: Drug discovery series (60). Royal Society of Chemistry: Cambridge, pp. 101-129. ISBN 9781782628897 (doi: 10.1039/9781788010177-00101)

Creek, D.J., Vincent, I.M. and Barrett, M.P. (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi: 10.1002/9783527670383.ch3)