Professor Colin Selman

Professor of Biogerontology (Molecular Biosciences)
Affiliate Researcher (School of Biodiversity, One Health & Veterinary Medicine)

telephone: 01413306077
email: Colin.Selman@glasgow.ac.uk

R230, School of Molecular Biosciences, The Davidson Building, G12 8QQ

Biography

I earned a BSc Honours degree in Zoology from the University of Glasgow, followed by a PhD in avian ecophysiology from Durham University, where my research focused on metabolism changes during migration in the Red knot Calidris canutus. After conducting field studies in The Gambia on pregnancy and malaria mosquito exposure, I delved deeper into whole-animal physiology with a postdoctoral position in Aberdeen, studying the relationship between metabolic rate and ageing. My subsequent postdoctoral work at the University of Florida explored the effects of voluntary exercise on mitochondrial function, oxidative stress, and lifespan. I concluded my postdoctoral research at Imperial College/UCL, investigating how both dietary restriction and targeted mutations in the nutrient sensing pathways insulin/IGF-1 and mTOR influence organismal aging. In 2007, I accepted a lectureship at Aberdeen University and in 2013, I returned to Glasgow as Professor of Biogerontology.

Research interests

Key words: Ageing, dietary restriction, insulin/IGF-1 signalling, mTOR signalling, mitochondria, frailty, ES-62

Google Scholar - Publications Profile

https://whoswho.senescence.info/

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

Number of items: 114.

2024

Selman, C. (2024) The dietary exposome: a brief history of diet, longevity and age-related health in rodents. Clinical Science, 138(21), pp. 1343-1356. (doi: 10.1042/CS20241248) (PMID:39444221)

Borland, G., Wilkie, S. E., Thomson, J., Wang, Z., Tullett, J. M.A., Alic, N. and Selman, C. (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23(5), e14141. (doi: 10.1111/acel.14141) (PMID:38465473) (PMCID:PMC11113255)

Harnett, M. M. , Doonan, J. , Tarafdar, A., Pineda, M. , Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P., Selman, C. and Harnett, W. (2024) The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in Tropical Diseases, 4, 1334705. (doi: 10.3389/fitd.2023.1334705)

2023

Neytchev, O. et al. (2023) Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing. Journal of Internal Medicine, 295(1), pp. 79-90. (doi: 10.1111/joim.13724)

Panagiotou, N. , McGuinness, D., Jaminon, A. M.G., Mees, B., Selman, C. , Schurgers, L. and Shiels, P. G. (2023) Microvesicle-mediated tissue regeneration mitigates the effects of cellular ageing. Cells, 12(13), 1707. (doi: 10.3390/cells12131707) (PMID:37443741) (PMCID:PMC10340655)

Wilkie, S. E., Marcu, D. E., Carter, R. N., Morton, N. M., Gonzalo, S. and Selman, C. (2023) Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome. Aging, 15(12), pp. 5266-5278. (doi: 10.18632/aging.204835) (PMID:37354210) (PMCID:PMC10333079)

Hamilton, K. L. and Selman, C. (2023) Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues. Journal of Physiology, 601(11), pp. 2053-2056. (doi: 10.1113/JP284583) (PMID:37130065)

Salmon, P. , Dawson, N. J. , Millet, C., Selman, C. and Monaghan, P. (2023) Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch. Aging Cell, 22(6), e13822. (doi: 10.1111/acel.13822) (PMID:36938671) (PMCID:PMC10265141)

Salmón, P. , Millet, C., Selman, C. , Monaghan, P. and Dawson, N. J. (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. GeroScience, 45(1), pp. 256-276. (doi: 10.1007/s11357-022-00624-1) (PMID:35986126) (PMCID:PMC9886749)

2022

Harnett, M. M. et al. (2022) The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing. Frontiers in Immunology, 13, 953053. (doi: 10.3389/fimmu.2022.953053) (PMID:36105811) (PMCID:PMC9465317)

Dawson, N. J. , Millet, C., Selman, C. and Metcalfe, N. B. (2022) Inter-individual variation in mitochondrial phosphorylation efficiency predicts growth rates in ectotherms at high temperatures. FASEB Journal, 36(6), e22333. (doi: 10.1096/fj.202101806RR) (PMID:35486025)

Javidnia, S., Cranwell, S., Mueller, S. H., Selman, C. , Tullet, J. M.A., Kuchenbaecker, K. and Alic, N. (2022) Mendelian randomization analyses implicate biogenesis of translation machinery in human aging. Genome Research, 32(2), pp. 258-265. (doi: 10.1101/gr.275636.121) (PMID:35078808) (PMCID:PMC8805714)

2021

Carter, R. N. et al. (2021) The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Reports, 37(6), 109958. (doi: 10.1016/j.celrep.2021.109958) (PMID:34758301) (PMCID:PMC8595646)

Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M. and Selman, C. (2021) Hydrogen sulfide in ageing, longevity and disease. Biochemical Journal, 478(19), pp. 3485-3504. (doi: 10.1042/BCJ20210517) (PMID:34613340) (PMCID:PMC8589328)

Mulvey, L., Wilkie, S. E., Borland, G., Griffiths, K., Sinclair, A., McGuinness, D., Watson, D. G. and Selman, C. (2021) Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice. Molecular and Cellular Endocrinology, 535, 111376. (doi: 10.1016/j.mce.2021.111376) (PMID:34246728) (PMCID:PMC8417819)

Salmón, P. , Millet, C., Selman, C. and Monaghan, P. (2021) Growth acceleration results in faster telomere shortening later in life. Proceedings of the Royal Society of London Series B: Biological Sciences, 288(1956), 20211118. (doi: 10.1098/rspb.2021.1118) (PMID:34375555)

Kulaberoglu, Y., Malik, Y., Borland, G., Selman, C. , Alic, N. and Tullet, J. M.A. (2021) RNA polymerase III, ageing and longevity. Frontiers in Genetics, 12, 705122. (doi: 10.3389/fgene.2021.705122) (PMID:34295356) (PMCID:PMC8290157)

2020

Crowe, J. et al. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing. PLoS Pathogens, 16(3), e1008391. (doi: 10.1371/journal.ppat.1008391) (PMID:32163524) (PMCID:PMC7108737)

Sáenz de Miera, C., Beymer, M., Routledge, K., Król, E., Selman, C. , Hazlerigg, D. G. and Simonneaux, V. (2020) Photoperiodic regulation in a wild-derived mouse strain. Journal of Experimental Biology, 223(6), jeb217687. (doi: 10.1242/jeb.217687) (PMID:32098881)

Dawson, N. J. , Millet, C., Selman, C. and Metcalfe, N. B. (2020) Measurement of mitochondrial respiration in permeabilized fish gills. Journal of Experimental Biology, 223(4), 216762. (doi: 10.1242/jeb.216762) (PMID:31974221) (PMCID:PMC7044462)

Wilkie, S. E., Mulvey, L., Sands, W., Marcu, D. E., Carter, R. N., Morton, N. M., Hine, C., Mitchell, J. R. and Selman, C. (2020) Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice. GeroScience, 42, pp. 801-812. (doi: 10.1007/s11357-020-00168-2) (PMID:32162209) (PMCID:PMC7205779)

2019

Lee, B. P., Mulvey, L., Barr, G., Garratt, J., Goodman, E., Selman, C. and Harries, L. W. (2019) Dietary restriction in ILSXISS mice is associated with widespread changes in splicing regulatory factor expression levels. Experimental Gerontology, 128, 110736. (doi: 10.1016/j.exger.2019.110736) (PMID:31521722)

Lumb, F. E., Crowe, J., Doonan, J., Suckling, C. J., Selman, C. , Harnett, M. M. and Harnett, W. (2019) Synthetic small molecule analogues of the immunomodulatory Acanthocheilonema viteae product ES-62 promote metabolic homeostasis during obesity in a mouse model. Molecular and Biochemical Parasitology, 111232. (doi: 10.1016/j.molbiopara.2019.111232) (PMID:31634505)

Shiels, P. G. , Buchanan, S., Selman, C. and Stenvinkel, P. (2019) Allostatic load and ageing; linking the microbiome and nutrition with age related health. Biochemical Society Transactions, 47(4), pp. 1165-1172. (doi: 10.1042/BST20190110) (PMID:31416886)

Salin, K., Villasevil, E. M., Anderson, G. J., Lamarre, S. G., Melanson, C. A., McCarthy, I., Selman, C. and Metcalfe, N. B. (2019) Differences in mitochondrial efficiency explain individual variation in growth performance. Proceedings of the Royal Society of London Series B: Biological Sciences, 286(1909), 20191466. (doi: 10.1098/rspb.2019.1466) (PMID:31431161) (PMCID:PMC6732382)

Rached, M.-T. et al. (2019) Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. Molecular Metabolism, 20, pp. 38-50. (doi: 10.1016/j.molmet.2018.11.010) (PMID:30553769) (PMCID:PMC6358539)

Wilkinson, M. J.A., Selman, C. , McLaughlin, L., Horan, L., Hamilton, L., Gilbert, C., Chadwick, C. and Flynn, J. N. (2019) Progressing the care, husbandry and management of ageing mice used in scientific studies. Laboratory Animals, 54(3), pp. 225-238. (doi: 10.1177/0023677219865291) (PMID:31403890) (PMCID:PMC7301645)

2018

Selman, C. and Swindell, W. R. (2018) Putting a strain on diversity. EMBO Journal, 37(22), e100862. (doi: 10.15252/embj.2018100862) (PMID:30389663) (PMCID:PMC6236330)

Salin, K., Villasevil, E. M., Anderson, G. J., Auer, S. K., Selman, C. , Hartley, R. C. , Mullen, W. , Chinopoulos, C. and Metcalfe, N. B. (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32(9), pp. 2149-2157. (doi: 10.1111/1365-2435.13125) (PMID:30333678) (PMCID:PMC6175143)

Panagiotou, N. , Neytchev, O. , Selman, C. and Shiels, P. G. (2018) Extracellular vesicles, ageing, and therapeutic interventions. Cells, 7(8), 110. (doi: 10.3390/cells7080110) (PMID:30126173) (PMCID:PMC6115766)

Pacios-Palma, I., Moreno, S., Selman, C. and Rouco, C. (2018) Oxidative stress in wild European rabbits naturally infected with myxoma virus and rabbit haemorrhagic disease virus. European Journal of Wildlife Research, 64(4), 47. (doi: 10.1007/s10344-018-1203-0)

Salin, K., Villasevil, E. M., Anderson, G. J., Selman, C. , Chinopoulos, C. and Metcalfe, N. B. (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integrative and Comparative Biology, 58(3), pp. 486-494. (doi: 10.1093/icb/icy085) (PMID:29982616)

Page, M. M., Schuster, E. F., Mudaliar, M. , Herzyk, P. , Withers, D. J. and Selman, C. (2018) Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. Aging, 10(5), pp. 1027-1052. (doi: 10.18632/aging.101446) (PMID:29779018) (PMCID:PMC5990393)

Babayan, S. A. , Sinclair, A., Duprez, J. S. and Selman, C. (2018) Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection. Scientific Reports, 8, 3802. (doi: 10.1038/s41598-018-22083-5) (PMID:29491449) (PMCID:PMC5830876)

2017

Mulvey, L., Sands, W. A., Salin, K., Carr, A. E. and Selman, C. (2017) Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice. Molecular and Cellular Endocrinology, 455, pp. 41-53. (doi: 10.1016/j.mce.2016.09.001) (PMID:27597651)

Sands, W. A., Page, M. M. and Selman, C. (2017) Proteostasis and ageing: insights from long-lived mutant mice. Journal of Physiology, 595(20), pp. 6383-6390. (doi: 10.1113/JP274334) (PMID:28718225) (PMCID:PMC5638872)

Hine, C. et al. (2017) Hypothalamic-pituitary axis regulates hydrogen sulfide production. Cell Metabolism, 25(6), 1320-1333.e5. (doi: 10.1016/j.cmet.2017.05.003) (PMID:28591635) (PMCID:PMC5722247)

Selman, C. and Withers, D. J. (2017) Physiology: an atypical switch for metabolism and ageing. Nature, 542, pp. 299-300. (doi: 10.1038/nature21500) (PMID:28178230)

2016

Figueira, I. et al. (2016) Interventions for age-related diseases: Shifting the paradigm. Mechanisms of Ageing and Development, 160, pp. 69-92. (doi: 10.1016/j.mad.2016.09.009)

Panagiotou, N. , Davies, R. W., Selman, C. and Shiels, P. G. (2016) Microvesicles as vehicles for tissue regeneration: Changing of the guards. Current Pathobiology Reports, 4(4), pp. 181-187. (doi: 10.1007/s40139-016-0115-5) (PMID:27882267) (PMCID:PMC5101251)

Salin, K., Auer, S. K., Rudolf, A. M., Anderson, G. J., Selman, C. and Metcalfe, N. B. (2016) Variation in metabolic rate among individuals is related to tissue-specific differences in mitochondrial leak respiration. Physiological and Biochemical Zoology, 89(6), pp. 511-523. (doi: 10.1086/688769) (PMID:27792536)

Salin, K., Villasevil, E. M., Auer, S. K., Anderson, G. J., Selman, C. , Metcalfe, N. B. and Chinopoulos, C. (2016) Simultaneous measurement of mitochondrial respiration and ATP production in tissue homogenates and calculation of effective P/O ratios. Physiological Reports, 4(20), e13007. (doi: 10.14814/phy2.13007) (PMID:27798358) (PMCID:PMC5099967)

Christensen, L. L. , Selman, C. , Blount, J. D., Pilkington, J. G., Watt, K. A., Pemberton, J. M., Reid, J. and Nussey, D. H. (2016) Marker-dependent associations among oxidative stress, growth and survival during early life in a wild mammal. Proceedings of the Royal Society of London Series B: Biological Sciences, 283(1840), 20161407. (doi: 10.1098/rspb.2016.1407) (PMID:9729611) (PMCID:PMC98936)

Salin, K., Auer, S. K., Anderson, G. J., Selman, C. and Metcalfe, N. B. (2016) Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity. Journal of Experimental Biology, 219(9), pp. 1356-1362. (doi: 10.1242/jeb.133025) (PMID:26944497)

Selman, C. , Sinclair, A., Pedroni, S. M.A., Irvine, E. E., Michie, A. M. and Withers, D. J. (2016) Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice. Oncotarget, 7, 21. (doi: 10.18632/oncotarget.8729) (PMID:27083004)

2015

Speakman, J. R. et al. (2015) Oxidative stress and life histories: unresolved issues and current needs. Ecology and Evolution, 5(24), pp. 5745-5757. (doi: 10.1002/ece3.1790)

Christensen, L. L., Selman, C. , Blount, J. D., Pilkington, J. G., Watt, K. A., Pemberton, J. M., Reid, J. M. and Nussey, D. H. (2015) Plasma markers of oxidative stress are uncorrelated in a wild mammal. Ecology and Evolution, 5(21), pp. 5096-5108. (doi: 10.1002/ece3.1771)

Fletcher, Q. and Selman, C. (2015) Aging in the wild: insights from free-living and non-model organisms. Experimental Gerontology, 71, pp. 1-3. (doi: 10.1016/j.exger.2015.09.015) (PMID:26403678)

Salin, K., Auer, S. k., Rudolf, A. M., Anderson, G. J., Cairns, A. G., Mullen, W. , Hartley, R. C. , Selman, C. and Metcalfe, N. B. (2015) Individuals with higher metabolic rates have lower levels of reactive oxygen species in vivo. Biology Letters, 11(9), 20150538. (doi: 10.1098/rsbl.2015.0538) (PMID:26382073)

Sharples, A.P., Hughes, D.C., Deane, C.S., Saini, A., Selman, C. and Stewart, C.E. (2015) Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell, 14(4), pp. 511-523. (doi: 10.1111/acel.12342) (PMID:25866088) (PMCID:PMC4531066)

Salin, K., Auer, S. K., Rey, B., Selman, C. and Metcalfe, N. B. (2015) Variation in the link between oxygen consumption and ATP production, and its relevance for animal performance. Proceedings of the Royal Society of London Series B: Biological Sciences, 282(1812), 20151028. (doi: 10.1098/rspb.2015.1028) (PMID:26203001)

2014

Jové, M., Naudí, A., Ramírez-Núñez, O., Portero-Otín, M., Selman, C. , Withers, D. J. and Pamplona, R. (2014) Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice. Aging Cell, 13(5), pp. 828-837. (doi: 10.1111/acel.12241)

Page, M. M., Sinclair, A., Robb, E. L., Stuart, J. A., Withers, D. J. and Selman, C. (2014) Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress. Aging Cell, 13(5), pp. 962-964. (doi: 10.1111/acel.12255) (PMID:25059507) (PMCID:PMC4331740)

Mulvey, L., Sinclair, A. and Selman, C. (2014) Lifespan modulation in mice and the confounding effects of genetic background. Journal of Genetics and Genomics, 41(9), pp. 497-503. (doi: 10.1016/j.jgg.2014.06.002) (PMID:25269675) (PMCID:PMC4257991)

Piper, M. D.W., Selman, C. , Speakman, J. R. and Partridge, L. (2014) Using doubly-labeled water to measure energy expenditure in an important small Ectotherm Drosophila melanogaster. Journal of Genetics and Genomics, 41(9), pp. 505-512. (doi: 10.1016/j.jgg.2014.07.004)

Selman, C. (2014) Dietary restriction and the pursuit of effective mimetics. Proceedings of the Nutrition Society, 73(02), pp. 260-270. (doi: 10.1017/S0029665113003832) (PMID:4411076)

Zhang, L.-N., Sinclair, R., Selman, C. , Mitchell, S., Morgan, D., Clapham, J. C. and Speakman, J. R. (2014) Effects of a specific MCHR1 antagonist (GW803430) on energy budget and glucose metabolism in diet-induced obese mice. Obesity, 22(3), pp. 681-690. (doi: 10.1002/oby.20418) (PMID:23512845)

2013

Selman, C. , Nussey, D.H. and Monaghan, P. (2013) Ageing: it’s a dog’s life. Current Biology, 23(10), R451-R453. (doi: 10.1016/j.cub.2013.04.005)

Fletcher, Q.E., Selman, C. , Boutin, S., McAdam, A.G., Woods, S.B., Seo, A.Y., Leeuwenburgh, C., Speakman, J.R. and Humphries, M.M. (2013) Oxidative damage increases with reproductive energy expenditure and is reduced by food supplementation. Evolution, 67(5), pp. 1527-1536. (doi: 10.1111/evo.12014)

Archer, C.R., Sakaluk, S.K., Selman, C. , Royle, N.J. and Hunt, J. (2013) Oxidative stress and the evolution of sex differences in life span and ageing in the decorated cricket, gryllodes sigillatus. Evolution, 67(3), pp. 620-634. (doi: 10.1111/j.1558-5646.2012.01805.x)

2012

Selman, C. , Blount, J.D., Nussey, D.H. and Speakman, J.R. (2012) Oxidative damage, ageing, and life-history evolution: where now? Trends in Ecology and Evolution, 27(10), pp. 570-577. (doi: 10.1016/j.tree.2012.06.006)

Lee, J.S. et al. (2012) Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mechanisms of Ageing and Development, 133(7), pp. 467-478. (doi: 10.1016/j.mad.2012.05.006)

Wijeyesekera, A., Selman, C. , Barton, R.H., Holmes, E., Nicholson, J.K. and Withers, D.J. (2012) Metabotyping of long-lived mice using1H NMR spectroscopy. Journal of Proteome Research, 11(4), pp. 2224-2235. (doi: 10.1021/pr2010154)

Page, M.M., Withers, D.J. and Selman, C. (2012) Longevity of insulin receptor substrate1 null mice is not associated with increased basal antioxidant protection or reduced oxidative damage. Age, 29, (doi: 10.1007/s11357-012-9395-9)

Selman, C. and Partridge, L. (2012) A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice. Cell Cycle, 11(1), pp. 13-18. (doi: 10.4161/cc.11.1.18736)

Hempenstall, S., Page, M.M., Wallen, K.R. and Selman, C. (2012) Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice. Mechanisms of Ageing and Development, 133(1), pp. 37-45. (doi: 10.1016/j.mad.2011.12.002)

Selman, C. and Hempenstall, S. (2012) Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 mice. Longevity and Healthspan, 1(2), (doi: 10.1186/2046-2395-1-2)

2011

Wyse, C.A., Selman, C. , Page, M.M., Coogan, A.N. and Hazlerigg, D.G. (2011) Circadian desynchrony and metabolic dysfunction; did light pollution make us fat? Medical Hypotheses, 77(6), pp. 1139-1144. (doi: 10.1016/j.mehy.2011.09.023)

Speakman, J.R. and Selman, C. (2011) The free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan. BioEssays, 33(4), pp. 255-259. (doi: 10.1002/bies.201000132)

Selman, C. and Withers, D.J. (2011) Mammalian models of extended healthy lifespan. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1561), pp. 99-107. (doi: 10.1098/rstb.2010.0243)

Selman, C. , Partridge, L. and Withers, D.J. (2011) Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1. PLoS ONE, 6(1), e16144. (doi: 10.1371/journal.pone.0016144) (PMID:21283571) (PMCID:PMC3026792)

2010

Wyse, C.A., Coogan, A.N., Selman, C. , Hazlerigg, D.G. and Speakman, J.R. (2010) Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited. Biology Letters, 6(5), pp. 696-698. (doi: 10.1098/rsbl.2010.0152)

Banks, R., Speakman, J.R. and Selman, C. (2010) Vitamin E supplementation and mammalian lifespan. Molecular Nutrition and Food Research, 54(5), pp. 719-725. (doi: 10.1002/mnfr.200900382)

Hempenstall, S., Picchio, L., Mitchell, S.E., Speakman, J.R. and Selman, C. (2010) The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice. Mechanisms of Ageing and Development, 131(2), pp. 111-118. (doi: 10.1016/j.mad.2009.12.008)

2009

Al-Qassab, H. et al. (2009) Dominant role of the p110β isoform of PI3K over p110α in energy homeostasis regulation by POMC and AgRP neurons. Cell Metabolism, 10(5), pp. 343-354. (doi: 10.1016/j.cmet.2009.09.008)

Selman, C. et al. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science, 326(5949), pp. 140-144. (doi: 10.1126/science.1177221)

Ruth Archer, C., Royle, N., South, S., Selman, C. and Hunt, J. (2009) Nutritional geometry provides food for thought. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64A(9), pp. 956-959. (doi: 10.1093/gerona/glp069)

Cantley, J. et al. (2009) Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice. Journal of Clinical Investigation, 119(1), pp. 125-135. (doi: 10.1172/JCI26934)

2008

Selman, C. , McLaren, J.S., Collins, A.R., Duthie, G.G. and Speakman, J.R. (2008) The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole microtus agrestis. Proceedings of the Royal Society of London Series B: Biological Sciences, 275(1645), pp. 1907-1916. (doi: 10.1098/rspb.2008.0355)

Selman, C. , Lingard, S., Gems, D., Partridge, L. and Withers, D.J. (2008) Comment on "brain IRS2 signaling coordinates life span and nutrient homeostasis". Science, 320(5879), 1012b-1012b. (doi: 10.1126/science.1152366)

Selman, C. et al. (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB Journal, 22(3), pp. 807-818. (doi: 10.1096/fj.07-9261com)

Selman, C. , McLaren, J.S., Mayer, C., Duncan, J.S., Collins, A.R., Duthie, G.G., Redman, P. and Speakman, J.R. (2008) Lifelongα-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage. Rejuvenation Research, 11(1), pp. 83-96. (doi: 10.1089/rej.2007.0586)

Piper, M.D.W., Selman, C. , McElwee, J.J. and Partridge, L. (2008) Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? Journal of Internal Medicine, 263(2), pp. 179-191. (doi: 10.1111/j.1365-2796.2007.01906.x)

2007

Claret, M. et al. (2007) AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. Journal of Clinical Investigation, 117(8), pp. 2325-2336. (doi: 10.1172/JCI31516)

Neganova, I. et al. (2007) Role of central nervous system and ovarian insulin receptor substrate 2 signaling in female reproductive function in the mouse. Biology of Reproduction, 76(6), pp. 1045-1053. (doi: 10.1095/biolreprod.106.059360)

Cantley, J., Choudhury, A.I., Asare-Anane, H., Selman, C. , Lingard, S., Heffron, H., Herrera, P., Persaud, S.J. and Withers, D.J. (2007) Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologia, 50(6), pp. 1248-1256. (doi: 10.1007/s00125-007-0637-9)

McElwee, J.J. et al. (2007) Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biology, 8(7), R132. (doi: 10.1186/gb-2007-8-7-r132)

2006

Selman, C. et al. (2006) Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiological Genomics, 27(3), pp. 187-200. (doi: 10.1152/physiolgenomics.00084.2006)

Selman, C. , McLaren, J.S., Meyer, C., Duncan, J.S., Redman, P., Collins, A.R., Duthie, G.G. and Speakman, J.R. (2006) Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes. Mechanisms of Ageing and Development, 127(12), pp. 897-904. (doi: 10.1016/j.mad.2006.09.008)

2005

Humphries, M.M., Boutin, S., Thomas, D.W., Ryan, J.D., Selman, C. , McAdam, A.G., Berteaux, D. and Speakman, J.R. (2005) Expenditure freeze: the metabolic response of small mammals to cold environments. Ecology Letters, 8(12), pp. 1326-1333. (doi: 10.1111/j.1461-0248.2005.00839.x)

Choudhury, A.I. et al. (2005) The role of insulin receptor substrate 2 in hypothalamic and β cell function. Journal of Clinical Investigation, 115(4), pp. 940-950. (doi: 10.1172/JCI24445)

Selman, C. and Evans, P.R. (2005) Alterations in tissue aerobic capacity may play a role in premigratory fattening in shorebirds. Biology Letters, 1(1), pp. 101-104. (doi: 10.1098/rsbl.2004.0248)

Piper, M.D.W., Selman, C. , McElwee, J.J. and Partridge, L. (2005) Models of insulin signalling and longevity. Drug Discovery Today: Disease Models, 2(4), pp. 249-256. (doi: 10.1016/j.ddmod.2005.11.001)

Selman, C. , Phillips, T., Staib, J.L., Duncan, J.S., Leeuwenburgh, C. and Speakman, J.R. (2005) Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mechanisms of Ageing and Development, 126(6-7), pp. 783-793. (doi: 10.1016/j.mad.2005.02.004)

2004

Judge, S., Jang, Y.M., Smith, A., Selman, C. , Phillips, T., Speakman, J.R., Hagen, T. and Leeuwenburgh, C. (2004) Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 289(6), R1564-R1572. (doi: 10.1152/ajpregu.00396.2005)

Jang, Y. M., Kendaiah, S., Drew, B., Phillips, T., Selman, C. , Julian, D. and Leeuwenburgh, C. (2004) Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats. FEBS Letters, 577(3), pp. 483-490. (doi: 10.1016/j.febslet.2004.10.053)

Wiersma, P., Selman, C. , Speakman, J.R. and Verhulst, S. (2004) Birds sacrifice oxidative protection for reproduction. Proceedings of the Royal Society of London Series B: Biological Sciences, 271(Sup 5), S360-S363. (doi: 10.1098/rsbl.2004.0171)

Itoh, M., Oh-ishi, S., Hatao, H., Leeuwenburgh, C., Selman, C. , Ohno, H., Kizaki, T., Nakamura, H. and Matsuoka, T. (2004) Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 287(1), R33-R38. (doi: 10.1152/ajpregu.00598.2003)

Gredilla, R., Phaneuf, S., Selman, C. , Kendaiah, S., Leeunwenburgh, C. and Barja, G. (2004) Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria. Annals of the New York Academy of Sciences, 1019, pp. 333-342. (doi: 10.1196/annals.1297.057)

Speakman, J.R., Talbot, D.A., Selman, C. , Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D.M., Johnson, M.S. and Brand, M.D. (2004) Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell, 3(3), pp. 87-95. (doi: 10.1111/j.1474-9728.2004.00097.x)

2003

Selman, C. , Kendaiah, S., Gredilla, R. and Leeuwenburgh, C. (2003) Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels. Experimental Gerontology, 38(8), pp. 897-903. (doi: 10.1016/S0531-5565(03)00091-3)

Speakman, J.R. and Selman, C. (2003) Physical activity and resting metabolic rate. Proceedings of the Nutrition Society, 62(3), pp. 621-634. (doi: 10.1079/PNS2003282)

Selman, C. , Gredilla, R., Phaneuf, S., Kendaiah, S., Barja, G. and Leeuwenburgh, C. (2003) Short-term caloric restriction and regulatory proteins of apoptosis in heart, skeletal muscle and kidney of Fischer 344 rats. Biogerontology, 4(3), pp. 141-147. (doi: 10.1023/A:1024149923693)

Selman, C. and Leeuwenburgh, C. (2003) The role of Id2 and apoptosis during skeletal muscle remodeling. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 284(2), R538-R539. (doi: 10.1152/ajpregu.00679.2002)

Drew, B., Phaneuf, S., Dirks, A., Selman, C. , Gredilla, R., Lezza, A., Barja, G. and Leeuwenburgh, C. (2003) Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 284(2), R474-80. (doi: 10.1152/ajpregu.00455.2002)

2002

Selman, C. , Grune, T., Stolzing, A., Jakstadt, M., McLaren, J.S. and Speakman, J.R. (2002) The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis. Free Radical Biology and Medicine, 33(2), pp. 259-265. (doi: 10.1016/S0891-5849(02)00874-2)

Selman, C. , McLaren, J.S., Collins, A.R. and Speakman, J.R. (2002) Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal. Journal of Nutrition, 132(6 Supp), 1784S-1786S.

Speakman, J.R., Selman, C. , McLaren, J.S. and Harper, E.J. (2002) Living fast, dying when? The link between aging and energetics. Journal of Nutrition, 132(6), 1583S-1597S.

Selman, C. , McLaren, J.S., Collins, A.R., Duthie, G.G. and Speakman, J.R. (2002) Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running. Archives of Biochemistry and Biophysics, 401(2), pp. 255-261. (doi: 10.1016/S0003-9861(02)00050-4)

2001

Selman, C. , Korhonen, T.K., Bünger, L., Hill, W.G. and Speakman, J.R. (2001) Thermoregulatory responses of two mouse Mus musculus strains selectively bred for high and low food intake. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 171(8), pp. 661-668.

Selman, C. , Lumsden, S., Bünger, L., Hill, W.G. and Speakman, J.R. (2001) Resting metabolic rate and morphology in mice (Mus musculus) selected for high and low food intake. Journal of Experimental Biology, 204(4), pp. 777-784.

2000

Lindsay, S., Ansell, J., Selman, C. , Cox, V., Hamilton, K. and Walraven, G. (2000) Effect of pregnancy on exposure to malaria mosquitoes. Lancet, 355(9219), p. 1972. (doi: 10.1016/S0140-6736(00)02334-5)

Selman, C. , McLaren, J.S., Himanka, M.J. and Speakman, J.R. (2000) Effect of long-term cold exposure on antioxidant enzyme activities in a small mammal. Free Radical Biology and Medicine, 28(8), pp. 1279-1285. (doi: 10.1016/S0891-5849(00)00263-X)

1999

Redman, P., Selman, C. and Speakman, J.R. (1999) Male short-tailed field voles (Microtus agrestis) build better insulated nests than females. Journal of Comparative Physiology B: Biochemical, Systems, and Environmental Physiology, 169(8), pp. 581-587.

This list was generated on Wed Nov 20 19:44:19 2024 GMT.

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