Professor Mhairi Macrae

Honorary Senior Research Fellow, Honorary Senior Research Fellow (School of Psychology & Neuroscience)

Wellcome Surgical Institute (WSI) Building, R214 Level 2, University of Glasgow, Garscube Estate, G61 1QH

Publications

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Number of items: 65.

2020

Biose, I. J., Dewar, D. , Macrae, I. M. and McCabe, C. (2020) Impact of stroke co-morbidities on cortical collateral flow following ischaemic stroke. Journal of Cerebral Blood Flow and Metabolism, 40(5), pp. 978-990. (doi: 10.1177/0271678X19858532) (PMID:31234703)

2019

Deuchar, G. A., Van Kralingen, J. C., Work, L. M. , Santosh, C., Muir, K. W. , McCabe, C. and Macrae, I. M. (2019) Preclinical validation of the therapeutic potential of Glasgow Oxygen Level Dependent (GOLD) technology: A theranostic for acute stroke. Translational Stroke Research, 10(5), pp. 583-595. (doi: 10.1007/s12975-018-0679-y) (PMID:30506268)

van Kralingen, J., McFall, A. , Ord, E. N.J. , Coyle, T. F., Bissett, M., McClure, J. D. , McCabe, C. , Macrae, I. M., Dawson, J. and Work, L. M. (2019) Altered extracellular vesicle microrna expression in ischemic stroke and small vessel disease. Translational Stroke Research, 10(5), pp. 495-508. (doi: 10.1007/s12975-018-0682-3) (PMID:30617992) (PMCID:PMC6733813)

2018

McCabe, C. , Arroja, M. M., Reid, E. and Macrae, I. M. (2018) Animal models of ischaemic stroke and characterisation of the ischaemic penumbra. Neuropharmacology, 134(Pt. B), pp. 169-177. (doi: 10.1016/j.neuropharm.2017.09.022) (PMID:28923277)

Horsburgh, K. et al. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132(8), pp. 851-868. (doi: 10.1042/CS20171620) (PMID:29712883)

Deuchar, G. A., Brennan, D., Holmes, W. M. , Shaw, M., Macrae, I. M. and Santosh, C. (2018) Perfluorocarbon Enhanced Glasgow Oxygen Level Dependent (GOLD) magnetic resonance metabolic imaging identifies the penumbra following acute ischemic stroke. Theranostics, 8(6), pp. 1706-1722. (doi: 10.7150/thno.21685)

Thow, L. A., MacDonald, K., Holmes, W. M. , Muir, K. W. , Macrae, I. M. and Dewar, D. (2018) Hyperglycaemia does not increase perfusion deficits after focal cerebral ischaemia in male Wistar rats. Brain and Neuroscience Advances, 2, pp. 1-13. (doi: 10.1177/2398212818794820)

2017

Percie du Sert, N. et al. (2017) The IMPROVE guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments). Journal of Cerebral Blood Flow and Metabolism, 37(11), pp. 3488-3517. (doi: 10.1177/0271678X17709185) (PMID:28797196) (PMCID:PMC5669349)

Arumugam, T. V. et al. (2017) An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism, 37(6), pp. 2098-2111. (doi: 10.1177/0271678X16661201) (PMID:27492949)

Dani, K. A., Moreton, F. C., Santosh, C., Lopez, R., Brennan, D., Schwarzbauer, C., Goutcher, C., O’Hare, K., Macrae, I. M. and Muir, K. W. (2017) Oxygen challenge magnetic resonance imaging in healthy human volunteers. Journal of Cerebral Blood Flow and Metabolism, 37(1), pp. 366-376. (doi: 10.1177/0271678x15627827) (PMID:26787107) (PMCID:PMC5363753)

Faller, K. M.E., Leach, J., Johnston, P. , Holmes, W. M. , Macrae, I. M. and Frenguelli, B. G. (2017) Proof of concept and feasibility studies examining the influence of combination ribose, adenine and allopurinol treatment on stroke outcome in the rat. Brain and Neuroscience Advances, 1, pp. 1-13. (doi: 10.1177/2398212817717112)

2016

Muir, K. W. and Macrae, I. M. (2016) Neuroimaging as a selection tool and endpoint in preclinical and clinical trials. Translational Stroke Research, 7(5), pp. 368-377. (doi: 10.1007/s12975-016-0487-1) (PMID:27543177)

2015

Murtha, L. A., McLeod, D. D., Pepperall, D., McCann, S. K., Beard, D. J., Tomkins, A. J., Holmes, W. M. , McCabe, C. , Macrae, I. M. and Spratt, N. J. (2015) Intracranial pressure elevation after ischemic stroke in rats: cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy. Journal of Cerebral Blood Flow and Metabolism, 35, pp. 592-600. (doi: 10.1038/jcbfm.2014.230) (PMID:25515213)

Baskerville, T. A., Macrae, I. M., Holmes, W. M. and McCabe, C. (2015) The influence of gender on ‘tissue at risk’ in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia. Journal of Cerebral Blood Flow and Metabolism, 36(2), pp. 381-386. (doi: 10.1177/0271678X15606137) (PMID:26661149)

2014

Rodie, M., Welsh, M., Holmes, W. , Wudy, S., Hartmann, M., Macrae, I. M. and Ahmed, S. F. (2014) Early Androgen Blockade Influences Longer-Term Brain Metabolism As Assessed By Magnetic Resonance Spectroscopy. In: Endocrine Society's 96th Annual Meeting and Expo, Chicago, IL, USA, 21-24 Jun 2014,

Campbell, B. C. V. and Macrae, I. M. (2014) Translational perspectives on perfusion-diffusion mismatch in ischemic stroke. International Journal of Stroke, 10(2), pp. 153-162. (doi: 10.1111/ijs.12186)

Robertson, C. A., McCabe, C. , Lopez-Gonzalez, M. R., Deuchar, G. A., Dani, K., Holmes, W. M. , Muir, K. W. , Santosh, C. and Macrae, I. M. (2014) Detection of ischemic penumbra using combined perfusion and T2* oxygen challenge imaging. International Journal of Stroke, 10(1), pp. 42-50. (doi: 10.1111/ijs.12327)

Wetterling, F., Gallagher, L., Mullin, J., Holmes, W. M. , McCabe, C. , Macrae, I. M. and Fagan, A. J. (2014) Sodium-23 magnetic resonance imaging has potential for improving penumbra detection but not for estimating stroke onset time. Journal of Cerebral Blood Flow and Metabolism, 35(1), pp. 103-110. (doi: 10.1038/jcbfm.2014.174)

2013

Baron, J.-C., Macrae, I.M., Adams, H.P. and Dirnagl, U. (2013) ESC-BRAIN: experimental and clinical stroke research - do they connect? Cerebrovascular Diseases, 36(4), pp. 306-321. (doi: 10.1159/000355027)

Ord, E. N.J. , Shirley, R., McClure, J. D. , McCabe, C. , Kremer, E. J., Macrae, I. M. and Work, L. M. (2013) Combined antiapoptotic and antioxidant approach to acute neuroprotection for stroke in hypertensive rats. Journal of Cerebral Blood Flow and Metabolism, 33(8), pp. 1215-1224. (doi: 10.1038/jcbfm.2013.70) (PMID:23632970) (PMCID:PMC3734772)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi: 10.1038/jcbfm.2013.14)

Deuchar, G.A., Brennan, D., Griffiths, H., Macrae, I.M. and Santosh, C. (2013) Perfluorocarbons enhance a T2*-based MRI technique for identifying the penumbra in a rat model of acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism, 33(9), pp. 1422-1428. (doi: 10.1038/jcbfm.2013.86)

Tarr, D., Graham, D. , Roy, L.A., Holmes, W.M. , McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi: 10.1038/jcbfm.2013.107)

2012

Ord, E. N.J. , Shirley, R., van Kralingen, J. C., Graves, A., McClure, J. D. , Wilkinson, M., McCabe, C. , Macrae, I. M. and Work, L. M. (2012) Positive impact of pre-stroke surgery on survival following transient focal ischemia in hypertensive rats. Journal of Neuroscience Methods, 211(2), pp. 305-308. (doi: 10.1016/j.jneumeth.2012.09.001)

Reid, E. , Graham, D. , Lopez-Gonzalez, M. R., Holmes, W. M. , Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi: 10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Baskerville, T., McCabe, C. , Weir, C.J., Macrae, I.M. and Holmes, W. (2012) Noninvasive MRI measurement of CBF: evaluating an arterial spin labelling sequence with ^99mTc- HMPAO CBF autoradiography in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 32(6), pp. 973-977. (doi: 10.1038/jcbfm.2012.19) (PMID:22472604) (PMCID:PMC3367221)

Wetterling, F., Hogler, M., Molkenthin, U., Junge, S., Gallagher, L., Macrae, I.M. and Fagan, A.J. (2012) The design of a double-tuned two-port surface resonator and its application to in vivo Hydrogen- and Sodium-MRI. Journal of Magnetic Resonance, 217, pp. 10-18.

Bingham, D., Martin, S.J., Macrae, I.M. and Carswell, H.V.O. (2012) Watermaze performance after middle cerebral artery occlusion in the rat: the role of sensorimotor versus memory impairments. Journal of Cerebral Blood Flow and Metabolism, 32, pp. 989-999. (doi: 10.1038/jcbfm.2012.16)

Holmes, W.M. , Lopez-Gonzalez, M.R., Gallagher, L., Deuchar, G., Macrae, I. and Santosh, C. (2012) Novel MRI detection of the ischemic penumbra: direct assessment of metabolic integrity. NMR in Biomedicine, 25(2), pp. 295-304. (doi: 10.1002/nbm.1748)

Wetterling, F., Gallagher, L., Macrae, I.M., Junge, S. and Fagan, A.J. (2012) Regional and temporal variations in tissue sodium concentration during the acute stroke phase. Magnetic Resonance in Medicine, 67(3), pp. 740-749. (doi: 10.1002/mrm.23031)

2011

Macrae, I.M. (2011) Preclinical stroke research - advantages and disadvantages of the most common rodent models of focal ischaemia. British Journal of Pharmacology, 164(4), pp. 1062-1078. (doi: 10.1111/j.1476-5381.2011.01398.x)

Baskerville, T., Deuchar, G. A., McCabe, C. , Robertson, C. A., Holmes, W. M. , Santosh, C. and Macrae, I. M. (2011) Influence of 100% and 40% oxygen on penumbral blood flow, oxygen level, and T2*-weighted MRI in a rat stroke model. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1799-1806. (doi: 10.1038/jcbfm.2011.65)

Robertson, C. A., McCabe, C. , Gallagher, L., Lopez Gonzalez, M. d., Holmes, W. M. , Condon, B., Muir, K. W. , Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 2. Validation based on the consequences of reperfusion. Journal of Cerebral Blood Flow and Metabolism, 31(8), pp. 1788-1798. (doi: 10.1038/jcbfm.2011.67)

Robertson, C. A., McCabe, C. , Gallagher, L., Lopez-Gonzalez, M. d., Holmes, W. M. , Condon, B., Muir, K. W. , Santosh, C. and Macrae, I. M. (2011) Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. validation using [14C]2-deoxyglucose autoradiography. Journal of Cerebral Blood Flow and Metabolism, 31, pp. 1778-1787. (doi: 10.1038/jcbfm.2011.66)

2010

Dani, K. A., Santosh, C., Brennan, D., McCabe, C. , Holmes, W. M. , Condon, B., Hadley, D. M., Macrae, I. M., Shaw, M. and Muir, K. W. (2010) T2*-weighted magnetic resonance imaging with hyperoxia in acute ischemic stroke. Annals of Neurology, 68(1), pp. 37-47. (doi: 10.1002/ana.22032)

Carswell, H.V.O., Macrae, I. M. and Farr, T.D. (2010) Complexities of oestrogen in stroke. Clinical Science, 118(5-6), pp. 375-389. (doi: 10.1042/CS20090018)

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi: 10.1161/STROKEAHA.109.575704)

Wetterling, F., Tabbert, M., Junge, S., Gallagher, L., Macrae, I.M. and Fagan, A.J. (2010) A double-tuned1H/23Na dual resonator system for tissue sodium concentration measurements in the rat brain via Na-MRI. Physics in Medicine and Biology, 55(24), pp. 7681-7695. (doi: 10.1088/0031-9155/55/24/019)

2009

McCabe, C. , Gallagher, L., Gsell, W., Graham, D. , Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi: 10.1161/STROKEAHA.109.559021)

Shah, I., Macrae, I. and Di Napoli, M. (2009) Neuroinflammation and Neuroprotective Strategies in Acute Ischaemic Stroke - from bench to bedside. Current Molecular Medicine, 9(3), pp. 336-354.

2008

Santosh, C. et al. (2008) Potential use of oxygen as a metabolic biosensor in combination with T2*-weighted MRI to define the ischemic penumbra. Journal of Cerebral Blood Flow and Metabolism, 28(10), pp. 1742-1753. (doi: 10.1038/jcbfm.2008.56)

McCabe, C. , White, F., Brown, S.M. and Macrae, I.M. (2008) GADD34 gene restores virulence in viral vector used in experimental stroke study. Journal of Cerebral Blood Flow and Metabolism, 28(4), pp. 747-751. (doi: 10.1038/sj.jcbfm.9600565)

Lecrux, C., McCabe, C. , Weir, C.J., Gallagher, L., Mullin, J., Touzani, O., Muir, K. , Lees, K.R. and Macrae, I.M. (2008) Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats. Stroke, 39(2), pp. 448-454. (doi: 10.1161/STROKEAHA.107.492934)

Fagan, A., Mullin, J., Gallagher, L., Hadley, D., Macrae, I. and Condon, B. (2008) Serial postmortem relaxometry in the normal rat brain and following stroke. Journal of Magnetic Resonance Imaging, 27(3), pp. 469-475.

Farr, T., Carswell, H., Mccann, D., Sato, M., Bryant, H., Dodge, J. and Macrae, I. (2008) The selective oestrogen receptor modulator, LY362321, is not neuroprotective in a rat model of transient focal ischaemia. Journal of Neuroendocrinology, 20(3), pp. 366-374.

2007

Farr, T., Carswell, H., Gsell, W. and Macrae, I. (2007) Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia. Brain Research, 1185, pp. 275-282.

2006

Morton, E., Macrae, I.M., McCabe, C., Brown, S.M. and White, F. (2006) Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. International Journal of Cardiology, 107(1), pp. 126-129. (doi: 10.1016/j.ijcard.2005.01.051)

Farr, T., Carswell, H., Gallagher, L., Condon, B., Fagan, A., Mullin, J. and Macrae, I. (2006) 17 beta-estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function. Neurobiology of Disease, 23, pp. 552-562. (doi: 10.1016/j.nbd.2006.04.009)

Macrae, I. and Carswell, H. (2006) Oestrogen and stroke: the potential for harm as well as benefit. Biochemical Society Transactions, 34, pp. 1362-1365.

2005

Bingham, D., Macrae, I. and Carswell, H. (2005) Detrimental effects of 17 beta-oestradiol after permanent middle cerebral artery occlusion. Journal of Cerebral Blood Flow and Metabolism, 25, pp. 414-420. (doi: 10.1038/sj.jcbfm.9600031)

Brown, S., Gallagher, L., Graham, D., Harland, J., Imai, H., Macrae, I. and McCaig, D. (2005) Evolution of GADD34 expression after focal cerebral ischaemia. Brain Research, 1034, pp. 51-61. (doi: 10.1016/j.brainres.2004.11.058)

Carswell, H., Dominiczak, A. , Garcia-Segura, L., Harada, N., Hutchison, J. and Macrae, I. (2005) Brain aromatase expression after experimental stroke: Topography and time course. Journal of Steroid Biochemistry and Molecular Biology, 96(1), pp. 89-91. (doi: 10.1016/j.jsbmb.2005.02.016)

Gordon, K., Macrae, I. and Carswell, H. (2005) Effects of 17 beta-oestradiol on cerebral ischaemic damage and lipid peroxidation. Brain Research, 1036, pp. 155-162. (doi: 10.1016/j.brainres.2004.12.052)

McGill, J.K., Gallagher, L., Carswell, H.V.O., Irving, E.A., Dominiczak, A.F. and Macrae, I.M. (2005) Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke, 36(1), pp. 135-141. (doi: 10.1161/01.STR.0000149629.32525.b7)

Nemoto, K. et al. (2005) No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats. Hypertension Research, 28(2), pp. 155-163. (doi: 10.1291/hypres.28.155)

2004

Antier, D., Carswell, H., Brosnan, M., Hamilton, C., Macrae, I., Groves, S., Jardine, E., Reid, J. and Dominiczak, A. (2004) Increased levels of superoxide in brains from old female rats. Free Radical Research, 38(2), pp. 177-183. (doi: 10.1080/10715760310001643294)

Brown, S., Graham, D., Harland, J., Macrae, I., McCaig, D. and White, F. (2004) Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. Neuropathology and Applied Neurobiology, 30, pp. 683-691. (doi: 10.1111/j.1365-2990.2004.00584.x)

Carswell, H.V.O., Gallagher, L., Harrop, E., Horsburgh, K.J. and Macrae, I.M. (2004) Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia. American Journal of Physiology: Heart and Circulatory Physiology, 287, H1501-H1504. (doi: 10.1152/ajpheart.00227.2004)

2003

Graham, D., Imai, H., Macrae, I. and Masayasu, H. (2003) Antioxidant ebselen reduces oxidative damage in focal cerebral ischemia. Free Radical Biology and Medicine, 34, pp. 56-63.

2002

Brown, S., Graham, D., Harland, J., Imai, H., Macrae, I. and McCulloch, J. (2002) Specific expression of the cell cycle regulation proteins, GADD34 and PCNA, in the peri-infarct zone after focal cerebral ischaemia in the rat. European Journal of Neuroscience, 15, pp. 1929-1936. (doi: 10.1046/j.1460-9568.2002.02025.x)

Graham, D., Imai, H., Macrae, I., Masayasu, H. and McCulloch, J. (2002) New method for the quantitative assessment of axonal damage in focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1080-1089.

Horsburgh, K., Macrae, I. and Carswell, H. (2002) Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia. Journal of Cerebral Blood Flow and Metabolism, 22, pp. 1189-1195.

McBride, M. , Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I. and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22, pp. 127-134. (doi: 10.1053/snep.2002.30213)

2001

Marks, L., Carswell, H., Peters, E., Graham, D., Patterson, J., Dominiczak, A. and Macrae, I. (2001) Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension, 38, pp. 116-122. (doi: 10.1161/01.HYP.38.1.116)

Negrin, C., McBride, M. , Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I. and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37, pp. 391-397. (doi: 10.1161/01.HYP.37.2.391)

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