Professor Matthew Walters

Professor of Clinical Pharmacology, Head of School, Medicine, Dentistry & Nursing (Medicine)

telephone: 0141 330 5691
email: Matthew.Walters@glasgow.ac.uk

Room 337, Wolfson Medical School Building, University of Glasgow, Glasgow G12 8QQ

Biography

Professor Matthew Walters is the Head of the School of Medicine, Dentistry and Nursing and Professor of Clinical Pharmacology at the University of Glasgow. The subjects of Medicine, Dentistry and Nursing have been ranked 2^nd, 1^st, and 1^st respectively in the UK since 2017 by the Good University Guide. He is an academic physician whose clinical and research interests lie in the treatment of cerebrovascular disease. He serves on steering, data monitoring and endpoint adjudication committees of major international clinical trials and directed the Scottish Stroke Research Network from 2009 until 2016.

Research interests

I am a CSO Clinician Scientist and Senior Lecturer within the division of Cardiovascular and Medical Sciences. My research interests involve the evaluation and treatment of disordered cerebral perfusion, and I run an active research programme in this area with 5 higher degree students currently under my supervision. Other research themes include the epidemiology of stroke disease, and outcome assessment after stroke.

Current projects include:

Studies of the relationship between carotid plaque composition and biological behaviour using magnetic resonance imaging and transcranial Doppler ultrasound.
Evaluation of reversibility of impaired cerebrovascular nitric oxide bioavailability in patients with diabetes.
Examination of the effect of xanthine oxidase inhibition on the cerebral vasculature.
A comprehensive evaluation of the impact of cerebrovascular disease in Scotland using the database of the Information and Statistics Division of the Scottish Executive.
Evaluation of the potential impact of video-based outcome assessment (using the modified Rankin score) in clinical trials of novel stroke therapies.

Key collaborators in these projects include Professor Henry Dargie, Dr Graeme Houston, Professor Peter Langhorne, Professor Simon Capewell, Professor John McMurray and Dr Kate McIntyre.

My work is supported by sources which include the Chief Scientist Office, Chest Heart and Stroke Scotland, the Translational Medicine Research Collaboration. Income from competitive sources was approximately £600,000 in 2006-2007.

In addition to non-commercial studies I am local Principal Investigator for a number of multicentre clinical trials. Our centre currently leads the UK in recruitment for the ECASS 3 trial of alteplase in acute ischaemic stroke.

Research:

Clinical Trials:

Member:

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999

Number of items: 164.

2024

Misra, S. et al. (2024) Antiseizure Medications in Post-stroke Seizures: A Systematic Review and Network Meta-analysis. American Academy of Neurology (AAN) 2024 Annual Meeting, Denver, Colorado, USA, 13-18 April 2024. (doi: 10.1212/wnl.0000000000205632)

MacDonald, A. S. et al. (2024) Allopurinol and blood pressure variability following ischemic stroke and transient ischemic attack: a secondary analysis of XILO-FIST. Journal of Human Hypertension, 38, pp. 307-313. (doi: 10.1038/s41371-024-00906-5) (PMID:38438602) (PMCID:PMC11001576)

Singh, K. and Walters, M. (2024) Use of mHealth in promoting maternal and child health in ‘BIMARU’ states of India “A health system strengthening strategy”: Systematic Literature Review. PLoS Digital Health, 3(2), e0000403. (doi: 10.1371/journal.pdig.0000403) (PMID:38306391) (PMCID:PMC10836675)

2023

Boyle, J. G., Walters, M. R. , Jamieson, S. and Durning, S. J. (2023) Reframing context specificity in team diagnosis using the theory of distributed cognition. Diagnosis, (doi: 10.1515/dx-2022-0100) (Early Online Publication)

Boyle, J. G., Walters, M. R. , Jamieson, S. and Durning, S. J. (2023) Distributed cognition: theoretical insights and practical applications to health professions education: AMEE Guide No. 159. Medical Teacher, (doi: 10.1080/0142159X.2023.2190479) (PMID:37043405) (Early Online Publication)

Dawson, J. et al. (2023) Xanthine oxidase inhibition and white matter hyperintensity progression following ischaemic stroke and transient ischaemic attack (XILO-FIST): a multicentre, double-blinded, randomised, placebo-controlled trial. EClinicalMedicine, 57, 101863. (doi: 10.1016/j.eclinm.2023.101863) (PMID:36864979) (PMCID:PMC9972492)

2022

Broomfield, N. M., West, R., Barber, M., Quinn, T. J. , Gillespie, D., Walters, M. and House, A. (2022) TEARS: a longitudinal investigation of the prevalence, psychological associations and trajectory of poststroke emotionalism. Journal of Neurology, Neurosurgery and Psychiatry, 93(8), pp. 886-894. (doi: 10.1136/jnnp-2022-329042) (PMID:35483914)

2021

Mark, P. B. et al. (2021) Stroke in hemodialysis patients randomized to different intravenous iron strategies: a prespecified analysis from the PIVOTAL trial. Kidney360, 2(11), pp. 1761-1769. (doi: 10.34067/KID.0004272021)

McPeake, J. , Quasim, T. , Henderson, P., Leyland, A. H. , Lone, N. I., Walters, M. , Iwashyna, T. J. and Shaw, M. (2021) Multimorbidity and its relationship with long-term outcomes following critical care discharge: a prospective cohort study. Chest, 160(5), pp. 1681-1692. (doi: 10.1016/j.chest.2021.05.069) (PMID:34153342)

Learmonth, G. , Benwell, C. S.Y., Märker, G., Dascalu, D., Checketts, M. , Santosh, C., Barber, M., Walters, M. , Muir, K. W. and Harvey, M. (2021) Non-invasive brain stimulation in stroke patients (NIBS): a prospective randomized open blinded end-point (PROBE) feasibility trial using transcranial direct current stimulation (tDCS) in post-stroke hemispatial neglect. Neuropsychological Rehabilitation, 31(8), pp. 1163-1189. (doi: 10.1080/09602011.2020.1767161) (PMID:32498606)

McPeake, J. , Iwashyna, T. J., Henderson, P., Leyland, A. H. , Mackay, D. , Quasim, T. , Walters, M. , Harhay, M. and Shaw, M. (2021) Long term outcomes following critical care hospital admission: a prospective cohort study of UK Biobank participants. Lancet Regional Health - Europe, 6, 100121. (doi: 10.1016/j.lanepe.2021.100121) (PMID:34291229) (PMCID:PMC8278491)

2020

Boyle, J. G., Walters, M. R. , Jamieson, S. and Durning, S. J. (2020) Clinical reasoning in the wild: premature closure during the COVID-19 pandemic. Diagnosis, 7(3), pp. 177-179. (doi: 10.1515/dx-2020-0061) (PMID:32710716)

Alsfouk, B. A. A., Brodie, M. J., Walters, M. , Kwan, P. and Chen, Z. (2020) Tolerability of antiseizure medications in individuals with newly diagnosed epilepsy. JAMA Neurology, 77(5), pp. 574-581. (doi: 10.1001/jamaneurol.2020.0032) (PMID:32091535)

2019

Malik, R. et al. (2019) Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics, (doi: 10.1038/s41588-019-0449-0) (PMID:31160810)

Larsson, S. C. et al. (2019) Serum magnesium and calcium levels in relation to ischemic stroke. Neurology, 92(9), e944-e950. (doi: 10.1212/WNL.0000000000007001) (PMID:30804065) (PMCID:PMC6404465)

Mazlan-Kepli, W., Dawson, J. , Berry, C. and Walters, M. (2019) Cessation of dual antiplatelet therapy and cardiovascular events following acute coronary syndrome. Heart, 105(1), pp. 67-74. (doi: 10.1136/heartjnl-2018-313148) (PMID:30030335)

2018

Learmonth, G. , Muir, K.W. , Benwell, C., Walters, M. and Harvey, M. (2018) Recruitment Issues with Non-invasive Brain Stimulation in Stroke Patients. UK Stroke Forum 2018, Telford, UK, 4-6 Dec 2018. (doi: 10.1177/1747493018801108)

Franceschini, N. et al. (2018) GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nature Communications, 9, 5141. (doi: 10.1038/s41467-018-07340-5) (PMID:30510157) (PMCID:PMC6277418)

Pulit, S. L. et al. (2018) Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. Neurology Genetics, 4(6), e293. (doi: 10.1212/NXG.0000000000000293) (PMID:30584597) (PMCID:PMC6283455)

Cole, J. W. et al. (2018) Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke. PLoS ONE, 13(11), e0206554. (doi: 10.1371/journal.pone.0206554) (PMID:30383853) (PMCID:PMC6211695)

Kaczynski, J., Home, R., Shields, K., Walters, M. , Whiteley, W., Wardlaw, J. and Newby, D. E. (2018) Reproducibility of Transcranial Doppler ultrasound in the middle cerebral artery. Cardiovascular Ultrasound, 16(1), 15. (doi: 10.1186/s12947-018-0133-z) (PMID:30200977) (PMCID:PMC6131943)

Dawson, J. et al. (2018) Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) – Protocol for a randomised double blind placebo-controlled clinical trial. European Stroke Journal, 3(3), pp. 281-290. (doi: 10.1177/2396987318771426) (PMID:30246149) (PMCID:PMC6120121)

Alem, M. M., Alshehri, A. M., Cahusac, P. M.B. and Walters, M. R. (2018) Effect of xanthine oxidase inhibition on arterial stiffness in patients with chronic heart failure. Clinical Medicine Insights: Cardiology, 12, pp. 1-10. (doi: 10.1177/1179546818779584) (PMID:29899669) (PMCID:PMC5992797)

Langhorne, P. et al. (2018) Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study. Lancet, 391(10134), pp. 2019-2027. (doi: 10.1016/S0140-6736(18)30802-X) (PMID:29864018)

Malik, R. et al. (2018) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics, 50(4), pp. 524-537. (doi: 10.1038/s41588-018-0058-3) (PMID:29531354) (PMCID:PMC5968830)

Ghouri, A., Boachie, C., McDowall, S. , Parle, J., Ditchfield, C. A. , McConnachie, A. , Walters, M. R. and Ghouri, N. (2018) Gaining an advantage by sitting an OSCE after your peers: a retrospective study. Medical Teacher, 40(11), pp. 1136-1142. (doi: 10.1080/0142159X.2018.1458085) (PMID:29687736)

Ghouri, A., Boachie, C., McDowall, S. , Parle, J., Ditchfield, C. A. , McConnachie, A. , Walters, M. R. and Ghouri, N. (2018) Response to: Is there such a thing as a fair OSCE? Medical Teacher, 40(11), pp. 1192-1193. (doi: 10.1080/0142159X.2018.1500949) (PMID:30422024)

Ghouri, A., Boachie, C., McDowall, S. , Parle, J., Ditchfield, C. A. , McConnachie, A. , Walters, M. R. and Ghouri, N. (2018) Response to: Response to: Gaining an advantage by sitting an OSCE after your peers: a retrospective study. Medical Teacher, 40(11), pp. 1194-1195. (doi: 10.1080/0142159X.2018.1500909) (PMID:30444172)

2017

Mazlan-Kepli, W., MacIsaac, R. L., Walters, M. , Bath, P. M. W. and Dawson, J. (2017) Interruption to antiplatelet therapy early after acute ischaemic stroke: A nested case-control study. British Journal of Clinical Pharmacology, 83(9), pp. 2045-2055. (doi: 10.1111/bcp.13290) (PMID:28299795)

MacDonald, T. M. et al. (2017) Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT). European Heart Journal, 38(23), pp. 1843-1850. (doi: 10.1093/eurheartj/ehw387) (PMID:27705888) (PMCID:PMC5837371)

Learmonth, G. , Benwell, C.S.Y., Walters, M. , Muir, K. and Harvey, M. (2017) Feasibility of Multi-Session tDCS in Rehabilitating Post-Stroke Hemispatial Neglect. 2nd International Congress on NeuroRehabilitation and Neural Repair, Maastricht, The Netherlands, 22-24 May 2017.

Cannon, J. A., Moffitt, P., Perez-Moreno, A. C., Walters, M. R. , Broomfield, N. M., McMurray, J. J.V. and Quinn, T. J. (2017) Cognitive impairment and heart failure: systematic review and meta-analysis. Journal of Cardiac Failure, (doi: 10.1016/j.cardfail.2017.04.007) (PMID:28433667)

Mazlan-Kepli, W., Macisaac, R. L., Walters, M. , Bath, P. M.W. and Dawson, J. (2017) Antiplatelet therapy following ischaemic stroke – continue or change pre-existing therapy? European Stroke Journal, 2(1), pp. 31-36. (doi: 10.1177/2396987316678728)

Wilson, A. et al. (2017) Understanding the relationship between costs and the modified Rankin Scale: A systematic review, multidisciplinary consensus and recommendations for future studies. European Stroke Journal, 2(1), pp. 3-12. (doi: 10.1177/2396987316684705)

Tziotzios, C., Dawson, J., Walters, M. and Lees, K. R. (2017) Stroke in Practice: From Diagnosis to Evidence-Based Management. CRC Press. ISBN 9781315383705 (doi: 10.4324/9781315383705)

2016

Al-Alshaikh, S., Quinn, T. , Dunn, W., Walters, M. and Dawson, J. (2016) Predictive factors of non-adherence to secondary preventative medication after stroke or transient ischaemic attack: A systematic review and meta-analyses. European Stroke Journal, 1(2), pp. 65-75. (doi: 10.1177/2396987316647187)

Oldroyd, C. K., Walters, M. and Dani, K. (2016) Raised intracranial pressure secondary to vitamin overdose. American Journal of Medicine, 129(6), e9-e10. (doi: 10.1016/j.amjmed.2015.11.023) (PMID:26706388)

Traylor, M., Adib-Samii, P., Harold, D., Dichgans, M., Williams, J., Lewis, C. M., Markus, H. S. and METASTROKE Group, (2016) Shared genetic contribution to ischemic stroke and Alzheimer's disease. Annals of Neurology, 79(5), pp. 739-747. (doi: 10.1002/ana.24621) (PMID:26913989) (PMCID:PMC4864940)

Al AlShaikh, S., Quinn, T. , Dunn, W., Walters, M. and Dawson, J. (2016) Multimodal interventions to enhance adherence to secondary preventive medication after stroke: a systematic review and meta-analyses. Cardiovascular Therapeutics, 34(2), pp. 85-93. (doi: 10.1111/1755-5922.12176)

Hewitt, J., Walters, M. , Padmanabhan, S. and Dawson, J. (2016) Cohort profile of the UK Biobank: diagnosis and characteristics of cerebrovascular disease. BMJ Open, 6(3), e009161. (doi: 10.1136/bmjopen-2015-009161) (PMID:27006341) (PMCID:PMC4809076)

MacIsaac, R., Janek, S., Higgins, P., Walters, M. R. , Padmanabhan, S. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2016) Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension, 67(3), pp. 535-540. (doi: 10.1161/HYPERTENSIONAHA.115.06344) (PMID:26865199)

Cheng, Y.-C. et al. (2016) Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2. Stroke, 47(2), pp. 307-316. (doi: 10.1161/STROKEAHA.115.011328) (PMID:26732560) (PMCID:PMC4729659)

Dawson, J. et al. (2016) Safety, feasibility, and efficacy of vagus nerve stimulation paired with upper-limb rehabilitation after ischemic stroke. Stroke, 47(1), pp. 143-150. (doi: 10.1161/STROKEAHA.115.010477) (PMID:26645257) (PMCID:PMC4689175)

2015

Cameron, A. C., Mccallum, L., Gardiner, T., Darroch, C., Walters, M. R. and Oldroyd, K. G. (2015) Impact of treatment algorithms on the prescribing of antithrombotic therapy in patients with suspected acute coronary syndrome - a prospective audit. British Journal of Clinical Pharmacology, 80(5), pp. 1176-1184. (doi: 10.1111/bcp.12714) (PMID:26147691)

Mccallum, L. et al. (2015) Longitudinal blood pressure control, long-term mortality and predictive utility of serum liver enzymes and bilirubin in hypertensive patients. Hypertension, 66(1), pp. 37-43. (doi: 10.1161/HYPERTENSIONAHA.114.04915) (PMID:25941342) (PMCID:PMC4461392)

Fulton, R. L., Walters, M. R. , Morton, R., Touyz, R. M. , Dominiczak, A. F. , Morrison, D. S., Padmanabhan, S. , Meredith, P. A., McInnes, G. T. and Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65(5), 1008-U596. (doi: 10.1161/HYPERTENSIONAHA.114.04945) (PMID:25801870)

Cowey, E. , Smith, L. N., Stott, D. J. , McAlpine, C. H., Mead, G. E., Barber, M. and Walters, M. (2015) Impact of a clinical pathway on end-of-life care following stroke: a mixed methods study. Palliative Medicine, 29(3), pp. 249-259. (doi: 10.1177/0269216314551378) (PMID:25249241)

Lewsey, J. et al. (2015) Temporal trends and risk factors for readmission for infections, gastrointestinal and immobility complications after an incident hospitalisation for stroke in Scotland between 1997 and 2005. BMC Neurology, 15(3), (doi: 10.1186/s12883-014-0257-1) (PMID:25591718) (PMCID:PMC4320501)

2014

Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S. , McCallum, L., Walters, M. R. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5), pp. 1102-1107. (doi: 10.1161/HYPERTENSIONAHA.114.03953) (PMID:25135183)

Dunn, W. G. and Walters, M. R. (2014) A randomised crossover trial of the acute effects of a deep-fried Mars bar or porridge on the cerebral vasculature. Scottish Medical Journal, 59(4), pp. 182-187. (doi: 10.1177/0036933014552359)

Broomfield, N. M., Quinn, T. , Abdul-Rahim, A. H. , Walters, M. R. and Evans, J. J. (2014) Depression and anxiety symptoms post-stroke/TIA: prevalence and associations in cross-sectional data from a regional stroke registry. BMC Neurology, 14, p. 198. (doi: 10.1186/s12883-014-0198-8)

Kilarski, L. L. et al. (2014) Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology, 83(8), pp. 678-685. (doi: 10.1212/WNL.0000000000000707) (PMID:25031287) (PMCID:PMC4150131)

Broomfield, N. M., Scoular, A., Welsh, P., Walters, M. and Evans, J. J. (2014) Poststroke anxiety is prevalent at the population level, especially among socially deprived and younger age community stroke survivors. International Journal of Stroke, 10(6), pp. 897-902. (doi: 10.1111/ijs.12109) (PMID:24206439)

Jennings, C. G. et al. (2014) Up-titration of allopurinol in patients with gout. Seminars in Arthritis and Rheumatism, 44(1), pp. 25-30. (doi: 10.1016/j.semarthrit.2014.01.004)

Traylor, M. et al. (2014) A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS Genetics, 10(7), e1004469. (doi: 10.1371/journal.pgen.1004469) (PMID:25078452) (PMCID:PMC4117446)

Higgins, P., Walters, M. R. , Murray, H. M., McArthur, K., McConnachie, A. , Lees, K. R. and Dawson, J. (2014) Allopurinol reduces brachial and central blood pressure, and carotid intima-media thickness progression after ischaemic stroke and transient ischaemic attack: a randomised controlled trial. Heart, 100(14), pp. 1085-1092. (doi: 10.1136/heartjnl-2014-305683)

Bushnell, C. et al. (2014) Guidelines for the prevention of stroke in women. Stroke, 45(5), pp. 1545-1588. (doi: 10.1161/01.str.0000442009.06663.48) (PMID:24503673)

Kepli, W. M., Fulton, R. L., Walters, M. , Ali, M. , Bath, P. M. and Dawson, J. (2014) Antiplatelet therapy following ischemic stroke - continue or change pre-existing therapy? In: International Stroke Conference 2014, San Diego, CA, USA, 12-14 Feb 2014, A135.

MacDonald, T. M. et al. (2014) Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia. BMJ Open, 4(7), e005354. (doi: 10.1136/bmjopen-2014-005354)

McCallum, L. et al. (2014) Response to effect of serum chloride on mortality in hypertensive patients. Hypertension, 63(3), e15-e15. (doi: 10.1161/HYPERTENSIONAHA.113.02926)

Williamson, C. et al. (2014) Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients. European Heart Journal, 35(9), pp. 563-570. (doi: 10.1093/eurheartj/eht539)

2013

McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62(5), pp. 836-843. (doi: 10.1161/HYPERTENSIONAHA.113.01793)

Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62(1), pp. 190-196. (doi: 10.1161/HYPERTENSIONAHA.111.00686)

Morgan, T.C. et al. (2013) The modified graeb score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome. Stroke, 44(3), pp. 635-641. (doi: 10.1161/STROKEAHA.112.670653)

Bottle, A., Mozid, A., Grocott, H.P., Walters, M.R. , Lees, K.R., Aylin, P. and Sanders, R.D. (2013) Preoperative risk factors in 10 418 patients with prior myocardial infarction and 5241 patients with prior unstable angina undergoing elective coronary artery bypass graft surgery. British Journal of Anaesthesia, 111(3), pp. 417-423. (doi: 10.1093/bja/aet107)

Dawson, J. et al. (2013) Acetaminophen use and change in blood pressure in a hypertensive population. Journal of Hypertension, 31(7), pp. 1485-1490. (doi: 10.1097/HJH.0b013e328360f6f8)

Dawson, J. et al. (2013) Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension, 62(1), pp. 105-111. (doi: 10.1161/HYPERTENSIONAHA.113.00859)

Hastie, C. et al. (2013) Long-term and ultra-long term blood pressure variability during follow–up and mortality in 14522 patients with hypertension. Hypertension, 62(4), pp. 698-705. (doi: 10.1161/HYPERTENSIONAHA.113.01343) (PMID:23959561)

Kaste, M., Murayama, S., Ford, G.A., Dippel, D.W.J., Walters, M.R. and Tatlisumak, T. (2013) Safety, tolerability and pharmacokinetics of MCI-186 in patients with acute ischemic stroke: new formulation and dosing regimen. Cerebrovascular Diseases, 36(3), pp. 196-204. (doi: 10.1159/000353680)

McArthur, K.S., Johnson, P.C.D. , Quinn, T. , Higgins, P., Langhorne, P. , Walters, M.R. , Weir, C.J., Dawson, J. and Lees, K.R. (2013) Improving the efficiency of stroke trials: feasibility and efficacy of group adjudication of functional end points. Stroke, 14(12), pp. 3422-3428. (doi: 10.1161/STROKEAHA.113.002266)

2012

Traylor, M. et al. (2012) Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. Lancet Neurology, 11(11), pp. 951-962. (doi: 10.1016/S1474-4422(12)70234-X)

Paul, L. et al. (2012) Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults. Hypertension, 60(3), pp. 631-638. (doi: 10.1161/HYPERTENSIONAHA.112.191510)

Dawson, J. , Quinn, T. , Lees, K.R. and Walters, M.R. (2012) Microembolic signals and aspirin resistance in patients with carotid stenosis. Cardiovascular Therapeutics, 30(4), pp. 234-239. (doi: 10.1111/j.1755-5922.2010.00259.x)

Higgins, P., Dawson, J. , Lees, K.R., McArthur, K., Quinn, T.J. and Walters, M.R. (2012) Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis. Cardiovascular Therapeutics, 30(4), pp. 217-226. (doi: 10.1111/j.1755-5922.2011.00277.x)

Bellenguez, C. et al. (2012) Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nature Genetics, 44(3), pp. 328-333. (doi: 10.1038/ng.1081)

Dawson, J. , Walters, M. , Delles, C. , Mischak, H. and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7(5), e35879. (doi: 10.1371/journal.pone.0035879) (PMID:22615742) (PMCID:PMC3353991)

2011

Quinn, T.J. , Dawson, J. and Walters, M.R. (2011) Sugar and stroke: cerebrovascular disease and blood glucose control. Cardiovascular Therapeutics, 29(6), e31-e42. (doi: 10.1111/j.1755-5922.2010.00166.x)

Yeap, P., Tziotzios, C., McMillan, N. and Walters, M. (2011) A small left pupil and a headache. Clinical Medicine, 11(4), pp. 402-404.

Macpherson, K.J. et al. (2011) Trends in incidence and in short term survival following a subarachnoid haemorrhage in Scotland, 1986 - 2005: a retrospective cohort study. BMC Neurology, 11(1), p. 38. (doi: 10.1186/1471-2377-11-38)

Cameron, A., Dawson, J. , Quinn, T.J. , Walters, M.R. , McInnes, G.T., Morrison, D., Sloan, W. and Lees, K.R. (2011) Long-term outcome following attendance at a transient ischemic attack clinic. International Journal of Stroke, 6(4), pp. 306-311. (doi: 10.1111/j.1747-4949.2011.00591.x)

Higgins, P., Dawson, J. and Walters, M. (2011) Nanomedicine: Nanotubes reduce stroke damage. Nature Nanotechnology, 6(6), pp. 83-84. (doi: 10.1038/nnano.2011.5)

Higgins, P., Ferguson, L. D. and Walters, M. R. (2011) Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Expert Review of Cardiovascular Therapy, 9(4), pp. 399-401. (doi: 10.1586/erc.11.29) (PMID:21517722)

Kerr, G.D., Higgins, P., Walters, M. , Ghosh, S.K., Wright, F., Langhorne, P. and Stott, D.J. (2011) Socioeconomic status and transient ischaemic attack / stroke: a prospective observational study. Cerebrovascular Diseases, 31(2), pp. 130-137. (doi: 10.1159/000321732)

McArthur, K.S., Quinn, T.J. , Dawson, J. and Walters, M.R. (2011) Diagnosis and management of transient ischaemic attack and ischaemic stroke in the acute phase. British Medical Journal, 342, d1938. (doi: 10.1136/bmj.d1938)

Nunn, K.P., Bridgett, M.R., Walters, M.R. and Walker, I. (2011) All I want for coagulation. Scottish Medical Journal, 56(4), pp. 183-187. (doi: 10.1258/smj.2011.011154)

Tziotzios, C. and Walters, M. (2011) Keep your eyes open: an unusual case of ptosis. QJM: An International Journal of Medicine, 104(3), pp. 257-258. (doi: 10.1093/qjmed/hcq093)

Tziotzios, C., Walters, M. and Biesecker, L.G. (2011) More than just a big thumb. QJM: An International Journal of Medicine, 104(11), pp. 989-991. (doi: 10.1093/qjmed/hcq226)

2010

Quinn, T.J. , Dawson, J. and Walters, M. (2010) Equality of access to “fast-track” stroke services in an older, socio-economically deprived Scottish population. Scottish Medical Journal, 55(3), pp. 18-21.

Bayes, H. K., Oyeniran, O., Shepherd, M. and Walters, M. (2010) Clinical Audit: Management of Acute Severe Asthma in West Glasgow. Scottish Medical Journal, 55(1), pp. 6-9. (doi: 10.1258/rsmsmj.55.1.6)

Dawson, J. , Quinn, T.J. , Rafferty, M., Higgins, P., Ray, G., Lees, K.R. and Walters, M.R. (2010) Aspirin resistance and compliance with therapy. Cardiovascular Therapeutics, 29(5), pp. 301-307. (doi: 10.1111/j.1755-5922.2010.00188.x)

Langhorne, P. et al. (2010) Estimating the impact of stroke unit care in a whole population: an epidemiological study using routine data. Journal of Neurology, Neurosurgery and Psychiatry, 81(2), pp. 1301-1305. (doi: 10.1136/jnnp.2009.195131)

Lewsey, J. et al. (2010) Temporal trends in hospitalisation for stroke recurrence following incident hospitalisation for stroke in Scotland. BMC Medicine, 8, p. 23. (doi: 10.1186/1741-7015-8-23)

McArthur, K., Dawson, J. and Walters, M. (2010) What is it with the weather and stroke? Expert Review of Neurotherapeutics, 10(2), pp. 243-249. (doi: 10.1586/ERN.09.154)

Rafferty, M., Walters, M.R. and Dawson, J. (2010) Anti-Platelet Therapy and Aspirin Resistance - Clinically and Chemically Relevant? Current Medicinal Chemistry, 17(36), pp. 4578-4586. (doi: 10.2174/092986710794182962)

2009

Dawson, J., Quinn, T.J., Harrow, C., Lees, K.R. and Walters, M. (2009) The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial. British Journal of Clinical Pharmacology, 68(5), pp. 662-668. (doi: 10.1111/j.1365-2125.2009.03497.x)

Lewsey, J. et al. (2009) Age- and sex-specific trends in fatal incidence and hospitalized incidence of stroke in Scotland, 1986 to 2005. Circulation: Cardiovascular Quality and Outcomes, 2(5), pp. 475-483. (doi: 10.1161/CIRCOUTCOMES.108.825968)

Quinn, T.J. , Dawson, J. , Walters, M. and Lees, K.R. (2009) Functional outcome measures in contemporary stroke trials. International Journal of Stroke, 4(3), pp. 200-205. (doi: 10.1111/j.1747-4949.2009.00271.x) (PMID:19659822)

Lewsey, J.D. et al. (2009) Sex differences in incidence, mortality, and survival in individuals with stroke in Scotland, 1986 to 2005. Stroke, 40(4), pp. 1038-1043. (doi: 10.1161/STROKEAHA.108.542787)

Dawson, J., Lees, K., Weir, C., Weir, C., Quinn, T., Ali, M., Hennerici, M. and Walters, M. (2009) Baseline Serum Urate and 90-Day Functional Outcomes following Acute Ischemic Stroke. Cerebrovascular Diseases, 28(2), pp. 202-203.

Dawson, J., Quinn, T. and Walters, M. (2009) Under the weather with stroke; more data emerge. International Journal of Stroke, 4(1), pp. 19-20.

Dawson, J. , Lamb, K.E., Quinn, T.J., Lees, K.R., Horvers, M., Verrijth, M.J. and Walters, M. (2009) A recognition tool for transient ischaemic attack. QJM: An International Journal of Medicine, 102(1), pp. 43-49. (doi: 10.1093/qjmed/hcn139)

Dawson, J., Quinn, T.J., Harrow, C., Lees, K.R., Weir, C., Cleland, S. and Walters, M. (2009) Allopurinol and nitric oxide activity in the cerebral circulation of those with diabetes. Diabetes Care, 32(1), pp. 135-137. (doi: 10.2337/dc08-1179)

Quinn, T.J. , Cameron, A., Dawson, J. , Lees, K.R. and Walters, M.R. (2009) ABCD2 scores and prediction of noncerebrovascular diagnoses in an outpatient population: a case-control study. Stroke, 40(3), pp. 749-753. (doi: 10.1161/STROKEAHA.108.530444)

Quinn, T.J. , Cameron, A.D., Dawson, J. , Walters, M. and Lees, K.R. (2009) A prospective study using the ABCD2 score in screening for minor stroke or transient ischaemic attack in referrals to a fast track clinic response. Stroke, 40(6), e468-e468. (doi: 10.1161/STROKEAHA.109.551077) (PMID:19390063)

Quinn, T.J. , Dawson, J. , Walters, M. and Lees, K.R. (2009) Exploring the reliability of the modified Rankin Scale. Stroke, 40(3), pp. 762-766. (doi: 10.1161/STROKEAHA.108.522516)

Quinn, T.J. , Dawson, J. , Walters, M. and Lees, K.R. (2009) Reliability of the modified Rankin Scale: a systematic review. Stroke, 40(10), pp. 3393-3395. (doi: 10.1161/STROKEAHA.109.557256)

Stewart, L., McInnes, G.T., Murray, L., Sloan, B., Walters, M., Morton, R., Padmanabhan, S., Reid, J.L. and Morrison, D.S. (2009) Risks of socioeconomic deprivation on mortality in hypertensive patients. Journal of Hypertension, 27(4), pp. 730-735. (doi: 10.1097/HJH.0b013e328324ed58)

2008

Muir, S.W., Harrow, C., Dawson, J. , Lees, K.R., Weir, C.J., Sattar, N. and Walters, M.R. (2008) Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial. Stroke, 39(12), pp. 3303-3307. (doi: 10.1161/STROKEAHA.108.519793)

Ahmad, F., Quinn, T. J. , Dawson, J. and Walters, M. (2008) A link between lunar phase and medically unexplained stroke symptoms: An unearthly influence? Journal of Psychosomatic Research, 65(2), pp. 131-133. (doi: 10.1016/j.jpsychores.2008.05.011) (PMID:18655857)

Quinn, T.J. , Dawson, J. , Lees, J.S. , Chang, T.P., Walters, M.R. and Lees, K.R. (2008) Time spent at home poststroke: “home-time” a meaningful and robust outcome measure for stroke trials. Stroke, 39(1), pp. 231-233. (doi: 10.1161/STROKEAHA.107.493320)

Dawson, J. , Quinn, T.J. , Lees, K.R. and Walters, M. (2008) The continued yin and yang of uric acid. Stroke, 39(1), e9-e9. (doi: 10.1161/STROKEAHA.107.502245)

Dawson, J. , Quinn, T.J. and Walters, M. (2008) Uric acid: neuroprotective or neurotoxic? [reply]. Stroke, 39(5), e89-e89. (doi: 10.1161/STROKEAHA.108.515635)

Dawson, J. , Weir, C., Wright, F., Bryden, C., Aslanyan, S., Lees, K., Bird, W. and Walters, M. (2008) Associations between meteorological variables and acute stroke hospital admissions in the west of Scotland. Acta Neurologica Scandinavica, 117(2), pp. 85-89. (doi: 10.1111/j.1600-0404.2007.00916.x)

Lees, K.R. et al. (2008) Thrombolytic therapy for acute stroke in the United Kingdom: experience from the safe implementation of thrombolysis in stroke (SITS) register. QJM: An International Journal of Medicine, 101(11), pp. 863-869. (doi: 10.1093/qjmed/hcn102)

Mackinnon, B., Padmanabhan, S., Murray, L., Sloan, W., Meredith, P., Reid, J., Walters, M., Jardine, A. , Simpson, K. and McInnes, G. (2008) Is end stage renal disease a common outcome among patients attending a hypertension clinic? Journal of Hypertension, 26, S112-S112.

McCormick, M.T., Muir, K.W. , Gray, C.S. and Walters, M.R. (2008) Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke, 39(7), pp. 2177-2185. (doi: 10.1161/STROKEAHA.107.496646)

McInnes, C., McAlpine, C. and Walters, M. (2008) Effect of gender on stroke management in Glasgow. Age and Ageing, 37(2), pp. 220-222.

Quinn, T.J. , Dawson, J. and Walters, M. (2008) Dr John Rankin; His life, legacy and the 50th anniversary of the Rankin stroke scale. Scottish Medical Journal, 53(1), pp. 44-47.

Quinn, T.J. , Dawson, J. , Walters, M. and Lees, K.R. (2008) Variability in modified rankin scoring across a large cohort of observers. Stroke, 39(11), pp. 2975-2979. (doi: 10.1161/STROKEAHA.108.515262)

Quinn, T.J. , Ray, G., Atula, S., Walters, M.R. , Dawson, J. and Lees, K.R. (2008) Deriving modified rankin scores from medical records. Stroke, 39(12), pp. 3421-3423. (doi: 10.1161/STROKEAHA.108.519306)

Shah, I.M., Walters, M. and McKillop, J.H. (2008) Acute medicine teaching in an undergraduate medical curriculum: a blended learning approach. Emergency Medicine Journal, 25(6), pp. 354-357. (doi: 10.1136/emj.2007.053082)

2007

Weir, R. A.P., Oldroyd, K. G. and Walters, M. R. (2007) Myocardial infarction after oral Sumatriptan use in a woman with normal coronary arteries. American Journal of Medicine, 120(11), E7-E8. (doi: 10.1016/j.amjmed.2006.03.047)

Quinn, T.J. , Dawson, J. , Walters, M.R. and Lees, K.R. (2007) Reliability of the modified rankin scale. Stroke, 38(11), e144. (doi: 10.1161/STROKEAHA.107.490110)

Alem, M., Cleland, S., Nazir, F., Small, M. and Walters, M. (2007) Inhibition of nitric oxide increases arterial stiffness in Type 2 diabetic patients. Diabetic Medicine, 24(7), pp. 803-804.

Dawson, J., Lamb, K., Horvers, M., Verrijth, M., Lees, K. and Walters, M. (2007) A recognition tool for evaluation of suspected transient ischemic attack. Stroke, 38(2), p. 487.

Dawson, J. et al. (2007) Serum uric acid and stroke in hypertension: Influence of gender. Journal of Hypertension, 25, S277-S278.

Dawson, J., Nalci, Y., McInnes, G., Murray, L., Morton, R., Radziwonik, S., Sloan, W. and Walters, M. (2007) Serum uric acid and stroke mortality in patients with hypertension. Journal of Human Hypertension, 21(10), pp. 843-844.

Dawson, J. , Lees, J.S. , Chang, T.P., Walters, M.R. , Ali, M. , Davis, S.M., Diener, H.C. and Lees, K.R. (2007) Association between disability measures and healthcare costs after initial treatment for acute stroke. Stroke, 38(6), pp. 1893-1898. (doi: 10.1161/STROKEAHA.106.472381)

Dawson, J. , Quinn, T.J. and Walters, M. (2007) Uric acid reduction: A new paradigm in the management of cardiovascular risk? Current Medicinal Chemistry, 14(17), pp. 1879-1886.

Finn, D., Dawson, J., Murray, L., Morton, R., Sloan, W., Walters, M. and McInnes, G. (2007) New-onset diabetes in hypertensive patients: an evaluation of the association with drug therapy and cardiovascular mortality. Journal of Human Hypertension, 21(10), pp. 842-843.

Quinn, T.J. , Lees, K.R., Hardemark, H.G., Dawson, J. and Walters, M.R. (2007) Initial experience of a digital training resource for modified Rankin scale assessment in clinical trials. Stroke, 38(8), pp. 2257-2261. (doi: 10.1161/STROKEAHA.106.480723)

Walker, T., McMahon, S. and Walters, M. (2007) Innovative orientation: a treasure hunt in Foundation Year one. Medical Education, 41(5), p. 514.

2006

Bain, C., Lees, K., Lumsden, M. and Walters, M. (2006) Sex hormones and cerebral hemodynamics - Author's reply. Climacteric, 9(1), p. 67.

Dawson, J. and Walters, M. (2006) New and emerging treatments for stroke. British Medical Bulletin, 77-78, pp. 87-102. (doi: 10.1093/bmb/ldl011)

Dawson, J. and Walters, M. (2006) Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? British Journal of Clinical Pharmacology, 62, pp. 633-644. (doi: 10.1111/j.1365-2125.2006.02785.x)

Dawson, J., Walters, M. and Lees, K. (2006) 21st century stroke - A medical emergency. Scottish Medical Journal, 51(3), pp. 34-41.

Milia, P., Muir, S., Alem, M., Lees, K. and Walters, M. (2006) Comparison of the effect of diuretics on carotid blood flow in stroke patients. Journal of Cardiovascular Pharmacology, 47, pp. 446-449.

Nazir, F., Alem, M., Small, M., Connell, J., Lees, K., Walters, M. and Cleland, S. (2006) Blunted response to systemic nitric oxide synthase inhibition in the cerebral circulation of patients with Type 2 diabetes. Diabetic Medicine, 23, pp. 398-402. (doi: 10.1111/j.1464-5491.2005.01815.x)

Newman, E.J., Rahman, F.S., Lees, K.R., Weir, C.J. and Walters, M. (2006) Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes. Diabetes: Metabolism Research and Reviews, 22(1), pp. 79-82.

Walters, M., Weir, C. and Lees, K. (2006) A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients. Cerebrovascular Diseases, 22, pp. 116-122. (doi: 10.1159/000093239)

2005

Aslanyan, S., Weir, C., McInnes, G., Reid, J., Walters, M. and Lees, K. (2005) Statin administration prior to ischaemic stroke onset and survival: exploratory evidence from matched treatment-control study. European Journal of Neurology, 12, pp. 493-498.

Bain, C., Lees, K., Lumsden, M. and Walters, M. (2005) Effect of a gonadotropin releasing hormone analog on cerebral hemodynamics in premenopausal women. Climacteric, 8, pp. 193-197. (doi: 10.1080/13697130500118068)

Dawson, J. and Walters, M. (2005) Development and validation of a stroke recognition tool. Lancet Neurology, 4(11), pp. 691-693.

Lees, K. and Walters, M. (2005) Acute stroke and diabetes. Cerebrovascular Diseases, 20(Suppl.), pp. 9-14. (doi: 10.1159/000088232)

Walters, M., Kaste, M., Lees, K., Diener, H., Hommel, M., De Keyser, J., Steiner, H. and Versavel, M. (2005) The AMPA antagonist ZK 200775 in patients with acute ischaemic stroke: A double-blind, multicentre, placebo-controlled safety and tolerability study. Cerebrovascular Diseases, 20, pp. 304-309. (doi: 10.1159/000087929)

Walters, M., Muir, K., Harbison, J., Lees, K. and Ford, G. (2005) Intravenous thrombolysis for acute ischaemic stroke: Preliminary experience with recombinant tissue plasminogen activator in the UK. Cerebrovascular Diseases, 20, pp. 438-442. (doi: 10.1159/000088982)

Walters, M., Weir, C., Adams, F. and Lees, K. (2005) The prognostic significance of visible infarction on computed tomography following lacunar stroke: Results of a long-term follow-up study. Journal of Neuroimaging, 15, pp. 331-335. (doi: 10.1177/1051228405279993)

2004

Alem, M., Nazir, F., Walters, M., Elliott, H., Lees, K., Connell, J. and Cleland, S. (2004) Arterial stiffness in type 2 diabetes: Altered pattern of response to systemic NOS inhibition. Journal of Hypertension, 22, S194-S195.

Bain, C., Walters, M., Lees, K. and Lumsden, M. (2004) The effect of HRT on cerebral haemodynamics and cerebral vasomotor reactivity in post-menopausal women. Human Reproduction, 19, pp. 2411-2414. (doi: 10.1093/humrep/deh396)

Muir, S., Shah, I., Walters, M. and Lees, K. (2004) Perindopril improves cerebral vasomotor reactivity in patients with lacunar infarction. Stroke, 35(1), p. 303.

Nazir, F., Alem, M., Walters, M., Cleland, S. and Lees, K. (2004) Cerebral nitric oxide - Mediated vasodilatation is impaired in diabetics. Stroke, 35(1), p. 306.

Walters, M., Muir, S., Shah, I. and Lees, K. (2004) Effect of perindopril on cerebral vasomotor reactivity in patients with lacunar infarction. Stroke, 35, pp. 1899-1902. (doi: 10.1161/01.STR.0000131748.12553.ed)

Weir, C., Muir, S., Walters, M. and Lees, K. (2004) Yin and Yang of uric acid in patients with stroke - Response. Stroke, 35(1), E11-E12.

2003

Dhanjal, T., Walters, M. and MacMillan, N. (2003) Claude's syndrome in association with posterior cerebral artery stenosis. Scottish Medical Journal, 48, pp. 91-92.

Shah, I., Walters, M. and McKillop, J. (2003) Interactive acute medicine. Medical Education, 37(11), pp. 1046-1047.

Walters, M., Shah, I., Van Acker, J., Carr, L., Weir, C. and Lees, K. (2003) Do transient ischaemic attacks attenuate severity of subsequent stroke? Stroke, 34(1), p. 320.

Weir, C., Muir, S., Walters, M. and Lees, K. (2003) Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke. Stroke, 34, pp. 1951-1956. (doi: 10.1161/01.STR.0000081983.34771.D2)

Weir, C., Sattar, N., Walters, M. and Lees, K. (2003) Low triglyceride, not low cholesterol concentration, independently predicts poor outcome following acute stroke. Cerebrovascular Diseases, 16, pp. 76-82. (doi: 10.1159/000070119)

2002

Walters, M., Bradford, A., Fischer, J. and Lees, K. (2002) Early clinical experience with the novel NMDA receptor antagonist CNS 5161. British Journal of Clinical Pharmacology, 53, pp. 305-311.

2001

Walters, M., Bolster, A., Dyker, A. and Lees, K. (2001) Effect of perindopril on cerebral and renal perfusion in stroke patients with carotid disease. Stroke, 32, pp. 473-478.

2000

Walters, M., Dyker, A. and Lees, K. (2000) The effect of perindopril on cerebral and renal perfusion in stroke patients with carotid disease. Journal of Hypertension, 18, S53-S53.

Walters, M. and Reid, J. (2000) Vasopeptidase inhibition: cardiovascular therapy for the new millennium? Journal of Human Hypertension, 14(9), pp. 537-539.

1999

Walters, M., Bradford, A. and Lees, K. (1999) Early clinical experience with the novel NMDA antagonist CNS 5161. Stroke, 30(1), p. 264.

Walters, M., Foster, J., Cockburn, M., McMillan, N. and Lees, K. (1999) Imaging of acute ischaemic stroke by diffusion-weighted magnetic resonance at 1.0 tesla. Stroke, 30(1), p. 277.

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