2024

Myburgh, E., Geoghegan, V., Alves-Ferreira, E. V.C., Nievas, Y. R., Grewal, J. S., Brown, E., McLuskey, K. and Mottram, J. C. (2024) TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania. EMBO Reports, 25(3), pp. 1075-1105. (doi: 10.1038/s44319-024-00084-y) (PMID:38396206) (PMCID:PMC10933368)

2021

McLuskey, K., Wandy, J. , Vincent, I. , Van Der Hooft, J. J.J. , Rogers, S. , Burgess, K. and Daly, R. (2021) Ranking metabolite sets by their activity levels. Metabolites, 11(2), 103. (doi: 10.3390/metabo11020103) (PMID:33670102) (PMCID:PMC7916825)

2016

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

McLuskey, K., Grewal, J. S., Das, D., Godzik, A., Lesley, S. A., Deacon, A. M., Coombs, G. H., Elsliger, M.-A., Wilson, I. A. and Mottram, J. C. (2016) Crystal structure and activity studies of the C11 cysteine peptidase from Parabacteroides merdae in the human gut microbiome. Journal of Biological Chemistry, 291, pp. 9482-9491. (doi: 10.1074/jbc.M115.706143) (PMID:26940874) (PMCID:PMC4850288)

2015

McLuskey, K. and Mottram, J. C. (2015) Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. Biochemical Journal, 466(2), pp. 219-232. (doi: 10.1042/BJ20141324) (PMID:25697094) (PMCID:PMC4357240)

2014

McLuskey, K., Moss, C. X. and Mottram, J. C. (2014) Purification, characterization, and crystallization of trypanosoma metacaspases. Methods in Molecular Biology, 1133, pp. 203-221. (doi: 10.1007/978-1-4939-0357-3_13)

2013

Machado, M.K.M., Marcondes, M.F., Juliano, M.A., McLuskey, K., Mottram, J.C. , Moss, C.X., Juliano, L. and Oliveira, V. (2013) Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2. FEBS Journal, 280(11), pp. 2608-2621. (doi: 10.1111/febs.12248)

Gabrielsen, M. , Roe, A.J. and McLuskey, K. (2013) High-throughput methods for the detection of protein overexpression using fluorescence markers. Methods in Cell Biology, 113, pp. 189-208. (doi: 10.1016/B978-0-12-407239-8.00010-0)

2012

McLuskey, K., Rudolf, J., Proto, W. R., Isaacs, N. W., Coombs, G. H., Moss, C. X. and Mottram, J. C. (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences of the United States of America, 109(19), pp. 7469-7474. (doi: 10.1073/pnas.1200885109)

2011

Gabrielsen, M. , Kroner, F., Black, I., Isaacs, N.W., Roe, A.J. and McLuskey, K. (2011) High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins. Molecular Membrane Biology, 28(7-8), pp. 445-453. (doi: 10.3109/09687688.2011.628954) (PMID:22034843)

Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

2010

McLuskey, K., Paterson, N. G., Bland, N. D., Isaacs, N. W. and Mottram, J. C. (2010) Crystal structure of leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. Journal of Biological Chemistry, 285(50), pp. 39249-39259. (doi: 10.1074/jbc.M110.156679)

McLuskey, K., Roszak, A. W., Zhu, Y. S. and Isaacs, N. W. (2010) Crystal structures of all-alpha type membrane proteins. European Biophysics Journal with Biophysics Letters, 39(5), pp. 723-755. (doi: 10.1007/s00249-009-0546-6)

2008

McLuskey, K., Gabrielsen, M. , Kroner, F., Black, I., Cogdell, R.J. and Isaacs, N.W. (2008) A protocol for high throughput methods for the expression and purification of inner membrane proteins. Molecular Membrane Biology, 25(8), pp. 599-608. (doi: 10.1080/09687680802510289)

Articles

Myburgh, E., Geoghegan, V., Alves-Ferreira, E. V.C., Nievas, Y. R., Grewal, J. S., Brown, E., McLuskey, K. and Mottram, J. C. (2024) TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania. EMBO Reports, 25(3), pp. 1075-1105. (doi: 10.1038/s44319-024-00084-y) (PMID:38396206) (PMCID:PMC10933368)

McLuskey, K., Wandy, J. , Vincent, I. , Van Der Hooft, J. J.J. , Rogers, S. , Burgess, K. and Daly, R. (2021) Ranking metabolite sets by their activity levels. Metabolites, 11(2), 103. (doi: 10.3390/metabo11020103) (PMID:33670102) (PMCID:PMC7916825)

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

McLuskey, K., Grewal, J. S., Das, D., Godzik, A., Lesley, S. A., Deacon, A. M., Coombs, G. H., Elsliger, M.-A., Wilson, I. A. and Mottram, J. C. (2016) Crystal structure and activity studies of the C11 cysteine peptidase from Parabacteroides merdae in the human gut microbiome. Journal of Biological Chemistry, 291, pp. 9482-9491. (doi: 10.1074/jbc.M115.706143) (PMID:26940874) (PMCID:PMC4850288)

McLuskey, K. and Mottram, J. C. (2015) Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. Biochemical Journal, 466(2), pp. 219-232. (doi: 10.1042/BJ20141324) (PMID:25697094) (PMCID:PMC4357240)

McLuskey, K., Moss, C. X. and Mottram, J. C. (2014) Purification, characterization, and crystallization of trypanosoma metacaspases. Methods in Molecular Biology, 1133, pp. 203-221. (doi: 10.1007/978-1-4939-0357-3_13)

Machado, M.K.M., Marcondes, M.F., Juliano, M.A., McLuskey, K., Mottram, J.C. , Moss, C.X., Juliano, L. and Oliveira, V. (2013) Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2. FEBS Journal, 280(11), pp. 2608-2621. (doi: 10.1111/febs.12248)

Gabrielsen, M. , Roe, A.J. and McLuskey, K. (2013) High-throughput methods for the detection of protein overexpression using fluorescence markers. Methods in Cell Biology, 113, pp. 189-208. (doi: 10.1016/B978-0-12-407239-8.00010-0)

McLuskey, K., Rudolf, J., Proto, W. R., Isaacs, N. W., Coombs, G. H., Moss, C. X. and Mottram, J. C. (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences of the United States of America, 109(19), pp. 7469-7474. (doi: 10.1073/pnas.1200885109)

Gabrielsen, M. , Kroner, F., Black, I., Isaacs, N.W., Roe, A.J. and McLuskey, K. (2011) High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins. Molecular Membrane Biology, 28(7-8), pp. 445-453. (doi: 10.3109/09687688.2011.628954) (PMID:22034843)

Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

McLuskey, K., Paterson, N. G., Bland, N. D., Isaacs, N. W. and Mottram, J. C. (2010) Crystal structure of leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. Journal of Biological Chemistry, 285(50), pp. 39249-39259. (doi: 10.1074/jbc.M110.156679)

McLuskey, K., Roszak, A. W., Zhu, Y. S. and Isaacs, N. W. (2010) Crystal structures of all-alpha type membrane proteins. European Biophysics Journal with Biophysics Letters, 39(5), pp. 723-755. (doi: 10.1007/s00249-009-0546-6)

McLuskey, K., Gabrielsen, M. , Kroner, F., Black, I., Cogdell, R.J. and Isaacs, N.W. (2008) A protocol for high throughput methods for the expression and purification of inner membrane proteins. Molecular Membrane Biology, 25(8), pp. 599-608. (doi: 10.1080/09687680802510289)