Dr Caroline Forrest
- Visiting Researcher (School of Psychology & Neuroscience)
email:
Caroline.Forrest@glasgow.ac.uk
R335 Level 3, West Medical Building, Glasgow G12 8QQ
Publications
2019
McNair, K. , Forrest, C. M., Vicenten, M. C.J., Darlington, L. G. and Stone, T. W. (2019) Serine protease modulation of dependence receptors and EMT protein expression. Cancer Biology and Therapy, 20(3), pp. 349-367. (doi: 10.1080/15384047.2018.1529109) (PMID:30403907) (PMCID:PMC6370372)
2017
Sternberg, J. M., Forrest, C. M., Dalton, R. N., Turner, C., Rodgers, J. , Stone, T. W. and Kennedy, P. G.E. (2017) Kynurenine pathway activation in Human African trypanosomiasis. Journal of Infectious Diseases, 215(5), pp. 806-812. (doi: 10.1093/infdis/jiw623) (PMID:28013248) (PMCID:PMC5388295)
Hernandez-Martinez, J.-M., Forrest, C. M., Darlington, L. G., Smith, R. A. and Stone, T. W. (2017) Quinolinic acid induces neuritogenesis in SH-SY5Y neuroblastoma cells independently of NMDA receptor activation. European Journal of Neuroscience, 45(5), pp. 700-711. (doi: 10.1111/ejn.13499) (PMID:27973747)
2016
Stone, T. W. , Darlington, L. G. and Forrest, C. M. (2016) Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation. Neuroscience, 336, pp. 49-62. (doi: 10.1016/j.neuroscience.2016.08.043)
Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi: 10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)
Forrest, C. M., McNair, K. , Vincenten, M. C.J., Darlington, L. G. and Stone, T. W. (2016) Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet, obesity and cancer. BMC Cancer, 16, 772. (doi: 10.1186/s12885-016-2795-y) (PMID:27716118) (PMCID:PMC5054602)
2015
Forrest, C.M., Mcnair, K. , Pisar, M., Khalil, O.S., Darlington, L.G. and Stone, T.W. (2015) Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine. Neuroscience, 310, pp. 91-105. (doi: 10.1016/j.neuroscience.2015.09.022) (PMID:26365611) (PMCID:PMC4642643)
Stone, T. W. , Forrest, C. M. and Darlington, L. G. (2015) Kynurenines and brain development. In: Mittal, S. (ed.) Targeting the Broadly Pathogenic Kynurenine Pathway. Springer: Cham, pp. 45-61. ISBN 9783319118697 (doi: 10.1007/978-3-319-11870-3_4)
2014
Pisar, M., Forrest, C. M., Khalil, O. S., Mcnair, K. , Vincenten, M. C.J., Qasem, S., Darlington, L. G. and Stone, T. W. (2014) Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway. Brain Research, 1576, pp. 1-17. (doi: 10.1016/j.brainres.2014.06.016) (PMID:24956103)
Khalil, O. S., Pisar, M., Forrest, C. M., Vincenten, M. C. J., Darlington, L. G. and Stone, T. W. (2014) Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring. European Journal of Neuroscience, 39(10), pp. 1558-1571. (doi: 10.1111/ejn.12535)
2013
Khalil, O.S., Forrest, C.M., Pisar, M., Smith, R.A., Darlington, L.G. and Stone, T.W. (2013) Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. Immunopharmacology and Immunotoxicology, 35(5), pp. 581-593. (doi: 10.3109/08923973.2013.828745)
Forrest, C. M., Khalil, O. S., Pisar, M., Darlington, L. G. and Stone, T. W. (2013) Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus. Brain Research, 1504, pp. 1-15. (doi: 10.1016/j.brainres.2013.01.031)
Forrest, C.M., Darlington, L.G. and Stone, T.W. (2013) Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin. Neuroscience, 231, pp. 233-246. (doi: 10.1016/j.neuroscience.2012.11.029)
2012
Forrest, C.M., Khalil, O.S., Pisar, M., Smith, R.A., Darlington, L. and Stone, T.W. (2012) Prenatal activation of toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring. Molecular Brain, 5(22), (doi: 10.1186/1756-6606-5-22)
Stone, T.W. , Forrest, C.M. and Darlington, L.G. (2012) Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS Journal, 279(8), pp. 1386-1397. (doi: 10.1111/j.1742-4658.2012.08487.x)
Stone, T.W. , Forrest, C.M., Stoy, N. and Darlington, L.G. (2012) Involvement of kynurenines in Huntington’s disease and stroke-induced brain damage. Journal of Neural Transmission, 119(2), pp. 261-274. (doi: 10.1007/s00702-011-0676-8)
2011
Forrest, C.M., Addae, J.I., Murthy, S., Darlington, L.G., Morris, B.J. and Stone, T.W. (2011) Molecular changes associated with hippocampal long-lasting depression induced by the serine protease subtilisin-A. European Journal of Neuroscience, 34(8), pp. 1241-1253. (doi: 10.1111/j.1460-9568.2011.07853.x)
Forrest, C.M., Mackay, G.M., Oxford, L., Millar, K., Gail Darlington, L., Higgins, M. and Stone, T.W. (2011) Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. Journal of Neurochemistry, 119(1), pp. 136-152. (doi: 10.1111/j.1471-4159.2011.07414.x)
2010
Forrest, C. M., Mackay, G. M., Stoy, N., Spiden, S. L., Taylor, R., Stone, T. W. and Darlington, L.G. (2010) Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease. Journal of Neurochemistry, 112(1), pp. 112-122. (doi: 10.1111/j.1471-4159.2009.06442.x)
Darlington, L.G., Forrest, C.M., Mackay, G.M., Smith, R.A., Smith, A.J., Stoy, N. and Stone, T.W. (2010) On the biological importance of the 3-hydroxyanthranilic acid: anthranilic acid ratio. International Journal of Tryptophan Research, 3, pp. 51-59.
Forrest, C.M., Mackay, G.M., Stoy, N., Spiden, S.L., Taylor, R., Stone, T.W. and Darlington, L.G. (2010) Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington’s disease. Journal of Neurochemistry, 112(1), pp. 112-122. (doi: 10.1111/j.1471-4159.2009.06442.x)
2009
MacKay, G.M., Forrest, C.M., Christofides, J., Bridel, M.A., Mitchell, S., Cowlard, R., Stone, T.W. and Darlington, L.G. (2009) Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. Clinical and Experimental Pharmacology and Physiology, 36(4), pp. 425-435. (doi: 10.1111/j.1440-1681.2008.05077.x)
Articles
McNair, K. , Forrest, C. M., Vicenten, M. C.J., Darlington, L. G. and Stone, T. W. (2019) Serine protease modulation of dependence receptors and EMT protein expression. Cancer Biology and Therapy, 20(3), pp. 349-367. (doi: 10.1080/15384047.2018.1529109) (PMID:30403907) (PMCID:PMC6370372)
Sternberg, J. M., Forrest, C. M., Dalton, R. N., Turner, C., Rodgers, J. , Stone, T. W. and Kennedy, P. G.E. (2017) Kynurenine pathway activation in Human African trypanosomiasis. Journal of Infectious Diseases, 215(5), pp. 806-812. (doi: 10.1093/infdis/jiw623) (PMID:28013248) (PMCID:PMC5388295)
Hernandez-Martinez, J.-M., Forrest, C. M., Darlington, L. G., Smith, R. A. and Stone, T. W. (2017) Quinolinic acid induces neuritogenesis in SH-SY5Y neuroblastoma cells independently of NMDA receptor activation. European Journal of Neuroscience, 45(5), pp. 700-711. (doi: 10.1111/ejn.13499) (PMID:27973747)
Stone, T. W. , Darlington, L. G. and Forrest, C. M. (2016) Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation. Neuroscience, 336, pp. 49-62. (doi: 10.1016/j.neuroscience.2016.08.043)
Forrest, C., Kennedy, P. G., Rodgers, J. , Dalton, R. N., Turner, C., Darlington, L. G., Cobb, S. and Stone, T. W. (2016) Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/- mice, using liquid chromatography-tandem mass spectrometry. Neurochemistry International, 100, pp. 110-119. (doi: 10.1016/j.neuint.2016.09.012) (PMID:27623092) (PMCID:PMC5115650)
Forrest, C. M., McNair, K. , Vincenten, M. C.J., Darlington, L. G. and Stone, T. W. (2016) Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet, obesity and cancer. BMC Cancer, 16, 772. (doi: 10.1186/s12885-016-2795-y) (PMID:27716118) (PMCID:PMC5054602)
Forrest, C.M., Mcnair, K. , Pisar, M., Khalil, O.S., Darlington, L.G. and Stone, T.W. (2015) Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine. Neuroscience, 310, pp. 91-105. (doi: 10.1016/j.neuroscience.2015.09.022) (PMID:26365611) (PMCID:PMC4642643)
Pisar, M., Forrest, C. M., Khalil, O. S., Mcnair, K. , Vincenten, M. C.J., Qasem, S., Darlington, L. G. and Stone, T. W. (2014) Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway. Brain Research, 1576, pp. 1-17. (doi: 10.1016/j.brainres.2014.06.016) (PMID:24956103)
Khalil, O. S., Pisar, M., Forrest, C. M., Vincenten, M. C. J., Darlington, L. G. and Stone, T. W. (2014) Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring. European Journal of Neuroscience, 39(10), pp. 1558-1571. (doi: 10.1111/ejn.12535)
Khalil, O.S., Forrest, C.M., Pisar, M., Smith, R.A., Darlington, L.G. and Stone, T.W. (2013) Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation. Immunopharmacology and Immunotoxicology, 35(5), pp. 581-593. (doi: 10.3109/08923973.2013.828745)
Forrest, C. M., Khalil, O. S., Pisar, M., Darlington, L. G. and Stone, T. W. (2013) Prenatal inhibition of the tryptophan–kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus. Brain Research, 1504, pp. 1-15. (doi: 10.1016/j.brainres.2013.01.031)
Forrest, C.M., Darlington, L.G. and Stone, T.W. (2013) Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin. Neuroscience, 231, pp. 233-246. (doi: 10.1016/j.neuroscience.2012.11.029)
Forrest, C.M., Khalil, O.S., Pisar, M., Smith, R.A., Darlington, L. and Stone, T.W. (2012) Prenatal activation of toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring. Molecular Brain, 5(22), (doi: 10.1186/1756-6606-5-22)
Stone, T.W. , Forrest, C.M. and Darlington, L.G. (2012) Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection. FEBS Journal, 279(8), pp. 1386-1397. (doi: 10.1111/j.1742-4658.2012.08487.x)
Stone, T.W. , Forrest, C.M., Stoy, N. and Darlington, L.G. (2012) Involvement of kynurenines in Huntington’s disease and stroke-induced brain damage. Journal of Neural Transmission, 119(2), pp. 261-274. (doi: 10.1007/s00702-011-0676-8)
Forrest, C.M., Addae, J.I., Murthy, S., Darlington, L.G., Morris, B.J. and Stone, T.W. (2011) Molecular changes associated with hippocampal long-lasting depression induced by the serine protease subtilisin-A. European Journal of Neuroscience, 34(8), pp. 1241-1253. (doi: 10.1111/j.1460-9568.2011.07853.x)
Forrest, C.M., Mackay, G.M., Oxford, L., Millar, K., Gail Darlington, L., Higgins, M. and Stone, T.W. (2011) Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. Journal of Neurochemistry, 119(1), pp. 136-152. (doi: 10.1111/j.1471-4159.2011.07414.x)
Forrest, C. M., Mackay, G. M., Stoy, N., Spiden, S. L., Taylor, R., Stone, T. W. and Darlington, L.G. (2010) Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington's disease. Journal of Neurochemistry, 112(1), pp. 112-122. (doi: 10.1111/j.1471-4159.2009.06442.x)
Darlington, L.G., Forrest, C.M., Mackay, G.M., Smith, R.A., Smith, A.J., Stoy, N. and Stone, T.W. (2010) On the biological importance of the 3-hydroxyanthranilic acid: anthranilic acid ratio. International Journal of Tryptophan Research, 3, pp. 51-59.
Forrest, C.M., Mackay, G.M., Stoy, N., Spiden, S.L., Taylor, R., Stone, T.W. and Darlington, L.G. (2010) Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington’s disease. Journal of Neurochemistry, 112(1), pp. 112-122. (doi: 10.1111/j.1471-4159.2009.06442.x)
MacKay, G.M., Forrest, C.M., Christofides, J., Bridel, M.A., Mitchell, S., Cowlard, R., Stone, T.W. and Darlington, L.G. (2009) Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. Clinical and Experimental Pharmacology and Physiology, 36(4), pp. 425-435. (doi: 10.1111/j.1440-1681.2008.05077.x)
Book Sections
Stone, T. W. , Forrest, C. M. and Darlington, L. G. (2015) Kynurenines and brain development. In: Mittal, S. (ed.) Targeting the Broadly Pathogenic Kynurenine Pathway. Springer: Cham, pp. 45-61. ISBN 9783319118697 (doi: 10.1007/978-3-319-11870-3_4)
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