Dr Shaun Chuah
- Clinical Senior Research Fellow (Immunology & Infection)
email:
Shaun.Chuah@glasgow.ac.uk
pronouns:
He/him/his
https://orcid.org/0000-0002-5936-3370Research interests
My specific research interest lies in the application of machine learning to better understand the clinical behaviour and biology of inflammatory bowel disease. Gaining a deeper understanding will hopefully allow the development of better tools and treatment for patients in the clinic. To do this, I am currently developing scalable approaches to patient recruitment and data collection as well as novel end-to-end data pipelines to allow the development and deployment of machine learning models as useful clinical tools.
Current studies
- MUSIC Study (www.musicstudy.uk)
- MARVEL Study (www.marvelstudy.uk)
Background
I obtained my MBChB from the University of Edinburgh in 2013. After completing foundation and core training across both Edinburgh and Glasgow, I returned to Edinburgh to undertake specialty training in Gastroenterology. During this time, I earned a postgraduate Doctor of Medicine research degree, completing a thesis that characterised the behaviour of circulating cell-free DNA in inflammatory bowel disease in Dr. Gwo-Tzer Ho's lab.
During my time in research, I developed a specialist interest in software/data engineering/ machine-learning and understand the challenges of building robust, scalable, end-to-end data infrastructure to manage platform translational studies.
Publications
Prior publications
Article
Rebecca Hall, Robert J Whelan, Peter D Cartlidge, Emily F Brownson, Craig Mowat, John P Seenan, Jonathan C MacDonald, Iona AM Campbell, Cher S Chuah, Gwo-Tzer Ho (2025) Characterisation of 3000 patient reported outcomes with predictive machine learning to develop a scientific platform to study fatigue in Inflammatory Bowel Disease Crossref. (doi: 10.1101/2025.01.18.25320777)
McAllister MJ et al. (2024) Formylated Peptide Receptor-1-Mediated Gut Inflammation as a Therapeutic Target in Inflammatory Bowel Disease. Europe PubMed Central. (doi: 10.1093/crocol/otae003)
Chuah CS, Fischer L, Ho GT (2023) Circulating Cell-Free DNA in Inflammatory Bowel Disease: Liquid Biopsies with Mechanistic and Translational Implications. Europe PubMed Central. (doi: 10.12703/r/12-14)
Drury B, Chuah CS, Hall R, Hardisty GR, Rossi AG, Ho GT (2023) Neutrophil-dependent Mitochondrial DNA Release Associated With Extracellular Trap Formation in Inflammatory Bowel Disease. Europe PubMed Central. (doi: 10.1016/j.gastha.2023.03.022)
Philip DJ Dunne, Young D, Chuah CS, Hayes P, Tripathi D, Leithead J, Smith L, Gaya D, Forrest E, Stanley AJ (2022) Letter: non-selective beta-blockers in cirrhosis-effect beyond portal hypertension. Authors' reply. Cher Shiong Chuah. (doi: 10.1111/apt.16982)
Philip DJ Dunne, David Young, Chuah CS, Hayes PC, Tripathi D, Leithead J, Smith LA, Gaya DR, Ewan Forrest, Stanley AJ (2022) Carvedilol versus endoscopic band ligation for secondary prophylaxis of variceal bleeding-long-term follow-up of a randomised control trial. Cher Shiong Chuah. (doi: 10.1111/apt.16901)
Chuah S, Hall R, Ward E, Drury B, Ho G (2022) Mitochondrial DAMPs as mechanistic biomarkers of mucosal inflammation in Crohn’s disease: Study protocol for prospective longitudinal cohort study in Scotland Europe PubMed Central. (doi: 10.1101/2022.03.21.22270313)
McAllister MJ, Kirkwood K, Chuah SC, Thompson EJ, Cartwright JA, Russell CD, Dorward DA, Christopher D Lucas, Gwo-tzer Ho (2021) Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection. Cher Shiong Chuah. (doi: 10.1007/s10753-021-01567-z)
McAllister MJ, Kirkwood K, Chuah SC, Thompson EJ, Cartwright JA, Russell CD, Dorward DA, Lucas CD, Ho G (2021) Intestinal Protein Characterisation of SARS-CoV-2 Entry Molecules ACE2 and TMPRSS2 in Inflammatory Bowel Disease (IBD) and Fatal COVID-19 Infection Europe PubMed Central. (doi: 10.21203/rs.3.rs-495949/v1)
Nikolas Plevris et al. (2021) Real-world effectiveness and safety of ustekinumab for the treatment of Crohn's disease: the Scottish ustekinumab cohort. Cher Shiong Chuah. (doi: 10.1111/jgh.15390)
Hannah McDowell, Cher Shiong Chuah, Tripathi D, Stanley AJ, Ewan Forrest, Hayes PC (2020) Carvedilol is associated with improved survival in patients with cirrhosis: a long-term follow-up study. Cher Shiong Chuah. (doi: 10.1111/apt.16189)
Nikolas Plevris et al. (2020) Normalization of Fecal Calprotectin Within 12 Months of Diagnosis Is Associated With Reduced Risk of Disease Progression in Patients With Crohn's Disease. Cher Shiong Chuah. (doi: 10.1016/j.cgh.2020.08.022)
Plevris N et al. (2019) Real-world Effectiveness and Safety of Vedolizumab for the Treatment of Inflammatory Bowel Disease: The Scottish Vedolizumab Cohort. Europe PubMed Central. (doi: 10.1093/ecco-jcc/jjz042)
Plevris N, Jenkinson PW, Chuah CS, Lyons M, Merchant LM, Pattenden RJ, Arnott ID, Jones GR, Lees CW (2019) Association of trough vedolizumab levels with clinical, biological and endoscopic outcomes during maintenance therapy in inflammatory bowel disease. Europe PubMed Central. (doi: 10.1136/flgastro-2019-101197)
Plevris N et al. (2019) Higher Adalimumab Drug Levels During Maintenance Therapy for Crohn's Disease Are Associated With Biologic Remission. Europe PubMed Central. (doi: 10.1093/ibd/izy320)
Plevris N et al. (2018) Implementation of CT-P13 via a Managed Switch Programme in Crohn's Disease: 12-Month Real-World Outcomes. Europe PubMed Central. (doi: 10.1007/s10620-018-5406-8)
Chuah CS, Noble C, Leitch A (2018) Case of steroid-resistant Crohn's-associated bronchiolitis in the setting of quiescent gastrointestinal disease treated with infliximab. Europe PubMed Central. (doi: 10.1136/bcr-2018-226934)
Chuah C, Kirkbride R, Alston R, Irons J (2013) Hydrogen ion concentration and coronary artery bypass graft surgery with and without cardiopulmonary bypass. Europe PubMed Central. (doi: 10.1186/1749-8090-8-184)
