Professor Shireen Davies
- Honorary Professor (School of Molecular Biosciences)
email:
Shireen.Davies@glasgow.ac.uk
R325 Level 3, Institute of MC&SB, Davidson Building, Glasgow G12 8QQ
https://orcid.org/0000-0002-0472-1302Publications
2023
Dornan, A. J. , Halberg, K. V., Beuter, L.-K., Davies, S. A. and Dow, J. A.T. (2023) Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants. Journal of Cell Science, 136(19), jcs261118. (doi: 10.1242/jcs.261118) (PMID:37694602) (PMCID:PMC10565245)
2021
Koyama, T., Terhzaz, S. , Naseem, M. T., Nagy, S., Rewitz, K., Dow, J. A.T. , Davies, S. A. and Halberg, K. V. (2021) A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila. Nature Communications, 12, 5178. (doi: 10.1038/s41467-021-25445-2) (PMID:34462441) (PMCID:PMC8405823)
2020
Dornan, A.J. , Halberg, K.A., Beuter, L.-K., Davies, S.-A. and Dow, J.A.T. (2020) The septate junction protein Snakeskin is critical for epithelial barrier function and tissue homeostasis in the Malpighian tubules of adult Drosophila. bioRxiv, (doi: 10.1101/2020.12.14.422678)
Cabrero, P. , Terhzaz, S. , Dornan, A. J. , Ghimire, S., Holmes, H. L., Turin, D. R., Romero, M. F., Davies, S. and Dow, J. A.T. (2020) Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Proceedings of the National Academy of Sciences of the United States of America, 117(3), pp. 1779-1787. (doi: 10.1073/pnas.1915943117) (PMID:31907321) (PMCID:PMC6983416)
2019
Ghimire, S., Terhzaz, S. , Cabrero, P. , Romero, M. F., Davies, S. and Dow, J. A.T. (2019) Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. American Journal of Physiology: Renal Physiology, 317(4), F930-F940. (doi: 10.1152/ajprenal.00551.2018) (PMID:31364377) (PMCID:PMC6843049)
Alford, L., Marley, R., Dornan, A. , Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment. Journal of Pest Science, 92, pp. 1123-1137. (doi: 10.1007/s10340-019-01100-0)
Alford, L., Marley, R., Dornan, A. , Pierre, J.-S., Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance. Pest Management Science, 75(6), pp. 1750-1759. (doi: 10.1002/ps.5372) (PMID:30734498) (PMCID:PMC6593983)
Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi: 10.1242/dev.178087) (PMID:31036543)
Davies, S.-A. , Cabrero, P. , Marley, R., Martinez-Corrales, G., Ghimire, S., Dornan, A. J. and Dow, J. A.T. (2019) Epithelial function in the Drosophila Malpighian tubule: an in vivo renal model. In: Vainio, Seppo (ed.) Kidney Organogenesis: Methods and Protocols. Series: Methods in molecular biology (1926). Humana Press: New York, NY, pp. 203-221. ISBN 9781493990207 (doi: 10.1007/978-1-4939-9021-4_17)
Dow, J. A.T. , Halberg, K. A., Terhzaz, S. and Davies, S. A. (2019) Drosophila as a model for neuroendocrine control of renal homeostasis. In: Ludwig, Mike and Levkowitz, Gil (eds.) Model Animals in Neuroendocrinology. Series: INF masterclass in neuroendocrinology series. Wiley: Hoboken, pp. 81-100. ISBN 9781119390947 (doi: 10.1002/9781119391128.ch4)
2018
Pandit, A. A. , Ragionieri, L., Marley, R., Yeoh, J. G.C. , Inward, D. J.G., Davies, S.-A. , Predel, R. and Dow, J. A.T. (2018) Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest. Insect Biochemistry and Molecular Biology, 101, pp. 94-107. (doi: 10.1016/j.ibmb.2018.08.003) (PMID:30165105)
Terhzaz, S. , Alford, L., Yeoh, J. G.C. , Marley, R., Dornan, A. J. , Dow, J. A.T. and Davies, S. A. (2018) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, 74(4), pp. 800-810. (doi: 10.1002/ps.4663) (PMID:28714258) (PMCID:PMC5888198)
Zandawala, M., Marley, R., Davies, S. A. and Nässel, D. R. (2018) Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Cellular and Molecular Life Sciences, 75(6), pp. 1099-1115. (doi: 10.1007/s00018-017-2682-y) (PMID:29043393)
2017
Leader, D. P. , Krause, S. A. , Pandit, A. , Davies, S. A. and Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, 46(D1), D809-D815. (doi: 10.1093/nar/gkx976) (PMID:29069479) (PMCID:PMC5753349)
Yeoh, J. G.C. , Pandit, A. A. , Zandawala, M., Nässel, D. R., Davies, S.-A. and Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi: 10.1016/j.ibmb.2017.05.001) (PMID:28502574)
Davies, S. (2017) nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology. International Pest Control, 59(3), pp. 164-165.
2016
Overend, G. , Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi: 10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)
Halberg, K. A., Rainey, S. M. , Veland, I. R., Neuert, H., Dornan, A. J. , Klämbt, C., Davies, S.-A. and Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, 11266. (doi: 10.1038/ncomms11266) (PMID:27072072) (PMCID:PMC4833865)
Cannell, E., Dornan, A. J. , Halberg, K. A., Terhzaza, S. , Dow, J. A.T. and Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi: 10.1016/j.peptides.2016.02.004) (PMID:26896569) (PMCID:PMC4889782)
2015
MacMillan, H. A., Andersen, J. L., Davies, S. A. and Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5, 18607. (doi: 10.1038/srep18607) (PMID:26678786) (PMCID:PMC4683515)
Brinzer, R. , Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S. and Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi: 10.1016/j.ibmb.2015.09.009) (PMID:26474926)
Dow, J. A. T. and Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, p. 1. (doi: 10.1016/j.ibmb.2015.10.013) (PMID:26518152)
Overend, G. , Cabrero, P. , Halberg, K. A.,, Ranford-Cartwright, L. C. , Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007) (PMID:26003916)
Terhzaz, S. , Cabrero, P. , Brinzer, R. A. , Halberg, K. A., Dow, J. A.T. and Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, 67, pp. 38-46. (doi: 10.1016/j.ibmb.2015.06.002) (PMID:26073628) (PMCID:PMC4673087)
Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G. , Davies, S. A. , Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi: 10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)
Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi: 10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)
Terhzaz, S. , Teets, N., Cabrero, P. , Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T. , Denlinger, D. L. and Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112(9), pp. 2882-2887. (doi: 10.1073/pnas.1501518112) (PMID:25730885) (PMCID:PMC4352776)
2014
Cabrero, P. , Terhzaz, S. , Romero, M. F., Davies, S. A. , Blumenthal, E. M. and Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proceedings of the National Academy of Sciences of the United States of America, 111(39), pp. 14301-14306. (doi: 10.1073/pnas.1412706111) (PMID:25228763) (PMCID:PMC4191759)
Terhzaz, S. , Overend, G. , Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)
Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)
2013
Davies, S.A. , Cabrero, P. , Povsic, M., Johnston, N.R., Terhzaz, S. and Dow, J.A.T. (2013) Signaling by drosophila capa neuropeptides. General and Comparative Endocrinology, 188, pp. 60-66. (doi: 10.1016/j.ygcen.2013.03.012)
Cabrero, P. , Richmond, L. , Nitabach, M., Davies, S.A. and Dow, J.A.T. (2013) A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in drosophila tubule stellate cells. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1757), Art. 20122943. (doi: 10.1098/rspb.2012.2943)
Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)
Chintapalli, V.R., Wang, J., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2013) Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. BMC Genomics, 14(518), (doi: 10.1186/1471-2164-14-518)
2012
Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi: 10.1523/JNEUROSCI.3286-12.2012)
Patel, U., Davies, S.A. and Myat, M.M. (2012) Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle. Biology Open, 1, pp. 507-515. (doi: 10.1242/bio.2012943)
Davies, S.A. , Overend, G. , Sebastian, S., Cundall, M., Cabrero, P. , Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi: 10.1016/j.jinsphys.2012.01.008) (PMID:22306292)
Overend, G. , Cabrero, P. , Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi: 10.1016/j.peptides.2011.08.019) (PMID:21893139)
Kanao, T., Sawada, T., Davies, S. , Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N. and Imai, Y. (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE, 7(2), e30958. (doi: 10.1371/journal.pone.0030958) (PMID:22393355) (PMCID:PMC3290610)
Chintapalli, V., Terhzaz, S. , Wang, J., Al Bratty, M., Watson, D.G., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2012) Functional correlates of positional and gender-specific renal asymmetry in drosophila. PLoS ONE, 7(4), e32577. (doi: 10.1371/journal.pone.0032577) (PMID:22496733) (PMCID:PMC3319558)
Terhzaz, S. , Cabrero, P. , Robben, J.H., Radford, J.C., Hudson, B.D. , Milligan, G. , Dow, J.A.T. and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7(1), e29897. (doi: 10.1371/journal.pone.0029897) (PMID:22253819) (PMCID:PMC3256212)
2010
Terhzaz, S., Finlayson, A. J., Stirrat, L., Yang, J., Tricoire, H., Woods, D. J., Dow, J. A.T. and Davies, S. A. (2010) Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cellular Signalling, 22(5), pp. 737-748. (doi: 10.1016/j.cellsig.2009.12.009) (PMID:20060894)
Terhzaz, S. , Cabrero, P. , Chintapalli, V.R., Davies, S.A. and Dow, J.A.T. (2010) Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiological Genomics, 41(1), pp. 33-41. (doi: 10.1152/physiolgenomics.00147.2009) (PMID:20009008) (PMCID:PMC2841493)
Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A. and Morton, D.B. (2010) Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics, 186(1), pp. 183-196. (doi: 10.1534/genetics.110.118166)
2009
Kettlewell, S., Cabrero, P., Nicklin, S.A. , Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi: 10.1016/j.yjmcc.2009.02.016) (PMID:19249308)
Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi: 10.1016/j.ygcen.2008.09.012) (PMID:18952086)
Davies, S.A. and Terhzaz, S. (2009) Organellar calcium signalling mechanisms in Drosophila epithelial function. Journal of Experimental Biology, 212(3), pp. 387-400. (doi: 10.1242/jeb.024513)
Stergiopoulos, K., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiological Genomics, 37(1), pp. 1-11. (doi: 10.1152/physiolgenomics.90360.2008) (PMID:19018044) (PMCID:PMC2661102)
2008
Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi: 10.1042/BJ20080560) (PMID:18503409)
Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi: 10.1242/jcs.033084) (PMID:18628302)
Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T. and Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP. Journal of Experimental Biology, 211, pp. 890-899. (doi: 10.1242/jeb.014837) (PMID:18310115)
2006
Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi: 10.1242/jcs.02983) (PMID:16735441)
Davies, S.-A. and Day, J.P. (2006) cGMP signalling in a transporting epithelium. Biochemical Society Transactions, 34, pp. 512-514. (doi: 10.1042/BST0340512) (PMID:16856847)
Davies, S. (2006) Signalling via cGMP: Lessons from Drosophila. Cellular Signalling, 18, pp. 409-421. (doi: 10.1016/j.cellsig.2005.08.011) (PMID:16260119)
Day, J., Houslay, M. and Davies, S. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393, pp. 481-488. (doi: 10.1042/BJ20051505) (PMID:16232123) (PMCID:PMC1360698)
Dow, J. A.T. and Davies, S. A. (2006) The Malpighian tubule: Rapid insights from post-genomic biology. Journal of Insect Physiology, 52(4), pp. 365-378. (doi: 10.1016/j.jinsphys.2005.10.007) (PMID:16310213)
Southall, T. D., Terhzaz, S. , Cabrero, P. , Chintapalli, V. R., Evans, J. M., Dow, J. A.T. and Davies, S.-A. (2006) Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Physiological Genomics, 26(1), pp. 35-45. (doi: 10.1152/physiolgenomics.00038.2006) (PMID:16609144)
Terhzaz, S. , Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi: 10.1074/jbc.M603002200) (PMID:16670086)
2005
Allan, A., Du, J., Davies, S. and Dow, J. (2005) Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiological Genomics, 22, pp. 128-138. (doi: 10.1152/physiolgenomics.00233.2004) (PMID:15855386)
Day, J., Dow, J., Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi: 10.1042/BJ20050057) (PMID:15673286) (PMCID:PMC1186723)
Evans, J., Allan, A., Davies, S. and Dow, J. (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Journal of Experimental Biology, 208, pp. 3771-3783. (PMID:16169954)
MacPherson, M., Pollock, V., Kean, L., Southall, T., Giannakou, M., Broderick, K., Dow, J., Hardie, R. and Davies, S. (2005) Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics, 169, pp. 1541-1552. (doi: 10.1534/genetics.104.035139) (PMID:15695363) (PMCID:PMC1449567)
McGettigan, J. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology, 35, pp. 741-754. (doi: 10.1016/j.ibmb.2005.02.017) (PMID:15894191)
2004
Broderick, K., Kean, L., Dow, J. , Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi: 10.1074/jbc.M304679200)
Cabrero, P., Pollock, V., Davies, S. and Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects. Journal of Experimental Biology, 207, pp. 3299-3305. (doi: 10.1242/jeb.01156) (PMID:15326206)
Kerr, M., Davies, S. and Down, J. (2004) Cell-specific manipulation of second messengers: A toolbox for integrative physiology in Drosophila. Current Biology, 14, pp. 1468-1474. (doi: 10.1016/j.cub.2004.08.020) (PMID:15324663)
MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi: 10.1242/jeb.01086)
MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi: 10.1074/jbc.M405619200)
Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J. and Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera. Journal of Experimental Biology, 207, pp. 4135-4145. (doi: 10.1242/jeb.01255) (PMID:15498959)
Radford, J.H.C., Terhzaz, S. , Cabrero, P. , Davies, S.A. and Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Journal of Experimental Biology, 207, pp. 4573-4586. (doi: 10.1242/jeb.01317) (PMID:15579553)
Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S. and Dow, J. (2004) Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences of the United States of America, 101(37), pp. 13689-13693. (doi: 10.1073/pnas.0403087101) (PMID:15347816) (PMCID:PMC518814)
Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P. and Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology, 5, (PMID:15345053) (PMCID:PMC522876)
2003
Broderick, K., MacPherson, M., Regulski, M., Tully, T., Dow, J. and Davies, S. (2003) Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. American Journal of Physiology: Cell Physiology, 285, C1207-C1218. (doi: 10.1152/ajpcell.00123.2003)
Dow, J. and Davies, S. (2003) Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiological Reviews, 83, pp. 687-729. (doi: 10.1152/physrev.00035.2002)
Pollock, V., Radford, J., Pyne, S., Hasan, G., Dow, J. and Davies, S. (2003) norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. Journal of Experimental Biology, 206, pp. 901-911. (doi: 10.1242/jeb.00189)
2002
Cabrero, P. , Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S. and Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology, 205(24), pp. 3799-3807. (PMID:12432004)
Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A. , Veenstra, J.A. and Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, R1297-R1307. (doi: 10.1152/ajpregu.00584.2001)
Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi: 10.1074/jbc.M203694200)
2001
Dow, J. and Davies, S. (2001) The Drosophila melanogaster malpighian tubule. Advances in Insect Physiology, 28, pp. 1-83.
MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J. and Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology: Cell Physiology, 280, C394-C407.
1999
Terhzaz, S. , O'Connell, F. C., Pollock, V. P., Kean, L., Davies, S. A. , Veenstra, J. A. and Dow, J. A. (1999) Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. Journal of Experimental Biology, 202(Pt 24), pp. 3667-3676. (PMID:10574744)
Articles
Dornan, A. J. , Halberg, K. V., Beuter, L.-K., Davies, S. A. and Dow, J. A.T. (2023) Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants. Journal of Cell Science, 136(19), jcs261118. (doi: 10.1242/jcs.261118) (PMID:37694602) (PMCID:PMC10565245)
Koyama, T., Terhzaz, S. , Naseem, M. T., Nagy, S., Rewitz, K., Dow, J. A.T. , Davies, S. A. and Halberg, K. V. (2021) A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila. Nature Communications, 12, 5178. (doi: 10.1038/s41467-021-25445-2) (PMID:34462441) (PMCID:PMC8405823)
Dornan, A.J. , Halberg, K.A., Beuter, L.-K., Davies, S.-A. and Dow, J.A.T. (2020) The septate junction protein Snakeskin is critical for epithelial barrier function and tissue homeostasis in the Malpighian tubules of adult Drosophila. bioRxiv, (doi: 10.1101/2020.12.14.422678)
Cabrero, P. , Terhzaz, S. , Dornan, A. J. , Ghimire, S., Holmes, H. L., Turin, D. R., Romero, M. F., Davies, S. and Dow, J. A.T. (2020) Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Proceedings of the National Academy of Sciences of the United States of America, 117(3), pp. 1779-1787. (doi: 10.1073/pnas.1915943117) (PMID:31907321) (PMCID:PMC6983416)
Ghimire, S., Terhzaz, S. , Cabrero, P. , Romero, M. F., Davies, S. and Dow, J. A.T. (2019) Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. American Journal of Physiology: Renal Physiology, 317(4), F930-F940. (doi: 10.1152/ajprenal.00551.2018) (PMID:31364377) (PMCID:PMC6843049)
Alford, L., Marley, R., Dornan, A. , Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment. Journal of Pest Science, 92, pp. 1123-1137. (doi: 10.1007/s10340-019-01100-0)
Alford, L., Marley, R., Dornan, A. , Pierre, J.-S., Dow, J. A.T. , Nachman, R. J. and Davies, S. A. (2019) Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance. Pest Management Science, 75(6), pp. 1750-1759. (doi: 10.1002/ps.5372) (PMID:30734498) (PMCID:PMC6593983)
Martinez Corrales, G., Cabrero, P. , Dow, J. A.T. , Terhzaz, S. and Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146(9), dev178087. (doi: 10.1242/dev.178087) (PMID:31036543)
Pandit, A. A. , Ragionieri, L., Marley, R., Yeoh, J. G.C. , Inward, D. J.G., Davies, S.-A. , Predel, R. and Dow, J. A.T. (2018) Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest. Insect Biochemistry and Molecular Biology, 101, pp. 94-107. (doi: 10.1016/j.ibmb.2018.08.003) (PMID:30165105)
Terhzaz, S. , Alford, L., Yeoh, J. G.C. , Marley, R., Dornan, A. J. , Dow, J. A.T. and Davies, S. A. (2018) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, 74(4), pp. 800-810. (doi: 10.1002/ps.4663) (PMID:28714258) (PMCID:PMC5888198)
Zandawala, M., Marley, R., Davies, S. A. and Nässel, D. R. (2018) Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila. Cellular and Molecular Life Sciences, 75(6), pp. 1099-1115. (doi: 10.1007/s00018-017-2682-y) (PMID:29043393)
Leader, D. P. , Krause, S. A. , Pandit, A. , Davies, S. A. and Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, 46(D1), D809-D815. (doi: 10.1093/nar/gkx976) (PMID:29069479) (PMCID:PMC5753349)
Yeoh, J. G.C. , Pandit, A. A. , Zandawala, M., Nässel, D. R., Davies, S.-A. and Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi: 10.1016/j.ibmb.2017.05.001) (PMID:28502574)
Davies, S. (2017) nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology. International Pest Control, 59(3), pp. 164-165.
Overend, G. , Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi: 10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)
Halberg, K. A., Rainey, S. M. , Veland, I. R., Neuert, H., Dornan, A. J. , Klämbt, C., Davies, S.-A. and Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, 11266. (doi: 10.1038/ncomms11266) (PMID:27072072) (PMCID:PMC4833865)
Cannell, E., Dornan, A. J. , Halberg, K. A., Terhzaza, S. , Dow, J. A.T. and Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi: 10.1016/j.peptides.2016.02.004) (PMID:26896569) (PMCID:PMC4889782)
MacMillan, H. A., Andersen, J. L., Davies, S. A. and Overgaard, J. (2015) The capacity to maintain ion and water homeostasis underlies interspecific variation in Drosophila cold tolerance. Scientific Reports, 5, 18607. (doi: 10.1038/srep18607) (PMID:26678786) (PMCID:PMC4683515)
Brinzer, R. , Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S. and Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi: 10.1016/j.ibmb.2015.09.009) (PMID:26474926)
Dow, J. A. T. and Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, p. 1. (doi: 10.1016/j.ibmb.2015.10.013) (PMID:26518152)
Overend, G. , Cabrero, P. , Halberg, K. A.,, Ranford-Cartwright, L. C. , Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007) (PMID:26003916)
Terhzaz, S. , Cabrero, P. , Brinzer, R. A. , Halberg, K. A., Dow, J. A.T. and Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, 67, pp. 38-46. (doi: 10.1016/j.ibmb.2015.06.002) (PMID:26073628) (PMCID:PMC4673087)
Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G. , Davies, S. A. , Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi: 10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)
Halberg, K., Terhzaz, S. , Cabrero, P. , Davies, S. A. and Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, 6800. (doi: 10.1038/ncomms7800) (PMID:25896425) (PMCID:PMC4410669)
Terhzaz, S. , Teets, N., Cabrero, P. , Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T. , Denlinger, D. L. and Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112(9), pp. 2882-2887. (doi: 10.1073/pnas.1501518112) (PMID:25730885) (PMCID:PMC4352776)
Cabrero, P. , Terhzaz, S. , Romero, M. F., Davies, S. A. , Blumenthal, E. M. and Dow, J. A. T. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proceedings of the National Academy of Sciences of the United States of America, 111(39), pp. 14301-14306. (doi: 10.1073/pnas.1412706111) (PMID:25228763) (PMCID:PMC4191759)
Terhzaz, S. , Overend, G. , Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)
Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)
Davies, S.A. , Cabrero, P. , Povsic, M., Johnston, N.R., Terhzaz, S. and Dow, J.A.T. (2013) Signaling by drosophila capa neuropeptides. General and Comparative Endocrinology, 188, pp. 60-66. (doi: 10.1016/j.ygcen.2013.03.012)
Cabrero, P. , Richmond, L. , Nitabach, M., Davies, S.A. and Dow, J.A.T. (2013) A biogenic amine and a neuropeptide act identically: tyramine signals through calcium in drosophila tubule stellate cells. Proceedings of the Royal Society of London Series B: Biological Sciences, 280(1757), Art. 20122943. (doi: 10.1098/rspb.2012.2943)
Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)
Chintapalli, V.R., Wang, J., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2013) Data-mining the FlyAtlas online resource to identify core functional motifs across transporting epithelia. BMC Genomics, 14(518), (doi: 10.1186/1471-2164-14-518)
Scheunemann, L., Jost, E., Richlitzki, A., Day, J.P., Sebastian, S., Thum, A.S., Efetova, M., Davies, S.-A. and Schwarzel, M. (2012) Consolidated and labile odor memory are separately encoded within the drosophila brain. Journal of Neuroscience, 32(48), pp. 17163-17171. (doi: 10.1523/JNEUROSCI.3286-12.2012)
Patel, U., Davies, S.A. and Myat, M.M. (2012) Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle. Biology Open, 1, pp. 507-515. (doi: 10.1242/bio.2012943)
Davies, S.A. , Overend, G. , Sebastian, S., Cundall, M., Cabrero, P. , Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi: 10.1016/j.jinsphys.2012.01.008) (PMID:22306292)
Overend, G. , Cabrero, P. , Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi: 10.1016/j.peptides.2011.08.019) (PMID:21893139)
Kanao, T., Sawada, T., Davies, S. , Ichinose, H., Hasegawa, K., Takahashi, R., Hattori, N. and Imai, Y. (2012) The nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in Drosophila. PLoS ONE, 7(2), e30958. (doi: 10.1371/journal.pone.0030958) (PMID:22393355) (PMCID:PMC3290610)
Chintapalli, V., Terhzaz, S. , Wang, J., Al Bratty, M., Watson, D.G., Herzyk, P. , Davies, S.A. and Dow, J.A.T. (2012) Functional correlates of positional and gender-specific renal asymmetry in drosophila. PLoS ONE, 7(4), e32577. (doi: 10.1371/journal.pone.0032577) (PMID:22496733) (PMCID:PMC3319558)
Terhzaz, S. , Cabrero, P. , Robben, J.H., Radford, J.C., Hudson, B.D. , Milligan, G. , Dow, J.A.T. and Davies, S.A. (2012) Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor. PLoS ONE, 7(1), e29897. (doi: 10.1371/journal.pone.0029897) (PMID:22253819) (PMCID:PMC3256212)
Terhzaz, S., Finlayson, A. J., Stirrat, L., Yang, J., Tricoire, H., Woods, D. J., Dow, J. A.T. and Davies, S. A. (2010) Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cellular Signalling, 22(5), pp. 737-748. (doi: 10.1016/j.cellsig.2009.12.009) (PMID:20060894)
Terhzaz, S. , Cabrero, P. , Chintapalli, V.R., Davies, S.A. and Dow, J.A.T. (2010) Mislocalization of mitochondria and compromised renal function and oxidative stress resistance in Drosophila SesB mutants. Physiological Genomics, 41(1), pp. 33-41. (doi: 10.1152/physiolgenomics.00147.2009) (PMID:20009008) (PMCID:PMC2841493)
Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A. and Morton, D.B. (2010) Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics, 186(1), pp. 183-196. (doi: 10.1534/genetics.110.118166)
Kettlewell, S., Cabrero, P., Nicklin, S.A. , Dow, J.A.T., Davies, S.A. and Smith, G.L. (2009) Changes of intra-mitochondrial Ca2+ in adult ventricular cardiomyocytes examined using a novel fluorescent Ca2+ indicator targeted to mitochondria. Journal of Molecular and Cellular Cardiology, 46(6), pp. 891-901. (doi: 10.1016/j.yjmcc.2009.02.016) (PMID:19249308)
Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi: 10.1016/j.ygcen.2008.09.012) (PMID:18952086)
Davies, S.A. and Terhzaz, S. (2009) Organellar calcium signalling mechanisms in Drosophila epithelial function. Journal of Experimental Biology, 212(3), pp. 387-400. (doi: 10.1242/jeb.024513)
Stergiopoulos, K., Cabrero, P., Davies, S.A. and Dow, J.A.T. (2009) Salty dog, an SLC5 symporter, modulates Drosophila response to salt stress. Physiological Genomics, 37(1), pp. 1-11. (doi: 10.1152/physiolgenomics.90360.2008) (PMID:19018044) (PMCID:PMC2661102)
Day, J. P., Cleghon, V., Houslay, M. D. and Davies, S. A. (2008) Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal, 414(Pt3), pp. 363-374. (doi: 10.1042/BJ20080560) (PMID:18503409)
Day, J.P., Wang, S.M., Allan, A.K., Kean, L., Davies, S.A., Gray, J.V. and Dow, J.A.T. (2008) Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa. Journal of Cell Science, 121(15), pp. 2612-2619. (doi: 10.1242/jcs.033084) (PMID:18628302)
Evans, J.M., Day, J.P., Cabrero, P., Dow, J.A.T. and Davies, S.A. (2008) A new role for a classical gene: white transports cyclic GMP. Journal of Experimental Biology, 211, pp. 890-899. (doi: 10.1242/jeb.014837) (PMID:18310115)
Du, J., Kean, L., Allan, A.K., Southall, T.D., Davies, S.A., McInerny, C.J. and Dow, J.A.T. (2006) The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Journal of Cell Science, 119(12), pp. 2542-2551. (doi: 10.1242/jcs.02983) (PMID:16735441)
Davies, S.-A. and Day, J.P. (2006) cGMP signalling in a transporting epithelium. Biochemical Society Transactions, 34, pp. 512-514. (doi: 10.1042/BST0340512) (PMID:16856847)
Davies, S. (2006) Signalling via cGMP: Lessons from Drosophila. Cellular Signalling, 18, pp. 409-421. (doi: 10.1016/j.cellsig.2005.08.011) (PMID:16260119)
Day, J., Houslay, M. and Davies, S. (2006) A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Biochemical Journal, 393, pp. 481-488. (doi: 10.1042/BJ20051505) (PMID:16232123) (PMCID:PMC1360698)
Dow, J. A.T. and Davies, S. A. (2006) The Malpighian tubule: Rapid insights from post-genomic biology. Journal of Insect Physiology, 52(4), pp. 365-378. (doi: 10.1016/j.jinsphys.2005.10.007) (PMID:16310213)
Southall, T. D., Terhzaz, S. , Cabrero, P. , Chintapalli, V. R., Evans, J. M., Dow, J. A.T. and Davies, S.-A. (2006) Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Physiological Genomics, 26(1), pp. 35-45. (doi: 10.1152/physiolgenomics.00038.2006) (PMID:16609144)
Terhzaz, S. , Southall, T. D., Lilley, K. S., Kean, L., Allan, A. K., Davies, S. A. and Dow, J. A.T. (2006) Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. Journal of Biological Chemistry, 281, pp. 18849-18858. (doi: 10.1074/jbc.M603002200) (PMID:16670086)
Allan, A., Du, J., Davies, S. and Dow, J. (2005) Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles. Physiological Genomics, 22, pp. 128-138. (doi: 10.1152/physiolgenomics.00233.2004) (PMID:15855386)
Day, J., Dow, J., Houslay, M. and Davies, S. (2005) Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochemical Journal, 388, pp. 333-342. (doi: 10.1042/BJ20050057) (PMID:15673286) (PMCID:PMC1186723)
Evans, J., Allan, A., Davies, S. and Dow, J. (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Journal of Experimental Biology, 208, pp. 3771-3783. (PMID:16169954)
MacPherson, M., Pollock, V., Kean, L., Southall, T., Giannakou, M., Broderick, K., Dow, J., Hardie, R. and Davies, S. (2005) Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics, 169, pp. 1541-1552. (doi: 10.1534/genetics.104.035139) (PMID:15695363) (PMCID:PMC1449567)
McGettigan, J. et al. (2005) Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection. Insect Biochemistry and Molecular Biology, 35, pp. 741-754. (doi: 10.1016/j.ibmb.2005.02.017) (PMID:15894191)
Broderick, K., Kean, L., Dow, J. , Pyne, N. and Davies, S. (2004) Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. Journal of Biological Chemistry, 279, pp. 8159-8168. (doi: 10.1074/jbc.M304679200)
Cabrero, P., Pollock, V., Davies, S. and Dow, J. (2004) A conserved domain of alkaline phosphatase expression in the Malpighian tubules of dipteran insects. Journal of Experimental Biology, 207, pp. 3299-3305. (doi: 10.1242/jeb.01156) (PMID:15326206)
Kerr, M., Davies, S. and Down, J. (2004) Cell-specific manipulation of second messengers: A toolbox for integrative physiology in Drosophila. Current Biology, 14, pp. 1468-1474. (doi: 10.1016/j.cub.2004.08.020) (PMID:15324663)
MacPherson, M., Broderick, K., Graham, S., Day, J., Houslay, M., Dow, J. and Davies, S. (2004) The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase. Journal of Experimental Biology, 207, pp. 2769-2776. (doi: 10.1242/jeb.01086)
MacPherson, M., Lohmann, S. and Davies, S. (2004) Analysis of Drosophila cGMP-dependent protein kinases and assessment of their in vivo roles by targeted expression in a renal transporting epithelium. Journal of Biological Chemistry, 279, pp. 40026-40034. (doi: 10.1074/jbc.M405619200)
Pollock, V., McGettigan, J., Cabrero, P., Maudlin, I., Dow, J. and Davies, S. (2004) Conservation of capa peptide-induced nitric oxide signalling in Diptera. Journal of Experimental Biology, 207, pp. 4135-4145. (doi: 10.1242/jeb.01255) (PMID:15498959)
Radford, J.H.C., Terhzaz, S. , Cabrero, P. , Davies, S.A. and Dow, J.A.T. (2004) Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. Journal of Experimental Biology, 207, pp. 4573-4586. (doi: 10.1242/jeb.01317) (PMID:15579553)
Torrie, L., Radford, J., Southall, T., Kean, L., Dinsmore, A., Davies, S. and Dow, J. (2004) Resolution of the insect ouabain paradox. Proceedings of the National Academy of Sciences of the United States of America, 101(37), pp. 13689-13693. (doi: 10.1073/pnas.0403087101) (PMID:15347816) (PMCID:PMC518814)
Wang, J., Kean, L., Yang, J., Allan, A., Davies, S., Herzyk, P. and Dow, J. (2004) Function-informed transcriptome analysis of Drosophila renal tubule. Genome Biology, 5, (PMID:15345053) (PMCID:PMC522876)
Broderick, K., MacPherson, M., Regulski, M., Tully, T., Dow, J. and Davies, S. (2003) Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. American Journal of Physiology: Cell Physiology, 285, C1207-C1218. (doi: 10.1152/ajpcell.00123.2003)
Dow, J. and Davies, S. (2003) Integrative physiology and functional genomics of epithelial function in a genetic model organism. Physiological Reviews, 83, pp. 687-729. (doi: 10.1152/physrev.00035.2002)
Pollock, V., Radford, J., Pyne, S., Hasan, G., Dow, J. and Davies, S. (2003) norpA and itpr mutants reveal roles for phospholipase C and inositol (1,4,5)-trisphosphate receptor in Drosophila melanogaster renal function. Journal of Experimental Biology, 206, pp. 901-911. (doi: 10.1242/jeb.00189)
Cabrero, P. , Radford, J., Broderick, K., Costes, L., Veenstra, J., Spana, E., Davies, S. and Dow, J. (2002) The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Journal of Experimental Biology, 205(24), pp. 3799-3807. (PMID:12432004)
Kean, L., Cazenave, W., Costes, L., Broderick, K.E., Graham, S., Pollock, V.P., Davies, S.A. , Veenstra, J.A. and Dow, J.A.T. (2002) Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 282, R1297-R1307. (doi: 10.1152/ajpregu.00584.2001)
Radford, J., Davies, S. and Dow, J. (2002) Systematic G-protein-coupled receptor analysis in Drosophila melanogaster identifies a leucokinin receptor with novel roles. Journal of Biological Chemistry, 277, pp. 38810-38817. (doi: 10.1074/jbc.M203694200)
Dow, J. and Davies, S. (2001) The Drosophila melanogaster malpighian tubule. Advances in Insect Physiology, 28, pp. 1-83.
MacPherson, M., Pollock, V., Broderick, K., Kean, L., OConnell, F., Dow, J. and Davies, S. (2001) Model organisms: New insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. American Journal of Physiology: Cell Physiology, 280, C394-C407.
Terhzaz, S. , O'Connell, F. C., Pollock, V. P., Kean, L., Davies, S. A. , Veenstra, J. A. and Dow, J. A. (1999) Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. Journal of Experimental Biology, 202(Pt 24), pp. 3667-3676. (PMID:10574744)
Book Sections
Davies, S.-A. , Cabrero, P. , Marley, R., Martinez-Corrales, G., Ghimire, S., Dornan, A. J. and Dow, J. A.T. (2019) Epithelial function in the Drosophila Malpighian tubule: an in vivo renal model. In: Vainio, Seppo (ed.) Kidney Organogenesis: Methods and Protocols. Series: Methods in molecular biology (1926). Humana Press: New York, NY, pp. 203-221. ISBN 9781493990207 (doi: 10.1007/978-1-4939-9021-4_17)
Dow, J. A.T. , Halberg, K. A., Terhzaz, S. and Davies, S. A. (2019) Drosophila as a model for neuroendocrine control of renal homeostasis. In: Ludwig, Mike and Levkowitz, Gil (eds.) Model Animals in Neuroendocrinology. Series: INF masterclass in neuroendocrinology series. Wiley: Hoboken, pp. 81-100. ISBN 9781119390947 (doi: 10.1002/9781119391128.ch4)
Supervision
- Li, Keqin
Genome-wide association studies of nephrolithiasis and water transport of renal tubule in Drosophila melanogaster