Dr Shaun Chuah
- Clinical Senior Research Fellow (Immunology & Infection)
email:
Shaun.Chuah@glasgow.ac.uk
pronouns:
He/him/his
https://orcid.org/0000-0002-5936-3370Biography
Shaun is an academic gastroenterologist with research interests in applying machine learning/AI, data engineering and cloud computation techniques in inflammatory bowel disease and other immune-related conditions.
Research interests
My specific research interest lies in the application of machine learning and AI techniques, to better understand the clinical behaviour and biology of inflammatory bowel disease, as well as develop new tools with the overall aim of improving the care of patients with IBD.
Current Projects
- MUSIC Study (www.musicstudy.uk)
- MARVEL Study (www.marvelstudy.uk)
- ChatIBD (www.chatibd.com)
Background
I obtained my MBChB from the University of Edinburgh in 2013. After completing foundation and core training across both Edinburgh and Glasgow, I returned to Edinburgh to undertake specialty training in Gastroenterology. During this time, I earned a postgraduate Doctor of Medicine research degree, completing a thesis that characterised the behaviour of circulating cell-free DNA in inflammatory bowel disease in Prof. Gwo-Tzer Ho's lab.
During my time in research, I developed a keen interest in software/data engineering/machine-learning/AI and understand the challenges of building robust, scalable, end-to-end data infrastructure to manage platform translational studies. In the University of Glasgow, I am also continuing to develop the digital infrastructure to support the application of generative AI tooling in IBD.
Publications
Prior publications
Article
Cher S Chuah et al. (2025) Machine learning approach to dissect the clinical heterogeneity of IBD-associated fatigue Crossref. (doi: 10.1101/2025.08.14.25333676)
Rebecca Hall, Robert J Whelan, Peter D Cartlidge, Emily F Brownson, Craig Mowat, John P Seenan, Jonathan C MacDonald, Iona AM Campbell, Cher S Chuah, Gwo-Tzer Ho (2025) Characterisation of 3000 patient reported outcomes with predictive machine learning to develop a scientific platform to study fatigue in Inflammatory Bowel Disease Crossref. (doi: 10.1101/2025.01.18.25320777)
McAllister MJ et al. (2024) Formylated Peptide Receptor-1-Mediated Gut Inflammation as a Therapeutic Target in Inflammatory Bowel Disease. Crohn's & colitis 360 Europe PubMed Central. (doi: 10.1093/crocol/otae003)
Chuah CS, Fischer L, Ho GT (2023) Circulating Cell-Free DNA in Inflammatory Bowel Disease: Liquid Biopsies with Mechanistic and Translational Implications. Faculty reviews Europe PubMed Central. (doi: 10.12703/r/12-14)
Drury B, Chuah CS, Hall R, Hardisty GR, Rossi AG, Ho GT (2023) Neutrophil-dependent Mitochondrial DNA Release Associated With Extracellular Trap Formation in Inflammatory Bowel Disease. Gastro hep advances Europe PubMed Central. (doi: 10.1016/j.gastha.2023.03.022)
Dunne P, Young D, Chuah CS, Hayes P, Tripathi D, Leithead J, Smith L, Gaya D, Forrest E, Stanley AJ (2022) Letter: non-selective beta-blockers in cirrhosis-effect beyond portal hypertension. Authors' reply. Alimentary pharmacology & therapeutics Cher Shiong Chuah. (doi: 10.1111/apt.16982)
Dunne PDJ, Young D, Chuah CS, Hayes PC, Tripathi D, Leithead J, Smith LA, Gaya DR, Forrest E, Stanley AJ (2022) Carvedilol versus endoscopic band ligation for secondary prophylaxis of variceal bleeding-long-term follow-up of a randomised control trial. Alimentary pharmacology & therapeutics Cher Shiong Chuah. (doi: 10.1111/apt.16901)
Chuah S, Hall R, Ward E, Drury B, Ho G (2022) Mitochondrial DAMPs as mechanistic biomarkers of mucosal inflammation in Crohn’s disease: Study protocol for prospective longitudinal cohort study in Scotland Europe PubMed Central. (doi: 10.1101/2022.03.21.22270313)
McAllister MJ, Kirkwood K, Chuah SC, Thompson EJ, Cartwright JA, Russell CD, Dorward DA, Lucas CD, Ho GT (2021) Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection. Inflammation Cher Shiong Chuah. (doi: 10.1007/s10753-021-01567-z)
McAllister MJ, Kirkwood K, Chuah SC, Thompson EJ, Cartwright JA, Russell CD, Dorward DA, Lucas CD, Ho G (2021) Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection Europe PubMed Central. (doi: 10.21203/rs.3.rs-495949/v1)
Plevris N et al. (2021) Real-world effectiveness and safety of ustekinumab for the treatment of Crohn's disease: the Scottish ustekinumab cohort. Journal of gastroenterology and hepatology Cher Shiong Chuah. (doi: 10.1111/jgh.15390)
McDowell HR, Chuah CS, Tripathi D, Stanley AJ, Forrest EH, Hayes PC (2020) Carvedilol is associated with improved survival in patients with cirrhosis: a long-term follow-up study. Alimentary pharmacology & therapeutics Cher Shiong Chuah. (doi: 10.1111/apt.16189)
Plevris N et al. (2020) Normalization of Fecal Calprotectin Within 12 Months of Diagnosis Is Associated With Reduced Risk of Disease Progression in Patients With Crohn's Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Cher Shiong Chuah. (doi: 10.1016/j.cgh.2020.08.022)
Plevris N, Jenkinson PW, Chuah CS, Lyons M, Merchant LM, Pattenden RJ, Arnott ID, Jones GR, Lees CW (2019) Association of trough vedolizumab levels with clinical, biological and endoscopic outcomes during maintenance therapy in inflammatory bowel disease. Frontline gastroenterology Europe PubMed Central. (doi: 10.1136/flgastro-2019-101197)
Plevris N et al. (2019) Higher Adalimumab Drug Levels During Maintenance Therapy for Crohn's Disease Are Associated With Biologic Remission. Inflammatory bowel diseases Europe PubMed Central. (doi: 10.1093/ibd/izy320)
Plevris N et al. (2018) Implementation of CT-P13 via a Managed Switch Programme in Crohn's Disease: 12-Month Real-World Outcomes. Digestive diseases and sciences Europe PubMed Central. (doi: 10.1007/s10620-018-5406-8)
Chuah CS, Noble C, Leitch A (2018) Case of steroid-resistant Crohn's-associated bronchiolitis in the setting of quiescent gastrointestinal disease treated with infliximab. BMJ case reports Europe PubMed Central. (doi: 10.1136/bcr-2018-226934)
Chuah C, Kirkbride R, Alston R, Irons J (2013) Hydrogen ion concentration and coronary artery bypass graft surgery with and without cardiopulmonary bypass. Journal of cardiothoracic surgery Europe PubMed Central. (doi: 10.1186/1749-8090-8-184)
