Dr Vanessa Cowton
- Investigator Scientist (Virology)
telephone:
01413304637
email:
Vanessa.Cowton@glasgow.ac.uk
Centre for Virus Research, 464 Bearsden Rd, Glasgow, G61 1qh
Research interests
Member of the Patel Group.
Publications
2024
Ogger, P. P. et al. (2024) SARS-CoV-2 strains bearing Omicron BA.1 spike replicate in C57BL/6 mice. Frontiers in Immunology, 15, 1383612. (doi: 10.3389/fimmu.2024.1383612) (PMID:38742107) (PMCID:PMC11089223)
Furnon, W. , Cowton, V., De Lorenzo, G. , Patel, A. and Palmarini, M. (2024) Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants. Nature Microbiology, 9, pp. 451-463. (doi: 10.1038/s41564-023-01588-4) (PMID:38228858) (PMCID:PMC10847042)
2023
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Bouhaddou, M. et al. (2023) SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell, 186(21), pp. 4597-4614. (doi: 10.1016/j.cell.2023.08.026) (PMID:37738970) (PMCID:PMC10604369)
2022
Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)
Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Cowton, V. M., Dunlop, J. I., Cole, S. J., Swann, R. E. and Patel, A. H. (2022) The neutralizing antibody responses of individuals that spontaneously resolve hepatitis C virus infection. Viruses, 14(7), 1391. (doi: 10.3390/v14071391) (PMID:35891372) (PMCID:PMC9318067)
Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)
Salas, J. H. et al. (2022) An antigenically diverse, representative panel of envelope glycoproteins for HCV vaccine development. Gastroenterology, 162(2), pp. 562-574. (doi: 10.1053/j.gastro.2021.10.005) (PMID:34655573) (PMCID:PMC8792218)
2021
Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2021) Design and synthesis of HCV-E2 glycoprotein epitope mimics in the molecular construction of potential as synthetic vaccines. Viruses, 13(2), 326. (doi: 10.3390/v13020326) (PMID:33672697) (PMCID:PMC7924389)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Cowton, V. M. et al. (2021) Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design. npj Vaccines, 6, 7. (doi: 10.1038/s41541-020-00269-1) (PMID:33420102) (PMCID:PMC7794244)
2020
Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2020) Improving the aqueous solubility of HCV-E2 glycoprotein epitope mimics by cyclization using polar hinges. Journal of Peptide Science, 26(1), e3222. (doi: 10.1002/psc.3222) (PMID:31984607)
2019
Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)
2018
Cowton, V. M., Singer, J. B., Gifford, R. J. and Patel, A. H. (2018) Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data. Frontiers in Immunology, 9, 1470. (doi: 10.3389/fimmu.2018.01470) (PMID:30013555) (PMCID:PMC6036255)
2017
Naiyer, M. M. et al. (2017) KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C. Science Immunology, 2(15), eaal5296. (doi: 10.1126/sciimmunol.aal5296) (PMID:28916719)
2016
Cowton, V. M., Angus, A. G.N., Cole, S. J., Markopoulou, C. K., Owsianka, A., Dunlop, J. I., Gardner, D., Krey, T. and Patel, A. H. (2016) Role of conserved E2 residue W420 in receptor binding and hepatitis C virus infection. Journal of Virology, 90(16), pp. 7456-7468. (doi: 10.1128/JVI.00685-16) (PMID:27279607) (PMCID:PMC4984626)
Swann, R. E. , Cowton, V. M., Robinson, M. W., Cole, S. J., Barclay, S. T., Mills, P. R., Thomson, E. C. , McLauchlan, J. and Patel, A. (2016) Broad anti-hepatitis C virus (HCV) antibody responses are associated with improved clinical disease parameters in chronic HCV infection. Journal of Virology, 90(9), pp. 4530-4543. (doi: 10.1128/JVI.02669-15) (PMID:26912610) (PMCID:PMC4836347)
2015
Dunlop, J., Owsianka, A., Cowton, V. and Patel, A. (2015) Current and future prophylactic vaccines for hepatitis C virus. Vaccine: Development and Therapy, 2015(5), pp. 31-44. (doi: 10.2147/VDT.S48437)
Articles
Ogger, P. P. et al. (2024) SARS-CoV-2 strains bearing Omicron BA.1 spike replicate in C57BL/6 mice. Frontiers in Immunology, 15, 1383612. (doi: 10.3389/fimmu.2024.1383612) (PMID:38742107) (PMCID:PMC11089223)
Furnon, W. , Cowton, V., De Lorenzo, G. , Patel, A. and Palmarini, M. (2024) Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants. Nature Microbiology, 9, pp. 451-463. (doi: 10.1038/s41564-023-01588-4) (PMID:38228858) (PMCID:PMC10847042)
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Bouhaddou, M. et al. (2023) SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell, 186(21), pp. 4597-4614. (doi: 10.1016/j.cell.2023.08.026) (PMID:37738970) (PMCID:PMC10604369)
Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)
Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Cowton, V. M., Dunlop, J. I., Cole, S. J., Swann, R. E. and Patel, A. H. (2022) The neutralizing antibody responses of individuals that spontaneously resolve hepatitis C virus infection. Viruses, 14(7), 1391. (doi: 10.3390/v14071391) (PMID:35891372) (PMCID:PMC9318067)
Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)
Salas, J. H. et al. (2022) An antigenically diverse, representative panel of envelope glycoproteins for HCV vaccine development. Gastroenterology, 162(2), pp. 562-574. (doi: 10.1053/j.gastro.2021.10.005) (PMID:34655573) (PMCID:PMC8792218)
Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2021) Design and synthesis of HCV-E2 glycoprotein epitope mimics in the molecular construction of potential as synthetic vaccines. Viruses, 13(2), 326. (doi: 10.3390/v13020326) (PMID:33672697) (PMCID:PMC7924389)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Cowton, V. M. et al. (2021) Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design. npj Vaccines, 6, 7. (doi: 10.1038/s41541-020-00269-1) (PMID:33420102) (PMCID:PMC7794244)
Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2020) Improving the aqueous solubility of HCV-E2 glycoprotein epitope mimics by cyclization using polar hinges. Journal of Peptide Science, 26(1), e3222. (doi: 10.1002/psc.3222) (PMID:31984607)
Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)
Cowton, V. M., Singer, J. B., Gifford, R. J. and Patel, A. H. (2018) Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data. Frontiers in Immunology, 9, 1470. (doi: 10.3389/fimmu.2018.01470) (PMID:30013555) (PMCID:PMC6036255)
Naiyer, M. M. et al. (2017) KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C. Science Immunology, 2(15), eaal5296. (doi: 10.1126/sciimmunol.aal5296) (PMID:28916719)
Cowton, V. M., Angus, A. G.N., Cole, S. J., Markopoulou, C. K., Owsianka, A., Dunlop, J. I., Gardner, D., Krey, T. and Patel, A. H. (2016) Role of conserved E2 residue W420 in receptor binding and hepatitis C virus infection. Journal of Virology, 90(16), pp. 7456-7468. (doi: 10.1128/JVI.00685-16) (PMID:27279607) (PMCID:PMC4984626)
Swann, R. E. , Cowton, V. M., Robinson, M. W., Cole, S. J., Barclay, S. T., Mills, P. R., Thomson, E. C. , McLauchlan, J. and Patel, A. (2016) Broad anti-hepatitis C virus (HCV) antibody responses are associated with improved clinical disease parameters in chronic HCV infection. Journal of Virology, 90(9), pp. 4530-4543. (doi: 10.1128/JVI.02669-15) (PMID:26912610) (PMCID:PMC4836347)
Dunlop, J., Owsianka, A., Cowton, V. and Patel, A. (2015) Current and future prophylactic vaccines for hepatitis C virus. Vaccine: Development and Therapy, 2015(5), pp. 31-44. (doi: 10.2147/VDT.S48437)
Research datasets
2024
Furnon, W. , Cowton, V. M., De Lorenzo, G. , Orton, R. , Herder, V. , Cantoni, D. , Ilia, G., Correa Mendonca, D. , Kerr, K., Allan, J., Upfold, N. , Meehan, G. R. , Bakshi, S., Das, U. R., Molina Arias, S., McElwee, M., Little, S., Logan, N., Kwok, K. , Smollett, K. , Willett, B. , Da Silva Filipe, A. , Robertson, D. L. , Grove, J. , Patel, A. H. and Palmarini, M. (2024) Phenotypic evolution of SARS-CoV-2 spike throughout the COVID-19 pandemic. [Data Collection]
2023
Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]
