Mr Ryan Ritchie
- Laboratory Technician (Parasitology)
Publications
2025
Richards, S. et al. (2025) Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of african animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania. PLoS Neglected Tropical Diseases, 19(1), e0012541. (doi: 10.1371/journal.pntd.0012541) (PMID:39836697) (PMCID:PMC11785308)
2023
Rao, S. P. S. et al. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380(6652), pp. 1349-1356. (doi: 10.1126/science.adh0614) (PMID:37384702)
2022
Koester, D. C. et al. (2022) Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry, 65(17), pp. 11776-11787. (doi: 10.1021/acs.jmedchem.2c00791) (PMID:35993839) (PMCID:PMC9469205)
Alpizar-Sosa, E. A. et al. (2022) Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response. PLoS Neglected Tropical Diseases, 16(9), e0010779. (doi: 10.1371/journal.pntd.0010779) (PMID:36170238) (PMCID:PMC9581426)
2021
Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)
McNae, I. W. et al. (2021) Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nature Communications, 12, 1052. (doi: 10.1038/s41467-021-21273-6) (PMID:33594070) (PMCID:PMC7887271)
2020
Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)
Rao, S. P.S. et al. (2020) Anti-Trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African Trypanosomiasis. Tropical Medicine and Infectious Disease, 5(1), 28. (doi: 10.3390/tropicalmed5010028) (PMID:32079320) (PMCID:PMC7157554)
Ritchie, R., Barrett, M. P. , Mottram, J. C. and Myburgh, E. (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)
2018
Ritchie, N. D., Ritchie, R., Bayes, H. K., Mitchell, T. J. and Evans, T. J. (2018) IL-17 can be protective or deleterious in murine pneumococcal pneumonia. PLoS Pathogens, 14(5), e1007099. (doi: 10.1371/journal.ppat.1007099) (PMID:29813133) (PMCID:PMC5993294)
Herbert, J. A., Mitchell, A. M., Ritchie, R., Ma, J., Ross-Hutchinson, K. and Mitchell, T. J. (2018) Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence. PLoS ONE, 13(1), e0189426. (doi: 10.1371/journal.pone.0189426) (PMID:29342160) (PMCID:PMC5771582)
2017
Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi: 10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)
2016
Myburgh, E. , Ritchie, R., Goundry, A. L., O’Neill, K., Marchesi, F. and Devaney, E. (2016) Attempts to image the early inflammatory response during infection with the lymphatic filarial nematode Brugia pahangi in a mouse model. PLoS ONE, 11(12), e0168602. (doi: 10.1371/journal.pone.0168602) (PMID:27992545) (PMCID:PMC5161388)
2015
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
2013
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
Articles
Richards, S. et al. (2025) Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of african animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania. PLoS Neglected Tropical Diseases, 19(1), e0012541. (doi: 10.1371/journal.pntd.0012541) (PMID:39836697) (PMCID:PMC11785308)
Rao, S. P. S. et al. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380(6652), pp. 1349-1356. (doi: 10.1126/science.adh0614) (PMID:37384702)
Koester, D. C. et al. (2022) Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry, 65(17), pp. 11776-11787. (doi: 10.1021/acs.jmedchem.2c00791) (PMID:35993839) (PMCID:PMC9469205)
Alpizar-Sosa, E. A. et al. (2022) Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response. PLoS Neglected Tropical Diseases, 16(9), e0010779. (doi: 10.1371/journal.pntd.0010779) (PMID:36170238) (PMCID:PMC9581426)
Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)
McNae, I. W. et al. (2021) Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nature Communications, 12, 1052. (doi: 10.1038/s41467-021-21273-6) (PMID:33594070) (PMCID:PMC7887271)
Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)
Rao, S. P.S. et al. (2020) Anti-Trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African Trypanosomiasis. Tropical Medicine and Infectious Disease, 5(1), 28. (doi: 10.3390/tropicalmed5010028) (PMID:32079320) (PMCID:PMC7157554)
Ritchie, N. D., Ritchie, R., Bayes, H. K., Mitchell, T. J. and Evans, T. J. (2018) IL-17 can be protective or deleterious in murine pneumococcal pneumonia. PLoS Pathogens, 14(5), e1007099. (doi: 10.1371/journal.ppat.1007099) (PMID:29813133) (PMCID:PMC5993294)
Herbert, J. A., Mitchell, A. M., Ritchie, R., Ma, J., Ross-Hutchinson, K. and Mitchell, T. J. (2018) Expression of the lux genes in Streptococcus pneumoniae modulates pilus expression and virulence. PLoS ONE, 13(1), e0189426. (doi: 10.1371/journal.pone.0189426) (PMID:29342160) (PMCID:PMC5771582)
Fernandez-Cortes, F., Serafim, T. D., Wilkes, J. M. , Jones, N. G., Ritchie, R., McCulloch, R. and Mottram, J. C. (2017) RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific Reports, 7, 6156. (doi: 10.1038/s41598-017-06501-8) (PMID:28733613) (PMCID:PMC5522463)
Myburgh, E. , Ritchie, R., Goundry, A. L., O’Neill, K., Marchesi, F. and Devaney, E. (2016) Attempts to image the early inflammatory response during infection with the lymphatic filarial nematode Brugia pahangi in a mouse model. PLoS ONE, 11(12), e0168602. (doi: 10.1371/journal.pone.0168602) (PMID:27992545) (PMCID:PMC5161388)
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
Book Sections
Ritchie, R., Barrett, M. P. , Mottram, J. C. and Myburgh, E. (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)