Dr Alasdair MacDonald
- Research Technician (Molecular Biosciences)
telephone:
01413307555
email:
Alasdair.MacDonald@glasgow.ac.uk
Room 492, Advanced Research Centre, 11 Chapel Lane, College of Medical, Veterinary & Life Sciences, University Avenue, Glasgow, G11 6EW
Publications
2024
MacDonald, A. I., Baksh, A., Holland, A., Shin, H., Rice, P. A., Stark, W. M. and Olorunniji, F. J. (2024) Variable orthogonality of serine integrase interactions within the ϕC31 family. Scientific Reports, 14(1), 26280. (doi: 10.1038/s41598-024-77570-9) (PMID:39487291)
2023
Scott, H. , Dong, L., Stevenson, A., MacDonald, A. I., Srinivasan, S., Massimi, P., Banks, L., Martin, P. E., Johnstone, S. R. and Graham, S. V. (2023) The human Discs large protein (Dlg1) interacts with and maintains Connexin 43 at the plasma membrane in keratinocytes. Journal of Cell Science, 136(11), jcs259984. (doi: 10.1242/jcs.259984) (PMID:37288673) (PMCID:PMC10309592)
Montaño, S. P., Rowland, S.-J., Fuller, J. R., Burke, M. E., MacDonald, A. I., Boocock, M. R., Stark, W. M. and Rice, P. A. (2023) Structural basis for topological regulation of Tn3 resolvase. Nucleic Acids Research, 51(3), pp. 1001-1018. (doi: 10.1093/nar/gkac733) (PMID:36100255) (PMCID:PMC9943657)
2017
Al-Rawhani, M. A. et al. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. IEEE Sensors Journal, 17(2), pp. 240-247. (doi: 10.1109/JSEN.2016.2629018)
Cheah, B. C. , MacDonald, A. I., Barrett, M. P. and Cumming, D. R.S. (2017) Metabolomics on integrated circuit. Procedia Technology, 27, pp. 53-54. (doi: 10.1016/j.protcy.2017.04.025)
2016
McGuinness, D., Anthony, D. F., Moulisova, V. , MacDonald, A. I., Macintyre, A., Thomson, J., Nag, A., Davies, R. W. and Shiels, P. G. (2016) Microvesicles but not exosomes from Pathfinder Cells stimulate functional recovery of the pancreas in a mouse streptozotocin-induced diabetes model. Rejuvenation Research, 19(3), pp. 223-232. (doi: 10.1089/rej.2015.1723)
Cheah, B. C. , MacDonald, A. I., Martin, C., Streklas, A. J., Campbell, G., Al-Rawhani, M. A., Nemeth, B., Grant, J. P. , Barrett, M. P. and Cumming, D. R.S. (2016) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. IEEE Transactions on Biomedical Circuits and Systems, 10(3), pp. 721-730. (doi: 10.1109/TBCAS.2015.2487603) (PMID:26742138)
Klymenko, T., Hernandez-Lopez, H., MacDonald, A.I., Bodily, J. M. and Graham, S. V. (2016) Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes. Journal of Virology, 90(10), pp. 5047-5058. (doi: 10.1128/JVI.03073-15) (PMID:26962216)
Roseweir, A. K. , Qayyum, T., Lim, Z., Hammond, R., MacDonald, A. I., Fraser, S., Oades, G. M., Aitchison, M., Jones, R. J. and Edwards, J. (2016) Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients. BMC Cancer, 16, p. 229. (doi: 10.1186/s12885-016-2254-9) (PMID:26984511) (PMCID:PMC4794832)
2015
Sun, P., Dong, L., MacDonald, A. I., Akbari, S., Edward, M., Hodgins, M. B., Johnstone, S. R. and Graham, S. V. (2015) HPV16 E6 controls the gap junction protein Cx43 in cervical tumour cells. Viruses, 7(10), pp. 5243-5256. (doi: 10.3390/v7102871) (PMID:26445057) (PMCID:PMC4632379)
McGlynn, L. M., McCluney, S., Jamieson, N. B. , Thomson, J., MacDonald, A. I., Oien, K. , Dickson, E. J., Carter, C. R., McKay, C. J. and Shiels, P. G. (2015) SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients. PLoS ONE, 10(6), e0131344. (doi: 10.1371/journal.pone.0131344) (PMID:26121130) (PMCID:PMC4487247)
McFarlane, M. , MacDonald, A. I., Stevenson, A. and Graham, S. V. (2015) Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35). Journal of Virology, 89(10), pp. 5276-5287. (doi: 10.1128/JVI.03434-14) (PMID:25717103)
2014
McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)
2013
McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi: 10.1089/rej.2012.1350)
McCusker, S.M., Macqueen, I., Lough, G., MacDonald, A.I., Campbell, C. and Graham, S.V. (2013) Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland. BMC Public Health, 13(264), (doi: 10.1186/1471-2458-13-264)
Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)
2012
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)
MacDonald, A.I. et al. (2012) A functional interaction between the MAGUK protein hDlg and the gap junction protein Connexin 43 in cervical tumour cells. Biochemical Journal, 446(1), pp. 9-21. (doi: 10.1042/BJ20111144)
2010
Salaun, C., MacDonald, A.I., Larralde, O., Howard, L., Lochtie, K., Burgess, H.M., Brook, M., Malik, P., Gray, N.K. and Graham, S.V. (2010) Poly(A)-binding protein 1 (PABP1) partially relocalises to the nucleus during HSV-1 infection in an ICP27-independent manner and does not inhibit virus replication. Journal of Virology, 84(17), pp. 8539-8548. (doi: 10.1128/JVI.00668-10) (PMID:20573819) (PMCID:PMC2919032)
2008
MacDonald, A.I., Lu, Y., Kilbride, E.A., Akopian, A. and Colloms, S.D. (2008) PepA and ArgR do not regulate Cre recombination at the bacteriophage P1 loxP site. Plasmid, 59(2), pp. 119-126. (doi: 10.1016/j.plasmid.2007.12.001) (PMID:18226834) (PMCID:PMC2409434)
2004
Zhang, M., MacDonald, A. I., Hoyt, M. A. and Coffino, P. (2004) Proteasomes begin ornithine decarboxylase digestion at the C terminus. Journal of Biological Chemistry, 279(20), pp. 20959-20965. (doi: 10.1074/jbc.M314043200) (PMID:15016805)
2002
Chen, H., MacDonald, A. and Coffino, P. (2002) Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Journal of Biological Chemistry, 277(48), pp. 45957-45961. (doi: 10.1074/jbc.M206799200) (PMID:12359729)
Articles
MacDonald, A. I., Baksh, A., Holland, A., Shin, H., Rice, P. A., Stark, W. M. and Olorunniji, F. J. (2024) Variable orthogonality of serine integrase interactions within the ϕC31 family. Scientific Reports, 14(1), 26280. (doi: 10.1038/s41598-024-77570-9) (PMID:39487291)
Scott, H. , Dong, L., Stevenson, A., MacDonald, A. I., Srinivasan, S., Massimi, P., Banks, L., Martin, P. E., Johnstone, S. R. and Graham, S. V. (2023) The human Discs large protein (Dlg1) interacts with and maintains Connexin 43 at the plasma membrane in keratinocytes. Journal of Cell Science, 136(11), jcs259984. (doi: 10.1242/jcs.259984) (PMID:37288673) (PMCID:PMC10309592)
Montaño, S. P., Rowland, S.-J., Fuller, J. R., Burke, M. E., MacDonald, A. I., Boocock, M. R., Stark, W. M. and Rice, P. A. (2023) Structural basis for topological regulation of Tn3 resolvase. Nucleic Acids Research, 51(3), pp. 1001-1018. (doi: 10.1093/nar/gkac733) (PMID:36100255) (PMCID:PMC9943657)
Al-Rawhani, M. A. et al. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. IEEE Sensors Journal, 17(2), pp. 240-247. (doi: 10.1109/JSEN.2016.2629018)
Cheah, B. C. , MacDonald, A. I., Barrett, M. P. and Cumming, D. R.S. (2017) Metabolomics on integrated circuit. Procedia Technology, 27, pp. 53-54. (doi: 10.1016/j.protcy.2017.04.025)
McGuinness, D., Anthony, D. F., Moulisova, V. , MacDonald, A. I., Macintyre, A., Thomson, J., Nag, A., Davies, R. W. and Shiels, P. G. (2016) Microvesicles but not exosomes from Pathfinder Cells stimulate functional recovery of the pancreas in a mouse streptozotocin-induced diabetes model. Rejuvenation Research, 19(3), pp. 223-232. (doi: 10.1089/rej.2015.1723)
Cheah, B. C. , MacDonald, A. I., Martin, C., Streklas, A. J., Campbell, G., Al-Rawhani, M. A., Nemeth, B., Grant, J. P. , Barrett, M. P. and Cumming, D. R.S. (2016) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. IEEE Transactions on Biomedical Circuits and Systems, 10(3), pp. 721-730. (doi: 10.1109/TBCAS.2015.2487603) (PMID:26742138)
Klymenko, T., Hernandez-Lopez, H., MacDonald, A.I., Bodily, J. M. and Graham, S. V. (2016) Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes. Journal of Virology, 90(10), pp. 5047-5058. (doi: 10.1128/JVI.03073-15) (PMID:26962216)
Roseweir, A. K. , Qayyum, T., Lim, Z., Hammond, R., MacDonald, A. I., Fraser, S., Oades, G. M., Aitchison, M., Jones, R. J. and Edwards, J. (2016) Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients. BMC Cancer, 16, p. 229. (doi: 10.1186/s12885-016-2254-9) (PMID:26984511) (PMCID:PMC4794832)
Sun, P., Dong, L., MacDonald, A. I., Akbari, S., Edward, M., Hodgins, M. B., Johnstone, S. R. and Graham, S. V. (2015) HPV16 E6 controls the gap junction protein Cx43 in cervical tumour cells. Viruses, 7(10), pp. 5243-5256. (doi: 10.3390/v7102871) (PMID:26445057) (PMCID:PMC4632379)
McGlynn, L. M., McCluney, S., Jamieson, N. B. , Thomson, J., MacDonald, A. I., Oien, K. , Dickson, E. J., Carter, C. R., McKay, C. J. and Shiels, P. G. (2015) SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients. PLoS ONE, 10(6), e0131344. (doi: 10.1371/journal.pone.0131344) (PMID:26121130) (PMCID:PMC4487247)
McFarlane, M. , MacDonald, A. I., Stevenson, A. and Graham, S. V. (2015) Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35). Journal of Virology, 89(10), pp. 5276-5287. (doi: 10.1128/JVI.03434-14) (PMID:25717103)
McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)
McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi: 10.1089/rej.2012.1350)
McCusker, S.M., Macqueen, I., Lough, G., MacDonald, A.I., Campbell, C. and Graham, S.V. (2013) Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland. BMC Public Health, 13(264), (doi: 10.1186/1471-2458-13-264)
Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)
MacDonald, A.I. et al. (2012) A functional interaction between the MAGUK protein hDlg and the gap junction protein Connexin 43 in cervical tumour cells. Biochemical Journal, 446(1), pp. 9-21. (doi: 10.1042/BJ20111144)
Salaun, C., MacDonald, A.I., Larralde, O., Howard, L., Lochtie, K., Burgess, H.M., Brook, M., Malik, P., Gray, N.K. and Graham, S.V. (2010) Poly(A)-binding protein 1 (PABP1) partially relocalises to the nucleus during HSV-1 infection in an ICP27-independent manner and does not inhibit virus replication. Journal of Virology, 84(17), pp. 8539-8548. (doi: 10.1128/JVI.00668-10) (PMID:20573819) (PMCID:PMC2919032)
MacDonald, A.I., Lu, Y., Kilbride, E.A., Akopian, A. and Colloms, S.D. (2008) PepA and ArgR do not regulate Cre recombination at the bacteriophage P1 loxP site. Plasmid, 59(2), pp. 119-126. (doi: 10.1016/j.plasmid.2007.12.001) (PMID:18226834) (PMCID:PMC2409434)
Zhang, M., MacDonald, A. I., Hoyt, M. A. and Coffino, P. (2004) Proteasomes begin ornithine decarboxylase digestion at the C terminus. Journal of Biological Chemistry, 279(20), pp. 20959-20965. (doi: 10.1074/jbc.M314043200) (PMID:15016805)
Chen, H., MacDonald, A. and Coffino, P. (2002) Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Journal of Biological Chemistry, 277(48), pp. 45957-45961. (doi: 10.1074/jbc.M206799200) (PMID:12359729)
Research datasets
2017
Al-Rawhani, M., Cheah, B. C., MacDonald, A., Martin, C., Hu, C. , Beeley, J., Gouveia, L., Grant, J. , Campbell, G., Barrett, M. and Cumming, D. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. [Data Collection]
2015
Cheah, B. C., MacDonald, A., Martin, C., Streklas, A.J., Campbell, G., Al-Rawhani, M., Nemeth, B., Grant, J. , Barrett, M. and Cumming, D. (2015) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. [Data Collection]