School of Molecular Biosciences

Selman, C. (2024) The dietary exposome: a brief history of diet, longevity and age-related health in rodents. Clinical Science, 138, pp. 1343-1356. (doi: 10.1042/CS20241248)

Ibrahim, R., Dobson, A., Bahilo Martinez, M. (2024) Rapamycin’s lifespan effect is modulated by mito-nuclear epistasis in Drosophila. Aging Cell, (doi: 10.1111/acel.14328)

Woodling, N. (2024) Sex- and strain-dependent effects of ageing on sleep and activity patterns in Drosophila. PLoS ONE, 19, (doi: 10.1371/journal.pone.0308652)

Borland, G., Wilkie, S. E., Thomson, J., Wang, Z., Tullett, J. M.A., Alic, N., Selman, C. (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23, (doi: 10.1111/acel.14141)

Tokatlidis, K. (2024) MIMAS is a new giant multifunctional player in the mitochondrial megacomplex playground. Cell Reports, 43, (doi: 10.1016/j.celrep.2024.113874)

Minnis, H., van Harmelen, A.-L., Gajwani, R., Rizeq, J., Combet, E., Reynolds, R. M., Gillberg, C., Henderson, M., Ho, F. K., Mondelli, V., Pell, J., Smith, J., Shiels, P. G. (2024) The bio-exposome: intracellular processes, stress physiology and the environment. Nature Mental Health, 2, pp. 132-140. (doi: 10.1038/s44220-023-00180-3)

Harnett, M. M., Doonan, J., Tarafdar, A., Pineda, M., Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P., Selman, C., Harnett, W. (2024) The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in Tropical Diseases, 4, (doi: 10.3389/fitd.2023.1334705)

Mafra, D., Ugochukwu, S. A., Borges, N. A., Cardozo, L. F. M. F., Stenvinkel, P., Shiels, P. G. (2024) Food for healthier aging: power on your plate. Critical Reviews in Food Science and Nutrition, 64, pp. 603-616. (doi: 10.1080/10408398.2022.2107611)

Neytchev, O., Erlandsson, H., Witasp, A., Nordfors, L., Qureshi, A. R., Iseri, K., Morohoshi, H., Selman, C., Ebert, T., Kublickiene, K., Stenvinkel, P., Shiels, P. G. (2023) Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing. Journal of Internal Medicine, 295, pp. 79-90. (doi: 10.1111/joim.13724)

Catterson, J. H., Minkley, L., Aspe, S., Judd-Mole, S., Moura, S., Dyson, M. C., Rajasingam, A., Woodling, N. S., Atilano, M. L., Ahmad, M., Durrant, C. S., Spires-Jones, T. L., Partridge, L. (2023) Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Neurobiology of Aging, 132, pp. 154-174. (doi: 10.1016/j.neurobiolaging.2023.09.008)

Gould, E. et al. (2023) Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology. EcoEvoRxiv, (doi: 10.32942/X2GG62)

Sannino, D. R., Dobson, A. J. (2023) Acetobacter pomorum in the Drosophila gut microbiota buffers against host metabolic impacts of dietary preservative formula and batch variation in dietary yeast. Applied and Environmental Microbiology, 89, (doi: 10.1128/aem.00165-23)

Craven, H., Erlandsson, H., McGuinness, D., McGuinness, D., Mafra, D., Ijaz, U. Z., Bergman, P., Shiels, P. G., Stenvinkel, P. (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137, pp. 1563-1575. (doi: 10.1042/CS20230779)

Shiels, P. G. (2023) ‘Debugging’ heart failure. Journal of Internal Medicine, 294, pp. 374-376. (doi: 10.1111/joim.13691)

Sahota, V. K., Stone, A., Woodling, N. S., Spiers, J. G., Steinert, J. R., Partridge, L., Augustin, H. (2023) Plum modulates Myoglianin and regulates synaptic function in D. melanogaster. Open Biology, 13, (doi: 10.1098/rsob.230171)

Dobson, A., Voigt, S., Kumpitsch, L., Langer, L., Voigt, E., Ibrahim, R., Dowling, D., Reinhardt, K. (2023) Mitonuclear interactions shape both direct and parental effects of diet on fitness, and involve a SNP in mitoribosomal 16s rRNA. PLoS Biology, 21, (doi: 10.1371/journal.pbio.3002218)

Zhou, Z., Lo, C. K.M., Chan, K. L., Chung, R. S.Y., Pell, J. P., Minnis, H., Shiels, P. G., Ip, P., Ho, F. K. (2023) Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants. British Journal of Psychiatry, 223, pp. 377-381. (doi: 10.1192/bjp.2023.33)

Panagiotou, N., McGuinness, D., Jaminon, A. M.G., Mees, B., Selman, C., Schurgers, L., Shiels, P. G. (2023) Microvesicle-mediated tissue regeneration mitigates the effects of cellular ageing. Cells, 12, (doi: 10.3390/cells12131707)

Wilkie, S. E., Marcu, D. E., Carter, R. N., Morton, N. M., Gonzalo, S., Selman, C. (2023) Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome. Aging, 15, pp. 5266-5278. (doi: 10.18632/aging.204835)

Kalogeropoulu, S. K., Rauch-Schmücking, H., Lloyd, E. J., Stenvinkel, P., Shiels, P. G., Johnson, R. J., Fröbert, O., Redtenbacher, I., Burgener, I. A., Painer-Gigler, J. (2023) Formerly bile-farmed bears as a model of accelerated ageing. Scientific Reports, 13, (doi: 10.1038/s41598-023-36447-z)

Hamilton, K. L., Selman, C. (2023) Can exercise prevent the age‐related decline in adaptive homeostasis? Evidence across organisms and tissues. Journal of Physiology, 601, pp. 2053-2056. (doi: 10.1113/JP284583)

Salmon, P., Dawson, N. J., Millet, C., Selman, C., Monaghan, P. (2023) Mitochondrial function declines with age within individuals but is not linked to the pattern of growth or mortality risk in zebra finch. Aging Cell, 22, (doi: 10.1111/acel.13822)

Baptista, B. G., Fanton, S., Ribeiro, M., Cardozo, L. F.M.F., Regis, B., Alvarenga, L., Ribeiro-Alves, M., Berretta, A. A., Shiels, P. G., Mafra, D. (2023) The effect of Brazilian green propolis extract on inflammation in patients with chronic kidney disease on peritoneal dialysis: a randomised double-blind controlled clinical trial. Phytomedicine, 114, (doi: 10.1016/j.phymed.2023.154731)

Dai, L., Mafra, D., Shiels, P. G., Hackeng, T. M., Stenvinkel, P., Schurgers, L. J. (2023) Vitamin K and hallmarks of ageing: focus on diet and gut microbiome. Nutrients, 15, (doi: 10.3390/nu15122727)

Hill, C., Duffy, S., Kettyle, L. M., McGlynn, L., Sandholm, N., Salem, R. M., Thompson, A., Swan, E. J., Kilner, J., Rossing, P., Shiels, P. G., Lajer, M., Groop, P.-H., Maxwell, A. P., McKnight, A. J. (2023) Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes. Genes, 14, (doi: 10.3390/genes14051029)

Shiels, P., Tran, N., McCavitt, J., Neytchev, O., Stenvinkel, P. (2023) Chronic kidney disease and the exposome of ageing. Springer

Hobson, S., Arefin, S., Witasp, A., Hernandez, L., Kublickiene, K., Shiels, P.G., Stenvinkel, P. (2023) Accelerated vascular aging in chronic kidney disease: the potential for novel therapies. Circulation Research, 132, pp. 950-969. (doi: 10.1161/CIRCRESAHA.122.321751)

Vitale, M., Sanz, A., Scialò, F. (2023) Mitochondrial redox signaling: a key player in aging and disease. Aging, (doi: 10.18632/aging.204659)

Castejon-Vega, B., Cordero, M. D., Sanz, A. (2023) How the disruption of mitochondrial redox signalling contributes to ageing. Antioxidants, 12, (doi: 10.3390/antiox12040831)

Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N., Kerr, F. (2023) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. Health Open Research, 4, (doi: 10.12688/amrcopenres.13091.2)

Salmón, P., Millet, C., Selman, C., Monaghan, P., Dawson, N. J. (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. GeroScience, 45, pp. 256-276. (doi: 10.1007/s11357-022-00624-1)

Moreira, L. d. S. G., Brum, I. d. S. d. C., de Vargas Reis, D. C.M., Trugilho, L., Chermut, T. R., Esgalhado, M., Cardozo, L. F.M.F., Stenvinkel, P., Shiels, P. G., Mafra, D. (2023) Cinnamon: an aromatic condiment applicable to chronic kidney disease. Kidney Research and Clinical Practice, 42, pp. 4-26. (doi: 10.23876/j.krcp.22.111)

Chan, K. L., Lo, C. K.M., Chen, X.-Y., Ip, P., Leung, W. C., Shiels, P. G., Pell, J. P., Minnis, H., Ho, F. K. (2023) Association between intimate partner violence and leukocyte telomere length: a retrospective cohort study of 144,049 UK Biobank participants. Epidemiology and Psychiatric Sciences, 32, (doi: 10.1017/S2045796023000112)

Mafra, D., Borges, N. A., Alvarenga, L., Ribeiro, M., Fonseca, L., Leal, V. O., Shiels, P. G., Stenvinkel, P. (2023) Fermented food: should patients with cardiometabolic diseases go back to an early neolithic diet? Critical Reviews in Food Science and Nutrition, 63, pp. 10173-10196. (doi: 10.1080/10408398.2022.2077300)

Martínez Corrales, G., Li, M., Svermova, T., Goncalves, A., Voicu, D., Dobson, A. J., Southall, T. D., Alic, N. (2022) Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodelling and Xbp1. Nature Aging, 2, pp. 1176-1190. (doi: 10.1038/s43587-022-00312-x)

Kataura, T. et al. (2022) Autophagy promotes cell survival by maintaining NAD levels. Developmental Cell, 57, pp. 2584-2598.e11. (doi: 10.1016/j.devcel.2022.10.008)

Mafra, D., Ribeiro, M., Fonseca, L., Regis, B., Cardozo, L. F. M. F., Fragoso Dos Santos, H., Emiliano de Jesus, H., Schultz, J., Shiels, P. G., Stenvinkel, P., Rosado, A. (2022) Archaea from the gut microbiota of humans: Could be linked to chronic diseases? Anaerobe, 77, (doi: 10.1016/j.anaerobe.2022.102629)

Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N., Kerr, F. (2022) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. AMRC Open Research, 4, (doi: 10.12688/amrcopenres.13091.1)

Harnett, M. M., Doonan, J., Lumb, F. E., Crowe, J., Damink, R. O., Buitrago, G., Duncombe-Moore, J., Wilkinson, D. I., Suckling, C. J., Selman, C., Harnett, W. (2022) The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing. Frontiers in Immunology, 13, (doi: 10.3389/fimmu.2022.953053)

Ebert, T., Tran, N., Schurgers, L., Stenvinkel, P., Shiels, P. G. (2022) Ageing – oxidative stress, PTMs and disease. Molecular Aspects of Medicine, 86, (doi: 10.1016/j.mam.2022.101099)

Caccavale, E., Johnson, M. P., Brijbassi, S., Andreazza, A. C., Tokatlidis, K. (2022) Mitochondria and Us: from exploration to global collective. Biochemist, 44, pp. 22-28. (doi: 10.1042/bio_2022_122)

Graham, C., Stefanatos, R., Yek, A. E.H., Spriggs, R. V., Loh, S. H.Y., Huerta Uribe, A., Zhang, T., Martins, L. M., Maddocks, O. D.K., Scialo, F., Sanz, A. (2022) Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies. GeroScience, 44, pp. 1961-1974. (doi: 10.1007/s11357-022-00555-x)

Mafra, D., Cardozo, L., Ribeiro-Alves, M., Bergman, P., Shiels, P. G., Stenvinkel, P. (2022) Short Report: Choline plasma levels are related to Nrf2 transcriptional expression in chronic kidney disease? Clinical Nutrition ESPEN, 50, pp. 318-321. (doi: 10.1016/j.clnesp.2022.06.008)

Ledahawsky, L. M., Terzenidou, M. E., Edwards, R., Kline, R. A., Graham, L. C., Eaton, S. L., van der Hoorn, D., Chaytow, H., Huang, Y.‐T., Groen, E. J.N., Motyl, A. A. L., Lamont, D. J., Tokatlidis, K., Wishart, T. M., Gillingwater, T. H. (2022) The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo. FEBS Journal, 289, pp. 3894-3914. (doi: 10.1111/febs.16377)

Dawson, N. J., Millet, C., Selman, C., Metcalfe, N. B. (2022) Inter-individual variation in mitochondrial phosphorylation efficiency predicts growth rates in ectotherms at high temperatures. FASEB Journal, 36, (doi: 10.1096/fj.202101806RR)

de Souza Gouveia Moreira, L., Fanton, S., Cardozo, L., Borges, N. A., Combet, E., Shiels, P. G., Stenvinkel, P., Mafra, D. (2022) Pink pressure: beetroot (Beta vulgaris rubra) as a possible novel medical therapy for chronic kidney disease. Nutrition Reviews, 80, pp. 1041-1061. (doi: 10.1093/nutrit/nuab074)

Javidnia, S., Cranwell, S., Mueller, S. H., Selman, C., Tullet, J. M.A., Kuchenbaecker, K., Alic, N. (2022) Mendelian randomization analyses implicate biogenesis of translation machinery in human aging. Genome Research, 32, pp. 258-265. (doi: 10.1101/gr.275636.121)

Witasp, A., Luttropp, K., Qureshi, A. R., Barany, P., Heimbürger, O., Wennberg, L., Ekström, T. J., Shiels, P. G., Stenvinkel, P., Nordfors, L. (2022) Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy. Scientific Reports, 12, (doi: 10.1038/s41598-021-04321-5)

Tokatlidis, K., Eaglesfield, R. (2021) Targeting and insertion of membrane proteins in mitochondria. Frontiers in Cell and Developmental Biology, 9, (doi: 10.3389/fcell.2021.803205)

Carter, R. N. et al. (2021) The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Reports, 37, (doi: 10.1016/j.celrep.2021.109958)

Cardozo, L. F.M.F., Alvarenga, L. A., Ribeiro, M., Dai, L., Shiels, P. G., Stenvinkel, P., Lindholm, B., Mafra, D. (2021) Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease. Nutrition Reviews, 79, pp. 1204-1224. (doi: 10.1093/nutrit/nuaa129)

Castejón-Vega, B., Rubio, A., Pérez-Pulido, A. J., Quiles, J. L., Lane, J. D., Fernández-Domínguez, B., Cachón-González, M. B., Martín-Ruiz, C., Sanz, A., Cox, T. M., Alcocer-Gómez, E., Cordero, M. D. (2021) L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation. Cells, 10, (doi: 10.3390/cells10113122)

Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M., Selman, C. (2021) Hydrogen sulfide in ageing, longevity and disease. Biochemical Journal, 478, pp. 3485-3504. (doi: 10.1042/BCJ20210517)

Kemp, J. A., Paiva, B. R., dos Santos, H. F., Jesus, H. E., Craven, H., Ijaz, U. Z., Borges, N. A., Shiels, P. G., Mafra, D. (2021) The impact of enriched resistant starch type‐2 cookies on the gut microbiome in hemodialysis patients: a randomized controlled trial. Molecular Nutrition and Food Research, 65, (doi: 10.1002/mnfr.202100374)

Bonfini, A., Dobson, A. J., Duneau, D., Revah, J., Liu, X., Houtz, P., Buchon, N. (2021) Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size. eLife, 10, (doi: 10.7554/elife.64125)

Mulvey, L., Wilkie, S. E., Borland, G., Griffiths, K., Sinclair, A., McGuinness, D., Watson, D. G., Selman, C. (2021) Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice. Molecular and Cellular Endocrinology, 535, (doi: 10.1016/j.mce.2021.111376)

Geldon, S., Fernandez-Vizarra, E., Tokatlidis, K. (2021) Redox-mediated regulation of mitochondrial biogenesis, dynamics and respiratory chain assembly in yeast and human cells. Frontiers in Cell and Developmental Biology, 9, (doi: 10.3389/fcell.2021.720656)

Salmón, P., Millet, C., Selman, C., Monaghan, P. (2021) Growth acceleration results in faster telomere shortening later in life. Proceedings of the Royal Society of London Series B: Biological Sciences, 288, (doi: 10.1098/rspb.2021.1118)

Kulaberoglu, Y., Malik, Y., Borland, G., Selman, C., Alic, N., Tullet, J. M.A. (2021) RNA polymerase III, ageing and longevity. Frontiers in Genetics, 12, (doi: 10.3389/fgene.2021.705122)

Craven, H., McGuinness, D., Buchanan, S., Galbraith, N., Mcguinness, D. H., Jones, B., Combet, E., Mafra, D., Bergman, P., Ellaway, A., Stenvinkel, P., Ijaz, U. Z., Shiels, P. G. (2021) Socioeconomic position links circulatory microbiota differences with biological age. Scientific Reports, 11, (doi: 10.1038/s41598-021-92042-0)

Navas, P., Sanz, A. (2021) Editorial: "Mitochondrial Coenzyme Q Homeostasis: signalling, respiratory chain stability and diseases." Free Radical Biology and Medicine, 169, pp. 12-13. (doi: 10.1016/j.freeradbiomed.2021.04.005)

Ebert, T., Neytchev, O., Witasp, A., Kublickiene, K., Stenvinkel, P., Shiels, P. (2021) Inflammation and oxidative stress in CKD and dialysis patients. Antioxidants and Redox Signaling, 35, pp. 1426-1448. (doi: 10.1089/ars.2020.8184)

Dai, L., Schurgers, L., Shiels, P. G., Stenvinkel, P. (2021) A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of life style diseases. Clinical Science, 135, pp. 1251-1272. (doi: 10.1042/CS20201452)

Edwards, R., Eaglesfield, R., Tokatlidis, K. (2021) The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways. Open Biology, 11, (doi: 10.1098/rsob.210002)

Kooman, J. P., Stenvinkel, P., Shiels, P. G., Feelisch, M., Canaud, B., Kotanko, P. (2021) The oxygen cascade in hemodialysis patients and native high altitude dwellers- lessons from extreme physiology to benefit patients with end-stage renal disease. American Journal of Physiology: Renal Physiology, 320, pp. F249-F261. (doi: 10.1152/ajprenal.00540.2020)

Bolukbasi, E., Woodling, N. S., Ivanov, D. K., Adcott, J., Foley, A., Rajasingam, A., Gittings, L. M., Aleyakpo, B., Niccoli, T., Thornton, J. M., Partridge, L. (2021) Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proceedings of the National Academy of Sciences of the United States of America, 118, (doi: 10.1073/pnas.2011491118)

Scialo, F., Sanz, A. (2021) Coenzyme Q redox signalling and longevity. Free Radical Biology and Medicine, 164, pp. 187-205. (doi: 10.1016/j.freeradbiomed.2021.01.018)

Stenvinkel, P., Painer, J., Shiels, P.G., Bansal, A., Fereidouni, S., Natterson-Horowitz, B., Johnson, R.J., Miranda, J.J. (2021) SARS-COV-2 and biomimetics: what saves the planet will save our health. Journal of Internal Medicine, 289, pp. 244-246. (doi: 10.1111/joim.13128)

Navarro-Pando, J. M., Alcocer-Gómez, E., Castejón-Vega, B., Navarro-Villarán, E., Condés-Hervás, M., Mundi-Roldan, M., Muntané, J., Pérez-Pulido, A. J., Bullon, P., Wang, C., Hoffman, H. M., Sanz, A., Mbalaviele, G., Ryffel, B., Cordero, M. D. (2021) Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances, 7, (doi: 10.1126/sciadv.abc7409)

Fanton, S., Cardozo, L. F.M.F., Combet, E., Shiels, P. G., Stenvinkel, P., Vieira, I. O., Narciso, H. R., Schmitz, J., Mafra, D. (2021) The sweet side of dark chocolate for chronic kidney disease patients. Clinical Nutrition, 40, pp. 15-26. (doi: 10.1016/j.clnu.2020.06.039)

Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G., Evenepoel, P., Stenvinkel, P. (2021) Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nature Reviews Nephrology, 17, pp. 153-171. (doi: 10.1038/s41581-020-00345-8)

Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) Autophagy, 17, pp. 1-382. (doi: 10.1080/15548627.2020.1797280)

Anoar, S., Woodling, N. S., Niccoli, T. (2021) Mitochondria dysfunction in frontotemporal dementia/amyotrophic lateral sclerosis: lessons from drosophila models. Frontiers in Neuroscience, 15, (doi: 10.3389/fnins.2021.786076)

Dimogkioka, A.-R., Lees, J., Tokatlidis, K., Lacko, E. (2021) Protein import in mitochondria biogenesis: Guided by targeting signals and sustained by dedicated chaperones. RSC Advances, 11, pp. 32476-32493. (doi: 10.1039/D1RA04497D)

Dickson-Murray, E., Nedara, K., Modjtahedi, N., Tokatlidis, K. (2021) The Mia40/CHCHD4 oxidative folding system: Redox regulation and signaling in the mitochondrial intermembrane space. Antioxidants, 10, (doi: 10.3390/antiox10040592)

Bjedov, I., Cochemé, H. M., Foley, A., Wieser, D., Woodling, N. S., Castillo-Quan, J. I., Norvaisas, P., Lujan, C., Regan, J. C., Toivonen, J. M., Murphy, M. P., Thornton, J., Kinghorn, K. J., Neufeld, T. P., Cabreiro, F., Partridge, L. (2020) Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in drosophila. PLoS Genetics, 16, (doi: 10.1371/journal.pgen.1009083)

Ebert, T., Painer, J., Bergman, P., Qureshi, A. R., Giroud, S., Stalder, G., Kublickiene, K., Göritz, F., Vetter, S., Bieber, C., Fröbert, O., Arnemo, J. M., Zedrosser, A., Redtenbacher, I., Shiels, P. G., Johnson, R. J., Stenvinkel, P. (2020) Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears. Scientific Reports, 10, (doi: 10.1038/s41598-020-76346-1)

Markopoulou, P., Panagiotou, N., Li, A., Bueno-Perez, R., Madden, D., Buchanan, S., Fairen-Jimenez, D., Shiels, P. G., Forgan, R. S. (2020) Identifying differing intracellular cargo release mechanisms by monitoring in vitro drug delivery from MOFs in real time. Cell Reports Physical Science, 1, (doi: 10.1016/j.xcrp.2020.100254)

Alvarenga, L., Cardozo, L. F.M.F., Borges, N., Bengt, L., Stenvinkel, P., Shiels, P. G., Fouque, D., Mafra, D. (2020) Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease? Food Research International, 136, (doi: 10.1016/j.foodres.2020.109306)

Woodling, N. S., Rajasingam, A., Minkley, L. J., Rizzo, A., Partridge, L. (2020) Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. BMC Biology, 18, (doi: 10.1186/s12915-020-00854-9)

Buchanan, S., Combet, E., Stenvinkel, P., Shiels, P.G. (2020) Klotho, ageing and the failing kidney. Frontiers in Endocrinology, 11, (doi: 10.3389/fendo.2020.00560)

Stenvinkel, P., Shiels, P. G., Painer, J., Miranda, J. J., Natterson-Horowitz, B., Johnson, R. J. (2020) A planetary health perspective for kidney disease. Kidney International, 98, pp. 261-265. (doi: 10.1016/j.kint.2020.03.024)

Yu, Y., Niccoli, T., Ren, Z., Woodling, N. S., Aleyakpo, B., Szabadkai, G., Partridge, L. (2020) PICALM rescues glutamatergic neurotransmission, behavioural function and survival in a Drosophila model of Aβ42 toxicity. Human Molecular Genetics, 29, pp. 2420-2434. (doi: 10.1093/hmg/ddaa125)

Reinhardt, C., Arena, G., Nedara, K., Edwards, R., Brenner, C., Tokatlidis, K., Modjtahedi, N. (2020) AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1866, (doi: 10.1016/j.bbadis.2020.165746)

Arefin, S., Buchanan, S., Hobson, S., Steinmetz, J., Alsalhi, S., Shiels, P. G., Kublickiene, K., Stenvinkel, P. (2020) Nrf2 in early vascular ageing: calcification, senescence and therapy. Clinica Chimica Acta, 505, pp. 108-118. (doi: 10.1016/j.cca.2020.02.026)

Scialò, F., Sriram, A., Stefanatos, R., Spriggs, R. V., Loh, S. H.Y., Martins, L. M., Sanz, A. (2020) Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster. Redox Biology, 32, (doi: 10.1016/j.redox.2020.101450)

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Ebert, T., Pawelzik, S.-C., Witasp, A., Arefin, S., Hobson, S., Kublickiene, K., Shiels, P. G., Bäck, M., Stenvinkel, P. (2020) Inflammation and premature ageing in chronic kidney disease. Toxins, 12, (doi: 10.3390/toxins12040227)

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O'Toole, P.W., Shiels, P. G. (2020) The role of the microbiota in sedentary life style disorders and ageing: lessons from the animal kingdom. Journal of Internal Medicine, 287, pp. 271-282. (doi: 10.1111/joim.13021)

Gray, S. C., Kinghorn, K. J., Woodling, N. S. (2020) Shifting equilibriums in Alzheimer's disease: The complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural Regeneration Research, 15, pp. 1208-1219. (doi: 10.4103/1673-5374.272571)

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Wilkie, S. E., Mulvey, L., Sands, W., Marcu, D. E., Carter, R. N., Morton, N. M., Hine, C., Mitchell, J. R., Selman, C. (2020) Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice. GeroScience, 42, pp. 801-812. (doi: 10.1007/s11357-020-00168-2)

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Stenvinkel, P., Shiels, P. G. (2019) Long-lived animals with negligible senescence: clues for ageing research. Biochemical Society Transactions, 47, pp. 1157-1164. (doi: 10.1042/BST20190105)

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Lang, J., McKie, J., Smith, H., McLaughlin, A., Gillberg, C., Shiels, P. G., Minnis, H. (2019) Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature. European Child and Adolescent Psychiatry, (doi: 10.1007/s00787-019-01329-1)

Ellaway, A., Dundas, R., Robertson, T., Shiels, P. G. (2019) More miles on the clock: neighbourhood stressors are associated with telomere length in a longitudinal study. PLoS ONE, 14, (doi: 10.1371/journal.pone.0214380)

Edwards, R., Tokatlidis, K. (2019) The yeast voltage-dependent anion channel Porin: more IMPORTant than just metabolite transport. Molecular Cell, 73, pp. 861-862. (doi: 10.1016/j.molcel.2019.02.028)

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Ledeganck, K. J., Gielis, E. M., Abramowicz, D., Stenvinkel, P., Shiels, P. G., Van Craenenbroeck, A. H. (2019) MicroRNAs in AKI and kidney transplantation. Clinical Journal of the American Society of Nephrology, 14, pp. 454-468. (doi: 10.2215/CJN.08020718)

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Hobson, S., Arefin, S., Kublickiene, K., Shiels, P. G., Stenvinkel, P. (2019) Senescent cells in early vascular ageing and bone disease of chronic kidney disease—a novel target for treatment. Toxins, 11, (doi: 10.3390/toxins11020082)

Purohit, P. K., Edwards, R., Tokatlidis, K., Saini, N. (2019) MiR-195 regulates mitochondrial function by targeting mitofusin-2 in breast cancer cells. RNA Biology, 16, pp. 918-929. (doi: 10.1080/15476286.2019.1600999)

Wilkinson, M. J.A., Selman, C., McLaughlin, L., Horan, L., Hamilton, L., Gilbert, C., Chadwick, C., Flynn, J. N. (2019) Progressing the care, husbandry and management of ageing mice used in scientific studies. Laboratory Animals, 54, pp. 225-238. (doi: 10.1177/0023677219865291)

Stevenson, R., Shapter, O., Aitken, E., Stevenson, K., Shiels, P.G., Kingsmore, D.B. (2018) Has the expansion in extended criteria deceased donors led to a different type of delayed graft function and poorer outcomes? Transplantation Proceedings, 50, pp. 3160-3164. (doi: 10.1016/j.transproceed.2018.07.022)

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Thompson, K. et al. (2018) OXA 1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Molecular Medicine, 10, (doi: 10.15252/emmm.201809060)

McGuinness, D., Mohammed, S., Monaghan, L., Wilson, P. A., Kingsmore, D. B., Shapter, O., Stevenson, K. S., Coley, S. M., Devey, L., Kirkpatrick, R. B., Shiels, P. G. (2018) A molecular signature for delayed graft function. Aging Cell, 17, (doi: 10.1111/acel.12825)

Salin, K., Villasevil, E. M., Anderson, G. J., Auer, S. K., Selman, C., Hartley, R. C., Mullen, W., Chinopoulos, C., Metcalfe, N. B. (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Functional Ecology, 32, pp. 2149-2157. (doi: 10.1111/1365-2435.13125)

Ellaway, A., Dundas, R., Olsen, J. R., Shiels, P. G. (2018) Perceived neighbourhood problems over time and associations with adiposity. International Journal of Environmental Research and Public Health, 15, (doi: 10.3390/ijerph15091854)

Panagiotou, N., Neytchev, O., Selman, C., Shiels, P. G. (2018) Extracellular vesicles, ageing, and therapeutic interventions. Cells, 7, (doi: 10.3390/cells7080110)

Pacios-Palma, I., Moreno, S., Selman, C., Rouco, C. (2018) Oxidative stress in wild European rabbits naturally infected with myxoma virus and rabbit haemorrhagic disease virus. European Journal of Wildlife Research, 64, (doi: 10.1007/s10344-018-1203-0)

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Maguire, D., Talwar, D., Shiels, P. G., McMillan, D. (2018) The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: a systematic review. Clinical Nutrition ESPEN, 25, pp. 8-17. (doi: 10.1016/j.clnesp.2018.02.007)

Page, M. M., Schuster, E. F., Mudaliar, M., Herzyk, P., Withers, D. J., Selman, C. (2018) Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice. Aging, 10, pp. 1027-1052. (doi: 10.18632/aging.101446)

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Lakhdar, R., McGuinness, D., Drost, E. M., Shiels, P. G., Bastos, R., MacNee, W., Rabinovich, R. A. (2018) Role of accelerated ageing in limb muscle wasting of patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease, 13, pp. 1987-1998. (doi: 10.2147/COPD.S155952)

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Dobson, A. J., Chaston, J. M., Douglas, A. E. (2017) Erratum to: The Drosophila transcriptional network is structured by microbiota. BMC Genomics, 18, (doi: 10.1186/s12864-017-3508-x)

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