Dr Jennifer Malcolm

  • Lecturer (Dental School)

telephone: 01412119763
email: Jennifer.Malcolm@glasgow.ac.uk

School of Medicine, Dentistry & Nursing, Level 9, L14, Glasgow Dental School, Glasgow, G2 3JZ

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-0020-0283

Biography

I graduated with a 1st Class BSc/Hons in Microbiology from Glasgow Caledonian University, where I first sparked an interest in host-pathogen interactions in health and disease. I pursued this interest during my PhD at the University of Glasgow, School of Medicine, Dentistry and Nursing, where I investigated oral biofilm development in young children coincident with the maturation of salivary immune responses.

After my PhD, I worked as a Post-Doctoral Research Associate at the University of Glasgow, School of Infection and Immunity, where I developed a discovery pipeline for therapeutic targets for periodontal disease. This work has formed the basis of further investigations of cellular mechanisms in oral health and disease. Subsequently, I was the lead post-doctoral researcher on a Versus Arthritis Research grant. In this project, I identified a novel mechanism of breach of immune tolerance related to non-endogenous bacterial citrullination. These data have implications for understanding how oral bacterial infection can drive autoimmune responses.

In 2018, I took up a teaching position at the University of Glasgow Dental School. Here, I am exploring how oral bacteria exploit innate immunity to subvert adaptive immune responses, and how this impacts the maintenance of immune tolerance in the oral mucosa.

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2018 | 2016 | 2015 | 2014 | 2011
Number of items: 16.

2024

Malcolm, J. and Culshaw, S. (2024) Aberrant immunity in the oral cavity—a link with rheumatoid arthritis? Frontiers in Oral Health, 5, 1430886. (doi: 10.3389/froh.2024.1430886) (PMID:38948089)

Lopez‐Oliva, I., Malcolm, J. and Culshaw, S. (2024) Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases. Periodontology 2000, (doi: 10.1111/prd.12530) (Early Online Publication)

2023

Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)

2021

McKerlie, R. A. , Malcolm, J. , Varsou, O. , Kennedy, C. E. , Colgan, L., Harper, V., McAllan, W., Forgie, A., Rea, P. and Bell, A. (2021) A rapid transition to blended learning: the journey of a dental degree programme pivoting online. Journal of Perspectives in Applied Academic Practice, 9(2), pp. 169-180. (doi: 10.14297/jpaap.v9i2.475)

Malcolm, J. and Rea, P. (2021) Using Microsoft Teams to Support Active Small Group Learning and Teaching. 14th Annual University of Glasgow Learning and Teaching Conference: Transforming Teaching and Taking Stock, University of Glasgow, 18th July 2021.

2018

Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)

Simon-Soro, A., Sherriff, A. , Sadique, S., Ramage, G. , Macpherson, L. , Mira, A., Culshaw, S. and Malcolm, J. (2018) Combined analysis of the salivary microbiome and host defence peptides predicts dental disease. Scientific Reports, 8, 1484. (doi: 10.1038/s41598-018-20085-x) (PMID:29367728) (PMCID:PMC5784018)

2016

Ramage, G. , Lappin, D.F., Millhouse, E., Malcolm, J. , Jose, A., Yang, J., Bradshaw, D.J., Pratten, J.R. and Culshaw, S. (2016) The epithelial cell response to health and disease associated oral biofilm models. Journal of Periodontal Research, 52(3), pp. 325-333. (doi: 10.1111/jre.12395) (PMID:27330034) (PMCID:PMC5412879)

Malcolm, J. et al. (2016) Mast cells contribute to Porphyromonas gingivalis–induced bone loss. Journal of Dental Research, 95(6), pp. 704-710. (doi: 10.1177/0022034516634630) (PMID:26933137)

Campbell, L., Millhouse, E., Malcolm, J. and Culshaw, S. (2016) T cells, teeth and tissue destruction - what do T cells do in periodontal disease? Molecular Oral Microbiology, 31(6), pp. 445-456. (doi: 10.1111/omi.12144) (PMID:26505640)

2015

O'Donnell, L. E., Millhouse, E., Sherry, L. , Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi: 10.1093/femsyr/fov077) (PMID:26298018)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi: 10.1177/0022034515577815) (PMID:25808546)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi: 10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

2014

Malcolm, J. , Sherriff, A. , Lappin, D. F., Ramage, G. , Conway, D. I. , Macpherson, L. M. and Culshaw, S. (2014) Salivary antimicrobial proteins associate with age-related changes in streptococcal composition in dental plaque. Molecular Oral Microbiology, 29(6), pp. 284-293. (doi: 10.1111/omi.12058)

2011

Butcher, J.P., Malcolm, J. , Benson, R.A. , Deng, D.M., Brewer, J.M. , Garside, P. and Culshaw, S. (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)

This list was generated on Thu Nov 21 02:22:31 2024 GMT.
Jump to: Articles | Conference or Workshop Item
Number of items: 16.

Articles

Malcolm, J. and Culshaw, S. (2024) Aberrant immunity in the oral cavity—a link with rheumatoid arthritis? Frontiers in Oral Health, 5, 1430886. (doi: 10.3389/froh.2024.1430886) (PMID:38948089)

Lopez‐Oliva, I., Malcolm, J. and Culshaw, S. (2024) Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases. Periodontology 2000, (doi: 10.1111/prd.12530) (Early Online Publication)

Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)

McKerlie, R. A. , Malcolm, J. , Varsou, O. , Kennedy, C. E. , Colgan, L., Harper, V., McAllan, W., Forgie, A., Rea, P. and Bell, A. (2021) A rapid transition to blended learning: the journey of a dental degree programme pivoting online. Journal of Perspectives in Applied Academic Practice, 9(2), pp. 169-180. (doi: 10.14297/jpaap.v9i2.475)

Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)

Simon-Soro, A., Sherriff, A. , Sadique, S., Ramage, G. , Macpherson, L. , Mira, A., Culshaw, S. and Malcolm, J. (2018) Combined analysis of the salivary microbiome and host defence peptides predicts dental disease. Scientific Reports, 8, 1484. (doi: 10.1038/s41598-018-20085-x) (PMID:29367728) (PMCID:PMC5784018)

Ramage, G. , Lappin, D.F., Millhouse, E., Malcolm, J. , Jose, A., Yang, J., Bradshaw, D.J., Pratten, J.R. and Culshaw, S. (2016) The epithelial cell response to health and disease associated oral biofilm models. Journal of Periodontal Research, 52(3), pp. 325-333. (doi: 10.1111/jre.12395) (PMID:27330034) (PMCID:PMC5412879)

Malcolm, J. et al. (2016) Mast cells contribute to Porphyromonas gingivalis–induced bone loss. Journal of Dental Research, 95(6), pp. 704-710. (doi: 10.1177/0022034516634630) (PMID:26933137)

Campbell, L., Millhouse, E., Malcolm, J. and Culshaw, S. (2016) T cells, teeth and tissue destruction - what do T cells do in periodontal disease? Molecular Oral Microbiology, 31(6), pp. 445-456. (doi: 10.1111/omi.12144) (PMID:26505640)

O'Donnell, L. E., Millhouse, E., Sherry, L. , Kean, R., Malcolm, J. , Nile, C. J. , Ramage, G. and Munro, C. (2015) Polymicrobial candida biofilms: friends and foe in the oral cavity. FEMS Yeast Research, 15(7), fov077. (doi: 10.1093/femsyr/fov077) (PMID:26298018)

Malcolm, J. et al. (2015) IL-33 exacerbates periodontal disease through induction of RANKL. Journal of Dental Research, 94(7), pp. 968-975. (doi: 10.1177/0022034515577815) (PMID:25808546)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

O’Donnell, L. E. et al. (2015) The oral microbiome of denture wearers is influenced by natural dentition. PLoS ONE, 10(9), e0137717. (doi: 10.1371/journal.pone.0137717) (PMID:26368937) (PMCID:PMC4569385)

Malcolm, J. , Sherriff, A. , Lappin, D. F., Ramage, G. , Conway, D. I. , Macpherson, L. M. and Culshaw, S. (2014) Salivary antimicrobial proteins associate with age-related changes in streptococcal composition in dental plaque. Molecular Oral Microbiology, 29(6), pp. 284-293. (doi: 10.1111/omi.12058)

Butcher, J.P., Malcolm, J. , Benson, R.A. , Deng, D.M., Brewer, J.M. , Garside, P. and Culshaw, S. (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)

Conference or Workshop Item

Malcolm, J. and Rea, P. (2021) Using Microsoft Teams to Support Active Small Group Learning and Teaching. 14th Annual University of Glasgow Learning and Teaching Conference: Transforming Teaching and Taking Stock, University of Glasgow, 18th July 2021.

This list was generated on Thu Nov 21 02:22:31 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • In vitro investigation of the interplay between stress, oral biofilms and oral epithelial barrier function
    Oral and Dental Research Trust
    2021 - 2022
     

Supervision

  • Piela, Krystyna
    Holding the front line – maintaining barrier integrity in the mouth