Dr Sreenu Vattipally
- Research Scientist (Virology)
telephone:
0141 3304019
email:
Sreenu.Vattipally@glasgow.ac.uk
MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, 464 Bearsden Road, Glasgow, G61 1QH
https://orcid.org/0000-0001-6673-4697Research interests
Viral genomics & bioinformatics programme
I am a computational biologist, working to understand behaviour and evolution of viruses by means of computational analysis. My passion is to develop new algorithms and theoretical models that help comprehend complex biological processes.
My experience spans large-scale biological data exploration, the theory and development of new algorithms, coding tailor-made programs and building web driven applications and databases.
My broad research interests include:
- Next generation sequence analysis
- Protein-ligand interactions and docking studies
- Analysis of viral epitope mutations
- Intra, inter and extra host evolution of viruses
- MicroRNA analysis
My main focus of current research is the genome sequence analysis of Hepatitis C virus (HCV). I am currently working on high throughput HCV genome sequence data to understand its intra and extra host genome dynamics. As part of this work, I am currently developing novel tools that will greatly improve next generation sequence mapping as well as locating mutations that play a key role in host immune response and anti-viral drug resistance. Additionally, I am also interested in understanding the relationship between human leukocyte antigen (HLA) types and the spontaneous clearance of viral diseases.
Colloborators
My current collaborators are Dr. Emma Thomson, Prof. John McLauchlan, Dr. Pablo Murcia and Dr. Carol Leitch from the Centre for Virus Research (CVR) and I always welcome new collaborations.
Additionally, I also collaborate with STOP-HCV, a nationwide multi-institutional led consortium initiated by Medical Research Council, UK to develop stratified medicine approaches to treat HCV patients.
Publications
2024
Ahovègbé, L. et al. (2024) Hepatitis C virus diversity and treatment outcomes in Benin; a prospective cohort study. Lancet Microbe, 5(7), pp. 697-706. (doi: 10.1016/S2666-5247(24)00041-7) (PMID:38889738)
Spinard, E. et al. (2024) Near-complete genome sequences of multiple genotype 1 African swine fever virus isolates from 2016 to 2018 in Cameroon. Microbiology Resource Announcements, 13(4), e00978-23. (doi: 10.1128/mra.00978-23) (PMID:38477459) (PMCID:PMC11008206)
2023
Leggewie, M. et al. (2023) The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses. PLoS Neglected Tropical Diseases, 17(7), e0011456. (doi: 10.1371/journal.pntd.0011456) (PMID:37440582) (PMCID:PMC10343070)
Jagtap, S. V., Brink, J., Frank, S. C., Badusche, M., Leggewie, M., Sreenu, V. B. , Fuss, J., Schnettler, E. and Altinli, M. (2023) Agua Salud alphavirus infection, dissemination and transmission in Aedes aegypti mosquitoes. Viruses, 15(5), 1113. (doi: 10.3390/v15051113) (PMID:37243199) (PMCID:PMC10223791)
Alexander, A. J.T. et al. (2023) Characterisation of the antiviral RNA interference response to Toscana virus in sand fly cells. PLoS Pathogens, 19(3), e1011283. (doi: 10.1371/journal.ppat.1011283) (PMID:36996243) (PMCID:PMC10112792)
Altinli, M., Leggewie, M., Schulze, J., Gyanwali, R., Badusche, M., Sreenu, V. B. , Fuss, J. and Schnettler, E. (2023) Antiviral RNAi response in Culex quinquefasciatus-derived HSU cells. Viruses, 15(2), 436. (doi: 10.3390/v15020436) (PMID:36851650) (PMCID:PMC9968050)
2022
Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)
Aranday-Cortes, E. et al. (2022) Real-world outcomes of direct-acting antiviral treatment and retreatment in United Kingdom–based patients infected with hepatitis C virus genotypes/subtypes endemic in Africa. Journal of Infectious Diseases, 226(6), pp. 995-1004. (doi: 10.1093/infdis/jiab110) (PMID:33668068) (PMCID:PMC9492310)
Xu, R., Rong, X., Aranday-Cortes, E., Vattipally, S. , Hughes, J. , McLauchlan, J. and Fu, Y. (2022) The transmission route and selection pressure in HCV subtype 3a and 3b Chinese infections: evolutionary kinetics and selective force analysis. Viruses, 14(7), 1514. (doi: 10.3390/v14071514) (PMID:35891494) (PMCID:PMC9324606)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Gestuveo, R. et al. (2022) Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs. PLoS Pathogens, 18(1), e1010202. (doi: 10.1371/journal.ppat.1010202) (PMID:34990484) (PMCID:PMC8769306)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
2021
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Falci Finardi, N., Kim, H., Hernandez, L. Z., Russell, M. R. G., Ho, C. M.-K., Sreenu, V. B. , Wenham, H. A., Merritt, A. and Strang, B. L. (2021) Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication. Journal of General Virology, 102(12), 001702. (doi: 10.1099/jgv.0.001702) (PMID:34882533)
Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83(1), pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020) (PMID:33895226) (PMCID:PMC8061788)
Scherer, C. et al. (2021) An Aedes aegypti-derived Ago2 knockout cell line to investigate arbovirus infections. Viruses, 13(6), 1066. (doi: 10.3390/v13061066) (PMID:34205194) (PMCID:PMC8227176)
Davis, C. A. et al. (2021) Hepatitis E virus: whole genome sequencing as a new tool for understanding HEV epidemiology and phenotypes. Journal of Clinical Virology, 139, 104738. (doi: 10.1016/j.jcv.2021.104738) (PMID:33933822)
Graham, M. S. et al. (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health, 6(5), e335-e345. (doi: 10.1016/S2468-2667(21)00055-4)
Volz, E. et al. (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), pp. 266-269. (doi: 10.1038/s41586-021-03470-x) (PMID:33767447)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Da Silva Filipe, A. et al. (2021) Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland. Nature Microbiology, 6(1), pp. 112-122. (doi: 10.1038/s41564-020-00838-z) (PMID:33349681)
2020
Gilbert, M. et al. (2020) Distemper, extinction and vaccination of the Amur tiger. Proceedings of the National Academy of Sciences of the United States of America, 117(50), pp. 31954-31962. (doi: 10.1073/pnas.2000153117) (PMID:33229566) (PMCID:PMC7749280)
Mokaya, J. et al. (2020) Evidence of tenofovir resistance in chronic hepatitis B virus (HBV) infection: An observational case series of South African adults. Journal of Clinical Virology, 129, 104548. (doi: 10.1016/j.jcv.2020.104548) (PMID:32663786) (PMCID:PMC7408481)
Alexander, A. J.T. et al. (2020) Development of a reverse genetics system for Toscana virus (lineage A). Viruses, 12(4), 411. (doi: 10.3390/v12040411)
2019
Jerome, H. et al. (2019) Metagenomic next-generation sequencing aids the diagnosis of viral infections in febrile returning travellers. Journal of Infection, 79(4), pp. 383-388. (doi: 10.1016/j.jinf.2019.08.003) (PMID:31398374) (PMCID:PMC6859916)
Ansari, M. A. et al. (2019) Interferon lambda 4 impacts the genetic diversity of hepatitis C virus. eLife, 8, e42463. (doi: 10.7554/eLife.42463) (PMID:31478835) (PMCID:PMC6721795)
Suárez, N. M. et al. (2019) Human cytomegalovirus genomes sequenced directly from clinical material: variation, multiple-strain infection, recombination and gene loss. Journal of Infectious Diseases, 220(5), pp. 781-791. (doi: 10.1093/infdis/jiz208) (PMID:31050742) (PMCID:PMC6667795)
Wignall-Fleming, E. B., Hughes, D. J., Vattipally, S. , Modha, S. , Goodbourn, S., Davison, A. J. and Randall, R. E. (2019) Analysis of paramyxovirus transcription and replication by high-throughput sequencing. Journal of Virology, 93(17), e00571-19. (doi: 10.1128/JVI.00571-19) (PMID:31189700) (PMCID:PMC6694822)
Bamford, C., Wignall-Fleming, E., Sreenu, V. B. , Randall, R., Duprex, P. and Rima, B. (2019) Unusual, stable replicating viruses generated from mumps virus cDNA clones. PLoS ONE, 14(7), e0219168. (doi: 10.1371/journal.pone.0219168) (PMID:31276568) (PMCID:PMC6611571)
Yen, P.-S., Chen, C.-H., Sreenu, V. , Kohl, A. and Failloux, A.-B. (2019) Assessing the potential interactions between cellular miRNA and arboviral genomic RNA in the Yellow Fever mosquito, Aedes aegypti. Viruses, 11(6), 540. (doi: 10.3390/v11060540) (PMID:31185697) (PMCID:PMC6631873)
Davis, C. et al. (2019) New highly diverse hepatitis C strains detected in sub‐Saharan Africa have unknown susceptibility to direct‐acting antiviral treatments. Hepatology, 69(4), pp. 1426-1441. (doi: 10.1002/hep.30342) (PMID:30387174) (PMCID:PMC6492010)
2018
Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)
Franzke, K. et al. (2018) Detection, infection dynamics and small RNA response against Culex Y virus in mosquito-derived cells. Journal of General Virology, 99, pp. 1739-1745. (doi: 10.1099/jgv.0.001173) (PMID:30394867)
Dunlop, J. I. et al. (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Neglected Tropical Diseases, 12(10), e0006884. (doi: 10.1371/journal.pntd.0006884) (PMID:30372452) (PMCID:PMC6245839)
Masembe, C. , Sreenu, V. B. , Da Silva Filipe, A. , Wilkie, G. S., Ogweng, P., Mayega, F. J., Muwanika, V. B., Biek, R. , Palmarini, M. and Davison, A. J. (2018) Genome sequences of five African swine fever virus genotype IX isolates from domestic pigs in Uganda. Microbiology Resource Announcements, 7(13), e01018-18. (doi: 10.1128/mra.01018-18) (PMID:30533685) (PMCID:PMC6256554)
McNaughton, A.L., Sreenu, V.B. , Wilkie, G., Gunson, R., Templeton, K. and Leitch, E.C.M. (2018) Prevalence of mixed genotype hepatitis C virus infections in the UK as determined by genotype‐specific PCR and deep sequencing. Journal of Viral Hepatitis, 25(5), pp. 524-534. (doi: 10.1111/jvh.12849) (PMID:29274184) (PMCID:PMC5947153)
da Silva Filipe, A. et al. (2018) Reply to: "Reply to: 'Response to DAA therapy in the NHS England Early Access Programme for rare HCV subtypes from low and middle income countries'". Journal of Hepatology, 68(4), pp. 864-866. (doi: 10.1016/j.jhep.2017.11.044) (PMID:29339112)
Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi: 10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)
2017
da Silva Filipe, A. et al. (2017) Response to DAA therapy in the NHS England early access programme for rare HCV subtypes from low and middle income countries. Journal of Hepatology, 67(6), pp. 1348-1350. (doi: 10.1016/j.jhep.2017.06.035) (PMID:28789880)
Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)
Varjak, M. et al. (2017) Aedes aegypti Piwi4 is a noncanonical PIWI protein involved in antiviral responses. mSphere, 2(3), 00144-17. (doi: 10.1128/mSphere.00144-17) (PMID:28497119) (PMCID:PMC5415634)
2016
Schnettler, E., Sreenu, V. B. , Mottram, T. and McFarlane, M. (2016) Wolbachia restricts insect specific flavivirus infection in Aedes aegypti cells. Journal of General Virology, 97(11), pp. 3024-3029. (doi: 10.1099/jgv.0.000617) (PMID:27692043) (PMCID:PMC5120408)
Thomson, E. et al. (2016) Comparison of next-generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes. Journal of Clinical Microbiology, 54(10), pp. 2470-2484. (doi: 10.1128/JCM.00330-16) (PMID:27385709) (PMCID:PMC5035407)
Polachek, W. S., Moshrif, H. F., Franti, M., Coen, D. M., Sreenu, V. B. and Strang, B. L. (2016) High-throughput small interfering RNA screening identifies phosphatidylinositol 3-kinase class II alpha as important for production of human cytomegalovirus virions. Journal of Virology, 90(18), pp. 8360-8371. (doi: 10.1128/JVI.01134-16) (PMID:27412598)
Jacobs, M. et al. (2016) Late Ebola virus relapse causing meningoencephalitis: a case report. Lancet, 388(10043), pp. 498-503. (doi: 10.1016/S0140-6736(16)30386-5) (PMID:27209148) (PMCID:PMC4967715)
Orton, R.J. , Gu, Q. , Hughes, J. , Maabar, M., Modha, S. , Vattipally, S. , Wilkie, G.S. and Davison, A. (2016) Bioinformatics tools for analysing viral genomic data. Revue scientifique et technique (International Office of Epizootics), 35(1), pp. 241-285. (doi: 10.20506/rst.35.1.2432) (PMID:27217183)
2015
Jerome, H., Vattipally, S. B. and Thomson, E. C. (2015) Can we identify potential viral zoonoses before they cross the species barrier? Microbiology Today, 42(4), pp. 150-153.
Chang, C.-H. et al. (2015) HIV-infected sex workers with beneficial HLA-variants are potential hubs for selection of HIV-1 recombinants that may affect disease progression. Scientific Reports, 5, 11253. (doi: 10.1038/srep11253) (PMID:26082240) (PMCID:PMC4469978)
Gaunt, E., Harvala, H., Osterback, R., Sreenu, V. B. , Thomson, E. , Waris, M. and Simmonds, P. (2015) Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity. Journal of General Virology, 96(5), pp. 1067-1079. (doi: 10.1099/vir.0.000062) (PMID:25614593) (PMCID:PMC4631059)
2014
Tenzer, S. et al. (2014) HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification. Cell Reports, 7(2), pp. 448-463. (doi: 10.1016/j.celrep.2014.03.031)
2013
Leggewie, M., Sreenu, V. B. , Abdelrahman, T., Leitch, E. C., Wilkie, G., Klymenko, T., Muir, D., Thursz, M., Main, J. and Thomson, E.C. (2013) Natural NS3 resistance polymorphisms occur frequently prior to treatment in HIV-positive patients with acute hepatitis C. AIDS, 27(15), pp. 2485-2488. (doi: 10.1097/QAD.0b013e328363b1f9) (PMID:23770494)
2011
Carmo, A. M. and Sreenu, V. B. (2011) A systematic and thorough search for domains of the scavenger receptor cysteine-rich Group-B family in the human genome. In: Mahdavi, Mahmood A. (ed.) Bioinformatics: Trends and Methodologies. IntechOpen. ISBN 9789533072821 (doi: 10.5772/19462)
2009
Gonçalves, C. M. et al. (2009) Molecular cloning and analysis of SSc5D, a new member of the scavenger receptor cysteine-rich superfamily. Molecular Immunology, 46(13), pp. 2585-2596. (doi: 10.1016/j.molimm.2009.05.006) (PMID:19535143)
2008
Abidi, S. H. I., Dong, T., Vuong, M. T., Sreenu, V. B. , Rowland-Jones, S. L., Evans, E. J. and Davis, S. J. (2008) Differential remodeling of a T-cell transcriptome following CD8- versus CD3-induced signaling. Cell Research, 18(6), pp. 641-648. (doi: 10.1038/cr.2008.56) (PMID:18475290) (PMCID:PMC2731849)
2007
Hene, L., Sreenu, V. B. , Vuong, M. T., Abidi, S. H. I., Sutton, J. K., Rowland-Jones, S. L., Davis, S. J. and Evans, E. J. (2007) Deep analysis of cellular transcriptomes – LongSAGE versus classic MPSS. BMC Genomics, 8(1), 333. (doi: 10.1186/1471-2164-8-333) (PMID:17892551) (PMCID:PMC2104538)
Sreenu, V. B. , Kumar, P., Nagaraju, J. and Nagarajaram, H. A. (2007) Simple sequence repeats in mycobacterial genomes. Journal of Biosciences, 32(1), pp. 3-15. (doi: 10.1007/s12038-007-0002-7) (PMID:17426376)
2006
Sreenu, V. B. , Kumar, P., Nagaraju, J. and Nagarajaram, H. A. (2006) Microsatellite polymorphism across the M. tuberculosis and M. bovis genomes: Implications on genome evolution and plasticity. BMC Genomics, 7(1), 78. (doi: 10.1186/1471-2164-7-78) (PMID:16603092) (PMCID:PMC1501019)
2005
Prasad, M.D. et al. (2005) SilkSatDb: a microsatellite database of the silkworm, Bombyx mori. Nucleic Acids Research, 33(Suppl1), D403-D406. (doi: 10.1093/nar/gki099) (PMID:15608226) (PMCID:PMC540053)
Gundu, R.K., Swamynathan, S., Sreenu, V.B. , Pavan, N., Acharya, S. and Nagarajaram, H.A. (2005) Frontiers in bioinformatics research: the biodiversity issues. In: Tandon, Pramod, Sharma, Manju and Swarup, Renu (eds.) Biodiversity: Status and Prospects. Narosa Publishing House: New Dehli. ISBN 9788173196768
2003
Sreenu, V. B. , Alevoor, V., Javaregowda, N. and Nagarajaram, H. A. (2003) MICdb: database of prokaryotic microsatellites. Nucleic Acids Research, 31(1), pp. 106-108. (doi: 10.1093/nar/gkg002) (PMID:12519959) (PMCID:PMC165449)
Ranjitkumar, G., Pavan, M. N., Bose, B., Swaminathan, S., Geetha, T., Prashanthi, P., Prasad, B. P., Sreenu, V.B. , Achary, M. S. and Nagarajaram, H.A. (2003) EMBnet India Node (EIN) at the Centre for DNA Fingerprinting and Diagnostics: serving the Indian sub-continent in bioinformatics. Bioinformatics India, 1(2), pp. 67-77.
Sreenu, V.B. , Ranjitkumar, G., Swaminathan, S., Priya, S., Bose, B., Pavan, M.N., Thanu, G., Nagaraju, J. and Nagarajaram, H.A. (2003) MICAS: a fully automated web server for microsatellite extraction and analysis from prokaryote and viral genomic sequences. Applied Bioinformatics, 2(3), pp. 165-168. (PMID:15130803)
2002
Kamal, A., Ramesh, G., Laxman, N., Ramulu, P., Srinivas, O., Neelima, K., Kondapi, A. K., Sreenu, V.B. and Nagarajaram, H.A. (2002) Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity. Journal of Medicinal Chemistry, 45(21), pp. 4679-4688. (doi: 10.1021/jm020124h) (PMID:12361394)
Articles
Ahovègbé, L. et al. (2024) Hepatitis C virus diversity and treatment outcomes in Benin; a prospective cohort study. Lancet Microbe, 5(7), pp. 697-706. (doi: 10.1016/S2666-5247(24)00041-7) (PMID:38889738)
Spinard, E. et al. (2024) Near-complete genome sequences of multiple genotype 1 African swine fever virus isolates from 2016 to 2018 in Cameroon. Microbiology Resource Announcements, 13(4), e00978-23. (doi: 10.1128/mra.00978-23) (PMID:38477459) (PMCID:PMC11008206)
Leggewie, M. et al. (2023) The Aedes aegypti RNA interference response against Zika virus in the context of co-infection with dengue and chikungunya viruses. PLoS Neglected Tropical Diseases, 17(7), e0011456. (doi: 10.1371/journal.pntd.0011456) (PMID:37440582) (PMCID:PMC10343070)
Jagtap, S. V., Brink, J., Frank, S. C., Badusche, M., Leggewie, M., Sreenu, V. B. , Fuss, J., Schnettler, E. and Altinli, M. (2023) Agua Salud alphavirus infection, dissemination and transmission in Aedes aegypti mosquitoes. Viruses, 15(5), 1113. (doi: 10.3390/v15051113) (PMID:37243199) (PMCID:PMC10223791)
Alexander, A. J.T. et al. (2023) Characterisation of the antiviral RNA interference response to Toscana virus in sand fly cells. PLoS Pathogens, 19(3), e1011283. (doi: 10.1371/journal.ppat.1011283) (PMID:36996243) (PMCID:PMC10112792)
Altinli, M., Leggewie, M., Schulze, J., Gyanwali, R., Badusche, M., Sreenu, V. B. , Fuss, J. and Schnettler, E. (2023) Antiviral RNAi response in Culex quinquefasciatus-derived HSU cells. Viruses, 15(2), 436. (doi: 10.3390/v15020436) (PMID:36851650) (PMCID:PMC9968050)
Sugrue, E. et al. (2022) The apparent interferon resistance of transmitted HIV-1 is possibly a consequence of enhanced replicative fitness. PLoS Pathogens, 18(11), e1010973. (doi: 10.1371/journal.ppat.1010973) (PMID:36399512) (PMCID:PMC9718408)
Aranday-Cortes, E. et al. (2022) Real-world outcomes of direct-acting antiviral treatment and retreatment in United Kingdom–based patients infected with hepatitis C virus genotypes/subtypes endemic in Africa. Journal of Infectious Diseases, 226(6), pp. 995-1004. (doi: 10.1093/infdis/jiab110) (PMID:33668068) (PMCID:PMC9492310)
Xu, R., Rong, X., Aranday-Cortes, E., Vattipally, S. , Hughes, J. , McLauchlan, J. and Fu, Y. (2022) The transmission route and selection pressure in HCV subtype 3a and 3b Chinese infections: evolutionary kinetics and selective force analysis. Viruses, 14(7), 1514. (doi: 10.3390/v14071514) (PMID:35891494) (PMCID:PMC9324606)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Gestuveo, R. et al. (2022) Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs. PLoS Pathogens, 18(1), e1010202. (doi: 10.1371/journal.ppat.1010202) (PMID:34990484) (PMCID:PMC8769306)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
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Donald, C. L. , Varjak, M. , Aguiar, E. R. G. R., Marques, J. T., Sreenu, V. B. , Schnettler, E. and Kohl, A. (2018) Antiviral RNA interference activity in cells of the predatory mosquito, Toxorhynchites amboinensis. Viruses, 10(12), 694. (doi: 10.3390/v10120694) (PMID:30563205) (PMCID:PMC6316411)
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Masembe, C. , Sreenu, V. B. , Da Silva Filipe, A. , Wilkie, G. S., Ogweng, P., Mayega, F. J., Muwanika, V. B., Biek, R. , Palmarini, M. and Davison, A. J. (2018) Genome sequences of five African swine fever virus genotype IX isolates from domestic pigs in Uganda. Microbiology Resource Announcements, 7(13), e01018-18. (doi: 10.1128/mra.01018-18) (PMID:30533685) (PMCID:PMC6256554)
McNaughton, A.L., Sreenu, V.B. , Wilkie, G., Gunson, R., Templeton, K. and Leitch, E.C.M. (2018) Prevalence of mixed genotype hepatitis C virus infections in the UK as determined by genotype‐specific PCR and deep sequencing. Journal of Viral Hepatitis, 25(5), pp. 524-534. (doi: 10.1111/jvh.12849) (PMID:29274184) (PMCID:PMC5947153)
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Lourenço-de-Oliveira, R., Marques, J. T., Sreenu, V. B. , Nten, C. A., Guimarães Rocha Aguiarr, E. R., Varjak, M. , Kohl, A. and Failloux, A.-B. (2018) Culex quinquefasciatus mosquitoes do not support replication of Zika virus. Journal of General Virology, 99, pp. 258-264. (doi: 10.1099/jgv.0.000949) (PMID:29076805) (PMCID:PMC5882084)
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Varjak, M. , Donald, C. L. , Mottram, T. J., Sreenu, V. B. , Merits, A., Maringer, K., Schnettler, E. and Kohl, A. (2017) Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Neglected Tropical Diseases, 11(10), e0006010. (doi: 10.1371/journal.pntd.0006010) (PMID:29040304) (PMCID:PMC5667879)
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Schnettler, E., Sreenu, V. B. , Mottram, T. and McFarlane, M. (2016) Wolbachia restricts insect specific flavivirus infection in Aedes aegypti cells. Journal of General Virology, 97(11), pp. 3024-3029. (doi: 10.1099/jgv.0.000617) (PMID:27692043) (PMCID:PMC5120408)
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Ranjitkumar, G., Pavan, M. N., Bose, B., Swaminathan, S., Geetha, T., Prashanthi, P., Prasad, B. P., Sreenu, V.B. , Achary, M. S. and Nagarajaram, H.A. (2003) EMBnet India Node (EIN) at the Centre for DNA Fingerprinting and Diagnostics: serving the Indian sub-continent in bioinformatics. Bioinformatics India, 1(2), pp. 67-77.
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Book Sections
Carmo, A. M. and Sreenu, V. B. (2011) A systematic and thorough search for domains of the scavenger receptor cysteine-rich Group-B family in the human genome. In: Mahdavi, Mahmood A. (ed.) Bioinformatics: Trends and Methodologies. IntechOpen. ISBN 9789533072821 (doi: 10.5772/19462)
Gundu, R.K., Swamynathan, S., Sreenu, V.B. , Pavan, N., Acharya, S. and Nagarajaram, H.A. (2005) Frontiers in bioinformatics research: the biodiversity issues. In: Tandon, Pramod, Sharma, Manju and Swarup, Renu (eds.) Biodiversity: Status and Prospects. Narosa Publishing House: New Dehli. ISBN 9788173196768
Research datasets
2021
Scherer, C., Knowles, J., Vattipally, S. , Fredericks, A., Fuss, J., Maringer, K., Fernandez-Sesma, A., Merits, A., Varjak, M. , Kohl, A. and Schnettler, E. (2021) An Aedes aegypti-derived Ago2 knockout cell line to investigate arbovirus infections. [Data Collection]
2020
Gilbert, M., Sulikhan, N., Uphyrkina, O., Goncharuk, M., Kerley, L., Hernandez Castro, E., Reeve, R. , Seimon, T., McAloose, D., Seryodkin, I. V., Naidenko, S. V., Davis, C. A., Wilkie, G. S., Vattipally, S. , Adamson, W., Hinds, C., Thomson, E. , Willett, B. , Hosie, M. , Logan, N., McDonald, M. , Ossiboff, R. J., Shevtsova, E. I., Belyakin, S., Yurlova, A. A., Osofsky, S. A., Miquelle, D. G., Matthews, L. and Cleaveland, S. (2020) Distemper, extinction and vaccination of the Amur tiger. [Data Collection]
Alexander, A., Confort, M.-P., Desloire, S., Dunlop, J., Kuchi, S., Vattipally, S. , Mair, D., Wilkie, G., Da Silva Felipe, A., Brennan, B. , Ratinier, M., Arnaud, F. and Kohl, A. (2020) Development of a reverse genetics system for Toscana virus (lineage A). [Data Collection]
