2024

Holt, C. and Carver, J.A. (2024) Invited review: Modeling milk stability. Journal of Dairy Science, 107(8), pp. 5259-5279. (doi: 10.3168/jds.2024-24779) (PMID:38522835)

Raynes, J. K., Mata, J., Wilde, K. L., Carver, J. A., Kelly, S. M. and Holt, C. (2024) Structure of biomimetic casein micelles: critical tests of the hydrophobic colloid and multivalent-binding models using recombinant deuterated and phosphorylated β-casein. Journal of Structural Biology: X, 9, 100096. (doi: 10.1016/j.yjsbx.2024.100096) (PMID:38318529) (PMCID:PMC10840362)

Carver, J. A. and Holt, C. (2024) Current concepts of casein and casein micelle structure, interactions, and dynamics. In: El-Bakry, M. and Mehta, B. M. (eds.) Casein: Structural Properties, Uses, Health Benefits and Nutraceutical Applications. Academic Press, pp. 63-98. ISBN 9780443158360 (doi: 10.1016/B978-0-443-15836-0.00002-0)

2022

Horvath, A., Fuxreiter, M., Vendruscolo, M., Holt, C. and Carver, J. A. (2022) Are casein micelles extracellular condensates formed by liquid-liquid phase separation? FEBS Letters, 596(16), pp. 2072-2085. (doi: 10.1002/1873-3468.14449) (PMID:35815989)

2020

Lenton, S., Wang, Q., Nylander, T., Teixeira, S. and Holt, C. (2020) Structural biology of calcium phosphate nanoclusters sequestered by phosphoproteins. Crystals, 10(9), 755. (doi: 10.3390/cryst10090755)

2018

Carver, J. A., Ecroyd, H., Truscott, R. J.W., Thorn, D. C. and Holt, C. (2018) Proteostasis and the regulation of intra- and extracellular protein aggregation by ATP-independent molecular chaperones: lens α-crystallins and milk caseins. Accounts of Chemical Research, 51(3), pp. 745-752. (doi: 10.1021/acs.accounts.7b00250) (PMID:29442498)

2017

Carver, J. A., Thorn, D. C., Ecroyd, H. and Holt, C. (2017) Letter to the Editor: a response to Horne and Lucey (2017). Journal of Dairy Science, 100(7), pp. 5121-5124. (doi: 10.3168/jds.2017-13053) (PMID:28624068)

Lenton, S. et al. (2017) Effect of phosphorylation on a human-like osteopontin peptide. Biophysical Journal, 112(8), pp. 1586-1596. (doi: 10.1016/j.bpj.2017.03.005) (PMID:28445750)

2016

Holt, C. (2016) Casein and casein micelle structures, functions and diversity in 20 species. International Dairy Journal, 60, pp. 2-13. (doi: 10.1016/j.idairyj.2016.01.004)

Lenton, S., Nylander, T., Holt, C. , Sawyer, L., Härtlein, M., Müller, H. and Teixeira, S. C. M. (2016) Structural studies of hydrated samples of amorphous calcium phosphate and phosphoprotein nanoclusters. European Biophysics Journal, 45(5), pp. 405-412. (doi: 10.1007/s00249-015-1109-7) (PMID:26780236)

2015

Lenton, S., Seydel, T., Nylander, T., Holt, C. , Härtlein, M., Teixeira, S. and Zaccai, G. (2015) Dynamic footprint of sequestration in the molecular fluctuations of osteopontin. Journal of the Royal Society: Interface, 12(110), 20150506. (doi: 10.1098/rsif.2015.0506) (PMID:26354827)

Thorn, D. C., Ecroyd, H., Carver, J. A. and Holt, C. (2015) Casein structures in the context of unfolded proteins. International Dairy Journal, 46, pp. 2-11. (doi: 10.1016/j.idairyj.2014.07.008)

Lenton, S., Nylander, T., Teixeira, S. C.M. and Holt, C. (2015) A review of the biology of calcium phosphate sequestration with special reference to milk. Dairy Science and Technology, 95(1), pp. 3-14. (doi: 10.1007/s13594-014-0177-2)

2014

Holt, C. , Lenton, S., Nylander, T., Sørensen, E. S. and Teixeira, S. C.M. (2014) Mineralisation of soft and hard tissues and the stability of biofluids. Journal of Structural Biology, 185(3), pp. 383-396. (doi: 10.1016/j.jsb.2013.11.009)[Book Review]

Rodriguez, D. E., Thula-Mata, T., Toro, E. J., Yeh, Y.-W., Holt, C. , Holliday, L.S. and Gower, L. B. (2014) Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts. Acta Biomaterialia, 10(1), pp. 494-507. (doi: 10.1016/j.actbio.2013.10.010)

2013

Holt, C. , Carver, J.A., Ecroyd, H. and Thorn, D.C. (2013) Caseins and the casein micelle: their biological functions, structures and behaviour in foods. Journal of Dairy Science, 96(10), pp. 6127-6146. (doi: 10.3168/jds.2013-6831)

Holt, C. (2013) Unfolded phosphopolypeptides enable soft and hard tissues to coexist in the same organism with relative ease. Current Opinion in Structural Biology, 23(3), pp. 420-425. (doi: 10.1016/j.sbi.2013.02.010)

2012

Ossowski, S., Jackson, A., Obiols-Rabasa, M., Holt, C. , Lenton, S., Porcar, L., Paulsson, M. and Nylander, T. (2012) Aggregation behavior of bovine κ- and β-casein studied with small angle neutron scattering, light scattering, and cryogenic transmission electron microscopy. Langmuir, 28(38), pp. 13577-13589. (doi: 10.1021/la302416p)

Holt, C. and Carver, J.A. (2012) Darwinian transformation of a 'scarcely nutritious fluid' into milk. Journal of Evolutionary Biology, 25(7), pp. 1253-1263. (doi: 10.1111/j.1420-9101.2012.02509.x)

2011

Follows, D., Holt, C. , Thomas, R.K., Tiberg, F., Fragneto, G. and Nylander, T. (2011) Co-adsorption of β-casein and calcium phosphate nanoclusters (CPN) at hydrophilic and hydrophobic solid–solution interfaces studied by neutron reflectometry. In: Food Colloids 2010: On the Road from Interfaces to Consumers, pp. 724-733. (doi: 10.1016/j.foodhyd.2010.09.001)

Articles

Holt, C. and Carver, J.A. (2024) Invited review: Modeling milk stability. Journal of Dairy Science, 107(8), pp. 5259-5279. (doi: 10.3168/jds.2024-24779) (PMID:38522835)

Raynes, J. K., Mata, J., Wilde, K. L., Carver, J. A., Kelly, S. M. and Holt, C. (2024) Structure of biomimetic casein micelles: critical tests of the hydrophobic colloid and multivalent-binding models using recombinant deuterated and phosphorylated β-casein. Journal of Structural Biology: X, 9, 100096. (doi: 10.1016/j.yjsbx.2024.100096) (PMID:38318529) (PMCID:PMC10840362)

Horvath, A., Fuxreiter, M., Vendruscolo, M., Holt, C. and Carver, J. A. (2022) Are casein micelles extracellular condensates formed by liquid-liquid phase separation? FEBS Letters, 596(16), pp. 2072-2085. (doi: 10.1002/1873-3468.14449) (PMID:35815989)

Lenton, S., Wang, Q., Nylander, T., Teixeira, S. and Holt, C. (2020) Structural biology of calcium phosphate nanoclusters sequestered by phosphoproteins. Crystals, 10(9), 755. (doi: 10.3390/cryst10090755)

Carver, J. A., Ecroyd, H., Truscott, R. J.W., Thorn, D. C. and Holt, C. (2018) Proteostasis and the regulation of intra- and extracellular protein aggregation by ATP-independent molecular chaperones: lens α-crystallins and milk caseins. Accounts of Chemical Research, 51(3), pp. 745-752. (doi: 10.1021/acs.accounts.7b00250) (PMID:29442498)

Carver, J. A., Thorn, D. C., Ecroyd, H. and Holt, C. (2017) Letter to the Editor: a response to Horne and Lucey (2017). Journal of Dairy Science, 100(7), pp. 5121-5124. (doi: 10.3168/jds.2017-13053) (PMID:28624068)

Lenton, S. et al. (2017) Effect of phosphorylation on a human-like osteopontin peptide. Biophysical Journal, 112(8), pp. 1586-1596. (doi: 10.1016/j.bpj.2017.03.005) (PMID:28445750)

Holt, C. (2016) Casein and casein micelle structures, functions and diversity in 20 species. International Dairy Journal, 60, pp. 2-13. (doi: 10.1016/j.idairyj.2016.01.004)

Lenton, S., Nylander, T., Holt, C. , Sawyer, L., Härtlein, M., Müller, H. and Teixeira, S. C. M. (2016) Structural studies of hydrated samples of amorphous calcium phosphate and phosphoprotein nanoclusters. European Biophysics Journal, 45(5), pp. 405-412. (doi: 10.1007/s00249-015-1109-7) (PMID:26780236)

Lenton, S., Seydel, T., Nylander, T., Holt, C. , Härtlein, M., Teixeira, S. and Zaccai, G. (2015) Dynamic footprint of sequestration in the molecular fluctuations of osteopontin. Journal of the Royal Society: Interface, 12(110), 20150506. (doi: 10.1098/rsif.2015.0506) (PMID:26354827)

Thorn, D. C., Ecroyd, H., Carver, J. A. and Holt, C. (2015) Casein structures in the context of unfolded proteins. International Dairy Journal, 46, pp. 2-11. (doi: 10.1016/j.idairyj.2014.07.008)

Lenton, S., Nylander, T., Teixeira, S. C.M. and Holt, C. (2015) A review of the biology of calcium phosphate sequestration with special reference to milk. Dairy Science and Technology, 95(1), pp. 3-14. (doi: 10.1007/s13594-014-0177-2)

Rodriguez, D. E., Thula-Mata, T., Toro, E. J., Yeh, Y.-W., Holt, C. , Holliday, L.S. and Gower, L. B. (2014) Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts. Acta Biomaterialia, 10(1), pp. 494-507. (doi: 10.1016/j.actbio.2013.10.010)

Holt, C. , Carver, J.A., Ecroyd, H. and Thorn, D.C. (2013) Caseins and the casein micelle: their biological functions, structures and behaviour in foods. Journal of Dairy Science, 96(10), pp. 6127-6146. (doi: 10.3168/jds.2013-6831)

Holt, C. (2013) Unfolded phosphopolypeptides enable soft and hard tissues to coexist in the same organism with relative ease. Current Opinion in Structural Biology, 23(3), pp. 420-425. (doi: 10.1016/j.sbi.2013.02.010)

Ossowski, S., Jackson, A., Obiols-Rabasa, M., Holt, C. , Lenton, S., Porcar, L., Paulsson, M. and Nylander, T. (2012) Aggregation behavior of bovine κ- and β-casein studied with small angle neutron scattering, light scattering, and cryogenic transmission electron microscopy. Langmuir, 28(38), pp. 13577-13589. (doi: 10.1021/la302416p)

Holt, C. and Carver, J.A. (2012) Darwinian transformation of a 'scarcely nutritious fluid' into milk. Journal of Evolutionary Biology, 25(7), pp. 1253-1263. (doi: 10.1111/j.1420-9101.2012.02509.x)

Book Sections

Carver, J. A. and Holt, C. (2024) Current concepts of casein and casein micelle structure, interactions, and dynamics. In: El-Bakry, M. and Mehta, B. M. (eds.) Casein: Structural Properties, Uses, Health Benefits and Nutraceutical Applications. Academic Press, pp. 63-98. ISBN 9780443158360 (doi: 10.1016/B978-0-443-15836-0.00002-0)

Book Reviews

Holt, C. , Lenton, S., Nylander, T., Sørensen, E. S. and Teixeira, S. C.M. (2014) Mineralisation of soft and hard tissues and the stability of biofluids. Journal of Structural Biology, 185(3), pp. 383-396. (doi: 10.1016/j.jsb.2013.11.009)[Book Review]

Conference Proceedings

Follows, D., Holt, C. , Thomas, R.K., Tiberg, F., Fragneto, G. and Nylander, T. (2011) Co-adsorption of β-casein and calcium phosphate nanoclusters (CPN) at hydrophilic and hydrophobic solid–solution interfaces studied by neutron reflectometry. In: Food Colloids 2010: On the Road from Interfaces to Consumers, pp. 724-733. (doi: 10.1016/j.foodhyd.2010.09.001)