Neurodegenerative diseases such as Alzheimer’s or Parkinson’s are devastating conditions with poorly understood mechanisms and no known cure. Yet a striking feature of these conditions is the characteristic pattern of invasion throughout the brain, leading to well-codified disease stages visible to neuropathology and associated with various cognitive deficits and pathologies. This evolution is associated with the aggregation of key toxic proteins. In this talk, I will show how we use multiscale modelling to gain insight into this process  In particular, by looking at protein dynamics on the neuronal network, we  that are driven by both the network topology and protein kinetics. By further coupling this approach with functional models of the brain, we will show that we can explain important aspects of cognitive loss during disease development and link neuronal activity to the emergence of the disease.

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