Dr Gayle Overend
- Research Associate (Molecular Biosciences)
telephone:
6220
email:
Gayle.Overend@glasgow.ac.uk
pronouns:
She/her/hers
Lab 422, Institute of MC&SB, Davidson Building, Glasgow, G12 8QQ
Publications
2022
Krause, S. A. , Overend, G. , Dow, J. A.T. and Leader, D. P. (2022) FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas. Nucleic Acids Research, 50(D1), D1010-D1015. (doi: 10.1093/nar/gkab971) (PMID:34718735) (PMCID:PMC8728208)
2020
Breton, É., Légaré, C., Overend, G. , Guay, S.-P., Monckton, D. , Mathieu, J., Gagnon, C., Richer, L., Gallais, B. and Bouchard, L. (2020) DNA methylation at the DMPK gene locus is associated with cognitive functions in myotonic dystrophy type 1. Epigenomics, 12(23), pp. 2051-2064. (doi: 10.2217/epi-2020-0328) (PMID:33301350)
Ballester‐Lopez, A. et al. (2020) A DM1 family with interruptions associated with atypical symptoms and late onset but not with a milder phenotype. Human Mutation, 41(2), pp. 420-431. (doi: 10.1002/humu.23932) (PMID:31608518)
2019
Overend, G. , Légaré, C., Mathieu, J., Bouchard, L., Gagnon, C. and Monckton, D. G. (2019) Allele length of the DMPK CTG repeat is a predictor of progressive myotonic dystrophy type 1 phenotypes. Human Molecular Genetics, 28(13), pp. 2245-2254. (doi: 10.1093/hmg/ddz055) (PMID:31220271)
Légaré, C., Overend, G. , Guay, S.-P., Monckton, D. G. , Mathieu, J., Gagnon, C. and Bouchard, L. (2019) gene DNA methylation levels are associated with muscular and respiratory profiles in DM1. Neurology Genetics, 5(3), e338. (doi: 10.1212/NXG.0000000000000338) (PMID:31334355) (PMCID:PMC6568328)
2016
Overend, G. , Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi: 10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)
2015
Overend, G. , Cabrero, P. , Halberg, K. A.,, Ranford-Cartwright, L. C. , Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007) (PMID:26003916)
Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G. , Davies, S. A. , Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi: 10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)
2014
Terhzaz, S. , Overend, G. , Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)
Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)
2013
Efetova, M., Petereit, L., Rosiewicz, K., Overend, G. , Haussig, F., Hovemann, B.T., Cabrero, P. , Dow, J.A.T. and Schwarzel, M. (2013) Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo. Journal of Cell Science, 126(3), pp. 778-788. (doi: 10.1242/jcs.114140) (PMID:23264735) (PMCID:PMC3619808)
2012
Davies, S.A. , Overend, G. , Sebastian, S., Cundall, M., Cabrero, P. , Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi: 10.1016/j.jinsphys.2012.01.008) (PMID:22306292)
Overend, G. , Cabrero, P. , Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi: 10.1016/j.peptides.2011.08.019) (PMID:21893139)
2010
Männikkö, R., Overend, G. , Perrey, C., Gavaghan, C.L., Valentin, J.-P., Morten, J., Armstrong, M. and Pollard, C.E. (2010) Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel. British Journal of Pharmacology, 159(1), pp. 102-114. (doi: 10.1111/j.1476-5381.2009.00334.x) (PMID:19673885) (PMCID:PMC2823356)
Articles
Krause, S. A. , Overend, G. , Dow, J. A.T. and Leader, D. P. (2022) FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas. Nucleic Acids Research, 50(D1), D1010-D1015. (doi: 10.1093/nar/gkab971) (PMID:34718735) (PMCID:PMC8728208)
Breton, É., Légaré, C., Overend, G. , Guay, S.-P., Monckton, D. , Mathieu, J., Gagnon, C., Richer, L., Gallais, B. and Bouchard, L. (2020) DNA methylation at the DMPK gene locus is associated with cognitive functions in myotonic dystrophy type 1. Epigenomics, 12(23), pp. 2051-2064. (doi: 10.2217/epi-2020-0328) (PMID:33301350)
Ballester‐Lopez, A. et al. (2020) A DM1 family with interruptions associated with atypical symptoms and late onset but not with a milder phenotype. Human Mutation, 41(2), pp. 420-431. (doi: 10.1002/humu.23932) (PMID:31608518)
Overend, G. , Légaré, C., Mathieu, J., Bouchard, L., Gagnon, C. and Monckton, D. G. (2019) Allele length of the DMPK CTG repeat is a predictor of progressive myotonic dystrophy type 1 phenotypes. Human Molecular Genetics, 28(13), pp. 2245-2254. (doi: 10.1093/hmg/ddz055) (PMID:31220271)
Légaré, C., Overend, G. , Guay, S.-P., Monckton, D. G. , Mathieu, J., Gagnon, C. and Bouchard, L. (2019) gene DNA methylation levels are associated with muscular and respiratory profiles in DM1. Neurology Genetics, 5(3), e338. (doi: 10.1212/NXG.0000000000000338) (PMID:31334355) (PMCID:PMC6568328)
Overend, G. , Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A. and Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, 27242. (doi: 10.1038/srep27242) (PMID:27250760) (PMCID:PMC4890030)
Overend, G. , Cabrero, P. , Halberg, K. A.,, Ranford-Cartwright, L. C. , Woods, D., Davies, S. A. and Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007) (PMID:26003916)
Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G. , Davies, S. A. , Romero, M. F. and Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112(37), pp. 11720-11725. (doi: 10.1073/pnas.1508031112) (PMID:26324901) (PMCID:PMC4577160)
Terhzaz, S. , Overend, G. , Sebastian, S., Dow, J. A.T. and Davies, S.-A. (2014) The D. melanogaster capa-1 neuropeptide activates renal NF-kB signaling. Peptides, 53, pp. 218-224. (doi: 10.1016/j.peptides.2013.08.004)
Davies, S.A. , Cabrero, P. , Overend, G. , Aitchison, L., Sebastian, S., Terhzaz, S. and Dow, J.A.T. (2014) Cell signalling mechanisms for insect stress tolerance. Journal of Experimental Biology, 217(1), pp. 119-128. (doi: 10.1242/jeb.090571) (PMID:24353211)
Efetova, M., Petereit, L., Rosiewicz, K., Overend, G. , Haussig, F., Hovemann, B.T., Cabrero, P. , Dow, J.A.T. and Schwarzel, M. (2013) Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo. Journal of Cell Science, 126(3), pp. 778-788. (doi: 10.1242/jcs.114140) (PMID:23264735) (PMCID:PMC3619808)
Davies, S.A. , Overend, G. , Sebastian, S., Cundall, M., Cabrero, P. , Dow, J.A.T. and Terhzaz, S. (2012) Immune and stress response 'cross-talk' in the Drosophila Malpighian tubule. Journal of Insect Physiology, 58(4), pp. 488-497. (doi: 10.1016/j.jinsphys.2012.01.008) (PMID:22306292)
Overend, G. , Cabrero, P. , Guo, A.X., Sebastian, S., Cundall, M., Armstrong, H., Mertens, I., Schoofs, L., Dow, J.A.T. and Davies, S.-A. (2012) The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides, 34(1), pp. 209-218. (doi: 10.1016/j.peptides.2011.08.019) (PMID:21893139)
Männikkö, R., Overend, G. , Perrey, C., Gavaghan, C.L., Valentin, J.-P., Morten, J., Armstrong, M. and Pollard, C.E. (2010) Pharmacological and electrophysiological characterization of nine, single nucleotide polymorphisms of the hERG-encoded potassium channel. British Journal of Pharmacology, 159(1), pp. 102-114. (doi: 10.1111/j.1476-5381.2009.00334.x) (PMID:19673885) (PMCID:PMC2823356)