Dr Paul Capewell

  • Lecturer in Molecular Biosciences (Molecular Biosciences)
  • Affiliate Researcher (School of Biodiversity, One Health & Veterinary Medicine)

email: Paul.Capewell@glasgow.ac.uk
pronouns: He/him/his

Room 244, Davidson Building, University of Glasgow, G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-8803-5034

Biography

My academic research has focused on parasitic/host interactions and the complex co-evolution that occurs as a result. This has primarily concentrated on Trypanosoma brucei, the causative agent of African Sleeping Sickness, and Giardia duodenalis, an important overlooked parasite endemic to Scotland. My research has applied a variety of molecular genetic approaches with an increasing focus on informatics, particularly whole genome sequencing, exome capture and RNAseq.

I have spent several years working in industry as an R&D bioinformatician and contributed to the development of diagnostic tests for veterinary and healthcare-focused businesses. I maintain links to industry by acting as an informatics consultant for university start-ups.

Research interests

I have an interest in the teaching of bioinformatics at all levels and I am keen to understand and reduce obstacles that limit engagement with the subject.

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010
Number of items: 36.

2024

Sinton, M. C. et al. (2024) Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 15, 1833. (doi: 10.1038/s41467-024-46299-4) (PMID:38418827) (PMCID:PMC10901872)

2023

Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)

Durrani, Z., Kinnaird, J., Cheng, C. W., Brühlmann, F., Capewell, P. , Jackson, A., Larcombe, S., Olias, P., Weir, W. and Shiels, B. (2023) A parasite DNA binding protein with potential to influence disease susceptibility acts as an analogue of mammalian HMGA transcription factors. PLoS ONE, 18(6), e0286526. (doi: 10.1371/journal.pone.0286526) (PMID:37276213) (PMCID:PMC10241358)

2022

Krumrie, S. , Capewell, P. , McDonald, M. , Dunbar, D., Panarese, R., Katzer, F., El Sakka, N., Mellor, D. , Alexander, C. L. and Weir, W. (2022) Molecular characterisation of Giardia duodenalis from human and companion animal sources in the United Kingdom using an improved triosephosphate isomerase molecular marker. Current Research in Parasitology and Vector-Borne Diseases, 2(2022), 100105. (doi: 10.1016/j.crpvbd.2022.100105) (PMID:36504596) (PMCID:PMC9731890)

Krumrie, S. , Capewell, P. , Smith-Palmer, A., Mellor, D. , Weir, W. and Alexander, C. L. (2022) A scoping review of risk factors and transmission routes associated with human giardiasis outbreaks in high-income settings. Current Research in Parasitology and Vector-Borne Diseases, 2, 100084. (doi: 10.1016/j.crpvbd.2022.100084)

Larcombe, S. D., Capewell, P. , Jensen, K., Weir, W. , Kinnaird, J., Glass, E. J. and Shiels, B. R. (2022) Susceptibility to disease (tropical theileriosis) is associated with differential expression of host genes that possess motifs recognised by a pathogen DNA binding protein. PLoS ONE, 17(1), e0262051. (doi: 10.1371/journal.pone.0262051) (PMID:35061738) (PMCID:PMC8782480)

2021

Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)

Gray, A., Capewell, P. , Zadoks, R. , Taggart, M. A., French, A. S., Katzer, F., Shiels, B. R. and Weir, W. (2021) Wild deer in the United Kingdom are a potential reservoir for the livestock parasite. Current Research in Parasitology and Vector-Borne Diseases, 1, 100019. (doi: 10.1016/j.crpvbd.2021.100019) (PMID:35284871) (PMCID:PMC8906096)

Capewell, P. , Krumrie, S. , Katzer, F., Alexander, C. L. and Weir, W. (2021) Molecular epidemiology of Giardia infections in the genomic era. Trends in Parasitology, 37(2), pp. 142-153. (doi: 10.1016/j.pt.2020.09.013) (PMID:33067130)

2020

Alfituri, O. A., Quintana, J. F. , MacLeod, A. , Garside, P. , Benson, R. A. , Brewer, J. M., Mabbott, N. A., Morrison, L. J. and Capewell, P. (2020) To the skin and beyond: the immune response to African trypanosomes as they enter and exit the vertebrate host. Frontiers in Immunology, 11, 1250. (doi: 10.3389/fimmu.2020.01250) (PMID:32595652) (PMCID:PMC7304505)

Capewell, P. , Rupp, A., Fuentes, M. , McDonald, M. and Weir, W. (2020) Fatal Clostridium sordellii-mediated hemorrhagic and necrotizing gastroenteropathy in a dog: case report. BMC Veterinary Research, 16(1), 152. (doi: 10.1186/s12917-020-02362-y) (PMID:32448314) (PMCID:PMC7245850)

2019

Gray, A., Capewell, P. , Loney, C. , Katzer, F., Shiels, B. R. and Weir, W. (2019) Sheep as host species for zoonotic Babesia venatorum, United Kingdom. Emerging Infectious Diseases, 25(12), pp. 2257-2260. (doi: 10.3201/eid2512.190459) (PMID:31742518) (PMCID:PMC6874260)

Kaboré, J. W. et al. (2019) Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infection, Genetics and Evolution, 71, pp. 108-115. (doi: 10.1016/j.meegid.2019.03.021) (PMID:30914286)

Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLoS Biology, 17(1), e3000105. (doi: 10.1371/journal.pbio.3000105) (PMID:30633739) (PMCID:PMC6345479)

2017

Cooper, A. et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, e25461. (doi: 10.7554/eLife.25461) (PMID:28537557) (PMCID:PMC5495568)

2016

Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)

Cooper, A. , Capewell, P. , Clucas, C. , Veitch, N. , Weir, W. , Thomson, R., Raper, J. and MacLeod, A. (2016) A primate APOL1 variant that kills Trypanosoma brucei gambiense. PLoS Neglected Tropical Diseases, 10(8), e0004903. (doi: 10.1371/journal.pntd.0004903) (PMID:27494254) (PMCID:PMC4975595)

Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi: 10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)

2015

Bühlmann, M., Walrad, P., Rico, E., Ivens, A., Capewell, P. , Naguleswaran, A., Roditi, I. and Matthews, K. R. (2015) NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway. Nucleic Acids Research, 43(9), pp. 4491-4504. (doi: 10.1093/nar/gkv330) (PMID:25873624) (PMCID:PMC4482084)

Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. and MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi: 10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)

Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. , Vaikkinen, H., Morrison, L., Tait, A. and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi: 10.1007/978-1-4939-1438-8_5) (PMID:25388109)

2014

Pickrell, W. O. et al. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8(12), e3349. (doi: 10.1371/journal.pntd.0003349) (PMID:25522322) (PMCID:PMC4270486)

2013

Kaboré, J., De Meeûs, T., MacLeod, A. , Ilboudo, H., Capewell, P. , Camara, M., Gaston Belem, A.M., Bucheton, B. and Jamonneau, V. (2013) A protocol to improve genotyping of problematic microsatellite loci of Trypanosoma brucei gambiense from body fluids. Infection, Genetics and Evolution, 20, pp. 171-176. (doi: 10.1016/j.meegid.2013.08.006)

Capewell, P. , Clucas, C. , Weir, W. , Veitch, N. and MacLeod, A. (2013) Normal human serum lysis of non-human trypanosomes and resistance of T. b. rhodesiense and T. b. gambiense. In: Magez, S. and Radwanska, M. (eds.) Trypanosomes and Trypanosomiasis. Springer, pp. 139-160. ISBN 9783709115558 (doi: 10.1007/978-3-7091-1556-5_6)

Capewell, P. , Monk, S., Ivens, A., MacGregor, P., Fenn, K., Walrad, P., Bringaud, F., Smith, T. K. and Matthews, K. R. (2013) Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host. PLoS ONE, 8(6), e67069. (doi: 10.1371/journal.pone.0067069) (PMID:23840587) (PMCID:PMC3694164)

Capewell, P. , Clucas, C. , DeJesus, E., Kieft, R., Hajduk, S., Veitch, N. , Steketee, P.C., Cooper, A. , Weir, W. and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi: 10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)

Capewell, P. , Cooper, A. , Duffy, C.W., Tait, A., Turner, C.M.R., Gibson, W., Mehlitz, D. and MacLeod, A. (2013) Human and animal trypanosomes in Côte d'Ivoire form a single breeding population. PLoS ONE, 8(7), e67852. (doi: 10.1371/journal.pone.0067852) (PMID:23844111) (PMCID:PMC3699513)

Goodhead, I. et al. (2013) Whole-genome sequencing of trypanosoma brucei reveals introgression between subspecies that is associated with virulence. mBio, 4(4), e00197-13. (doi: 10.1128/mBio.00197-13)

2012

Walrad, P. B., Capewell, P. , Fenn, K. and Matthews, K. R. (2012) The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei. Nucleic Acids Research, 40(7), pp. 2869-2883. (doi: 10.1093/nar/gkr1106) (PMID:22140102) (PMCID:PMC3326296)

Bullard, W., Kieft, R., Capewell, P. , Veitch, N. J. , Macleod, A. and Hajduk, S. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors. Virulence, 3(1), pp. 72-76. (doi: 10.4161/viru.3.1.18295) (PMID:22286709) (PMCID:PMC3337153)

Harrington, J.M., Scelsi, C., Hartel, A., Jones, N.G., Engstler, M., Capewell, P. , MacLeod, A. and Hajduk, S. (2012) Novel African trypanocidal agents: membrane rigidifying peptides. PLoS ONE, 7(9), e44384. (doi: 10.1371/journal.pone.0044384) (PMID:22970207) (PMCID:PMC3436892)

Kieft, R., Stephens, N.A., Capewell, P. , MacLeod, A. and Hajduk, S.L. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Molecular and Biochemical Parasitology, 183(1), pp. 8-14. (doi: 10.1016/j.molbiopara.2011.12.004)

2011

Capewell, P., Veitch, N.J. , Turner, C.M.R., Raper, J., Berriman, M., Hajduk, S.L. and MacLeod, A. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1. PLoS Neglected Tropical Diseases, 5(9), e1287. (doi: 10.1371/journal.pntd.0001287) (PMID:21909441) (PMCID:PMC3167774)

2010

Kieft, R., Capewell, P. , Turner, C.M.R., Veitch, N.J. , MacLeod, A. and Hajduk, S. (2010) Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proceedings of the National Academy of Sciences of the United States of America, 107(37), pp. 16137-16141. (doi: 10.1073/pnas.1007074107)

Harrington, J. M., Widener, J., Stephens, N., Johnson, T., Francia, M., Capewell, P. , MacLeod, A. and Hajduk, S. L. (2010) The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides. Journal of Biological Chemistry, 285(37), pp. 28659-28666. (doi: 10.1074/jbc.M110.151886) (PMID:20615879) (PMCID:PMC2937892)

Jackson, A. et al. (2010) The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis. PLoS Neglected Tropical Diseases, 4(4), e658. (doi: 10.1371/journal.pntd.0000658) (PMID:20404998) (PMCID:PMC2854126)

This list was generated on Thu Nov 21 06:15:28 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 36.

Articles

Sinton, M. C. et al. (2024) Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 15, 1833. (doi: 10.1038/s41467-024-46299-4) (PMID:38418827) (PMCID:PMC10901872)

Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)

Durrani, Z., Kinnaird, J., Cheng, C. W., Brühlmann, F., Capewell, P. , Jackson, A., Larcombe, S., Olias, P., Weir, W. and Shiels, B. (2023) A parasite DNA binding protein with potential to influence disease susceptibility acts as an analogue of mammalian HMGA transcription factors. PLoS ONE, 18(6), e0286526. (doi: 10.1371/journal.pone.0286526) (PMID:37276213) (PMCID:PMC10241358)

Krumrie, S. , Capewell, P. , McDonald, M. , Dunbar, D., Panarese, R., Katzer, F., El Sakka, N., Mellor, D. , Alexander, C. L. and Weir, W. (2022) Molecular characterisation of Giardia duodenalis from human and companion animal sources in the United Kingdom using an improved triosephosphate isomerase molecular marker. Current Research in Parasitology and Vector-Borne Diseases, 2(2022), 100105. (doi: 10.1016/j.crpvbd.2022.100105) (PMID:36504596) (PMCID:PMC9731890)

Krumrie, S. , Capewell, P. , Smith-Palmer, A., Mellor, D. , Weir, W. and Alexander, C. L. (2022) A scoping review of risk factors and transmission routes associated with human giardiasis outbreaks in high-income settings. Current Research in Parasitology and Vector-Borne Diseases, 2, 100084. (doi: 10.1016/j.crpvbd.2022.100084)

Larcombe, S. D., Capewell, P. , Jensen, K., Weir, W. , Kinnaird, J., Glass, E. J. and Shiels, B. R. (2022) Susceptibility to disease (tropical theileriosis) is associated with differential expression of host genes that possess motifs recognised by a pathogen DNA binding protein. PLoS ONE, 17(1), e0262051. (doi: 10.1371/journal.pone.0262051) (PMID:35061738) (PMCID:PMC8782480)

Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)

Gray, A., Capewell, P. , Zadoks, R. , Taggart, M. A., French, A. S., Katzer, F., Shiels, B. R. and Weir, W. (2021) Wild deer in the United Kingdom are a potential reservoir for the livestock parasite. Current Research in Parasitology and Vector-Borne Diseases, 1, 100019. (doi: 10.1016/j.crpvbd.2021.100019) (PMID:35284871) (PMCID:PMC8906096)

Capewell, P. , Krumrie, S. , Katzer, F., Alexander, C. L. and Weir, W. (2021) Molecular epidemiology of Giardia infections in the genomic era. Trends in Parasitology, 37(2), pp. 142-153. (doi: 10.1016/j.pt.2020.09.013) (PMID:33067130)

Alfituri, O. A., Quintana, J. F. , MacLeod, A. , Garside, P. , Benson, R. A. , Brewer, J. M., Mabbott, N. A., Morrison, L. J. and Capewell, P. (2020) To the skin and beyond: the immune response to African trypanosomes as they enter and exit the vertebrate host. Frontiers in Immunology, 11, 1250. (doi: 10.3389/fimmu.2020.01250) (PMID:32595652) (PMCID:PMC7304505)

Capewell, P. , Rupp, A., Fuentes, M. , McDonald, M. and Weir, W. (2020) Fatal Clostridium sordellii-mediated hemorrhagic and necrotizing gastroenteropathy in a dog: case report. BMC Veterinary Research, 16(1), 152. (doi: 10.1186/s12917-020-02362-y) (PMID:32448314) (PMCID:PMC7245850)

Gray, A., Capewell, P. , Loney, C. , Katzer, F., Shiels, B. R. and Weir, W. (2019) Sheep as host species for zoonotic Babesia venatorum, United Kingdom. Emerging Infectious Diseases, 25(12), pp. 2257-2260. (doi: 10.3201/eid2512.190459) (PMID:31742518) (PMCID:PMC6874260)

Kaboré, J. W. et al. (2019) Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population. Infection, Genetics and Evolution, 71, pp. 108-115. (doi: 10.1016/j.meegid.2019.03.021) (PMID:30914286)

Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLoS Biology, 17(1), e3000105. (doi: 10.1371/journal.pbio.3000105) (PMID:30633739) (PMCID:PMC6345479)

Cooper, A. et al. (2017) APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis. eLife, 6, e25461. (doi: 10.7554/eLife.25461) (PMID:28537557) (PMCID:PMC5495568)

Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)

Cooper, A. , Capewell, P. , Clucas, C. , Veitch, N. , Weir, W. , Thomson, R., Raper, J. and MacLeod, A. (2016) A primate APOL1 variant that kills Trypanosoma brucei gambiense. PLoS Neglected Tropical Diseases, 10(8), e0004903. (doi: 10.1371/journal.pntd.0004903) (PMID:27494254) (PMCID:PMC4975595)

Weir, W. et al. (2016) Population genomics reveals the origin and asexual evolution of human infective trypanosomes. eLife, 5, e11473. (doi: 10.7554/eLife.11473) (PMID:26809473) (PMCID:PMC4739771)

Bühlmann, M., Walrad, P., Rico, E., Ivens, A., Capewell, P. , Naguleswaran, A., Roditi, I. and Matthews, K. R. (2015) NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway. Nucleic Acids Research, 43(9), pp. 4491-4504. (doi: 10.1093/nar/gkv330) (PMID:25873624) (PMCID:PMC4482084)

Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. and MacLeod, A. (2015) A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome. Parasitology, 142(S1), S108-S119. (doi: 10.1017/S0031182014000602) (PMID:25656360) (PMCID:PMC4413828)

Capewell, P. , Cooper, A. , Clucas, C. , Weir, W. , Vaikkinen, H., Morrison, L., Tait, A. and MacLeod, A. (2015) Exploiting genetic variation to discover genes involved in important disease phenotypes. Methods in Molecular Biology, 1201, pp. 91-107. (doi: 10.1007/978-1-4939-1438-8_5) (PMID:25388109)

Pickrell, W. O. et al. (2014) Human African Trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical disease? PLoS Neglected Tropical Diseases, 8(12), e3349. (doi: 10.1371/journal.pntd.0003349) (PMID:25522322) (PMCID:PMC4270486)

Kaboré, J., De Meeûs, T., MacLeod, A. , Ilboudo, H., Capewell, P. , Camara, M., Gaston Belem, A.M., Bucheton, B. and Jamonneau, V. (2013) A protocol to improve genotyping of problematic microsatellite loci of Trypanosoma brucei gambiense from body fluids. Infection, Genetics and Evolution, 20, pp. 171-176. (doi: 10.1016/j.meegid.2013.08.006)

Capewell, P. , Monk, S., Ivens, A., MacGregor, P., Fenn, K., Walrad, P., Bringaud, F., Smith, T. K. and Matthews, K. R. (2013) Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host. PLoS ONE, 8(6), e67069. (doi: 10.1371/journal.pone.0067069) (PMID:23840587) (PMCID:PMC3694164)

Capewell, P. , Clucas, C. , DeJesus, E., Kieft, R., Hajduk, S., Veitch, N. , Steketee, P.C., Cooper, A. , Weir, W. and MacLeod, A. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathogens, 9(10), e1003686. (doi: 10.1371/journal.ppat.1003686) (PMID:24098129) (PMCID:PMC3789759)

Capewell, P. , Cooper, A. , Duffy, C.W., Tait, A., Turner, C.M.R., Gibson, W., Mehlitz, D. and MacLeod, A. (2013) Human and animal trypanosomes in Côte d'Ivoire form a single breeding population. PLoS ONE, 8(7), e67852. (doi: 10.1371/journal.pone.0067852) (PMID:23844111) (PMCID:PMC3699513)

Goodhead, I. et al. (2013) Whole-genome sequencing of trypanosoma brucei reveals introgression between subspecies that is associated with virulence. mBio, 4(4), e00197-13. (doi: 10.1128/mBio.00197-13)

Walrad, P. B., Capewell, P. , Fenn, K. and Matthews, K. R. (2012) The post-transcriptional trans-acting regulator, TbZFP3, co-ordinates transmission-stage enriched mRNAs in Trypanosoma brucei. Nucleic Acids Research, 40(7), pp. 2869-2883. (doi: 10.1093/nar/gkr1106) (PMID:22140102) (PMCID:PMC3326296)

Bullard, W., Kieft, R., Capewell, P. , Veitch, N. J. , Macleod, A. and Hajduk, S. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors. Virulence, 3(1), pp. 72-76. (doi: 10.4161/viru.3.1.18295) (PMID:22286709) (PMCID:PMC3337153)

Harrington, J.M., Scelsi, C., Hartel, A., Jones, N.G., Engstler, M., Capewell, P. , MacLeod, A. and Hajduk, S. (2012) Novel African trypanocidal agents: membrane rigidifying peptides. PLoS ONE, 7(9), e44384. (doi: 10.1371/journal.pone.0044384) (PMID:22970207) (PMCID:PMC3436892)

Kieft, R., Stephens, N.A., Capewell, P. , MacLeod, A. and Hajduk, S.L. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Molecular and Biochemical Parasitology, 183(1), pp. 8-14. (doi: 10.1016/j.molbiopara.2011.12.004)

Capewell, P., Veitch, N.J. , Turner, C.M.R., Raper, J., Berriman, M., Hajduk, S.L. and MacLeod, A. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by Trypanolytic factor 1. PLoS Neglected Tropical Diseases, 5(9), e1287. (doi: 10.1371/journal.pntd.0001287) (PMID:21909441) (PMCID:PMC3167774)

Kieft, R., Capewell, P. , Turner, C.M.R., Veitch, N.J. , MacLeod, A. and Hajduk, S. (2010) Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proceedings of the National Academy of Sciences of the United States of America, 107(37), pp. 16137-16141. (doi: 10.1073/pnas.1007074107)

Harrington, J. M., Widener, J., Stephens, N., Johnson, T., Francia, M., Capewell, P. , MacLeod, A. and Hajduk, S. L. (2010) The plasma membrane of bloodstream-form African trypanosomes confers susceptibility and specificity to killing by hydrophobic peptides. Journal of Biological Chemistry, 285(37), pp. 28659-28666. (doi: 10.1074/jbc.M110.151886) (PMID:20615879) (PMCID:PMC2937892)

Jackson, A. et al. (2010) The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic Human African Trypanosomiasis. PLoS Neglected Tropical Diseases, 4(4), e658. (doi: 10.1371/journal.pntd.0000658) (PMID:20404998) (PMCID:PMC2854126)

Book Sections

Capewell, P. , Clucas, C. , Weir, W. , Veitch, N. and MacLeod, A. (2013) Normal human serum lysis of non-human trypanosomes and resistance of T. b. rhodesiense and T. b. gambiense. In: Magez, S. and Radwanska, M. (eds.) Trypanosomes and Trypanosomiasis. Springer, pp. 139-160. ISBN 9783709115558 (doi: 10.1007/978-3-7091-1556-5_6)

This list was generated on Thu Nov 21 06:15:28 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Is there a skin or fat reservoir of trypanosomes in equines?
    Petplan Charitable Trust
    2019 - 2021
     
  • Investigating the epidemiology of endemic Giardia in Scotland using a whole genome sequencing approach
    Office of the Chief Scientific Adviser
    2019 - 2023
     
  • Investigating the epidemiology of endemic Giardia in Scotland using a whole genome sequencing approach
    Chief Scientist Office (CSO)
    2018 - 2021
     
  • Characterising Polyclonal T cell activation in animal trypanosomiasis
    Wellcome Trust
    2016 - 2018
     
  • The potential use of synthetic HDL as a therapy for African trypanosomiasis
    The Carnegie Trust for the Universities of Scotland
    2015 - 2015
     
  • Genetic Determinants of Trypanotolerance in Humans
    Tenovus Scotland
    2015 - 2015
     
  • Genetic Determinants of Trypanotolerance in Humans
    Wellcome Trust
    2014 - 2015
     

Supervision

  • Raftery, Alexandra
    Exploration of variation in disease phenotype in equid trypanosomiasis