Dr Martin Rennie

  • Research Associate (Molecular Biosciences)

Biography

Martin completed his PhD at the University of Auckland, New Zealand, in the lab of Dr Richard Kingston. He then moved to the University of Galway, Ireland, where he did a postdoc with Prof Peter Crowley. He is currently doing a postdoc with Prof Helen Walden at the University of Glasgow in the School of Molecular Biosciences.

Research interests

Martin uses cryo-electron microscopy, biophysics, and biochemistry to understand the molecular function of proteins. He is particularly interested in proteins involved in DNA repair.

  • DNA Repair
  • Protein-Protein Interactions
  • Structural Biology
  • Multi-Body/Linkage Thermodynamics

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020
Number of items: 8.

2024

Rennie, M. L. , Gundogdu, M., Arkinson, C., Liness, S., Frame, S. and Walden, H. (2024) Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01184) (PMID:39190802) (Early Online Publication)

2023

Lemonidis, K. , Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. and Walden, H. (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258) (PMCID:PMC9890228)

2022

Rennie, M. L. , Arkinson, C., Chaugule, V. K. and Walden, H. (2022) Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Science Advances, 8(39), eabq6353. (doi: 10.1126/sciadv.abq6353) (PMID:36170365) (PMCID:PMC9519042)

Lemonidis, K. , Arkinson, C., Rennie, M. L. and Walden, H. (2022) Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination. FEBS Journal, 289(16), pp. 4811-4829. (doi: 10.1111/febs.16077) (PMID:34137174)

2021

Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Toth, R. and Walden, H. (2021) Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nature Structural and Molecular Biology, 28(4), pp. 356-364. (doi: 10.1038/s41594-021-00576-8) (PMID:33795880)

2020

Rennie, M. L. , Lemonidis, K. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. , Spagnolo, L. and Walden, H. (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133) (PMID:32510829) (PMCID:PMC7332966)

Rennie, M. L. , Chaugule, V. K. and Walden, H. (2020) Modes of allosteric regulation of the ubiquitination machinery. Current Opinion in Structural Biology, 62, pp. 189-196. (doi: 10.1016/j.sbi.2020.02.003) (PMID:32305021)

Chaugule, V. K., Arkinson, C., Rennie, M. L. , Kämäräinen, O., Toth, R. and Walden, H. (2020) Allosteric mechanism for site-specific ubiquitination of FANCD2. Nature Chemical Biology, 16, pp. 291-301. (doi: 10.1038/s41589-019-0426-z) (PMID:31873223)

This list was generated on Thu Nov 21 06:16:43 2024 GMT.
Jump to: Articles
Number of items: 8.

Articles

Rennie, M. L. , Gundogdu, M., Arkinson, C., Liness, S., Frame, S. and Walden, H. (2024) Structural and biochemical insights on the mechanism of action of the clinical USP1 inhibitor, KSQ-4279. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01184) (PMID:39190802) (Early Online Publication)

Lemonidis, K. , Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. and Walden, H. (2023) Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination. EMBO Journal, 42(3), e111898. (doi: 10.15252/embj.2022111898) (PMID:36385258) (PMCID:PMC9890228)

Rennie, M. L. , Arkinson, C., Chaugule, V. K. and Walden, H. (2022) Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site. Science Advances, 8(39), eabq6353. (doi: 10.1126/sciadv.abq6353) (PMID:36170365) (PMCID:PMC9519042)

Lemonidis, K. , Arkinson, C., Rennie, M. L. and Walden, H. (2022) Mechanism, specificity and function of FANCD2‐FANCI ubiquitination and deubiquitination. FEBS Journal, 289(16), pp. 4811-4829. (doi: 10.1111/febs.16077) (PMID:34137174)

Rennie, M. L. , Arkinson, C., Chaugule, V. K. , Toth, R. and Walden, H. (2021) Structural basis of FANCD2 deubiquitination by USP1-UAF1. Nature Structural and Molecular Biology, 28(4), pp. 356-364. (doi: 10.1038/s41594-021-00576-8) (PMID:33795880)

Rennie, M. L. , Lemonidis, K. , Arkinson, C., Chaugule, V. K. , Clarke, M. , Streetley, J. , Spagnolo, L. and Walden, H. (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21(7), e50133. (doi: 10.15252/embr.202050133) (PMID:32510829) (PMCID:PMC7332966)

Rennie, M. L. , Chaugule, V. K. and Walden, H. (2020) Modes of allosteric regulation of the ubiquitination machinery. Current Opinion in Structural Biology, 62, pp. 189-196. (doi: 10.1016/j.sbi.2020.02.003) (PMID:32305021)

Chaugule, V. K., Arkinson, C., Rennie, M. L. , Kämäräinen, O., Toth, R. and Walden, H. (2020) Allosteric mechanism for site-specific ubiquitination of FANCD2. Nature Chemical Biology, 16, pp. 291-301. (doi: 10.1038/s41589-019-0426-z) (PMID:31873223)

This list was generated on Thu Nov 21 06:16:43 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Structural basis of Hsp90-CHIP association
    Wellcome Trust
    2021 - 2022
     

Selfie of Martin Rennie