Dr Hannah Donnelly
- Research Fellow (Molecular Biosciences)
Publications
2024
Donnelly, H. et al. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0)
Doherty-Boyd, W. S., Tsimbouri, M. P. , Donnelly, H. and Dalby, M. J. (2024) Building bones for blood and beyond: the growing field of bone marrow niche model development. Experimental Hematology, 135, 104232. (doi: 10.1016/j.exphem.2024.104232) (PMID:38729553)
2023
Donnelly, H., Sprott, M. R. , Poudel, A., Campsie, P., Childs, P., Reid, S., Salmeron-Sanchez, M. and Biggs, M. (2023) Surface modified piezoelectric co-polymer poly (vinylidene fluoride-trifluoroethylene) supports physiological extracellular matrices to enhance mesenchymal stem cell adhesion for nanoscale mechanical stimulation. ACS Applied Materials and Interfaces, 15(44), pp. 50652-50662. (doi: 10.1021/acsami.3c05128) (PMID:37718477) (PMCID:PMC10636716)
Pirillo, C. et al. (2023) Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Science Immunology, 8(85), eadg8249. (doi: 10.1126/sciimmunol.adg8249) (PMID:37478193) (PMCID:PMC7616026)
Donnelly, H., Kurjan, A., Yong, L. Y., Xiao, Y., Lemgruber, L. , West, C., Salmeron-Sanchez, M. and Dalby, M. J. (2023) Fibronectin matrix assembly and TGFβ1 presentation for chondrogenesis of patient derived pericytes for microtia repair. Biomaterials Advances, 148, 213370. (doi: 10.1016/j.bioadv.2023.213370) (PMID:36931082)
Ross, E. A. et al. (2023) Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells. Nature Communications, 14, 753. (doi: 10.1038/s41467-023-36293-7) (PMID:36765065) (PMCID:PMC9918539)
2022
Xiao, Y., Donnelly, H., Sprott, M. , Luo, J., Jayawarna, V., Lemgruber, L. , Tsimbouri, P. M. , Meek, R.M. D., Salmeron-Sanchez, M. and Dalby, M. J. (2022) Material-driven fibronectin and vitronectin assembly enhances BMP-2 presentation and osteogenesis. Materials Today Bio, 16, 100367. (doi: 10.1016/j.mtbio.2022.100367) (PMID:35937570) (PMCID:PMC9352550)
Luo, J., Walker, M. , Xiao, Y., Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2022) The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review. Bioactive Materials, 15, pp. 145-159. (doi: 10.1016/j.bioactmat.2021.11.024)
Xiao, Y., McGuinness, C. A.S., Doherty-Boyd, W. S., Salmeron-Sanchez, M. , Donnelly, H. and Dalby, M. J. (2022) Current insights into the bone marrow niche: from biology in vivo to bioengineering ex vivo. Biomaterials, 286, 121568. (doi: 10.1016/j.biomaterials.2022.121568) (PMID:35580474)
2021
Gavazzo, P., Viti, F., Donnelly, H., Oliva, M. A. G., Salmeron-Sanchez, M. , Dalby, M. J. and Vassalli, M. (2021) Biophysical phenotyping of mesenchymal stem cells along the osteogenic differentiation pathway. Cell Biology and Toxicology, 37(6), pp. 915-933. (doi: 10.1007/s10565-020-09569-7) (PMID:33420657)
2020
Cantini, M. , Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2020) The plot thickens: the emerging role of matrix viscosity in cell mechanotransduction. Advanced Healthcare Materials, 9(8), 1901259. (doi: 10.1002/adhm.201901259) (PMID:31815372)
2019
Cheng, Z. A. et al. (2019) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, 6(2), 1800361. (doi: 10.1002/advs.201800361) (PMID:30693176) (PMCID:PMC6343071)
2018
Donnelly, H., Dalby, M. J. , Salmeron-Sanchez, M. and Sweeten, P. E. (2018) Current approaches for modulation of the nanoscale interface in the regulation of cell behavior. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), pp. 2455-2464. (doi: 10.1016/j.nano.2017.03.020) (PMID:28552647) (PMCID:PMC6173683)
Donnelly, H., Salmeron-Sanchez, M. and Dalby, M. J. (2018) Designing stem cell niches for differentiation and self-renewal. Journal of the Royal Society: Interface, 15(145), 20180388. (doi: 10.1098/rsif.2018.0388) (PMID:30158185) (PMCID:PMC6127175)
Robertson, S. N. et al. (2018) Control of cell behaviour through nanovibrational stimulation: nanokicking. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376(2120), 20170290. (doi: 10.1098/rsta.2017.0290) (PMID:29661978) (PMCID:PMC5915650)
2017
Donnelly, H., Smith, C.-A. , Sweeten, P. E., Gadegaard, N. , Meek, D., D'Este, M., Mata, A., Eglin, D. and Dalby, M. J. (2017) Bone and cartilage differentiation of a single stem cell population driven by material interface. Journal of Tissue Engineering, 8, pp. 1-10. (doi: 10.1177/2041731417705615) (PMID:28567273) (PMCID:PMC5438107)
Articles
Donnelly, H. et al. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0)
Doherty-Boyd, W. S., Tsimbouri, M. P. , Donnelly, H. and Dalby, M. J. (2024) Building bones for blood and beyond: the growing field of bone marrow niche model development. Experimental Hematology, 135, 104232. (doi: 10.1016/j.exphem.2024.104232) (PMID:38729553)
Donnelly, H., Sprott, M. R. , Poudel, A., Campsie, P., Childs, P., Reid, S., Salmeron-Sanchez, M. and Biggs, M. (2023) Surface modified piezoelectric co-polymer poly (vinylidene fluoride-trifluoroethylene) supports physiological extracellular matrices to enhance mesenchymal stem cell adhesion for nanoscale mechanical stimulation. ACS Applied Materials and Interfaces, 15(44), pp. 50652-50662. (doi: 10.1021/acsami.3c05128) (PMID:37718477) (PMCID:PMC10636716)
Pirillo, C. et al. (2023) Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Science Immunology, 8(85), eadg8249. (doi: 10.1126/sciimmunol.adg8249) (PMID:37478193) (PMCID:PMC7616026)
Donnelly, H., Kurjan, A., Yong, L. Y., Xiao, Y., Lemgruber, L. , West, C., Salmeron-Sanchez, M. and Dalby, M. J. (2023) Fibronectin matrix assembly and TGFβ1 presentation for chondrogenesis of patient derived pericytes for microtia repair. Biomaterials Advances, 148, 213370. (doi: 10.1016/j.bioadv.2023.213370) (PMID:36931082)
Ross, E. A. et al. (2023) Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells. Nature Communications, 14, 753. (doi: 10.1038/s41467-023-36293-7) (PMID:36765065) (PMCID:PMC9918539)
Xiao, Y., Donnelly, H., Sprott, M. , Luo, J., Jayawarna, V., Lemgruber, L. , Tsimbouri, P. M. , Meek, R.M. D., Salmeron-Sanchez, M. and Dalby, M. J. (2022) Material-driven fibronectin and vitronectin assembly enhances BMP-2 presentation and osteogenesis. Materials Today Bio, 16, 100367. (doi: 10.1016/j.mtbio.2022.100367) (PMID:35937570) (PMCID:PMC9352550)
Luo, J., Walker, M. , Xiao, Y., Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2022) The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review. Bioactive Materials, 15, pp. 145-159. (doi: 10.1016/j.bioactmat.2021.11.024)
Xiao, Y., McGuinness, C. A.S., Doherty-Boyd, W. S., Salmeron-Sanchez, M. , Donnelly, H. and Dalby, M. J. (2022) Current insights into the bone marrow niche: from biology in vivo to bioengineering ex vivo. Biomaterials, 286, 121568. (doi: 10.1016/j.biomaterials.2022.121568) (PMID:35580474)
Gavazzo, P., Viti, F., Donnelly, H., Oliva, M. A. G., Salmeron-Sanchez, M. , Dalby, M. J. and Vassalli, M. (2021) Biophysical phenotyping of mesenchymal stem cells along the osteogenic differentiation pathway. Cell Biology and Toxicology, 37(6), pp. 915-933. (doi: 10.1007/s10565-020-09569-7) (PMID:33420657)
Cantini, M. , Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2020) The plot thickens: the emerging role of matrix viscosity in cell mechanotransduction. Advanced Healthcare Materials, 9(8), 1901259. (doi: 10.1002/adhm.201901259) (PMID:31815372)
Cheng, Z. A. et al. (2019) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, 6(2), 1800361. (doi: 10.1002/advs.201800361) (PMID:30693176) (PMCID:PMC6343071)
Donnelly, H., Dalby, M. J. , Salmeron-Sanchez, M. and Sweeten, P. E. (2018) Current approaches for modulation of the nanoscale interface in the regulation of cell behavior. Nanomedicine: Nanotechnology, Biology and Medicine, 14(7), pp. 2455-2464. (doi: 10.1016/j.nano.2017.03.020) (PMID:28552647) (PMCID:PMC6173683)
Donnelly, H., Salmeron-Sanchez, M. and Dalby, M. J. (2018) Designing stem cell niches for differentiation and self-renewal. Journal of the Royal Society: Interface, 15(145), 20180388. (doi: 10.1098/rsif.2018.0388) (PMID:30158185) (PMCID:PMC6127175)
Robertson, S. N. et al. (2018) Control of cell behaviour through nanovibrational stimulation: nanokicking. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376(2120), 20170290. (doi: 10.1098/rsta.2017.0290) (PMID:29661978) (PMCID:PMC5915650)
Donnelly, H., Smith, C.-A. , Sweeten, P. E., Gadegaard, N. , Meek, D., D'Este, M., Mata, A., Eglin, D. and Dalby, M. J. (2017) Bone and cartilage differentiation of a single stem cell population driven by material interface. Journal of Tissue Engineering, 8, pp. 1-10. (doi: 10.1177/2041731417705615) (PMID:28567273) (PMCID:PMC5438107)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Lymph node organoids come of age
Biotechnology and Biological Sciences Research Council
2024 - 2027
- Molecular basis for Rift Valley fever phlebovirus NSs protein function
Biotechnology and Biological Sciences Research Council
2022 - 2023
- Engineered microenvironments to support CRISPR-edited hematopoietic stem cells in vitro.
The Carnegie Trust for the Universities of Scotland
2020 - 2020
Research datasets
2024
Donnelly, H., Dalby, M. and Xiao, Y. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. [Data Collection]