Multiscale Modelling for Tendon Tissue Engineering

Dr Amy Kent (University of Oxford)

Thursday 23rd March, 2023 14:00-15:00 Maths 311B / (ID: 893 4281 9809)

Abstract

Tendon tissue engineering aims to grow functional tissue in vivo. Tissue is typically grown in a bioreactor chamber which controls the mechanical and biochemical environment of the growing cells. In this talk, I will present of multiscale models motivated by the humanoid robotic bioreactor under development at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences. Cells are grown on a fibrous scaffold, with mechanical stimulation provided by motion of the robot, and nutrients supplied by the flow of cell media through the bioreactor chamber. Our work thus far has focused on developing a model of fluid-fibre interaction in the bioreactor scaffold using homogenisation via multiscale asymptotics. We will present extensions to the standard asymptotic homogenisation required to treat this problem and give examples of simple solutions to this model which illustrate the role of parameters in determining fluid-induced shear stresses and nutrient delivery to the growing cells.  

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