Dr Wilma Leslie
- Honorary Research Fellow (School of Medicine, Dentistry & Nursing)
email:
Wilma.Leslie@glasgow.ac.uk
School of Medicine, Dentistry & Nursing,, New Lister Building, Glasgow Royal Infirmary, G31 2ER
Research interests
Visit her Google Scholar page
Dr Leslie, a registered nurse, joined Human Nutrition in 1997 after nine years research experience with the World Health Organisation MONICA project.
Since joining Human Nutrition her research has focused on adult obesity management interventions for weight loss and prevention of weight gain, and interventions to improve nutritional status in the undernourished frail elderly.
Her current role is coordinator for the Diabetes Remission Controlled Trial (DiRECT), the largest study ever funded by Diabetes UK.
Human Nutrition Web page
Publications
2024
Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)
2023
Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)
Sattar, N. , Welsh, P. , Leslie, W. S., Thom, G. , McCombie, L., Brosnahan, N. , Richardson, J. , Gill, J. M. R. , Crawford, L. and Lean, M. E. J. (2023) Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby). Lancet Regional Health – Southeast Asia, 9, 100111. (doi: 10.1016/j.lansea.2022.100111) (PMID:36777452) (PMCID:PMC9904218)
2022
Rehackova, L., Taylor, R., Lean, M. , Barnes, A., McCombie, L., Thom, G. , Brosnahan, N. , Leslie, W. S. and Sniehotta, F. F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)
Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)
2021
Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)
Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)
Brosnahan, N. , Leslie, W., McCombie, L., Barnes, A., Thom, G. , McConnachie, A. , Messow, C. M. , Sattar, N. , Taylor, R. and Lean, M. E.J. (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)
Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)
2020
Xin, Y. , Davies, A., Briggs, A. , McCombie, L., Messow, C. M. , Grieve, E. , Leslie, W. S., Taylor, R. and Lean, M. E.J. (2020) Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme. Diabetologia, 63, pp. 2112-2122. (doi: 10.1007/s00125-020-05224-2) (PMID:32776237) (PMCID:PMC7476973)
2019
Xin, Y. , Davies, A., McCombie, L., Briggs, A. , Messow, C.-M. , Grieve, E. , Leslie, W.S., Taylor, R. and Lean, M.E.J. (2019) Type 2 diabetes remission: economic evaluation of the DiRECT/Counterweight‐Plus weight management programme within a primary care randomized controlled trial. Diabetic Medicine, 36(8), pp. 1003-1012. (doi: 10.1111/dme.13981) (PMID:31026353)
Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)
Xin, Y. , Davies, A., McCombie, L., Briggs, A. , Messow, C.-M. , Grieve, E. , Leslie, W. S., Taylor, R. and Lean, M. E.J. (2019) Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes. Lancet Diabetes and Endocrinology, 7(3), pp. 169-172. (doi: 10.1016/S2213-8587(18)30346-2) (PMID:30581081)
Angelopoulou, K., Leslie, W., McCombie, L., Lean, M. and Hankey, C. (2019) Diabetes and travel insurance costs: let's talk about remission. Practical Diabetes, 36(1), pp. 20-21. (doi: 10.1002/pdi.2205)
2018
Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)
Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)
2017
McCombie, L., Leslie, W., Taylor, R., Kennon, B., Sattar, N. and Lean, M. E.J. (2017) Beating type 2 diabetes into remission. British Medical Journal, 358, j4030. (doi: 10.1136/bmj.j4030) (PMID:28903916)
Leslie, W.S., Taylor, R., Harris, L. and Lean, M.E.J. (2017) Weight losses with low energy formula diets in obese patients with and without type 2 diabetes: Systematic review and meta-analysis. International Journal of Obesity, 41(1), pp. 96-101. (doi: 10.1038/ijo.2016.175) (PMID:27698345)
2016
Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)
2015
Leslie, W. and Hankey, C. (2015) Aging, nutritional status and health. Healthcare, 3(3), pp. 648-658. (doi: 10.3390/healthcare3030648) (PMID:27417787) (PMCID:PMC4939559)
2014
Leslie, W. S., Eunson, J., Murray, L., Lean, M. E. and Hankey, C. R. (2014) What, not just salad and veg? Consumer testing of the eatwell week. Public Health Nutrition, 17(7), pp. 1640-1646. (doi: 10.1017/S1368980013001663)
Al-Gindan, Y.Y., Hankey, C.R., Leslie, W., Govan, L. and Lean, M.E. (2014) Predicting muscle mass from anthropometry using magnetic resonance imaging as reference: a systematic review. Nutrition Reviews, 72(2), pp. 113-126. (doi: 10.1111/nure.12096)
2013
Leslie, W.S., Woodward, M., Lean, M.E.J. , Theobald, H., Watson, L. and Hankey, C.R. (2013) Improving the dietary intake of under nourished older people in residential care homes using an energy-enriching food approach: a cluster randomised controlled study. Journal of Human Nutrition and Dietetics, 26(4), pp. 387-394. (doi: 10.1111/jhn.12020)
Leslie, W.S., Comrie, F., Lean, M.E.J. and Hankey, C.R. (2013) Designing the eatwell week: the application of eatwell plate advice to weekly food intake. Public Health Nutrition, 16(05), pp. 795-802. (doi: 10.1017/S1368980012004193)
Leslie, W.S., Gibson, A. and Hankey, C.R. (2013) Prevention and management of excessive gestational weight gain: a survey of overweight and obese pregnant women. BMC Pregnancy and Childbirth, 13(10), (doi: 10.1186/1471-2393-13-10)
2012
Hankey, C. and Leslie, W. (2012) Obesity: is weight gain after smoking cessation an important concern? Nature Reviews Endocrinology, 8(11), pp. 630-632. (doi: 10.1038/nrendo.2012.175)
Koshy, P., Mackenzie, M. , Leslie, W., Lean, M. and Hankey, C. (2012) Eating the elephant whole or in slices: views of participants in a smoking cessation intervention trial on multiple behaviour changes as sequential or concurrent tasks. BMC Public Health, 12(500), (doi: 10.1186/1471-2458-12-500)
Leslie, W.S., Koshy, P.R., Mackenzie, M. , Murray, H.M., Boyle, S., Lean, M.E.J. , Walker, A. and Hankey, C.R. (2012) Changes in body weight and food choice in those attempting smoking cessation: a cluster randomised controlled trial. BMC Public Health, 12(389), (doi: 10.1186/1471-2458-12-389)
2011
Leslie, W.S. (2011) Improving the dietary intake of frail older people. Proceedings of the Nutrition Society, 70(2), pp. 1-5. (doi: 10.1017/S0029665111000036)
2010
Leslie, W. S., Watson, L. and Hankey, C. R. (2010) An evaluation of an obesity and weight management resource pack. Journal of Human Nutrition and Dietetics, 23(3), pp. 260-263. (doi: 10.1111/j.1365-277X.2009.01034.x)
2009
Mackenzie, M. , Koshy, P., Leslie, W., Lean, M. and Hankey, C. (2009) Getting beyond outcomes: a realist approach to help understand the impact of nutritional intervention during smoking cessation. European Journal of Clinical Nutrition, 63(9), pp. 1136-1142. (doi: 10.1038/ejcn.2009.38)
2002
Hankey, C., Leslie, W.S. and Lean, M.E.J. (2002) Why lose weight? Reasons for seeking weight loss by overweight but otherwise healthy men. International Journal of Obesity, 26, pp. 880-882. (doi: 10.1038/sj.ijo.0801999)
Articles
Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)
Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)
Sattar, N. , Welsh, P. , Leslie, W. S., Thom, G. , McCombie, L., Brosnahan, N. , Richardson, J. , Gill, J. M. R. , Crawford, L. and Lean, M. E. J. (2023) Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby). Lancet Regional Health – Southeast Asia, 9, 100111. (doi: 10.1016/j.lansea.2022.100111) (PMID:36777452) (PMCID:PMC9904218)
Rehackova, L., Taylor, R., Lean, M. , Barnes, A., McCombie, L., Thom, G. , Brosnahan, N. , Leslie, W. S. and Sniehotta, F. F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)
Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)
Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)
Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)
Brosnahan, N. , Leslie, W., McCombie, L., Barnes, A., Thom, G. , McConnachie, A. , Messow, C. M. , Sattar, N. , Taylor, R. and Lean, M. E.J. (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)
Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)
Xin, Y. , Davies, A., Briggs, A. , McCombie, L., Messow, C. M. , Grieve, E. , Leslie, W. S., Taylor, R. and Lean, M. E.J. (2020) Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme. Diabetologia, 63, pp. 2112-2122. (doi: 10.1007/s00125-020-05224-2) (PMID:32776237) (PMCID:PMC7476973)
Xin, Y. , Davies, A., McCombie, L., Briggs, A. , Messow, C.-M. , Grieve, E. , Leslie, W.S., Taylor, R. and Lean, M.E.J. (2019) Type 2 diabetes remission: economic evaluation of the DiRECT/Counterweight‐Plus weight management programme within a primary care randomized controlled trial. Diabetic Medicine, 36(8), pp. 1003-1012. (doi: 10.1111/dme.13981) (PMID:31026353)
Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)
Xin, Y. , Davies, A., McCombie, L., Briggs, A. , Messow, C.-M. , Grieve, E. , Leslie, W. S., Taylor, R. and Lean, M. E.J. (2019) Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes. Lancet Diabetes and Endocrinology, 7(3), pp. 169-172. (doi: 10.1016/S2213-8587(18)30346-2) (PMID:30581081)
Angelopoulou, K., Leslie, W., McCombie, L., Lean, M. and Hankey, C. (2019) Diabetes and travel insurance costs: let's talk about remission. Practical Diabetes, 36(1), pp. 20-21. (doi: 10.1002/pdi.2205)
Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)
Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)
McCombie, L., Leslie, W., Taylor, R., Kennon, B., Sattar, N. and Lean, M. E.J. (2017) Beating type 2 diabetes into remission. British Medical Journal, 358, j4030. (doi: 10.1136/bmj.j4030) (PMID:28903916)
Leslie, W.S., Taylor, R., Harris, L. and Lean, M.E.J. (2017) Weight losses with low energy formula diets in obese patients with and without type 2 diabetes: Systematic review and meta-analysis. International Journal of Obesity, 41(1), pp. 96-101. (doi: 10.1038/ijo.2016.175) (PMID:27698345)
Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)
Leslie, W. and Hankey, C. (2015) Aging, nutritional status and health. Healthcare, 3(3), pp. 648-658. (doi: 10.3390/healthcare3030648) (PMID:27417787) (PMCID:PMC4939559)
Leslie, W. S., Eunson, J., Murray, L., Lean, M. E. and Hankey, C. R. (2014) What, not just salad and veg? Consumer testing of the eatwell week. Public Health Nutrition, 17(7), pp. 1640-1646. (doi: 10.1017/S1368980013001663)
Al-Gindan, Y.Y., Hankey, C.R., Leslie, W., Govan, L. and Lean, M.E. (2014) Predicting muscle mass from anthropometry using magnetic resonance imaging as reference: a systematic review. Nutrition Reviews, 72(2), pp. 113-126. (doi: 10.1111/nure.12096)
Leslie, W.S., Woodward, M., Lean, M.E.J. , Theobald, H., Watson, L. and Hankey, C.R. (2013) Improving the dietary intake of under nourished older people in residential care homes using an energy-enriching food approach: a cluster randomised controlled study. Journal of Human Nutrition and Dietetics, 26(4), pp. 387-394. (doi: 10.1111/jhn.12020)
Leslie, W.S., Comrie, F., Lean, M.E.J. and Hankey, C.R. (2013) Designing the eatwell week: the application of eatwell plate advice to weekly food intake. Public Health Nutrition, 16(05), pp. 795-802. (doi: 10.1017/S1368980012004193)
Leslie, W.S., Gibson, A. and Hankey, C.R. (2013) Prevention and management of excessive gestational weight gain: a survey of overweight and obese pregnant women. BMC Pregnancy and Childbirth, 13(10), (doi: 10.1186/1471-2393-13-10)
Hankey, C. and Leslie, W. (2012) Obesity: is weight gain after smoking cessation an important concern? Nature Reviews Endocrinology, 8(11), pp. 630-632. (doi: 10.1038/nrendo.2012.175)
Koshy, P., Mackenzie, M. , Leslie, W., Lean, M. and Hankey, C. (2012) Eating the elephant whole or in slices: views of participants in a smoking cessation intervention trial on multiple behaviour changes as sequential or concurrent tasks. BMC Public Health, 12(500), (doi: 10.1186/1471-2458-12-500)
Leslie, W.S., Koshy, P.R., Mackenzie, M. , Murray, H.M., Boyle, S., Lean, M.E.J. , Walker, A. and Hankey, C.R. (2012) Changes in body weight and food choice in those attempting smoking cessation: a cluster randomised controlled trial. BMC Public Health, 12(389), (doi: 10.1186/1471-2458-12-389)
Leslie, W.S. (2011) Improving the dietary intake of frail older people. Proceedings of the Nutrition Society, 70(2), pp. 1-5. (doi: 10.1017/S0029665111000036)
Leslie, W. S., Watson, L. and Hankey, C. R. (2010) An evaluation of an obesity and weight management resource pack. Journal of Human Nutrition and Dietetics, 23(3), pp. 260-263. (doi: 10.1111/j.1365-277X.2009.01034.x)
Mackenzie, M. , Koshy, P., Leslie, W., Lean, M. and Hankey, C. (2009) Getting beyond outcomes: a realist approach to help understand the impact of nutritional intervention during smoking cessation. European Journal of Clinical Nutrition, 63(9), pp. 1136-1142. (doi: 10.1038/ejcn.2009.38)
Hankey, C., Leslie, W.S. and Lean, M.E.J. (2002) Why lose weight? Reasons for seeking weight loss by overweight but otherwise healthy men. International Journal of Obesity, 26, pp. 880-882. (doi: 10.1038/sj.ijo.0801999)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Food Choice and changes in body weight and shape in those attempting smoking cessation
Food Standards Agency
2007 - 2010
- Is iron status in dieting pre-menopausal women affected by red meat consumption?
Meat and Livestock Commission
2005 - 2006
