Hypothesis Summary
Faecal calprotectin rises rapidly in children with Crohn’s disease following treatment with exclusive enteral nutrition (EEN). Current methods of monitoring disease status in CD rely on measurements of inflammatory markers in both faeces and plasma. These inflammatory cytokines are also present in sweat and can be measured continuously using novel proprietary wearable technology. In this study, we measure the concentration of inflammatory markers excreted in sweat in paediatric CD patients who have responded well to a course of EEN. We will test their association with concentrations measured in serial faecal samples and blood samples over a 3-week period.