Mr Ryan Ritchie
- Laboratory Technician (Parasitology)
Publications
2023
Rao, S. P. S. et al. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380(6652), pp. 1349-1356. (doi: 10.1126/science.adh0614) (PMID:37384702)
2022
Koester, D. C. et al. (2022) Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry, 65(17), pp. 11776-11787. (doi: 10.1021/acs.jmedchem.2c00791) (PMID:35993839) (PMCID:PMC9469205)
Alpizar-Sosa, E. A. et al. (2022) Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response. PLoS Neglected Tropical Diseases, 16(9), e0010779. (doi: 10.1371/journal.pntd.0010779) (PMID:36170238) (PMCID:PMC9581426)
2021
Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)
McNae, I. W. et al. (2021) Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nature Communications, 12, 1052. (doi: 10.1038/s41467-021-21273-6) (PMID:33594070) (PMCID:PMC7887271)
2020
Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)
Rao, S. P.S. et al. (2020) Anti-Trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African Trypanosomiasis. Tropical Medicine and Infectious Disease, 5(1), 28. (doi: 10.3390/tropicalmed5010028) (PMID:32079320) (PMCID:PMC7157554)
Ritchie, R., Barrett, M. P. , Mottram, J. C. and Myburgh, E. (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)
2018
Ritchie, N. D., Ritchie, R., Bayes, H. K., Mitchell, T. J. and Evans, T. J. (2018) IL-17 can be protective or deleterious in murine pneumococcal pneumonia. PLoS Pathogens, 14(5), e1007099. (doi: 10.1371/journal.ppat.1007099) (PMID:29813133) (PMCID:PMC5993294)
Herbert, J. A., Mitchell, A. M., Ritchie, R., Ma, J., Ross-Hutchinson, K. and Mitchell, T. J. (2018) Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence. PLoS ONE, 13(1), e0189426. (doi: 10.1371/journal.pone.0189426) (PMID:29342160) (PMCID:PMC5771582)
2017
Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi: 10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)
2016
Myburgh, E. , Ritchie, R., Goundry, A. L., O’Neill, K., Marchesi, F. and Devaney, E. (2016) Attempts to image the early inflammatory response during infection with the lymphatic filarial nematode Brugia pahangi in a mouse model. PLoS ONE, 11(12), e0168602. (doi: 10.1371/journal.pone.0168602) (PMID:27992545) (PMCID:PMC5161388)
2015
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
2013
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
Articles
Rao, S. P. S. et al. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380(6652), pp. 1349-1356. (doi: 10.1126/science.adh0614) (PMID:37384702)
Koester, D. C. et al. (2022) Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry, 65(17), pp. 11776-11787. (doi: 10.1021/acs.jmedchem.2c00791) (PMID:35993839) (PMCID:PMC9469205)
Alpizar-Sosa, E. A. et al. (2022) Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response. PLoS Neglected Tropical Diseases, 16(9), e0010779. (doi: 10.1371/journal.pntd.0010779) (PMID:36170238) (PMCID:PMC9581426)
Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)
McNae, I. W. et al. (2021) Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nature Communications, 12, 1052. (doi: 10.1038/s41467-021-21273-6) (PMID:33594070) (PMCID:PMC7887271)
Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)
Rao, S. P.S. et al. (2020) Anti-Trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African Trypanosomiasis. Tropical Medicine and Infectious Disease, 5(1), 28. (doi: 10.3390/tropicalmed5010028) (PMID:32079320) (PMCID:PMC7157554)
Ritchie, N. D., Ritchie, R., Bayes, H. K., Mitchell, T. J. and Evans, T. J. (2018) IL-17 can be protective or deleterious in murine pneumococcal pneumonia. PLoS Pathogens, 14(5), e1007099. (doi: 10.1371/journal.ppat.1007099) (PMID:29813133) (PMCID:PMC5993294)
Herbert, J. A., Mitchell, A. M., Ritchie, R., Ma, J., Ross-Hutchinson, K. and Mitchell, T. J. (2018) Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence. PLoS ONE, 13(1), e0189426. (doi: 10.1371/journal.pone.0189426) (PMID:29342160) (PMCID:PMC5771582)
Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi: 10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)
Myburgh, E. , Ritchie, R., Goundry, A. L., O’Neill, K., Marchesi, F. and Devaney, E. (2016) Attempts to image the early inflammatory response during infection with the lymphatic filarial nematode Brugia pahangi in a mouse model. PLoS ONE, 11(12), e0168602. (doi: 10.1371/journal.pone.0168602) (PMID:27992545) (PMCID:PMC5161388)
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
Book Sections
Ritchie, R., Barrett, M. P. , Mottram, J. C. and Myburgh, E. (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, P. A.M., Ginger, M. L. and Zilberstein, D. (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)