Professor Alastair Gracie
- Honorary Senior Research Fellow (Undergraduate Medical School)
Publications
2015
Agarwal, P. K., Rotchford, A. P., Gracie, A., Lim, L. T., Cameron, A. D. and Ramaesh, K. (2015) Does amniotic membrane absorb cytokines and growth factors from the local engrafted environment? A novel mechanism of therapeutic action. Clinical and Experimental Ophthalmology, 45(9), pp. 586-589. (doi: 10.1111/ceo.12507) (PMID:25676083)
2014
Gracie, J. A. and Farrell, A. (2014) The immune response. In: Baynes, John W. and Dominiczak, Marek H. (eds.) Medical Biochemistry. Saunders/Elsevier: Edinburgh, pp. 496-512. ISBN 9781455745807
2013
Cameron, K. R., Grosset, A., Gracie, A. and Burke, J. (2013) Evaluating a Medical Curriculum: How Best to Proceed? AMEE 2013: Colouring Outside the Lines, Prague, Czech Republic, 24-28 Aug 2013.
Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi: 10.1136/annrheumdis-2012-202872) (PMID:23434566)
2012
Pineda, M.A. , McGrath, M.A., Smith, P.C., Al-Riyami, L., Rzepecka, J., Gracie, J.A., Harnett, W. and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64(10), pp. 3168-3178. (doi: 10.1002/art.34581) (PMID:22729944)
Crilly, A. et al. (2012) PAR2 expression in peripheral blood monocytes of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71(6), pp. 1049-1054. (doi: 10.1136/annrheumdis-2011-200703) (PMID:22294632)
Jagger, A. L. et al. (2012) FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells. Journal of Autoimmunity, 38(1), pp. 29-38. (doi: 10.1016/j.jaut.2011.11.015) (PMID:22197557)
2011
Crilly, A., Robertson, S.E., Reilly, J.H., Gracie, J.A., Lai, W.-Q., Leung, B.P., Life, P.F. and McInnes, I.B. (2011) Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane. Annals of the Rheumatic Diseases, 70(6), pp. 1130-1137. (doi: 10.1136/ard.2010.134825) (PMID:21342916)
2008
Wong, S.C. , Macrae, V.E., Gracie, J.A., McInnes, I.B. , Galea, P., Gardner-Medwin, J. and Ahmed, S.F. (2008) Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis. Growth Hormone and IGF Research, 18(5), pp. 369-378. (doi: 10.1016/j.ghir.2008.01.006) (PMID:18378173)
Harnett, M. et al. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67(4), pp. 518-523. (doi: 10.1136/ard.2007.073502) (PMID:17704067)
2007
Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. and McInnes, I. B. (2007) Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: Ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis and Rheumatism, 56(3), pp. 765-771. (doi: 10.1002/art.22423) (PMID:17328048)
2005
Jongbloed, S. L., Lebre, M. C., Fraser, A. R., Gracie, J. A., Sturrock, R. D., Tak, P. P. and McInnes, I. B. (2005) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Research and Therapy, 8(1), R15. (doi: 10.1186/ar1864) (PMID:16507115) (PMCID:PMC1526567)
2004
McInnes, I. B. and Gracie, J. A. (2004) Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Current Opinion in Pharmacology, 4(4), pp. 392-397. (doi: 10.1016/j.coph.2004.04.003) (PMID:15251134)
Maffia, P. , Brewer, J. M. , Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi: 10.4049/jimmunol.173.1.151) (PMID:15210769)
2003
McInnes, I. B. , Leung, B.P., Harnett, M. , Gracie, J.A., Liew, F. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. Journal of Immunology, 171(4), pp. 2127-2133. (doi: 10.4049/jimmunol.171.4.2127) (PMID:12902519)
Gracie, J.A., Robertson, S.E. and McInnes, I.B. (2003) Interleukin-18. Journal of Leukocyte Biology, 73(2), pp. 213-224. (doi: 10.1189/jlb.0602313) (PMID:12554798)
2001
Leung, B. P., Culshaw, S. , Gracie, J. A., Hunter, D., Canetti, C. A., Campbell, C., Cunha, F., Liew, F. Y. and McInnes, I. B. (2001) A role for IL-18 in neutrophil activation. Journal of Immunology, 167, pp. 2879-2886. (doi: 10.4049/jimmunol.167.5.2879) (PMID:11509635)
McInnes, I. B. , Gracie, J. A. and Liew, F. Y. (2001) Interleukin-18: A novel cytokine in inflammatory rheumatic disease. Arthritis and Rheumatism, 44(7), pp. 1481-1483. (doi: 10.1002/1529-0131(200107)44:7<1481::AID-ART268>3.0.CO;2-1) (PMID:11465697)
2000
Xu, D., Trajkovic, V., Hunter, D., Leung, B. P., Schulz, K., Gracie, J. A., McInnes, I. B. and Liew, F. Y. (2000) IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. European Journal of Immunology, 30(11), pp. 3147-3156. (doi: 10.1002/1521-4141(200011)30:11<3147::AID-IMMU3147>3.0.CO;2-J) (PMID:11093129)
Articles
Agarwal, P. K., Rotchford, A. P., Gracie, A., Lim, L. T., Cameron, A. D. and Ramaesh, K. (2015) Does amniotic membrane absorb cytokines and growth factors from the local engrafted environment? A novel mechanism of therapeutic action. Clinical and Experimental Ophthalmology, 45(9), pp. 586-589. (doi: 10.1111/ceo.12507) (PMID:25676083)
Asquith, D.L. et al. (2013) The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Annals of the Rheumatic Diseases, 72(12), pp. 2024-2031. (doi: 10.1136/annrheumdis-2012-202872) (PMID:23434566)
Pineda, M.A. , McGrath, M.A., Smith, P.C., Al-Riyami, L., Rzepecka, J., Gracie, J.A., Harnett, W. and Harnett, M.M. (2012) The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites. Arthritis and Rheumatism, 64(10), pp. 3168-3178. (doi: 10.1002/art.34581) (PMID:22729944)
Crilly, A. et al. (2012) PAR2 expression in peripheral blood monocytes of patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 71(6), pp. 1049-1054. (doi: 10.1136/annrheumdis-2011-200703) (PMID:22294632)
Jagger, A. L. et al. (2012) FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25- responder T cells, but not CD4+CD25+ regulatory T cells. Journal of Autoimmunity, 38(1), pp. 29-38. (doi: 10.1016/j.jaut.2011.11.015) (PMID:22197557)
Crilly, A., Robertson, S.E., Reilly, J.H., Gracie, J.A., Lai, W.-Q., Leung, B.P., Life, P.F. and McInnes, I.B. (2011) Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane. Annals of the Rheumatic Diseases, 70(6), pp. 1130-1137. (doi: 10.1136/ard.2010.134825) (PMID:21342916)
Wong, S.C. , Macrae, V.E., Gracie, J.A., McInnes, I.B. , Galea, P., Gardner-Medwin, J. and Ahmed, S.F. (2008) Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis. Growth Hormone and IGF Research, 18(5), pp. 369-378. (doi: 10.1016/j.ghir.2008.01.006) (PMID:18378173)
Harnett, M. et al. (2008) The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis. Annals of the Rheumatic Diseases, 67(4), pp. 518-523. (doi: 10.1136/ard.2007.073502) (PMID:17704067)
Kelso, E. B., Ferrell, W. R., Lockhart, J. C., Elias-Jones, I., Hembrough, T., Dunning, L., Gracie, J. A. and McInnes, I. B. (2007) Expression and proinflammatory role of proteinase-activated receptor 2 in rheumatoid synovium: Ex vivo studies using a novel proteinase-activated receptor 2 antagonist. Arthritis and Rheumatism, 56(3), pp. 765-771. (doi: 10.1002/art.22423) (PMID:17328048)
Jongbloed, S. L., Lebre, M. C., Fraser, A. R., Gracie, J. A., Sturrock, R. D., Tak, P. P. and McInnes, I. B. (2005) Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. Arthritis Research and Therapy, 8(1), R15. (doi: 10.1186/ar1864) (PMID:16507115) (PMCID:PMC1526567)
McInnes, I. B. and Gracie, J. A. (2004) Interleukin-15: a new cytokine target for the treatment of inflammatory diseases. Current Opinion in Pharmacology, 4(4), pp. 392-397. (doi: 10.1016/j.coph.2004.04.003) (PMID:15251134)
Maffia, P. , Brewer, J. M. , Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi: 10.4049/jimmunol.173.1.151) (PMID:15210769)
McInnes, I. B. , Leung, B.P., Harnett, M. , Gracie, J.A., Liew, F. and Harnett, W. (2003) A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62. Journal of Immunology, 171(4), pp. 2127-2133. (doi: 10.4049/jimmunol.171.4.2127) (PMID:12902519)
Gracie, J.A., Robertson, S.E. and McInnes, I.B. (2003) Interleukin-18. Journal of Leukocyte Biology, 73(2), pp. 213-224. (doi: 10.1189/jlb.0602313) (PMID:12554798)
Leung, B. P., Culshaw, S. , Gracie, J. A., Hunter, D., Canetti, C. A., Campbell, C., Cunha, F., Liew, F. Y. and McInnes, I. B. (2001) A role for IL-18 in neutrophil activation. Journal of Immunology, 167, pp. 2879-2886. (doi: 10.4049/jimmunol.167.5.2879) (PMID:11509635)
McInnes, I. B. , Gracie, J. A. and Liew, F. Y. (2001) Interleukin-18: A novel cytokine in inflammatory rheumatic disease. Arthritis and Rheumatism, 44(7), pp. 1481-1483. (doi: 10.1002/1529-0131(200107)44:7<1481::AID-ART268>3.0.CO;2-1) (PMID:11465697)
Xu, D., Trajkovic, V., Hunter, D., Leung, B. P., Schulz, K., Gracie, J. A., McInnes, I. B. and Liew, F. Y. (2000) IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. European Journal of Immunology, 30(11), pp. 3147-3156. (doi: 10.1002/1521-4141(200011)30:11<3147::AID-IMMU3147>3.0.CO;2-J) (PMID:11093129)
Book Sections
Gracie, J. A. and Farrell, A. (2014) The immune response. In: Baynes, John W. and Dominiczak, Marek H. (eds.) Medical Biochemistry. Saunders/Elsevier: Edinburgh, pp. 496-512. ISBN 9781455745807
Conference or Workshop Item
Cameron, K. R., Grosset, A., Gracie, A. and Burke, J. (2013) Evaluating a Medical Curriculum: How Best to Proceed? AMEE 2013: Colouring Outside the Lines, Prague, Czech Republic, 24-28 Aug 2013.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- PAR2 as a therapeutic target in osteoarthritis
Arthritis Research UK
2010 - 2013
- Exploiting the host-parasite relationship to develop novel safe anti-inflammatory therapies
Arthritis Research UK
2009 - 2012
- PAR2 in the pathogenesis of osteoarthritis
Arthritis Research UK
2007 - 2010
- Therapeutic potential of a humanised PAR2 antibody to alleviate chronic joint inflammation
Scottish Executive Health Department
2006 - 2009
- PAR-2 in the pathogenesis of rheumatoid arthritis
Arthritis Research UK
2005 - 2006
- Study of Multiple Inflammatory Mediators from Small Clinical Research Samples: Approach to Better Understanding of Disease Mechanisms
Tenovus Scotland
2005 - 2006
- Unrecognised herpes virus infections in the intensive therapy unit
West Research Endowment Funds
2004 - 2005