2017

Tanaka, M. et al. (2017) Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease. Journal of Clinical Investigation, 127(4), pp. 1438-1450. (doi: 10.1172/JCI85594) (PMID:28263187)

2015

DeLeeuw, J., Weir, J., Copsey, D., Roden, C., Deeley, S. , Huston, E. , McVey, M. and Finlay, C. (2015) Developing Graduate Attributes and Improving Student Employability Through Work-based Learning: Opportunities, Successes and Challenges. 8th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 14 Apr 2015.

2014

Sheppard, C. L. et al. (2014) Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression. Cellular Signalling, 26(9), pp. 1958-1974. (doi: 10.1016/j.cellsig.2014.04.023)

2013

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)

2011

Day, J. P. et al. (2011) Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). Journal of Medicinal Chemistry, 54(9), pp. 3331-3347. (doi: 10.1021/jm200070e)

2010

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E. , Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M. D. and Ryu, S. H. (2010) cAMP controls mTOR through regulation of the dynamic interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30(22), pp. 5406-5420. (doi: 10.1128/MCB.00217-10)

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E. , Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M. D. and Ryu, S. H. (2010) Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30(22), pp. 5406-5420. (doi: 10.1128/MCB.00217-10)

Rampersad, S. N., Ovens, J. D., Huston, E. , Umana, M. B., Wilson, L. S., Netherton, S. J., Lynch, M. J., Baillie, G. S. , Houslay, M. D. and Maurice, D. H. (2010) Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability. Journal of Biological Chemistry, 285(44), pp. 33614-33622. (doi: 10.1074/jbc.M110.140004)

Zhu, H. et al. (2010) Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D. Molecular and Cellular Biology, 30(18), pp. 4379-4390. (doi: 10.1128/MCB.01193-09)

2009

Meng, D., Lynch, M. J., Huston, E. , Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. and Baillie, G. S. (2009) MEK1 binds directly to βArrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. Journal of Biological Chemistry, 284(17), pp. 11425-11435. (doi: 10.1074/jbc.M806395200) (PMID:19153083) (PMCID:PMC2670148)

2008

Huston, E. , Lynch, M. J., Mohamed, A., Collins, D. M., Hill, E. V., McLeod, R., Krause, E., Baillie, G. S. and Houslay, M. D. (2008) EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proceedings of the National Academy of Sciences of the United States of America, 105(35), pp. 12791-12796. (doi: 10.1073/pnas.0805167105)

McCahill, A., Huston, E. , Li, X. and Houslay, M.D. (2008) PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases. In: Klussman, E. and Scott, J. (eds.) Protein-Protein Interactions as New Drug Targets. Series: Handbook of Experimental Pharmacology (186). Springer: Berlin, Germany, pp. 125-166. ISBN 9783540728429 (doi: 10.1007/978-3-540-72843-6_6)

Articles

Tanaka, M. et al. (2017) Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease. Journal of Clinical Investigation, 127(4), pp. 1438-1450. (doi: 10.1172/JCI85594) (PMID:28263187)

Sheppard, C. L. et al. (2014) Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression. Cellular Signalling, 26(9), pp. 1958-1974. (doi: 10.1016/j.cellsig.2014.04.023)

Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)

Day, J. P. et al. (2011) Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). Journal of Medicinal Chemistry, 54(9), pp. 3331-3347. (doi: 10.1021/jm200070e)

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E. , Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M. D. and Ryu, S. H. (2010) cAMP controls mTOR through regulation of the dynamic interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30(22), pp. 5406-5420. (doi: 10.1128/MCB.00217-10)

Kim, H. W., Ha, S. H., Lee, M. N., Huston, E. , Kim, D.-H., Jang, S. K., Suh, P.-G., Houslay, M. D. and Ryu, S. H. (2010) Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D. Molecular and Cellular Biology, 30(22), pp. 5406-5420. (doi: 10.1128/MCB.00217-10)

Rampersad, S. N., Ovens, J. D., Huston, E. , Umana, M. B., Wilson, L. S., Netherton, S. J., Lynch, M. J., Baillie, G. S. , Houslay, M. D. and Maurice, D. H. (2010) Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability. Journal of Biological Chemistry, 285(44), pp. 33614-33622. (doi: 10.1074/jbc.M110.140004)

Zhu, H. et al. (2010) Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D. Molecular and Cellular Biology, 30(18), pp. 4379-4390. (doi: 10.1128/MCB.01193-09)

Meng, D., Lynch, M. J., Huston, E. , Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. and Baillie, G. S. (2009) MEK1 binds directly to βArrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. Journal of Biological Chemistry, 284(17), pp. 11425-11435. (doi: 10.1074/jbc.M806395200) (PMID:19153083) (PMCID:PMC2670148)

Huston, E. , Lynch, M. J., Mohamed, A., Collins, D. M., Hill, E. V., McLeod, R., Krause, E., Baillie, G. S. and Houslay, M. D. (2008) EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proceedings of the National Academy of Sciences of the United States of America, 105(35), pp. 12791-12796. (doi: 10.1073/pnas.0805167105)

Book Sections

McCahill, A., Huston, E. , Li, X. and Houslay, M.D. (2008) PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases. In: Klussman, E. and Scott, J. (eds.) Protein-Protein Interactions as New Drug Targets. Series: Handbook of Experimental Pharmacology (186). Springer: Berlin, Germany, pp. 125-166. ISBN 9783540728429 (doi: 10.1007/978-3-540-72843-6_6)

Conference or Workshop Item

DeLeeuw, J., Weir, J., Copsey, D., Roden, C., Deeley, S. , Huston, E. , McVey, M. and Finlay, C. (2015) Developing Graduate Attributes and Improving Student Employability Through Work-based Learning: Opportunities, Successes and Challenges. 8th Annual University of Glasgow Learning and Teaching Conference, Glasgow, UK, 14 Apr 2015.