Dr Ian Salt

  • Reader (Molecular Biosciences)

telephone: 01413302049
email: Ian.Salt@glasgow.ac.uk

R241 Level 2, School of Molecular Biosciences, Davidson Building, Glasgow G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-0055-3724

Biography

Ian graduated as a biochemist at the University of Bristol prior to gaining his Ph.D. in beta-cell biochemistry from the University of Dundee in 1997.  He held a British Heart Foundation Intermediate Fellowship and the Diabetes UK R.D. Lawrence Fellowship before taking up his current academic post at the University of Glasgow. 

Research interests

My laboratory is interested in identifying the molecular and cellular mechanisms that underlie the link between diabetes and cardiovascular disease. In particular, we and others have previously shown that insulin itself acts on the endothelial cells that line blood vessels to produce nitric oxide, which relaxes blood vessels and prevents atherosclerosis. In addition, we have demonstrated that AMP-activated protein kinase (AMPK) has similar beneficial effects on endothelial cells. Research in my laboratory currently concentrates the on: i) How changes in nutrient supply regulate insulin action ii) How nutrient supply regulates inflammatory signalling found in obesity and vascular disease iii) How nutrient supply regulates cell growth. Our hope is that the results of our work will further expand our knowledge of how insulin and AMPK affect metabolic and cardiovascular tissues, which will aid the development of future drugs and new therapies for the treatment of diabetes and its associated cardiovascular complications.

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008 | 2007 | 2005 | 2004 | 2003 | 2001 | 2000
Number of items: 55.

2024

Hwej, A., Al-Ferjani, A., Alshuweishi, Y., Naji, A., Kennedy, S. and Salt, I. (2024) Lack of AMP-activated protein kinase-α1 reduces nitric oxide synthesis in thoracic aorta perivascular adipose tissue. Vascular Pharmacology, 157, 107437. (doi: 10.1016/j.vph.2024.107437) (PMID:39433170)

Salt, I. P. and Carling, D. (2024) A special issue of Essays in Biochemistry on AMPK and AMPK-related kinases. Essays In Biochemistry, (Accepted for Publication)

2023

Irshad, Z. et al. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37(11), e23209. (doi: 10.1096/fj.202300960RR) (PMID:37779421)

Dowsett, L. , Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P. and Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

2021

Ahwazi, D. et al. (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochemical Journal, 478(15), pp. 2977-2997. (doi: 10.1042/BCJ20210284) (PMID:34259310)

Palmer, T. M. and Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

Salt, I. P. , Nunes, J. R.C. and Fullerton, M. D. (2021) Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1. Cardiovascular Research, 117(5), pp. 1233-1234. (doi: 10.1093/cvr/cvab065) (PMID:33681999)

Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, K., Salt, I. P. and Göransson, O. (2021) A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner. Biochemical Journal, 478(3), pp. 633-646. (doi: 10.1042/BCJ20200659) (PMID:33493298)

2020

Alghamdi, F., Alshuweishi, Y. and Salt, I. P. (2020) Regulation of nutrient uptake by AMP-activated protein kinase. Cellular Signalling, 76, 109807. (doi: 10.1016/j.cellsig.2020.109807) (PMID:33038517)

2019

Katwan, O. J., Alghamdi, F., Almabrouk, T. A. , Mancini, S. J., Kennedy, S. , Oakhill, J. S., Scott, J. W. and Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis. Biochemical Journal, 476(12), pp. 1725-1740. (doi: 10.1042/BCJ20180714) (PMID:31189568) (PMCID:PMC6595317)

Petrie, J. R. and Salt, I. P. (2019) Diabetes and vascular disease. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 429-437. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_40)

Rezig, I. M., Bremner, S. K. , Bhutta, M. S., Salt, I. P. , Gould, G. W. and McInerny, C. J. (2019) Genetic and cytological methods to study ESCRT cell cycle function in fission yeast. In: Culetto, E. and Legouis, R. (eds.) The ESCRT Complexes: Methods and Protocols. Series: Methods in molecular biology (1998). Humana Press: New York, pp. 239-250. ISBN 9781493994915 (doi: 10.1007/978-1-4939-9492-2_18)

2018

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S. , Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi: 10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Speirs, C., Williams, J. J.L., Riches, K., Salt, I. P. and Palmer, T. M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001) (PMID:29037480)

Mancini, S. J. and Salt, I. P. (2018) Investigating the role of AMPK in inflammation. In: Neumann, D. and Viollet, B. (eds.) AMPK: Methods and Protocols. Series: Methods in Molecular Biology, 1732. Humana Press, pp. 307-319. ISBN 9781493975976 (doi: 10.1007/978-1-4939-7598-3_20)

2017

Almabrouk, T. A. M. , Ugusman, A. B., Katwan, O. J., Salt, I. P. and Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174(20), pp. 3398-3410. (doi: 10.1111/bph.13633) (PMID:27668984)

Kennedy, S. and Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174(20), pp. 3385-3387. (doi: 10.1111/bph.13969) (PMID:28940457)

Salt, I. P. and Hardie, G. (2017) AMP-activated protein kinase: an ubiquitous signalling pathway with key roles in the cardiovascular system. Circulation Research, 120(11), pp. 1825-1841. (doi: 10.1161/CIRCRESAHA.117.309633) (PMID:28546359) (PMCID:PMC5447810)

Chen, S.C., Brooks, R., Houskeeper, J., Bremner, S.K., Dunlop, J. , Viollet, B., Logan, P.J., Salt, I.P. , Ahmed, S.F. and Yarwood, S.J. (2017) Corrigendum to "Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms" [Mol. Cell. Endocrinol. 440 15 January 2017 57-68]. Molecular and Cellular Endocrinology, 443, p. 176. (doi: 10.1016/j.mce.2017.01.049) (PMID:28183460)

Chen, S. C., Brooks, R., Houskeeper, J., Bremner, S. K., Dunlop, J. , Viollet, B., Logan, P. J., Salt, I. P. , Ahmed, S. F. and Yarwood, S. J. (2017) Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. Molecular and Cellular Endocrinology, 440, pp. 57-68. (doi: 10.1016/j.mce.2016.11.011) (PMID:27856330) (PMCID:PMC5228588)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

2016

Docherty, C. K., Salt, I. P. and Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7(1), 78. (doi: 10.1186/s13287-016-0323-2)

Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., Gould, G. W. and Salt, I. P. (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochemical Journal, 473(24), pp. 4681-4697. (doi: 10.1042/BCJ20160211) (PMID:27784766) (PMCID:PMC5147050)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)

Hawley, S. A., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S., Pitt, R. D., Day, E. A., Salt, I. P. , Steinberg, G. R. and Hardie, D. G. (2016) The Na+ glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes, 65(9), pp. 2784-2794. (doi: 10.2337/db16-0058) (PMID:27381369) (PMCID:PMC5689380)

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. and MacLean, M. R. (2016) Metformin reverses development of pulmonary hypertension via aromatase inhibition. Hypertension, 68(2), pp. 446-454. (doi: 10.1161/HYPERTENSIONAHA.116.07353) (PMID:27296990)

2015

Choudhury, Y., Salt, I. and Leung, H. (2015) AMPK—friend or foe for targeted therapy? Cell Cycle, 14(12), pp. 1761-1762. (doi: 10.1080/15384101.2015.1022066) (PMID:26036305)

2014

Choudhury, Y., Yang, Z., Ahmad, I. , Nixon, C., Salt, I. P. and Leung, H. Y. (2014) AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience, 1(6), pp. 446-456. (doi: 10.18632/oncoscience.49) (PMID:25594043) (PMCID:PMC4284621)

Almabrouk, T.A.M. , Ewart, M.-A., Salt, I.P. and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi: 10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075)

Salt, I.P. , Harnett, M.M. and Goodridge, H.S. (2014) Membrane receptors and signal transduction. In: Baynes, J. and Dominiczak, M. (eds.) Medical Biochemistry [4th Edition]. Saunders Elsevier. ISBN 9781455745807

2013

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi: 10.1042/CS20120239)

Salt, I. P. (2013) Examining the role of insulin in the regulation of cardiovascular health. Future Cardiology, 9(1), pp. 39-52. (doi: 10.2217/fca.12.77) (PMID:23259474)

Bijland, S., Mancini, S.J. and Salt, I.P. (2013) Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clinical Science, 124(8), pp. 491-507. (doi: 10.1042/CS20120536) (PMID:23298225)

2012

Salt, I. P. and Palmer, T. M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)

2011

Reihill, J. A., Ewart, M.-A. and Salt, I. P. (2011) The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells. Vascular Cell, 3(1), 9. (doi: 10.1186/2045-824X-3-9) (PMID:21507243) (PMCID:PMC3094250)

Boyle, J.G., Logan, P.J., Jones, G.C., Small, M., Sattar, N. , Connell, J.M.C., Cleland, S.J. and Salt, I.P. (2011) AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. Diabetologia, 54(7), pp. 1799-1809. (doi: 10.1007/s00125-011-2126-4)

Kohlhaas, C.F., Morrow, V.A., Jhakra, N., Patil, V., Connell, J.M.C., Petrie, J.R. and Salt, I.P. (2011) Insulin rapidly stimulates l-arginine transport in human aortic endothelial cells via Akt. Biochemical and Biophysical Research Communications, 412(4), pp. 747-751. (doi: 10.1016/j.bbrc.2011.08.048)

2010

Boyle, J.G., Salt, I.P. and McKay, G.A. (2010) Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target. Diabetic Medicine, 27(10), pp. 1097-1106. (doi: 10.1111/j.1464-5491.2010.03098.x) (PMID:20854376)

Ritchie, S. A., Kohlhaas, C. F., Boyd, A. R., Yalla, K. C., Walsh, K., Connell, J. M.C. and Salt, I. P. (2010) Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis. Biochemical Journal, 426(1), pp. 85-90. (doi: 10.1042/BJ20091580)

Hall, L.M.L., Moran, C.N., Milne, G.R., MacFarlane, N.G., Forouhi, N.G., Hariharan, N., Salt, I.P. , Sattar, N. and Gill, J.M.R. (2010) Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS ONE, 5(12), e14197. (doi: 10.1371/journal.pone.0014197) (PMID:21152018) (PMCID:PMC2995737)

2008

Ewart, M.-A., Kohlhaas, C.F. and Salt, I.P. (2008) Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(12), pp. 2255-2257. (doi: 10.1161/ATVBAHA.108.175919)

Boyle, J. G., Logan, P. J., Ewart, M.-A., Reihill, J. A., Ritchie, S. A., Connell, J. M.C., Cleland, S. J. and Salt, I. P. (2008) Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase. Journal of Biological Chemistry, 283(17), pp. 11210-11217. (doi: 10.1074/jbc.M710048200)

2007

Reihill, J.A., Ewart, M.-A., Hardie, D.G. and Salt, I. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354(4), pp. 1084-1088. (doi: 10.1016/j.bbrc.2007.01.110)

Kohlhaas, C. and Salt, I.P. (2007) Experimental hyperinsulinaemia does not alter insulin sensitivity of human endothelial cells or increase monocyte adhesion. Diabetic Medicine, 24(S1), p. 40. (doi: 10.1111/j.1464-5491.2007.02126.x)

Reihill, J., Ewart, M., Hardie, D. and Salt, I. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354, pp. 1084-1088. (doi: 10.1016/j.bbrc.2007.01.110)

2005

Collison, M., James, D., Graham, D., Holman, G., Connell, J., Dominiczak, A.F., Gould, G. and Salt, I. (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia, 48(3), pp. 539-546. (doi: 10.1007/s00125-005-1674-x)

2004

Ritchie, S., Ewart, M., Perry, C., Connell, J. and Salt, I. (2004) The role of insulin and the adipocytokines in regulation of vascular endothelial function. Clinical Science, 107(6), pp. 519-532. (doi: 10.1042/CS20040190)

2003

Morrow, V., Foufelle, F., Connell, J., Petrie, J. , Gould, G. and Salt, I. (2003) Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. Journal of Biological Chemistry, 278(34), pp. 31629-31639. (doi: 10.1074/jbc.M212831200)

Perry, C., Palmer, T., Cleland, S., Morton, I., Salt, I. , Petrie, J. , Gould, G. and Connell, J. (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi: 10.1042/CS20020320)

Salt, I., Morrow, V., Brandie, F., Connell, J. and Petrie, J. (2003) High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser(1177) phosphorylation in human aortic endothelial cells. Journal of Biological Chemistry, 278(21), pp. 18791-18797. (doi: 10.1074/jbc.M210618200)

2001

James, D.J., Cairns, F., Salt, I.P. , Murphy, G.J., Dominiczak, A.F., Connell, J.M.C. and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50(9), pp. 2148-2156. (doi: 10.2337/diabetes.50.9.2148)

2000

Collison, M., Campbell, I., Salt, I. , Dominiczak, A., Connell, J., Lyall, H. and Gould, G. (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43(11), pp. 1374-1380. (doi: 10.1007/s001250051541)

Salt, I. , Connell, J. and Gould, G. (2000) 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes, 49(10), pp. 1649-1656. (doi: 10.2337/diabetes.49.10.1649)

This list was generated on Wed Nov 20 19:44:14 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 55.

Articles

Hwej, A., Al-Ferjani, A., Alshuweishi, Y., Naji, A., Kennedy, S. and Salt, I. (2024) Lack of AMP-activated protein kinase-α1 reduces nitric oxide synthesis in thoracic aorta perivascular adipose tissue. Vascular Pharmacology, 157, 107437. (doi: 10.1016/j.vph.2024.107437) (PMID:39433170)

Salt, I. P. and Carling, D. (2024) A special issue of Essays in Biochemistry on AMPK and AMPK-related kinases. Essays In Biochemistry, (Accepted for Publication)

Irshad, Z. et al. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37(11), e23209. (doi: 10.1096/fj.202300960RR) (PMID:37779421)

Dowsett, L. , Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P. and Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

Ahwazi, D. et al. (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochemical Journal, 478(15), pp. 2977-2997. (doi: 10.1042/BCJ20210284) (PMID:34259310)

Palmer, T. M. and Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135(13), pp. 1563-1590. (doi: 10.1042/CS20190768) (PMID:34231841)

Salt, I. P. , Nunes, J. R.C. and Fullerton, M. D. (2021) Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1. Cardiovascular Research, 117(5), pp. 1233-1234. (doi: 10.1093/cvr/cvab065) (PMID:33681999)

Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, K., Salt, I. P. and Göransson, O. (2021) A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner. Biochemical Journal, 478(3), pp. 633-646. (doi: 10.1042/BCJ20200659) (PMID:33493298)

Alghamdi, F., Alshuweishi, Y. and Salt, I. P. (2020) Regulation of nutrient uptake by AMP-activated protein kinase. Cellular Signalling, 76, 109807. (doi: 10.1016/j.cellsig.2020.109807) (PMID:33038517)

Katwan, O. J., Alghamdi, F., Almabrouk, T. A. , Mancini, S. J., Kennedy, S. , Oakhill, J. S., Scott, J. W. and Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis. Biochemical Journal, 476(12), pp. 1725-1740. (doi: 10.1042/BCJ20180714) (PMID:31189568) (PMCID:PMC6595317)

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S. , Palmer, T. M. and Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, 5276. (doi: 10.1038/s41598-018-23420-4) (PMID:29588466) (PMCID:PMC5869674)

Almabrouk, T. A.M. , White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M. , Salt, I. P. and Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, 51. (doi: 10.3389/fphys.2018.00051) (PMID:29479319) (PMCID:PMC5812172)

Speirs, C., Williams, J. J.L., Riches, K., Salt, I. P. and Palmer, T. M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001) (PMID:29037480)

Almabrouk, T. A. M. , Ugusman, A. B., Katwan, O. J., Salt, I. P. and Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174(20), pp. 3398-3410. (doi: 10.1111/bph.13633) (PMID:27668984)

Kennedy, S. and Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174(20), pp. 3385-3387. (doi: 10.1111/bph.13969) (PMID:28940457)

Salt, I. P. and Hardie, G. (2017) AMP-activated protein kinase: an ubiquitous signalling pathway with key roles in the cardiovascular system. Circulation Research, 120(11), pp. 1825-1841. (doi: 10.1161/CIRCRESAHA.117.309633) (PMID:28546359) (PMCID:PMC5447810)

Chen, S.C., Brooks, R., Houskeeper, J., Bremner, S.K., Dunlop, J. , Viollet, B., Logan, P.J., Salt, I.P. , Ahmed, S.F. and Yarwood, S.J. (2017) Corrigendum to "Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms" [Mol. Cell. Endocrinol. 440 15 January 2017 57-68]. Molecular and Cellular Endocrinology, 443, p. 176. (doi: 10.1016/j.mce.2017.01.049) (PMID:28183460)

Chen, S. C., Brooks, R., Houskeeper, J., Bremner, S. K., Dunlop, J. , Viollet, B., Logan, P. J., Salt, I. P. , Ahmed, S. F. and Yarwood, S. J. (2017) Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms. Molecular and Cellular Endocrinology, 440, pp. 57-68. (doi: 10.1016/j.mce.2016.11.011) (PMID:27856330) (PMCID:PMC5228588)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Docherty, C. K., Salt, I. P. and Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7(1), 78. (doi: 10.1186/s13287-016-0323-2)

Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., Gould, G. W. and Salt, I. P. (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487. Biochemical Journal, 473(24), pp. 4681-4697. (doi: 10.1042/BCJ20160211) (PMID:27784766) (PMCID:PMC5147050)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)

Hawley, S. A., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S., Pitt, R. D., Day, E. A., Salt, I. P. , Steinberg, G. R. and Hardie, D. G. (2016) The Na+ glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels. Diabetes, 65(9), pp. 2784-2794. (doi: 10.2337/db16-0058) (PMID:27381369) (PMCID:PMC5689380)

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P. and MacLean, M. R. (2016) Metformin reverses development of pulmonary hypertension via aromatase inhibition. Hypertension, 68(2), pp. 446-454. (doi: 10.1161/HYPERTENSIONAHA.116.07353) (PMID:27296990)

Choudhury, Y., Salt, I. and Leung, H. (2015) AMPK—friend or foe for targeted therapy? Cell Cycle, 14(12), pp. 1761-1762. (doi: 10.1080/15384101.2015.1022066) (PMID:26036305)

Choudhury, Y., Yang, Z., Ahmad, I. , Nixon, C., Salt, I. P. and Leung, H. Y. (2014) AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience, 1(6), pp. 446-456. (doi: 10.18632/oncoscience.49) (PMID:25594043) (PMCID:PMC4284621)

Almabrouk, T.A.M. , Ewart, M.-A., Salt, I.P. and Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. British Journal of Pharmacology, 171(3), pp. 595-617. (doi: 10.1111/bph.12479) (PMID:24490856) (PMCID:PMC3969075)

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi: 10.1042/CS20120239)

Salt, I. P. (2013) Examining the role of insulin in the regulation of cardiovascular health. Future Cardiology, 9(1), pp. 39-52. (doi: 10.2217/fca.12.77) (PMID:23259474)

Bijland, S., Mancini, S.J. and Salt, I.P. (2013) Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation. Clinical Science, 124(8), pp. 491-507. (doi: 10.1042/CS20120536) (PMID:23298225)

Salt, I. P. and Palmer, T. M. (2012) Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation. Expert Opinion on Investigational Drugs, 21(8), pp. 1155-1167. (doi: 10.1517/13543784.2012.696609)

Reihill, J. A., Ewart, M.-A. and Salt, I. P. (2011) The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells. Vascular Cell, 3(1), 9. (doi: 10.1186/2045-824X-3-9) (PMID:21507243) (PMCID:PMC3094250)

Boyle, J.G., Logan, P.J., Jones, G.C., Small, M., Sattar, N. , Connell, J.M.C., Cleland, S.J. and Salt, I.P. (2011) AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study. Diabetologia, 54(7), pp. 1799-1809. (doi: 10.1007/s00125-011-2126-4)

Kohlhaas, C.F., Morrow, V.A., Jhakra, N., Patil, V., Connell, J.M.C., Petrie, J.R. and Salt, I.P. (2011) Insulin rapidly stimulates l-arginine transport in human aortic endothelial cells via Akt. Biochemical and Biophysical Research Communications, 412(4), pp. 747-751. (doi: 10.1016/j.bbrc.2011.08.048)

Boyle, J.G., Salt, I.P. and McKay, G.A. (2010) Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target. Diabetic Medicine, 27(10), pp. 1097-1106. (doi: 10.1111/j.1464-5491.2010.03098.x) (PMID:20854376)

Ritchie, S. A., Kohlhaas, C. F., Boyd, A. R., Yalla, K. C., Walsh, K., Connell, J. M.C. and Salt, I. P. (2010) Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis. Biochemical Journal, 426(1), pp. 85-90. (doi: 10.1042/BJ20091580)

Hall, L.M.L., Moran, C.N., Milne, G.R., MacFarlane, N.G., Forouhi, N.G., Hariharan, N., Salt, I.P. , Sattar, N. and Gill, J.M.R. (2010) Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS ONE, 5(12), e14197. (doi: 10.1371/journal.pone.0014197) (PMID:21152018) (PMCID:PMC2995737)

Ewart, M.-A., Kohlhaas, C.F. and Salt, I.P. (2008) Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(12), pp. 2255-2257. (doi: 10.1161/ATVBAHA.108.175919)

Boyle, J. G., Logan, P. J., Ewart, M.-A., Reihill, J. A., Ritchie, S. A., Connell, J. M.C., Cleland, S. J. and Salt, I. P. (2008) Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase. Journal of Biological Chemistry, 283(17), pp. 11210-11217. (doi: 10.1074/jbc.M710048200)

Reihill, J.A., Ewart, M.-A., Hardie, D.G. and Salt, I. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354(4), pp. 1084-1088. (doi: 10.1016/j.bbrc.2007.01.110)

Kohlhaas, C. and Salt, I.P. (2007) Experimental hyperinsulinaemia does not alter insulin sensitivity of human endothelial cells or increase monocyte adhesion. Diabetic Medicine, 24(S1), p. 40. (doi: 10.1111/j.1464-5491.2007.02126.x)

Reihill, J., Ewart, M., Hardie, D. and Salt, I. (2007) AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production. Biochemical and Biophysical Research Communications, 354, pp. 1084-1088. (doi: 10.1016/j.bbrc.2007.01.110)

Collison, M., James, D., Graham, D., Holman, G., Connell, J., Dominiczak, A.F., Gould, G. and Salt, I. (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia, 48(3), pp. 539-546. (doi: 10.1007/s00125-005-1674-x)

Ritchie, S., Ewart, M., Perry, C., Connell, J. and Salt, I. (2004) The role of insulin and the adipocytokines in regulation of vascular endothelial function. Clinical Science, 107(6), pp. 519-532. (doi: 10.1042/CS20040190)

Morrow, V., Foufelle, F., Connell, J., Petrie, J. , Gould, G. and Salt, I. (2003) Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. Journal of Biological Chemistry, 278(34), pp. 31629-31639. (doi: 10.1074/jbc.M212831200)

Perry, C., Palmer, T., Cleland, S., Morton, I., Salt, I. , Petrie, J. , Gould, G. and Connell, J. (2003) Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action. Clinical Science, 105(2), pp. 187-194. (doi: 10.1042/CS20020320)

Salt, I., Morrow, V., Brandie, F., Connell, J. and Petrie, J. (2003) High glucose inhibits insulin-stimulated nitric oxide production without reducing endothelial nitric-oxide synthase Ser(1177) phosphorylation in human aortic endothelial cells. Journal of Biological Chemistry, 278(21), pp. 18791-18797. (doi: 10.1074/jbc.M210618200)

James, D.J., Cairns, F., Salt, I.P. , Murphy, G.J., Dominiczak, A.F., Connell, J.M.C. and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50(9), pp. 2148-2156. (doi: 10.2337/diabetes.50.9.2148)

Collison, M., Campbell, I., Salt, I. , Dominiczak, A., Connell, J., Lyall, H. and Gould, G. (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43(11), pp. 1374-1380. (doi: 10.1007/s001250051541)

Salt, I. , Connell, J. and Gould, G. (2000) 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes, 49(10), pp. 1649-1656. (doi: 10.2337/diabetes.49.10.1649)

Book Sections

Petrie, J. R. and Salt, I. P. (2019) Diabetes and vascular disease. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 429-437. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_40)

Rezig, I. M., Bremner, S. K. , Bhutta, M. S., Salt, I. P. , Gould, G. W. and McInerny, C. J. (2019) Genetic and cytological methods to study ESCRT cell cycle function in fission yeast. In: Culetto, E. and Legouis, R. (eds.) The ESCRT Complexes: Methods and Protocols. Series: Methods in molecular biology (1998). Humana Press: New York, pp. 239-250. ISBN 9781493994915 (doi: 10.1007/978-1-4939-9492-2_18)

Mancini, S. J. and Salt, I. P. (2018) Investigating the role of AMPK in inflammation. In: Neumann, D. and Viollet, B. (eds.) AMPK: Methods and Protocols. Series: Methods in Molecular Biology, 1732. Humana Press, pp. 307-319. ISBN 9781493975976 (doi: 10.1007/978-1-4939-7598-3_20)

Salt, I.P. , Harnett, M.M. and Goodridge, H.S. (2014) Membrane receptors and signal transduction. In: Baynes, J. and Dominiczak, M. (eds.) Medical Biochemistry [4th Edition]. Saunders Elsevier. ISBN 9781455745807

This list was generated on Wed Nov 20 19:44:14 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Adipose tissue immunometabolic function in viscerally obese individuals at risk of poor ICU outcome in sepsis
    NHS Greater Glasgow and Clyde Endowment Funds
    2023 - 2024
     
  • Regulation of Adipose Tissue Metabolism by Assymetric Dimethylarginine
    Diabetes UK
    2022 - 2025
     
  • The role of AMPK in the development of high fat diet-induced liver and kidney inflammation
    NHS Greater Glasgow and Clyde Endowment Funds
    2020 - 2021
     
  • Host mitochrondria dysfunction by viral hijacking as a key pathogenicity mechanism in COVID-19
    Wellcome Trust
    2020 - 2021
     
  • Role of alternative pathway of triglyceride synthesis in determining insulin sensitivity in muscle of individuals at risk of type 2 diabetes
    Diabetes UK
    2016 - 2019
     
  • Inhibition of endothelial mitogen-activated protein kinases by amp-activated protein kinase
    British Heart Foundation
    2014 - 2017
     
  • The role of insulin-dependent signalling pathways in the control of Mesenchymal stem cell differentiation twoards bone and fat
    Tenovus Scotland
    2014 - 2016
     
  • Regulation of the renin angiotension aldosterone system in adipose tissue by AMP-activated protein kinase
    Diabetes UK
    2013 - 2016
     
  • Mechanisms underlying the regulation of endothelial nitric oxide synthesis by glucose and insulin.
    Diabetes UK
    2013 - 2015
     
  • Inhibition of vascular Stat Signalling by Amp-Activated Protein Kinase (AMPK).
    British Heart Foundation
    2012 - 2015
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling - utilising a knockout mouse model
    Diabetes UK
    2012 - 2013
     
  • The sensitive assessment of the activity of cellular signalling pathways regulating insulin action and the cardiovascular complications of diabetes
    Diabetes UK
    2011 - 2014
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling
    Diabetes UK
    2010 - 2013
     
  • A pilot study of the effect of experimental hyperinsulinaemia on human endothelial cell nitric oxide synthase function
    Diabetes UK
    2008 - 2009
     
  • The role of the AMP activated protein kinase in adipocyte insulin action
    Tenovus Scotland
    2007 - 2008
     
  • Impaired skeletal muscle oxidative capacity as a mechanism for greater insulin resistance in South Asians?
    Diabetes UK
    2006 - 2009
     
  • Regulation of endothelial nitric oxide synthesis by the AMP-activated protein kinase cascade
    British Heart Foundation
    2004 - 2007
     
  • Modulation and regulation of insulin-stimulated nitric oxide production in endothelial cells (Dr I P Salt)
    Diabetes UK
    2004 - 2007
     
  • The role of Tumour Necrosis Factor-alpha and Adiponectin in insulin-stimulated endothelial nitric oxide production
    Medical Research Council
    2004 - 2007
     
  • A biochemical investigation of the regulation of blood vessel growth and blood pressure
    Tenovus Scotland
    2004 - 2005
     
  • The effects of metformin on vascular function and adipocyte AMPK activation in type 2 diabetes
    British Heart Foundation
    2004 - 2006
     

Supervision

Teaching

  • Co-ordinator of  “Molecular Basis of Cardiometabolic Disease”
  • 3rd year Biochemistry/MCB degree leader for Signalling and Metabolism blocks

Professional activities & recognition

Research fellowships

  • 2004 - 2007: Diabetes UK RD Lawrence Fellowship
  • 2001 - 2004: British Heart Foundation Fellowship

Grant committees & research advisory boards

  • 2023 - 2023: Diabetes UK, Early Career Small Grant Panel
  • 2022 - 2022: Diabetes UK, RD Lawrence Fellowship Panel
  • 2020 - 2020: Diabetes UK, RD Lawrence Fellowship Interview Panel Chair
  • 2018 - 2023: Diabetes UK, PhD Studentships Committee (Chair 2019, 2022, 2023)
  • 2018 - 2018: Diabetes UK, RD Lawrence Fellowship Interview Panel Chair
  • 2013 - 2014: Diabetes UK, RD Lawrence Fellowship Interview Panel Chair
  • 2012 - 2017: Diabetes Research and Wellness Foundation, Research Advisory Board Member
  • 2012 - 2017: Diabetes UK, Research Grant Committee Member
  • 2009 - 2011: Diabetes UK, Member of Science & Research Advisory Group
  • 2008 - 2011: Diabetes UK, Annual professional conference committee (Vice Chair 2009-2010; Chair 2010-2011)
  • 2005 - 2009: Diabetes UK, Research Grant Committee Member
  • 2006 - 2009: Diabetes UK, Member of Professional Advisory Council (Science & Research Working Group)
  • 2004 - 2009: MRC, Physiological Systems and Clinical Sciences Board (PSCSB) Special Review Panel
  • 2004 - 2009: MRC, College of Experts, Physiological Systems and Clinical Sciences Board

Editorial boards

  • 2019 - 2021: Scientific Reports
  • 2011 - 2014: ISRN Vascular Medicine

Professional & learned societies

  • 2021: Member, Society for Endocrinology
  • 2012: Member, Physiology Society
  • 2010: Member, British Society for Cell Biology
  • 2009 - 2018: Member, European Association for the Study of Diabetes
  • 2004 - 2010: Member, American Diabetes Association
  • 2003: Member, Scottish Society for Experimental Medicine
  • 1994: Member, Biochemical Society

Selected international presentations

  • 2023: Invited speaker at Université catholique de Louvain/ de Duve Institute mini Symposium: "Physiology, Metabolism & Beyond": presentation entitled "AMPK, fat and inflammation" (Brussels, Belgium)
  • 2019: Invited Speaker at the 4th European AMPK Workshop, Presentation entitled "AMPK and inflammation" (Louvain-La-Neuve, Belgium)
  • 2015: Invited Speaker at "Pharmacology 2015" Conference. Presentation titled "AMPK: a link between PVAT and vascular function?" (London, UK)
  • 2015: Invited Speaker at British Atherosclerosis Society "Atherosclerosis: Crossroads of Metabolism and Inflammation" Meeting. Presentation titled "Regulation of vascular inflammation and metabolism by AMPK " (Cambridge, UK)
  • 2014: Invited Speaker at Diabetes UK Annual Professional Conference 2014. Presentation titled, 'Signalling in adipose tissue: regulation of glucose transport by AMPK.' (Liverpool, England, UK)
  • 2012: Chair, 'Signalling and Diabetes' at Diabetes UK Annual Professional Conference 2012 (Glasgow, Scotland, UK)
  • 2011: Chair of session "Genetics for everyone" at Diabetes UK Annual Professional Conference 2011 (London, UK)
  • 2010: Chair of 'Signalling' Session at the Diabetes UK Annual Professional Conference (Liverpool, UK)
  • 2009: Chair 'Mechanisms and Implications of Vascular Dysfunction in Diabetes' at the Diabetes UK Annual Professional Conference (Glasgow, Scotland)
  • 2008: Chair,'Regulation of Gene Expression' at the Diabetes UK Annual Professional Conference (Glasgow, Scotland)
  • 2006: Invited Speaker at 197th Meeting of the Society for Endocrinology (London, UK)
  • 2005: INYS workshop on diabetes and cardiovascular disease (Lund, Sweden)
  • 2004: Co-chair of the "Metabolic syndrome and Cardiovascular Risk" workshop at the 9th European Council for Cardiovascular Research Meeting (Nice, France)

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