Dr Shikha Shikha
- Research Associate (Parasitology)
Publications
2025
Shikha, S. , Tobiasson, V., Ferreira Silva, M., Ovciarikova, J., Beraldi, D., Mühleip, A. and Sheiner, L. (2025) Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements. Nature Communications, 16, 817. (doi: 10.1038/s41467-025-56057-9)
Edgar, R. C.S., Hanna, J. , Novotná, M., Campillo Poveda, M. , Rawat, M., Shikha, S. , Venter, F. and Ridgway, M. C. (2025) SPPIRIT: a network connecting Scottish early-career researchers in parasitology. Trends in Parasitology, 41(1), pp. 8-12. (doi: 10.1016/j.pt.2024.11.009) (PMID:39658486)
2024
Ovciarikova, J. et al. (2024) Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. Journal of Cell Biology, 223(4), e202304075. (doi: 10.1083/jcb.202304075) (PMID:38456969)
2022
Ovciarikova, J., Shikha, S. and Sheiner, L. (2022) Nuclear interactions: a spotlight on nuclear mitochondrial membrane contact sites. Contact, 5, p. 25152564221096217. (doi: 10.1177/25152564221096217) (PMID:36338149) (PMCID:PMC9623421)
Shikha, S. , Ferreira Silva, M. and Sheiner, L. (2022) Identification and validation of Toxoplasma gondii mitoribosomal large subunit components. Microorganisms, 10(5), 863. (doi: 10.3390/microorganisms10050863) (PMID:35630308) (PMCID:PMC9145746)
2020
Shikha, S. , Huot, J. L., Schneider, A. and Niemann, M. (2020) tRNA import across the mitochondrial inner membrane in T. brucei requires TIM subunits but is independent of protein import. Nucleic Acids Research, 48(21), pp. 12269-12281. (doi: 10.1093/nar/gkaa1098) (PMID:33231678) (PMCID:PMC7708065)
Shikha, S. and Schneider, A. (2020) The single CCA-adding enzyme of T. brucei has distinct functions in the cytosol and in mitochondria. Journal of Biological Chemistry, 295(18), pp. 6138-6150. (doi: 10.1074/jbc.ra119.011877) (PMID:32234763) (PMCID:PMC7196653)
2019
Huot, J. L., Shikha, S. and Schneider, A. (2019) Inducible orthogonal aminoacylation demonstrates that charging is required for mitochondrial tRNA import in Trypanosoma brucei. Scientific Reports, 9, 10836. (doi: 10.1038/s41598-019-47268-4) (PMID:31346230) (PMCID:PMC6658472)
Shikha, S. , Brogli, R., Schneider, A. and Polacek, N. (2019) tRNA Biology in Trypanosomes. CHIMIA International Journal for Chemistry, 73(5), pp. 395-405. (doi: 10.2533/chimia.2019.395) (PMID:31118122)
2015
Kumar, A., Shikha, S. , Majhi, R. K., Swain, N., Yadav, M. and Goswami, C. (2015) Regulation of TRP channels by steroids: Implications in physiology and diseases. General and Comparative Endocrinology, 220, pp. 23-32. (doi: 10.1016/j.ygcen.2014.10.004) (PMID:25449179)
Shikha, K. , Kumar, A., Sardar, P., Yadav, M., Majhi, R. K., Kumar, A. and Goswami, C. (2015) Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4. Biochemical and Biophysical Research Communications, 456(1), pp. 312-319. (doi: 10.1016/j.bbrc.2014.11.077) (PMID:25434996)
2014
Pradhan, N. et al. (2014) Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells: Fe(salen)Cl induces apoptosis in tumor cells. Cell Biology International, 38(10), pp. 1118-1131. (doi: 10.1002/cbin.10308) (PMID:24804954)
2013
Majhi, R. K. et al. (2013) Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility. Channels, 7(6), pp. 483-492. 23912940. (doi: 10.4161/chan.25793) (PMID:PMC4042483)
Articles
Shikha, S. , Tobiasson, V., Ferreira Silva, M., Ovciarikova, J., Beraldi, D., Mühleip, A. and Sheiner, L. (2025) Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements. Nature Communications, 16, 817. (doi: 10.1038/s41467-025-56057-9)
Edgar, R. C.S., Hanna, J. , Novotná, M., Campillo Poveda, M. , Rawat, M., Shikha, S. , Venter, F. and Ridgway, M. C. (2025) SPPIRIT: a network connecting Scottish early-career researchers in parasitology. Trends in Parasitology, 41(1), pp. 8-12. (doi: 10.1016/j.pt.2024.11.009) (PMID:39658486)
Ovciarikova, J. et al. (2024) Two ancient membrane pores mediate mitochondrial-nucleus membrane contact sites. Journal of Cell Biology, 223(4), e202304075. (doi: 10.1083/jcb.202304075) (PMID:38456969)
Ovciarikova, J., Shikha, S. and Sheiner, L. (2022) Nuclear interactions: a spotlight on nuclear mitochondrial membrane contact sites. Contact, 5, p. 25152564221096217. (doi: 10.1177/25152564221096217) (PMID:36338149) (PMCID:PMC9623421)
Shikha, S. , Ferreira Silva, M. and Sheiner, L. (2022) Identification and validation of Toxoplasma gondii mitoribosomal large subunit components. Microorganisms, 10(5), 863. (doi: 10.3390/microorganisms10050863) (PMID:35630308) (PMCID:PMC9145746)
Shikha, S. , Huot, J. L., Schneider, A. and Niemann, M. (2020) tRNA import across the mitochondrial inner membrane in T. brucei requires TIM subunits but is independent of protein import. Nucleic Acids Research, 48(21), pp. 12269-12281. (doi: 10.1093/nar/gkaa1098) (PMID:33231678) (PMCID:PMC7708065)
Shikha, S. and Schneider, A. (2020) The single CCA-adding enzyme of T. brucei has distinct functions in the cytosol and in mitochondria. Journal of Biological Chemistry, 295(18), pp. 6138-6150. (doi: 10.1074/jbc.ra119.011877) (PMID:32234763) (PMCID:PMC7196653)
Huot, J. L., Shikha, S. and Schneider, A. (2019) Inducible orthogonal aminoacylation demonstrates that charging is required for mitochondrial tRNA import in Trypanosoma brucei. Scientific Reports, 9, 10836. (doi: 10.1038/s41598-019-47268-4) (PMID:31346230) (PMCID:PMC6658472)
Shikha, S. , Brogli, R., Schneider, A. and Polacek, N. (2019) tRNA Biology in Trypanosomes. CHIMIA International Journal for Chemistry, 73(5), pp. 395-405. (doi: 10.2533/chimia.2019.395) (PMID:31118122)
Kumar, A., Shikha, S. , Majhi, R. K., Swain, N., Yadav, M. and Goswami, C. (2015) Regulation of TRP channels by steroids: Implications in physiology and diseases. General and Comparative Endocrinology, 220, pp. 23-32. (doi: 10.1016/j.ygcen.2014.10.004) (PMID:25449179)
Shikha, K. , Kumar, A., Sardar, P., Yadav, M., Majhi, R. K., Kumar, A. and Goswami, C. (2015) Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4. Biochemical and Biophysical Research Communications, 456(1), pp. 312-319. (doi: 10.1016/j.bbrc.2014.11.077) (PMID:25434996)
Pradhan, N. et al. (2014) Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells: Fe(salen)Cl induces apoptosis in tumor cells. Cell Biology International, 38(10), pp. 1118-1131. (doi: 10.1002/cbin.10308) (PMID:24804954)
Majhi, R. K. et al. (2013) Thermosensitive ion channel TRPV1 is endogenously expressed in the sperm of a fresh water teleost fish (Labeo rohita) and regulates sperm motility. Channels, 7(6), pp. 483-492. 23912940. (doi: 10.4161/chan.25793) (PMID:PMC4042483)