Dr Mairi Clarke
- Examinations Invigilator (Academic Services)
telephone:
01413304025
email:
Mairi.Clarke@glasgow.ac.uk
Publications
2023
Lemonidis, K. , Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. and Walden, H. (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258) (PMCID:PMC9890228)
2022
Haney, J., Vijayakrishnan, S. , Streetley, J. , Dee, K., Goldfarb, D. M., Clarke, M. , Mullin, M., Carter, S. D. , Bhella, D. and Murcia, P. R. (2022) Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles. Nature Microbiology, 7(11), pp. 1879-1890. (doi: 10.1038/s41564-022-01242-5) (PMID:36280786)
Plucinski, A., Pavlovic, M., Clarke, M. , Bhella, D. and Schmidt, B. V.K.J. (2022) Stimuli-responsive aggregation of high molar mass poly(N,N-diethylacrylamide)-b-poly(4-acryloylmorpholine) in tetrahydrofuran. Macromolecular Rapid Communications, 43(3), 2100656. (doi: 10.1002/marc.202100656) (PMID:34783099)
2021
Junglas, B., Huber, S. T., Heidler, T., Schlosser, L., Mann, D., Hennig, R., Clarke, M. , Hellmann, N., Schneider, D. and Sachse, C. (2021) PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. Cell, 184(14), 3674-3688.e18. (doi: 10.1016/j.cell.2021.05.042) (PMID:34166616)
2020
Wan, W., Clarke, M. , Norris, M. J., Kolesnikova, L., Koehler, A., Bornholdt, Z. A., Becker, S., Ollmann Saphire, E. and Briggs, J. A.G. (2020) Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers. eLife, 9, e59225. (doi: 10.7554/eLife.59225) (PMID:33016878) (PMCID:PMC7588233)
Rennie, M. L. , Lemonidis, K. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. , Spagnolo, L. and Walden, H. (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133) (PMID:32510829) (PMCID:PMC7332966)
2018
Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)
2017
Wan, W., Kolesnikova, L., Clarke, M. , Koehler, A., Noda, T., Becker, S. and Briggs, J. A.G. (2017) Structure and assembly of the Ebola virus nucleocapsid. Nature, 551(7680), pp. 394-397. (doi: 10.1038/nature24490) (PMID:29144446) (PMCID:PMC5714281)
Schorb, M., Gaechter, L., Avinoam, O., Sieckmann, F., Clarke, M. , Bebeacua, C., Bykov, Y. S., Sonnen, A. F.-P., Lihl, R. and Briggs, J. A.G. (2017) New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography. Journal of Structural Biology, 197(2), pp. 83-93. (doi: 10.1016/j.jsb.2016.06.020) (PMID:27368127) (PMCID:PMC5287355)
2016
Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)
2014
Teoh, P. J., Menzies, F. M., Hansell, C. A.H., Clarke, M. , Waddell, C., Burton, G. J., Nelson, S. M. and Nibbs, R. J.B. (2014) Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice. Journal of Immunology, 193(10), pp. 5218-5228. (doi: 10.4049/jimmunol.1401096)
2012
Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)
2009
Bordon, Y., Hansell, C. A. H., Sester, D. P., Clarke, M. , Mowat, A. M. and Nibbs, R. J. B. (2009) The atypical chemokine receptor D6 contributes to the development of experimental colitis. Journal of Immunology, 182(8), pp. 5032-5040. (doi: 10.4049/jimmunol.0802802)
2006
Clarke, M. , Ewart, M.A., Santy, L.C., Prekeris, R. and Gould, G.W. (2006) ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochemical and Biophysical Research Communications, 342, pp. 1361-1367. (doi: 10.1016/j.bbrc.2006.02.102) (PMID:16516854)
2005
Ewart, M.-A., Clarke, M. , Kane, S., Chamberlain, L.H. and Gould, G.W. (2005) Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes. Journal of Biological Chemistry, 280, pp. 3812-3816. (doi: 10.1074/jbc.M409928200) (PMID:15550383)
2001
Ferlenghi, I., Clarke, M. , Ruttan, T., Allison, S. L., Schalich, J., Heinz, F. X., Harrison, S. C., Rey, F. A. and Fuller, S. D. (2001) Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Molecular Cell, 7(3), pp. 593-602. (doi: 10.1016/s1097-2765(01)00206-4) (PMID:11463384)
2000
Hill, E., Clarke, M. and Barr, F. A. (2000) The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO Journal, 19(21), pp. 5711-5719. (doi: 10.1093/emboj/19.21.5711) (PMID:11060022) (PMCID:PMC305783)
Mancini, E. J., Clarke, M. , Gowen, B. E., Rutten, T. and Fuller, S. D. (2000) Cryo-electron microscopy reveals the functional organization of an enveloped virus, Semliki Forest virus. Molecular Cell, 5(2), pp. 255-266. (doi: 10.1016/s1097-2765(00)80421-9) (PMID:10882067)
1999
Shorter, J., Watson, R., Giannakou, M.-E., Clarke, M. , Warren, G. and Barr, F. A. (1999) GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. EMBO Journal, 18(18), pp. 4949-4960. (doi: 10.1093/emboj/18.18.4949) (PMID:10487747) (PMCID:PMC1171566)
1994
Portella, G., Liddell, J., Crombie, R., Haddow, S., Clarke, M. , Stoler, A.B. and Balmain, A. (1994) Molecular mechanisms of invasion and metastasis during mouse skin tumour progression. Invasion and Metastasis, 14(1-6), pp. 7-16. (PMID:7657534)
1991
Burns, P.A., Brown, K., Brenmer, R., Clarke, M. and Balmain, A. (1991) Molecular alterations in oncogenes or tumor suppressor genes during chemical carcinogenesis. Progress in Histochemistry and Cytochemistry, 23(1-4), pp. 100-106. (doi: 10.1016/S0079-6336(11)80174-9) (PMID:1947131)
Articles
Lemonidis, K. , Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. and Walden, H. (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258) (PMCID:PMC9890228)
Haney, J., Vijayakrishnan, S. , Streetley, J. , Dee, K., Goldfarb, D. M., Clarke, M. , Mullin, M., Carter, S. D. , Bhella, D. and Murcia, P. R. (2022) Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles. Nature Microbiology, 7(11), pp. 1879-1890. (doi: 10.1038/s41564-022-01242-5) (PMID:36280786)
Plucinski, A., Pavlovic, M., Clarke, M. , Bhella, D. and Schmidt, B. V.K.J. (2022) Stimuli-responsive aggregation of high molar mass poly(N,N-diethylacrylamide)-b-poly(4-acryloylmorpholine) in tetrahydrofuran. Macromolecular Rapid Communications, 43(3), 2100656. (doi: 10.1002/marc.202100656) (PMID:34783099)
Junglas, B., Huber, S. T., Heidler, T., Schlosser, L., Mann, D., Hennig, R., Clarke, M. , Hellmann, N., Schneider, D. and Sachse, C. (2021) PspA adopts an ESCRT-III-like fold and remodels bacterial membranes. Cell, 184(14), 3674-3688.e18. (doi: 10.1016/j.cell.2021.05.042) (PMID:34166616)
Wan, W., Clarke, M. , Norris, M. J., Kolesnikova, L., Koehler, A., Bornholdt, Z. A., Becker, S., Ollmann Saphire, E. and Briggs, J. A.G. (2020) Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers. eLife, 9, e59225. (doi: 10.7554/eLife.59225) (PMID:33016878) (PMCID:PMC7588233)
Rennie, M. L. , Lemonidis, K. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. , Spagnolo, L. and Walden, H. (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133) (PMID:32510829) (PMCID:PMC7332966)
Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)
Wan, W., Kolesnikova, L., Clarke, M. , Koehler, A., Noda, T., Becker, S. and Briggs, J. A.G. (2017) Structure and assembly of the Ebola virus nucleocapsid. Nature, 551(7680), pp. 394-397. (doi: 10.1038/nature24490) (PMID:29144446) (PMCID:PMC5714281)
Schorb, M., Gaechter, L., Avinoam, O., Sieckmann, F., Clarke, M. , Bebeacua, C., Bykov, Y. S., Sonnen, A. F.-P., Lihl, R. and Briggs, J. A.G. (2017) New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy/tomography. Journal of Structural Biology, 197(2), pp. 83-93. (doi: 10.1016/j.jsb.2016.06.020) (PMID:27368127) (PMCID:PMC5287355)
Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)
Teoh, P. J., Menzies, F. M., Hansell, C. A.H., Clarke, M. , Waddell, C., Burton, G. J., Nelson, S. M. and Nibbs, R. J.B. (2014) Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice. Journal of Immunology, 193(10), pp. 5218-5228. (doi: 10.4049/jimmunol.1401096)
Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)
Bordon, Y., Hansell, C. A. H., Sester, D. P., Clarke, M. , Mowat, A. M. and Nibbs, R. J. B. (2009) The atypical chemokine receptor D6 contributes to the development of experimental colitis. Journal of Immunology, 182(8), pp. 5032-5040. (doi: 10.4049/jimmunol.0802802)
Clarke, M. , Ewart, M.A., Santy, L.C., Prekeris, R. and Gould, G.W. (2006) ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway. Biochemical and Biophysical Research Communications, 342, pp. 1361-1367. (doi: 10.1016/j.bbrc.2006.02.102) (PMID:16516854)
Ewart, M.-A., Clarke, M. , Kane, S., Chamberlain, L.H. and Gould, G.W. (2005) Evidence for a role of the exocyst in insulin-stimulated Glut4 trafficking in 3T3-L1 adipocytes. Journal of Biological Chemistry, 280, pp. 3812-3816. (doi: 10.1074/jbc.M409928200) (PMID:15550383)
Ferlenghi, I., Clarke, M. , Ruttan, T., Allison, S. L., Schalich, J., Heinz, F. X., Harrison, S. C., Rey, F. A. and Fuller, S. D. (2001) Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus. Molecular Cell, 7(3), pp. 593-602. (doi: 10.1016/s1097-2765(01)00206-4) (PMID:11463384)
Hill, E., Clarke, M. and Barr, F. A. (2000) The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO Journal, 19(21), pp. 5711-5719. (doi: 10.1093/emboj/19.21.5711) (PMID:11060022) (PMCID:PMC305783)
Mancini, E. J., Clarke, M. , Gowen, B. E., Rutten, T. and Fuller, S. D. (2000) Cryo-electron microscopy reveals the functional organization of an enveloped virus, Semliki Forest virus. Molecular Cell, 5(2), pp. 255-266. (doi: 10.1016/s1097-2765(00)80421-9) (PMID:10882067)
Shorter, J., Watson, R., Giannakou, M.-E., Clarke, M. , Warren, G. and Barr, F. A. (1999) GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. EMBO Journal, 18(18), pp. 4949-4960. (doi: 10.1093/emboj/18.18.4949) (PMID:10487747) (PMCID:PMC1171566)
Portella, G., Liddell, J., Crombie, R., Haddow, S., Clarke, M. , Stoler, A.B. and Balmain, A. (1994) Molecular mechanisms of invasion and metastasis during mouse skin tumour progression. Invasion and Metastasis, 14(1-6), pp. 7-16. (PMID:7657534)
Burns, P.A., Brown, K., Brenmer, R., Clarke, M. and Balmain, A. (1991) Molecular alterations in oncogenes or tumor suppressor genes during chemical carcinogenesis. Progress in Histochemistry and Cytochemistry, 23(1-4), pp. 100-106. (doi: 10.1016/S0079-6336(11)80174-9) (PMID:1947131)