Dr Gonzalo Tejeda
- Research Associate (Molecular Biosciences)
Publications
2023
Wright, T. A., Gemmell, A. O., Tejeda, G. S. , Blair, C. M. and Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)
2022
Dwomoh, L. , Tejeda, G. S. and Tobin, A. B. (2022) Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease. Neuronal Signaling, 6(1), NS20210004. (doi: 10.1042/NS20210004) (PMID:35571495) (PMCID:PMC9069568)
Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)
2021
Scarpa, M. et al. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America, 118(50), e2107389118. (doi: 10.1073/pnas.2107389118) (PMID:34893539) (PMCID:PMC8685681)
Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)
Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)
2020
Tejeda, G. S. , Whiteley, E. L., Deeb, T. Z., Bürli, R. W., Moss, S. J., Sheridan, E., Brandon, N. J. and Baillie, G. S. (2020) Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme. Proceedings of the National Academy of Sciences of the United States of America, 117(1), pp. 677-688. (doi: 10.1073/pnas.1916398117) (PMID:31871190) (PMCID:PMC6955301)
2019
Baillie, G. S. , Tejeda, G. S. and Kelly, M. P. (2019) Therapeutic targeting of 3’,5’-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nature Reviews Drug Discovery, 18, pp. 770-796. (doi: 10.1038/s41573-019-0033-4) (PMID:31388135)
Tibbo, A. J., Tejeda, G. S. and Baillie, G. S. (2019) Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches. Biochemical Society Transactions, 47(5), pp. 1557-1565. (doi: 10.1042/BST20190763) (PMID:31642904) (PMCID:PMC6824677)
Whiteley, E. L., Tejeda, G. S. , Baillie, G. S. and Brandon, N. J. (2019) PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders. Cellular Signalling, 60, pp. 31-38. (doi: 10.1016/j.cellsig.2019.04.001) (PMID:30951862)
2017
Tejeda, G. and Díaz-Guerra, M. (2017) Integral characterization of defective BDNF/TrkB signalling in neurological and psychiatric disorders leads the way to new therapies. International Journal of Molecular Sciences, 18(2), 268. (doi: 10.3390/ijms18020268) (PMID:28134845) (PMCID:PMC5343804)
2016
Tejeda, G. S. , Ayuso-Dolado, S., Arbeteta, R., Esteban-Ortega, G. M., Vidaurre, O. G. and Díaz-Guerra, M. (2016) Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases. Journal of Pathology, 238(5), pp. 627-640. (doi: 10.1002/path.4684) (PMID:26712630)
2015
Gamir-Morralla, A., López-Menéndez, C., Ayuso-Dolado, S., Tejeda, G.S. , Montaner, J., Rosell, A., Iglesias, T. and Díaz-Guerra, M. (2015) Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity. Cell Death and Disease, 6(10), e1939. (doi: 10.1038/cddis.2015.307) (PMID:26492372) (PMCID:PMC4632323)
2013
Nishijima, T., Llorens-Martín, M., Tejeda, G. S. , Inoue, K., Yamamura, Y., Soya, H., Trejo, J. L. and Torres-Alemán, I. (2013) Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice. Behavioural Brain Research, 245, pp. 34-41. (doi: 10.1016/j.bbr.2013.02.009) (PMID:23428744)
2011
Llorens-Martín, M., Tejeda, G. S. and Trejo, J. L. (2011) Antidepressant and proneurogenic influence of environmental enrichment in mice: Protective effects vs recovery. Neuropsychopharmacology, 36(12), pp. 2460-2468. (doi: 10.1038/npp.2011.134) (PMID:21796111) (PMCID:PMC3194073)
2010
Llorens-Martín, M.V., Rueda, N., Tejeda, G.S. , Flórez, J., Trejo, J.L. and Martínez-Cué, C. (2010) Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome. Neuroscience, 171(4), pp. 1228-1240. (doi: 10.1016/j.neuroscience.2010.09.043) (PMID:20875841)
Tsien, J. Z., Llorens-Martín, M., Tejeda, G. S. and Trejo, J. L. (2010) Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: A dual birthdating analysis. PLoS ONE, 5(8), e12188. (doi: 10.1371/journal.pone.0012188) (PMID:20808440) (PMCID:PMC2922333)
2009
Bodega, G., Ciordia, S., Suárez, I., López-Fernández, L. A., Vacas, E., Tejeda, G. S. , Albert, M. A., Juárez, S., Albar, J. P. and Fernández, B. (2009) Astrocytes express Mxi2, a splice isoform of p38MAPK. Journal of Molecular Histology, 40(5-6), pp. 325-329. (doi: 10.1007/s10735-009-9248-8) (PMID:20043236)
Articles
Wright, T. A., Gemmell, A. O., Tejeda, G. S. , Blair, C. M. and Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)
Dwomoh, L. , Tejeda, G. S. and Tobin, A. B. (2022) Targeting the M1 muscarinic acetylcholine receptor in Alzheimer’s disease. Neuronal Signaling, 6(1), NS20210004. (doi: 10.1042/NS20210004) (PMID:35571495) (PMCID:PMC9069568)
Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)
Scarpa, M. et al. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America, 118(50), e2107389118. (doi: 10.1073/pnas.2107389118) (PMID:34893539) (PMCID:PMC8685681)
Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)
Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)
Tejeda, G. S. , Whiteley, E. L., Deeb, T. Z., Bürli, R. W., Moss, S. J., Sheridan, E., Brandon, N. J. and Baillie, G. S. (2020) Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme. Proceedings of the National Academy of Sciences of the United States of America, 117(1), pp. 677-688. (doi: 10.1073/pnas.1916398117) (PMID:31871190) (PMCID:PMC6955301)
Baillie, G. S. , Tejeda, G. S. and Kelly, M. P. (2019) Therapeutic targeting of 3’,5’-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nature Reviews Drug Discovery, 18, pp. 770-796. (doi: 10.1038/s41573-019-0033-4) (PMID:31388135)
Tibbo, A. J., Tejeda, G. S. and Baillie, G. S. (2019) Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches. Biochemical Society Transactions, 47(5), pp. 1557-1565. (doi: 10.1042/BST20190763) (PMID:31642904) (PMCID:PMC6824677)
Whiteley, E. L., Tejeda, G. S. , Baillie, G. S. and Brandon, N. J. (2019) PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders. Cellular Signalling, 60, pp. 31-38. (doi: 10.1016/j.cellsig.2019.04.001) (PMID:30951862)
Tejeda, G. and Díaz-Guerra, M. (2017) Integral characterization of defective BDNF/TrkB signalling in neurological and psychiatric disorders leads the way to new therapies. International Journal of Molecular Sciences, 18(2), 268. (doi: 10.3390/ijms18020268) (PMID:28134845) (PMCID:PMC5343804)
Tejeda, G. S. , Ayuso-Dolado, S., Arbeteta, R., Esteban-Ortega, G. M., Vidaurre, O. G. and Díaz-Guerra, M. (2016) Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity activation of metalloproteinases and γ-secretases. Journal of Pathology, 238(5), pp. 627-640. (doi: 10.1002/path.4684) (PMID:26712630)
Gamir-Morralla, A., López-Menéndez, C., Ayuso-Dolado, S., Tejeda, G.S. , Montaner, J., Rosell, A., Iglesias, T. and Díaz-Guerra, M. (2015) Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity. Cell Death and Disease, 6(10), e1939. (doi: 10.1038/cddis.2015.307) (PMID:26492372) (PMCID:PMC4632323)
Nishijima, T., Llorens-Martín, M., Tejeda, G. S. , Inoue, K., Yamamura, Y., Soya, H., Trejo, J. L. and Torres-Alemán, I. (2013) Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice. Behavioural Brain Research, 245, pp. 34-41. (doi: 10.1016/j.bbr.2013.02.009) (PMID:23428744)
Llorens-Martín, M., Tejeda, G. S. and Trejo, J. L. (2011) Antidepressant and proneurogenic influence of environmental enrichment in mice: Protective effects vs recovery. Neuropsychopharmacology, 36(12), pp. 2460-2468. (doi: 10.1038/npp.2011.134) (PMID:21796111) (PMCID:PMC3194073)
Llorens-Martín, M.V., Rueda, N., Tejeda, G.S. , Flórez, J., Trejo, J.L. and Martínez-Cué, C. (2010) Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome. Neuroscience, 171(4), pp. 1228-1240. (doi: 10.1016/j.neuroscience.2010.09.043) (PMID:20875841)
Tsien, J. Z., Llorens-Martín, M., Tejeda, G. S. and Trejo, J. L. (2010) Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: A dual birthdating analysis. PLoS ONE, 5(8), e12188. (doi: 10.1371/journal.pone.0012188) (PMID:20808440) (PMCID:PMC2922333)
Bodega, G., Ciordia, S., Suárez, I., López-Fernández, L. A., Vacas, E., Tejeda, G. S. , Albert, M. A., Juárez, S., Albar, J. P. and Fernández, B. (2009) Astrocytes express Mxi2, a splice isoform of p38MAPK. Journal of Molecular Histology, 40(5-6), pp. 325-329. (doi: 10.1007/s10735-009-9248-8) (PMID:20043236)
Research datasets
2021
Scarpa, M., Molloy, C. , Jenkins, L. , Strellis, B., Budgett, R., Hesse, S., Dwomoh, L. , Marsango, S., Tejeda, G. , Rossi, M., Ahmed, Z., Milligan, G. , Hudson, B. , Tobin, A. , Bradley, S. and Heptares, S. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. [Data Collection]