Professor Malcolm Shepherd
- Professor, Head of Undergraduate Medical School, Honorary Professor (Undergraduate Medical School)
email:
Malcolm.Shepherd@glasgow.ac.uk
Wolfson Medical School Building Rm 338, University Avenue, Glasgow, United Kingdom, G12 8QQ
Publications
2024
Huser, C. A.M. , Ahmed, W., Basu, N., Donald, G. K. and Shepherd, M. (2024) Solving a paradox: can learning about climate change and sustainable healthcare be fun? Journal of Learning Development in Higher Education, (Accepted for Publication)
2022
Yang, F. et al. (2022) Corticosteroid responsiveness following mepolizumab in severe eosinophilic asthma—a randomized, placebo-controlled crossover trial (MAPLE). Journal of Allergy and Clinical Immunology: In Practice, 10(11), 2925-2934.e12. (doi: 10.1016/j.jaip.2022.06.050) (PMID:35863669)
2018
Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)
2016
Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)
Boyle, J.G., Cullen, J.M., Sneddon, S. , Sartania, N. and Shepherd, M. (2016) Using Facebook as a platform for self-regulated curriculum evaluation and feedback for medical students. Medical Teacher, 38(9), pp. 959-960. (doi: 10.1080/0142159X.2016.1209473) (PMID:27552338)
2015
Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)
2014
Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)
2012
Menzies, F.M., Higgins, C.A., Shepherd, M.C., Nibbs, R.J.B. and Nelson, S.M. (2012) Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor. Immunology and Cell Biology, 90, pp. 321-329. (doi: 10.1038/icb.2011.40)
Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)
2011
Xia, Y.C. et al. (2011) Functional expression of IgG-Fc receptors in human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology, 44(5), pp. 665-672. (doi: 10.1165/rcmb.2009-0371OC)
Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2011) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq053)
Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)
2010
Bayes, H. K., Oyeniran, O., Shepherd, M. and Walters, M. (2010) Clinical Audit: Management of Acute Severe Asthma in West Glasgow. Scottish Medical Journal, 55(1), pp. 6-9. (doi: 10.1258/rsmsmj.55.1.6)
Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2010) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq0532)
2009
Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)
Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)
Perez-Zoghbi, J., Karner, C., Ito, S., Shepherd, M., Alrashdan, Y. and Sanderson, M. (2009) Ion channel regulation of intracellular calcium and airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), pp. 388-397. (doi: 10.1016/j.pupt.2008.09.006)
2007
Shepherd, M., Duffy, S., Harris, T., Cruse, G., Schuliga, M., Brightling, C., Neylon, C., Bradding, P. and Stewart, A. (2007) K(Ca)3.1 Ca2+-Activated K+ channels regulate human airway smooth muscle proliferation. American Journal of Respiratory Cell and Molecular Biology, 37, pp. 525-531. (doi: 10.1165/rcmb.2006-03580C)
2006
Shepherd, M. (2006) Phosphodiesterase 4 regulation of cyclic AMP in pulmonary remodelling: Potential roles for isoform selective inhibitors. Pulmonary Pharmacology and Therapeutics, 19, pp. 24-31. (doi: 10.1016/j.pupt.2005.05.002)
Articles
Huser, C. A.M. , Ahmed, W., Basu, N., Donald, G. K. and Shepherd, M. (2024) Solving a paradox: can learning about climate change and sustainable healthcare be fun? Journal of Learning Development in Higher Education, (Accepted for Publication)
Yang, F. et al. (2022) Corticosteroid responsiveness following mepolizumab in severe eosinophilic asthma—a randomized, placebo-controlled crossover trial (MAPLE). Journal of Allergy and Clinical Immunology: In Practice, 10(11), 2925-2934.e12. (doi: 10.1016/j.jaip.2022.06.050) (PMID:35863669)
Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)
Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)
Boyle, J.G., Cullen, J.M., Sneddon, S. , Sartania, N. and Shepherd, M. (2016) Using Facebook as a platform for self-regulated curriculum evaluation and feedback for medical students. Medical Teacher, 38(9), pp. 959-960. (doi: 10.1080/0142159X.2016.1209473) (PMID:27552338)
Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)
Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)
Menzies, F.M., Higgins, C.A., Shepherd, M.C., Nibbs, R.J.B. and Nelson, S.M. (2012) Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor. Immunology and Cell Biology, 90, pp. 321-329. (doi: 10.1038/icb.2011.40)
Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)
Xia, Y.C. et al. (2011) Functional expression of IgG-Fc receptors in human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology, 44(5), pp. 665-672. (doi: 10.1165/rcmb.2009-0371OC)
Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2011) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq053)
Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)
Bayes, H. K., Oyeniran, O., Shepherd, M. and Walters, M. (2010) Clinical Audit: Management of Acute Severe Asthma in West Glasgow. Scottish Medical Journal, 55(1), pp. 6-9. (doi: 10.1258/rsmsmj.55.1.6)
Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2010) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq0532)
Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)
Perez-Zoghbi, J., Karner, C., Ito, S., Shepherd, M., Alrashdan, Y. and Sanderson, M. (2009) Ion channel regulation of intracellular calcium and airway smooth muscle function. Pulmonary Pharmacology and Therapeutics, 22(5), pp. 388-397. (doi: 10.1016/j.pupt.2008.09.006)
Shepherd, M., Duffy, S., Harris, T., Cruse, G., Schuliga, M., Brightling, C., Neylon, C., Bradding, P. and Stewart, A. (2007) K(Ca)3.1 Ca2+-Activated K+ channels regulate human airway smooth muscle proliferation. American Journal of Respiratory Cell and Molecular Biology, 37, pp. 525-531. (doi: 10.1165/rcmb.2006-03580C)
Shepherd, M. (2006) Phosphodiesterase 4 regulation of cyclic AMP in pulmonary remodelling: Potential roles for isoform selective inhibitors. Pulmonary Pharmacology and Therapeutics, 19, pp. 24-31. (doi: 10.1016/j.pupt.2005.05.002)
Conference Proceedings
Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Imaging immune cells in lung in order to understand asthma
Asthma UK
2012 - 2012
- Characterisation of the interaction of mast cells and myometrial smooth muscle in regulating parturition.
Cunningham Trust
2008 - 2010
- A pilot study to examine the epidemiology of Chronic Obstructive Pulmonary Disease (COPD) in Scotland
Scottish Executive Health Department
2008 - 2009
- Airway remodelling promotes asthmatic airway inflammation
North Glasgow University Hospitals NHS Trust
2006 - 2008
- The impact of G-protein couples receptor regulation on human airway smooth muscle cell behaviour in asthma
Asthma UK
2004 - 2007