Dr Kenneth Watterson
- Lecturer (Molecular Biosciences)
telephone:
1900
email:
Kenneth.Watterson@glasgow.ac.uk
Room 1008, Level 10, Boyd Orr Building, Glasgow, G12 8QQ
Research interests
Research groups
Publications
2017
Shaw, A., Jeromson, S., Watterson, K. R., Pediani, J. D. , Gallagher, I., Whalley, T., Dreczkowski, G., Brooks, N., Galloway, S. and Hamilton, D. L. (2017) Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes. American Journal of Physiology: Cell Physiology, 312(6), C689-C696. (doi: 10.1152/ajpcell.00026.2016) (PMID:28298333)
Watterson, K. R. et al. (2017) Probe-dependent negative allosteric modulators of the long-chain free fatty acid receptor FFA4. Molecular Pharmacology, 91(6), pp. 630-641. (doi: 10.1124/mol.116.107821) (PMID:28385906) (PMCID:PMC5438128)
2016
Azevedo, C. M. G. et al. (2016) Non-acidic free fatty acid receptor 4 agonists with antidiabetic activity. Journal of Medicinal Chemistry, 59(19), pp. 8868-8878. (doi: 10.1021/acs.jmedchem.6b00685)
2015
Milligan, G. , Alvarez-Curto, E. , Watterson, K.R., Ulven, T. and Hudson, B.D. (2015) Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. British Journal of Pharmacology, 172(13), pp. 3254-3265. (doi: 10.1111/bph.12879) (PMID:25131623)
Christiansen, E. et al. (2015) Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. British Journal of Nutrition, 113(11), pp. 1677-1688. (doi: 10.1017/S000711451500118X) (PMID:25916176)
2014
Watterson, K. R., Hudson, B. D. , Ulven, T. and Milligan, G. (2014) Treatment of type 2 diabetes by free fatty acid receptor agonists. Frontiers in Endocrinology, 5, 137. (doi: 10.3389/fendo.2014.00137) (PMID:25221541) (PMCID:PMC4147718)
2013
Beall, C., Watterson, K. R., McCrimmon, R. J. and Ashford, M. L.J. (2013) AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. Journal of Bioenergetics and Biomembranes, 45(3), pp. 229-241. (doi: 10.1007/s10863-013-9509-9) (PMID:23575945)
Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. and Ashford, M. L.J. (2013) Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. Neurosignals, 21(1-2), pp. 28-41. (doi: 10.1159/000334144) (PMID:22456226) (PMCID:PMC3704126)
2009
Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C. and Ashford, M. L.J. (2009) Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. Journal of Biological Chemistry, 284(14), pp. 9331-9340. (doi: 10.1074/jbc.M806774200) (PMID:19208634) (PMCID:PMC2666585)
2007
Watterson, K. R., Berg, K. M., Kapitonov, D., Payne, S. G., Miner, A. S., Bittman, R., Milstien, S., Ratz, P. H. and Spiegel, S. (2007) Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. FASEB Journal, 21(11), pp. 2818-2828. (doi: 10.1096/fj.06-7326com) (PMID:17449719)
Watterson, K. R., Lanning, D. A., Diegelmann, R. F. and Spiegel, S. (2007) Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing. Wound Repair and Regeneration, 15(5), pp. 607-616. (doi: 10.1111/j.1524-475X.2007.00292.x) (PMID:17971005)
2005
Watterson, K. R., Ratz, P. H. and Spiegel, S. (2005) The role of sphingosine-1-phosphate in smooth muscle contraction. Cellular Signalling, 17(3), pp. 289-298. (doi: 10.1016/j.cellsig.2004.09.013) (PMID:15567060)
Goparaju, S. K. et al. (2005) The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Molecular and Cellular Biology, 25(10), pp. 4237-4249. (doi: 10.1128/MCB.25.10.4237-4249.2005) (PMID:15870293) (PMCID:PMC1087716)
Jolly, P. S., Bektas, M., Watterson, K. R., Sankala, H., Payne, S. G., Milstien, S. and Spiegel, S. (2005) Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood, 105(12), pp. 4736-4742. (doi: 10.1182/blood-2004-12-4686) (PMID:15741218) (PMCID:PMC1894993)
2004
Toman, R. E., Payne, S. G., Watterson, K. R., Maceyka, M., Lee, N. H., Milstien, S., Bigbee, J. W. and Spiegel, S. (2004) Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. Journal of Cell Biology, 166(3), pp. 381-92. (doi: 10.1083/jcb.200402016) (PMID:15289497) (PMCID:PMC2172260)
2003
Rosenfeldt, H. M., Amrani, Y., Watterson, K. R., Murthy, K. S., Panettieri, R. A. and Spiegel, S. (2003) Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB Journal, 17(13), pp. 1789-1799. (doi: 10.1096/fj.02-0836com) (PMID:14519658)
Watterson, K., Sankala, H., Milstien, S. and Spiegel, S. (2003) Pleiotropic actions of sphingosine-1-phosphate. Progress in Lipid Research, 42(4), pp. 344-357. (doi: 10.1016/S0163-7827(03)00015-8) (PMID:12790117)
2002
Ferguson, G., Watterson, K.R. and Palmer, T.M. (2002) Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A(1) and rat A(3) adenosine receptors: Consequences for agonist-stimulated translocation of arrestin3. Biochemistry, 41, pp. 14748-14761. (doi: 10.1021/bi0262911)
Watterson, K., Johnston, E., Chalmers, C., Pronin, A., Cook, S., Benovic, J. and Palmer, T. (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)
2000
Ferguson, G., Watterson, K. R. and Palmer, T. M. (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Molecular Pharmacology, 57(3), pp. 546-552. (doi: 10.1124/mol.57.3.546) (PMID:10692495)
Articles
Shaw, A., Jeromson, S., Watterson, K. R., Pediani, J. D. , Gallagher, I., Whalley, T., Dreczkowski, G., Brooks, N., Galloway, S. and Hamilton, D. L. (2017) Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes. American Journal of Physiology: Cell Physiology, 312(6), C689-C696. (doi: 10.1152/ajpcell.00026.2016) (PMID:28298333)
Watterson, K. R. et al. (2017) Probe-dependent negative allosteric modulators of the long-chain free fatty acid receptor FFA4. Molecular Pharmacology, 91(6), pp. 630-641. (doi: 10.1124/mol.116.107821) (PMID:28385906) (PMCID:PMC5438128)
Azevedo, C. M. G. et al. (2016) Non-acidic free fatty acid receptor 4 agonists with antidiabetic activity. Journal of Medicinal Chemistry, 59(19), pp. 8868-8878. (doi: 10.1021/acs.jmedchem.6b00685)
Milligan, G. , Alvarez-Curto, E. , Watterson, K.R., Ulven, T. and Hudson, B.D. (2015) Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4. British Journal of Pharmacology, 172(13), pp. 3254-3265. (doi: 10.1111/bph.12879) (PMID:25131623)
Christiansen, E. et al. (2015) Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. British Journal of Nutrition, 113(11), pp. 1677-1688. (doi: 10.1017/S000711451500118X) (PMID:25916176)
Watterson, K. R., Hudson, B. D. , Ulven, T. and Milligan, G. (2014) Treatment of type 2 diabetes by free fatty acid receptor agonists. Frontiers in Endocrinology, 5, 137. (doi: 10.3389/fendo.2014.00137) (PMID:25221541) (PMCID:PMC4147718)
Beall, C., Watterson, K. R., McCrimmon, R. J. and Ashford, M. L.J. (2013) AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. Journal of Bioenergetics and Biomembranes, 45(3), pp. 229-241. (doi: 10.1007/s10863-013-9509-9) (PMID:23575945)
Watterson, K. R., Bestow, D., Gallagher, J., Hamilton, D. L., Ashford, F. B., Meakin, P. J. and Ashford, M. L.J. (2013) Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. Neurosignals, 21(1-2), pp. 28-41. (doi: 10.1159/000334144) (PMID:22456226) (PMCID:PMC3704126)
Ning, K., Miller, L. C., Laidlaw, H. A., Watterson, K. R., Gallagher, J., Sutherland, C. and Ashford, M. L.J. (2009) Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. Journal of Biological Chemistry, 284(14), pp. 9331-9340. (doi: 10.1074/jbc.M806774200) (PMID:19208634) (PMCID:PMC2666585)
Watterson, K. R., Berg, K. M., Kapitonov, D., Payne, S. G., Miner, A. S., Bittman, R., Milstien, S., Ratz, P. H. and Spiegel, S. (2007) Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone. FASEB Journal, 21(11), pp. 2818-2828. (doi: 10.1096/fj.06-7326com) (PMID:17449719)
Watterson, K. R., Lanning, D. A., Diegelmann, R. F. and Spiegel, S. (2007) Regulation of fibroblast functions by lysophospholipid mediators: potential roles in wound healing. Wound Repair and Regeneration, 15(5), pp. 607-616. (doi: 10.1111/j.1524-475X.2007.00292.x) (PMID:17971005)
Watterson, K. R., Ratz, P. H. and Spiegel, S. (2005) The role of sphingosine-1-phosphate in smooth muscle contraction. Cellular Signalling, 17(3), pp. 289-298. (doi: 10.1016/j.cellsig.2004.09.013) (PMID:15567060)
Goparaju, S. K. et al. (2005) The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Molecular and Cellular Biology, 25(10), pp. 4237-4249. (doi: 10.1128/MCB.25.10.4237-4249.2005) (PMID:15870293) (PMCID:PMC1087716)
Jolly, P. S., Bektas, M., Watterson, K. R., Sankala, H., Payne, S. G., Milstien, S. and Spiegel, S. (2005) Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. Blood, 105(12), pp. 4736-4742. (doi: 10.1182/blood-2004-12-4686) (PMID:15741218) (PMCID:PMC1894993)
Toman, R. E., Payne, S. G., Watterson, K. R., Maceyka, M., Lee, N. H., Milstien, S., Bigbee, J. W. and Spiegel, S. (2004) Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. Journal of Cell Biology, 166(3), pp. 381-92. (doi: 10.1083/jcb.200402016) (PMID:15289497) (PMCID:PMC2172260)
Rosenfeldt, H. M., Amrani, Y., Watterson, K. R., Murthy, K. S., Panettieri, R. A. and Spiegel, S. (2003) Sphingosine-1-phosphate stimulates contraction of human airway smooth muscle cells. FASEB Journal, 17(13), pp. 1789-1799. (doi: 10.1096/fj.02-0836com) (PMID:14519658)
Watterson, K., Sankala, H., Milstien, S. and Spiegel, S. (2003) Pleiotropic actions of sphingosine-1-phosphate. Progress in Lipid Research, 42(4), pp. 344-357. (doi: 10.1016/S0163-7827(03)00015-8) (PMID:12790117)
Ferguson, G., Watterson, K.R. and Palmer, T.M. (2002) Subtype-specific regulation of receptor internalization and recycling by the carboxyl-terminal domains of the human A(1) and rat A(3) adenosine receptors: Consequences for agonist-stimulated translocation of arrestin3. Biochemistry, 41, pp. 14748-14761. (doi: 10.1021/bi0262911)
Watterson, K., Johnston, E., Chalmers, C., Pronin, A., Cook, S., Benovic, J. and Palmer, T. (2002) Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. Journal of Biological Chemistry, 277, pp. 5767-5777. (doi: 10.1074/jbc.M110647200)
Ferguson, G., Watterson, K. R. and Palmer, T. M. (2000) Subtype-specific kinetics of inhibitory adenosine receptor internalization are determined by sensitivity to phosphorylation by G protein-coupled receptor kinases. Molecular Pharmacology, 57(3), pp. 546-552. (doi: 10.1124/mol.57.3.546) (PMID:10692495)