Professor Rick Maizels

Professor (Parasitology)
Director of Research (Immunology & Infection)

telephone: 0141 330 3745
email: Rick.Maizels@glasgow.ac.uk

https://orcid.org/0000-0003-3216-1944

Biography

Rick Maizels is Professor of Parasitology at the Wellcome Centre for Integrative Parasitology in the University of Glasgow's Institute of Infection, Immunity and Inflammation

An immunologist interested in fundamental questions of how and why parasites manipulate the sophisticated mammalian immune system, and how that system has evolved in the face of parasite immunomodulatory strategies, Rick moved to the University of Glasgow in 2016.

Between 1995 and 2015 he held the Chair of Zoology at the University of Edinburgh, and was previously Professor of Parasite Immunology at Imperial College London (ICL).

Prior to his move to ICL in 1983, he held positions at the National Institute for Medical Research in London (1973-1976 and 1979-1983), as well as UCLA (1977-1979) and California Institute of Technology (1986-1977).

He was elected Fellow of the Royal Society of Edinburgh in 2002, and made a Senior Fellow of the American Asthma Foundation in 2010.

His laboratory focuses on the most complex parasites to invade the body – multicellular helminths –which cause widespread tropical diseases while displaying profound immuno-regulatory capability.

The central questions his group addresses are:

How do parasites manipulate the host immune system?
What is the impact of this modulation on immunological diseases?
What parasite molecules are responsible for immunomodulation?

Please visit the Maizels Lab Website for full information about the group's work.

Research interests

Summary

We aim to integrate detailed studies at the level of individual parasite molecules, with system-level immunology of suppressing inflammatory diseases and inducing protective immunity. Our techniques combine molecular biology of parasite genes, protein function and structure, cellular immunology and host gene expression, and a range of pathology models representing allergy, autoimmunity and inflammatory bowel disease.

We study nematode parasites because they display remarkable biological properties and are tractable at a molecular and cellular level. For example, the filarial nematode is transmitted by mosquito and infects 120 million people in developing countries. Parasites can live for 5 years or more, acting as successful tissue transplants. If we can analyse how they achieve this feat, we may discover important new pathways to control both parasites and the immune system.

In particular, we are now testing the hypothesis that helminth parasites exploit the body's own safety mechanisms which have evolved to minimise the risk of autoimmunity. For example, regulatory T cells naturally arise to limit autoreactivity, but are also associated with chronic helminth infection. The expansion of regulatory T cell populations may underlie the epidemiological association between infection and reduced levels of allergy.

Please visit the Maizels Lab Website for full information about the group's work.

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2009 | 2007

Number of items: 103.

2024

Ndjim, M. et al. (2024) Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity. Immunity, 57(6), 1260-1273.e7. (doi: 10.1016/j.immuni.2024.04.018) (PMID:38744292)

Cunningham, K. T. and Maizels, R. M. (2024) We are what we eat: macrophages and efferocytosis. Trends in Parasitology, 40(6), pp. 446-448. (doi: 10.1016/j.pt.2024.05.004) (PMID:38772757)

Perez, M. , Laing, R. , Hildersley, K., McNeilly, T., Maizels, R. , Devaney, E. and Britton, C. (2024) A MicroRNA in the Excretory-secretory Products of Helminth Parasites Induces De-differentiation in Epithelial Cells Within Gastrointestinal Organoids. British Society for Parasitology (BSP) Spring Meeting, Liverpool, UK, 2-4 April 2024. (Unpublished)

Redgrave, R. E., Singh, E., Tual-Chalot, S., Park, C., Hall, D., Bennaceur, K., Smyth, D. J. , Maizels, R. M. , Spyridopoulos, I. and Arthur, H. M. (2024) Exogenous transforming growth factor-β1 and its helminth-derived mimic attenuate the heart's inflammatory response to ischemic injury and reduce mature scar size. American Journal of Pathology, 194(4), pp. 562-573. (doi: 10.1016/j.ajpath.2023.09.014) (PMID:37832870)

Colomb, F., Ogunkanbi, A., Jamwal, A., Dong, B., Maizels, R. M. , Finney, C. A.M., Wasmuth, J. D., Higgins, M. K. and McSorley, H. J. (2024) IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing type 2 immune responses. Infection and Immunity, 92(3), e0039523. (doi: 10.1128/iai.00395-23) (PMID:38294241) (PMCID:PMC10929406)

Rekima, A. et al. (2024) Colostrum is required for the postnatal ontogeny of small intestine innate lymphoid type 2 cells and successful anti‐helminth defences. Allergy, (doi: 10.1111/all.16054) (Early Online Publication)

Kelly, C. J., Lindsay, S. L. , Smith, R. S., Keh, S., Cunningham, K. T. , Thümmler, K. , Maizels, R. M. , Campbell, J. D.M. and Barnett, S. C. (2024) Development of good manufacturing practice-compatible isolation and culture methods for human olfactory mucosa-derived mesenchymal stromal cells. International Journal of Molecular Sciences, 25(2), 743. (doi: 10.3390/ijms25020743) (PMID:38255817)

2023

Campillo Poveda, M. , Drurey, C. and Maizels, R. M. (2023) Generation, culture and stimulation of small intestinal murine organoids in parasitology research. STAR Protocols, 4(4), 102608. (doi: 10.1016/j.xpro.2023.102608) (PMID:37751353) (PMCID:PMC10520931)

Campillo Poveda, M. , Britton, C. , Devaney, E. , McNeilly, T. N., Gerbe, F., Jay, P. and Maizels, R. M. (2023) Tuft cells: detectors, amplifiers, effectors and targets in parasite infection. Cells, 12(20), 2477. (doi: 10.3390/cells12202477) (PMID:37887321) (PMCID:PMC10605326)

Maizels, R. M. and Gause, W. C. (2023) Targeting helminths: the expanding world of type 2 immune effector mechanisms. Journal of Experimental Medicine, 220(10), e20221381. (doi: 10.1084/jem.20221381) (PMID:37638887) (PMCID:PMC10460967)

van Dinther, M. et al. (2023) CD44 acts as a co-receptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic. Proceedings of the National Academy of Sciences of the United States of America, 120(34), e230237012. (doi: 10.1073/pnas.2302370120) (PMID:37590410) (PMCID:PMC10450677)

Britton, C. , Laing, R. , McNeilly, T. N., Perez, M. G. , Otto, T. D. , Hildersley, K. A., Maizels, R. M. , Devaney, E. and Gillan, V. (2023) New technologies to study helminth development and host-parasite interactions. International Journal for Parasitology, 53(8), pp. 393-403. (doi: 10.1016/j.ijpara.2022.11.012) (PMID:36931423)

McManus, C. M. and Maizels, R. M. (2023) Regulatory T cells in parasite infections: susceptibility, specificity and specialisation. Trends in Parasitology, 39(7), pp. 547-562. (doi: 10.1016/j.pt.2023.04.002) (PMID:37225557)

Robb, C. T. et al. (2023) Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses. Allergy, 78(3), pp. 714-730. (doi: 10.1111/all.15541) (PMID:36181709)

White, R. et al. (2023) Special considerations for studies of extracellular vesicles from parasitic helminths: a community‐led roadmap to increase rigour and reproducibility. Journal of Extracellular Vesicles, 12(1), 12298. (doi: 10.1002/jev2.12298) (PMID:36604533) (PMCID:PMC9816087)

Smyth, D. J. , White, M. P.J., Johnston, C. J.C., Donachie, A.-M., Campillo Poveda, M. , McSorley, H. J. and Maizels, R. M. (2023) Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-ß, Hp-TGM. Discovery Immunology, 2(1), kyad001. (doi: 10.1093/discim/kyad001) (PMID:36855464) (PMCID:PMC9958376)

2022

Chauché, C. , Rasid, O., Donachie, A. M., McManus, C. M., Löser, S., Campion, T., Richards, J., Smyth, D. J. , McSorley, H. J. and Maizels, R. M. (2022) Suppression of airway allergic eosinophilia by Hp-TGM, a helminth mimic of TGF-β. Immunology, 167(2), pp. 197-211. (doi: 10.1111/imm.13528) (PMID:35758054) (PMCID:PMC9885513)

Mukundan, A., Byeon, C.-H., Hinck, C. S., Cunningham, K. , Campion, T., Smyth, D. J. , Maizels, R. M. and Hinck, A. P. (2022) Convergent evolution of a parasite-encoded complement control protein-scaffold to mimic binding of mammalian TGF-ß to its receptors, TßRI and TßRII. Journal of Biological Chemistry, 298(6), 101994. (doi: 10.1016/j.jbc.2022.101994) (PMID:35500648) (PMCID:PMC9163516)

Varyani, F. et al. (2022) The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF). Mucosal Immunology, 15(6), pp. 1243-1256. (doi: 10.1038/s41385-022-00496-w) (PMID:35288645) (PMCID:PMC9705247)

Webster, H. C., Gamino, V., Andrusaite, A. T., Ridgewell, O., McCowan, J., Shergold, A. L., Heieis, G. A., Milling, S. W.F. , Maizels, R. M. and Perona-Wright, G. (2022) Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response. Mucosal Immunology, 15(6), pp. 1257-1269. (doi: 10.1038/s41385-022-00513-y) (PMID:35428872) (PMCID:PMC9705258)

Lindholm, H. T., Parmar, N., Drurey, C. , Campillo Poveda, M. , Vornewald, P. M., Ostrop, J., Díez-Sanchez, A., Maizels, R. M. and Oudhoff, M. J. (2022) BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia. Science Immunology, 7(71), eabl6543. (doi: 10.1126/sciimmunol.abl6543) (PMID:35559665) (PMCID:PMC7614132)

Maizels, R. M. (2022) Ascarosides from helminths pack a punch against allergy. Proceedings of the National Academy of Sciences of the United States of America, 119(14), e2202250119. (doi: 10.1073/pnas.2202250119) (PMID:35353624) (PMCID:PMC9169083)

Drurey, C. et al. (2022) Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products. Journal of Experimental Medicine, 219(1), e20211140. (doi: 10.1084/jem.20211140) (PMID:34779829) (PMCID:PMC8597987)

2021

Hildersley, K. A., Mcneilly, T. N., Gillan, V. , Otto, T. D. , Löser, S., Gerbe, F., Jay, P., Maizels, R. M. , Devaney, E. and Britton, C. (2021) Tuft cells increase following ovine intestinal parasite infections and define evolutionarily conserved and divergent responses. Frontiers in Immunology, 12, 781108. (doi: 10.3389/fimmu.2021.781108) (PMID:34880874) (PMCID:PMC8646091)

Smyth, D. J. et al. (2021) Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model. Journal of Biotechnology, 340, pp. 1-12. (doi: 10.1016/j.jbiotec.2021.08.006) (PMID:34390759) (PMCID:PMC8516079)

Maizels, R. M. (2021) Identifying novel candidates and configurations for human helminth vaccines. Expert Review of Vaccines, 20(11), pp. 1389-1393. (doi: 10.1080/14760584.2021.1999810) (PMID:34720028) (PMCID:PMC8734949)

Cook, L. et al. (2021) Induction of stable human FOXP3 + Tregs by a parasite‐derived TGF‐β mimic. Immunology and Cell Biology, 99(8), pp. 833-847. (doi: 10.1111/imcb.12475) (PMID:33929751)

Drurey, C. and Maizels, R. M. (2021) Helminth extracellular vesicles: interactions with the host immune system. Molecular Immunology, 137, pp. 124-133. (doi: 10.1016/j.molimm.2021.06.017) (PMID:34246032) (PMCID:PMC8636279)

White, M. P.J., Smyth, D. J. , Cook, L., Ziegler, S. F., Levings, M. K. and Maizels, R. M. (2021) The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-β on murine CD4+ T cells. Immunology and Cell Biology, 99(8), pp. 848-864. (doi: 10.1111/imcb.12479) (PMID:33988885) (PMCID:PMC9214624)

Oftedal, B. E. et al. (2021) The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function. Communications Biology, 4, 681. (doi: 10.1038/s42003-021-02203-0) (PMID:34083746) (PMCID:PMC8175432)

2020

White, M. P., Johnston, C. J., Grainger, J. R., Konkel, J. E., O'Connor, R. A., Anderton, S. M. and Maizels, R. M. (2020) The helminth parasite Heligmosomoides polygyrus attenuates EAE in an IL-4Rα-dependent manner. Frontiers in Immunology, 11, 1830. (doi: 10.3389/fimmu.2020.01830) (PMID:33117327) (PMCID:PMC7552805)

Drurey, C. , Coakley, G. and Maizels, R. M. (2020) Extracellular vesicles: new targets for vaccines against helminth parasites. International Journal for Parasitology, 50(9), pp. 623-633. (doi: 10.1016/j.ijpara.2020.04.011) (PMID:32659278)

White, M. P.J., McManus, C. M. and Maizels, R. M. (2020) Regulatory T cells in helminth infection: induction, function and therapeutic potential. Immunology, 160(3), pp. 248-260. (doi: 10.1111/imm.13190) (PMID:32153025) (PMCID:PMC7341546)

Maizels, R. M. (2020) Regulation of immunity and allergy by helminth parasites. Allergy, 75(3), pp. 524-534. (doi: 10.1111/all.13944) (PMID:31187881)

2019

Filbey, K. J. et al. (2019) Macrophage migration inhibitory factor (MIF) is essential for Type 2 effector cell immunity to an intestinal helminth parasite. Frontiers in Immunology, 10, 2375. (doi: 10.3389/fimmu.2019.02375) (PMID:31708913) (PMCID:PMC6821780)

Löser, S., Smith, K. A. and Maizels, R. M. (2019) Innate lymphoid cells in helminth infections—obligatory or accessory? Frontiers in Immunology, 10, 620. (doi: 10.3389/fimmu.2019.00620) (PMID:31024526) (PMCID:PMC6467944)

Minutti, C. M. et al. (2019) A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced transforming growth factor beta activation. Immunity, 50(3), 645-654.e6. (doi: 10.1016/j.immuni.2019.01.008) (PMID:30770250) (PMCID:PMC6436929)

International Helminth Genomes Consortium, et al. (2019) Comparative genomics of the major parasitic worms. Nature Genetics, 51(1), pp. 163-174. (doi: 10.1038/s41588-018-0262-1) (PMID:30397333) (PMCID:PMC6349046)

Sánchez-Quintero, A., Bradford, B. M., Maizels, R. , Donaldson, D. S. and Mabbott, N. A. (2019) Effect of co-infection with a small intestine-restricted helminth pathogen on oral prion disease pathogenesis in mice. Scientific Reports, 9, 6674. (doi: 10.1038/s41598-019-42900-9) (PMID:31040320) (PMCID:PMC6491469)

2018

Robertson, E., Harcus, Y., Johnston, C. J.C., Page, A. P. , Walkinshaw, M. D., Maizels, R. M. and Houston, D. (2018) Demonstration of the anthelmintic potency of marimastat in the Heligmosomoides polygyrus rodent model. Journal of Parasitology, 104(6), pp. 705-709. (doi: 10.1645/18-33) (PMID:30085900)

Maizels, R. , Smits, H. H. and McSorley, H. J. (2018) Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules. Immunity, 49(5), pp. 801-818. (doi: 10.1016/j.immuni.2018.10.016) (PMID:30462997) (PMCID:PMC6269126)

Wilbers, R. H.P., Schneiter, R., Holterman, M. H.M., Drurey, C. , Smant, G., Asojo, O. A., Maizels, R. M. and Lozano-Torres, J. L. (2018) Secreted venom allergen-like proteins of helminths: Conserved modulators of host responses in animals and plants. PLoS Pathogens, 14(10), e1007300. (doi: 10.1371/journal.ppat.1007300) (PMID:30335852) (PMCID:PMC6193718)

Smith, K. A., Loser, S., Varyani, F., Harcus, Y., McSorley, H. J., McKenzie, A. N.J. and Maizels, R. (2018) Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion. eLife, 7, e38269. (doi: 10.7554/eLife.38269) (PMID:30238872) (PMCID:PMC6173579)

Alimi, D., Abidi, A., Sebai, E., Rekik, M., Maizels, R.M. , Dhibi, M. and Akkari, H. (2018) In vivo nematicidal potential of camel milk on Heligmosomoides polygyrus gastro-intestinal nematode of rodents. Helminthologia, 55(2), pp. 112-118. (doi: 10.2478/helm-2018-0001)

Asojo, O. A., Darwiche, R., Gebremedhin, S., Smant, G., Lozano-Torres, J. L., Drurey, C. , Pollet, J., Maizels, R. M. , Schneiter, R. and Wilbers, R. H.P. (2018) Heligmosomoides polygyrus venom allergen-like protein-4 (HpVAL-4) is a sterol binding protein. International Journal for Parasitology, 48(5), pp. 359-369. (doi: 10.1016/j.ijpara.2018.01.002) (PMID:29505764) (PMCID:PMC5893428)

Darwiche, R., Lugo, F., Drurey, C. , Varossieau, K., Smant, G., Wilbers, R. H.P., Maizels, R. M. , Schneiter, R. and Asojo, O. A. (2018) Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis. International Journal for Parasitology, 48(5), pp. 371-378. (doi: 10.1016/j.ijpara.2017.12.003) (PMID:29501266)

Selkirk, M. E., Davis, R. E., Gounaris, K. and Maizels, R. M. (2018) Special issue: molecular and cellular biology of helminth parasites XI. International Journal for Parasitology, 48(5), pp. 319-320. (doi: 10.1016/j.ijpara.2018.03.001) (PMID:29631700)

Smyth, D. J. et al. (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. International Journal for Parasitology, 48(5), pp. 379-385. (doi: 10.1016/j.ijpara.2017.12.004) (PMID:29510118) (PMCID:PMC5904571)

Löser, S. and Maizels, R. M. (2018) Immunology: the neuronal pathway to mucosal immunity. Current Biology, 28(1), R33-R36. (doi: 10.1016/j.cub.2017.11.025) (PMID:29316420)

Ma, G., Holland, C. V., Wang, T., Hofmann, A., Fan, C.-K., Maizels, R. M. , Hotez, P. J. and Gasser, R. B. (2018) Human toxocariasis. Lancet Infectious Diseases, 18(1), e14-e24. (doi: 10.1016/S1473-3099(17)30331-6) (PMID:28781085)

Rolot, M. et al. (2018) Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection. Nature Communications, 9, 4516. (doi: 10.1038/s41467-018-06978-5) (PMID:30375396) (PMCID:PMC6207712)

2017

Johnston, C. J.C. et al. (2017) A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 8, 1741. (doi: 10.1038/s41467-017-01886-6) (PMID:29170498) (PMCID:PMC5701006)

Minutti, C. M. et al. (2017) Epidermal growth factor receptor expression licenses type-2 helper T cells to function in a T cell receptor-independent fashion. Immunity, 47(4), 710-722.e6. (doi: 10.1016/j.immuni.2017.09.013) (PMID:29045902) (PMCID:PMC5654729)

Osbourn, M. et al. (2017) HpARI protein secreted by a helminth parasite suppresses interleukin-33. Immunity, 47(4), 739-751.e5. (doi: 10.1016/j.immuni.2017.09.015) (PMID:29045903) (PMCID:PMC5655542)

McFarlane, A. J. et al. (2017) Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota. Journal of Allergy and Clinical Immunology, 140(4), 1068-1078.e6. (doi: 10.1016/j.jaci.2017.01.016) (PMID:28196762) (PMCID:PMC6485385)

Pastille, E. et al. (2017) Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer. PLoS Pathogens, 13(9), e1006649. (doi: 10.1371/journal.ppat.1006649) (PMID:28938014) (PMCID:PMC5627963)

Varyani, F., Fleming, J. O. and Maizels, R. (2017) Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 312(6), G537-G549. (doi: 10.1152/ajpgi.00024.2017) (PMID:28302598) (PMCID:5495915)

Coakley, G., McCaskill, J. L., Borger, J. G., Simbari, F., Robertson, E., Millar, M., Harcus, Y., McSorley, H. J., Maizels, R. M. and Buck, A. H. (2017) Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity. Cell Reports, 19(8), pp. 1545-1557. (doi: 10.1016/j.celrep.2017.05.001) (PMID:28538175) (PMCID:PMC5457486)

Rückerl, D., Campbell, S. M., Duncan, S., Sutherland, T. E., Jenkins, S. J., Hewitson, J. P., Barr, T. A., Jackson-Jones, L. H. and Maizels, R. M. (2017) Macrophage origin limits functional plasticity in helminth-bacterial co-infection. PLoS Pathogens, 13(3), e1006233. (doi: 10.1371/journal.ppat.1006233) (PMID:28334040) (PMCID:PMC5364000)

Mutapi, F., Maizels, R. , Fenwick, A. and Woolhouse, M. (2017) Human schistosomiasis in the post Mass Drug Administration (MDA) era. Lancet Infectious Diseases, 17(2), e42-e48. (doi: 10.1016/S1473-3099(16)30475-3) (PMID:27988094)

Maizels, R. M. and Hewiston, J. P. (2017) Myeloid cell phenotypes in susceptibility and resistance to parasitic infections. In: Gordon, S. (ed.) Myeloid Cells in Health and Disease: a Synthesis. ASM Press: Washington, DC, pp. 759-769. ISBN 9781555819187 (doi: 10.1128/microbiolspec.MCHD-0043-2016)

2016

Jackson-Jones, L. H. et al. (2016) IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. European Journal of Immunology, 46(10), pp. 2311-2321. (doi: 10.1002/eji.201646442) (PMID:27592711)

Jackson-Jones, L. H., Duncan, S. M., Magalhaes, M. S., Campbell, S. M., Maizels, R. M. , McSorley, H. J., Allen, J. E. and Bénézech, C. (2016) Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nature Communications, 7, 12651. (doi: 10.1038/ncomms12651) (PMID:27582256) (PMCID:PMC5025788)

Maizels, R. M. and McSorley, H. (2016) Regulation of the host immune system by helminth parasites. Journal of Allergy and Clinical Immunology, 138(3), pp. 666-675. (doi: 10.1016/j.jaci.2016.07.007) (PMID:27476889) (PMCID:PMC5010150)

Gause, W. C. and Maizels, R. M. (2016) Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis. Current Opinion in Microbiology, 32, pp. 14-18. (doi: 10.1016/j.mib.2016.04.004) (PMID:27116368) (PMCID:PMC4983462)

Coakley, G., Buck, A. H. and Maizels, R. M. (2016) Host parasite communications—Messages from helminths for the immune system: parasite communication and cell-cell interactions. Molecular and Biochemical Parasitology, 208(1), pp. 33-40. (doi: 10.1016/j.molbiopara.2016.06.003) (PMID:27297184)

Simbari, F., McCaskill, J., Coakley, G., Millar, M., Maizels, R. M. , Fabriás, G., Casas, J. and Buck, A. H. (2016) Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology. Journal of Extracellular Vesicles, 5, 30741. (doi: 10.3402/jev.v5.30741) (PMID:27389011) (PMCID:PMC4937767)

Maizels, R.M. (2016) Parasitic helminth infections and the control of human allergic and autoimmune disorders. Clinical Microbiology and Infection, 22(6), pp. 481-486. (doi: 10.1016/j.cmi.2016.04.024) (PMID:27172808)

Lundie, R. J. et al. (2016) A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection. Immunology and Cell Biology, 94(4), pp. 400-410. (doi: 10.1038/icb.2015.114) (PMID:26657145) (PMCID:PMC4817239)

Obieglo, K. et al. (2016) Chronic gastrointestinal nematode infection mutes immune responses to mycobacterial infection distal to the gut. Journal of Immunology, 196(5), pp. 2262-2271. (doi: 10.4049/jimmunol.1500970) (PMID:26819205) (PMCID:PMC4760231)

Duffin, R. et al. (2016) Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis. Science, 351(6279), pp. 1333-1338. (doi: 10.1126/science.aad9903) (PMID:26989254)

Hewitson, J. P., Nguyen, D. L., van Diepen, A., Smit, C. H., Koeleman, C. A., McSorley, H. J., Murray, J., Maizels, R. M. and Hokke, C. H. (2016) Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus. International Journal for Parasitology, 46(3), pp. 157-170. (doi: 10.1016/j.ijpara.2015.10.004) (PMID:26688390) (PMCID:PMC4776704)

Smith, K.A., Filbey, K.J., Reynolds, L.A., Hewitson, J.P., Harcus, Y., Boon, L., Sparwasser, T., Hämmerling, G. and Maizels, R.M. (2016) Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology, 9(2), pp. 428-443. (doi: 10.1038/mi.2015.73) (PMID:26286232) (PMCID:PMC4677460)

Smits, H. H. et al. (2016) Microbes and asthma: opportunities for intervention. Journal of Allergy and Clinical Immunology, 137(3), pp. 690-697. (doi: 10.1016/j.jaci.2016.01.004) (PMID:26947981)

Gerbe, F. et al. (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature, 529(7585), pp. 226-230. (doi: 10.1038/nature16527) (PMID:26762460)

Johnston, C. J.C., Smyth, D. J. , Dresser, D. W. and Maizels, R. M. (2016) TGF-β in tolerance, development and regulation of immunity. Cellular Immunology, 299, pp. 14-22. (doi: 10.1016/j.cellimm.2015.10.006) (PMID:26617281) (PMCID:PMC4711336)

Maizels, R. M. (2016) Regulatory T-cell control of type 2 inflammation. In: Gause, W. C. and Artis, D. (eds.) The Th2 Type Immune Response in Health and Disease: From Host Defense and Allergy to Metabolic Homeostasis and Beyond. Springer: New York, pp. 73-95. ISBN 9781493929108 (doi: 10.1007/978-1-4939-2911-5_5)

2015

Reynolds, L. A., Finlay, B. B. and Maizels, R. M. (2015) Cohabitation in the intestine: interactions among helminth parasites, bacterial microbiota, and host immunity. Journal of Immunology, 195(9), pp. 4059-4066. (doi: 10.4049/jimmunol.1501432) (PMID:26477048) (PMCID:PMC4617609)

McSorley, H. J., Blair, N. F., Robertson, E. and Maizels, R. M. (2015) Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation. Experimental Parasitology, 158, pp. 8-17. (doi: 10.1016/j.exppara.2015.02.009) (PMID:25728231) (PMCID:PMC6485390)

Antia, R., Tyagi, N., Farnell, E. J., Fitzsimmons, C. M., Ryan, S., Tukahebwa, E., Maizels, R. M. , Dunne, D. W., Thornton, J. M. and Furnham, N. (2015) Comparisons of allergenic and metazoan parasite proteins: allergy the price of immunity. PLoS Computational Biology, 11(10), e1004546. (doi: 10.1371/journal.pcbi.1004546) (PMID:26513360) (PMCID:PMC4626114)

Coakley, G., Maizels, R. M. and Buck, A. H. (2015) Exosomes and other extracellular vesicles: the new communicators in parasite infections. Trends in Parasitology, 31(10), pp. 477-489. (doi: 10.1016/j.pt.2015.06.009) (PMID:26433251) (PMCID:PMC4685040)

Redpath, S. A., van der Werf, N., MacDonald, A. S., Maizels, R. M. , Taylor, M. D. and Appleton, J. A. (2015) Schistosoma mansoni larvae do not expand or activate Foxp3+ regulatory T Cells during their migratory phase. Infection and Immunity, 83(10), pp. 3881-3889. (doi: 10.1128/IAI.00408-15) (PMID:26195548) (PMCID:PMC4567639)

Cook, P. C. et al. (2015) A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells. Nature Communications, 6, 6920. (doi: 10.1038/ncomms7920) (PMID:25908537) (PMCID:PMC4413429)

Johnston, C. J.C., Robertson, E., Harcus, Y., Grainger, J. R., Coakley, G., Smyth, D. J. , McSorley, H. J. and Maizels, R. (2015) Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products. Journal of Visualized Experiments(98), e52412. (doi: 10.3791/52412) (PMID:25867600) (PMCID:PMC4401400)

Loke, P.'n. et al. (2015) Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection. PLoS Pathogens, 11(3), e1004676. (doi: 10.1371/journal.ppat.1004676) (PMID:25816012) (PMCID:PMC4376884)

Farnell, E. J. et al. (2015) Known allergen structures predict Schistosoma mansoni IgE-binding antigens in human infection. Frontiers in Immunology, 6, 26. (doi: 10.3389/fimmu.2015.00026) (PMID:25691884) (PMCID:PMC4315118)

Mackley, E. C. et al. (2015) CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature Communications, 6, (doi: 10.1038/ncomms6862) (PMID:25575242) (PMCID:PMC4354100)

2014

Sutherland, T. E., Logan, N., Rückerl, D., Humbles, A. A., Allan, S. M., Papayannopoulos, V., Stockinger, B., Maizels, R. M. and Allen, J. E. (2014) Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage. Nature Immunology, 15(12), pp. 1116-1125. (doi: 10.1038/ni.3023) (PMID:25326751) (PMCID:PMC4338525)

Buck, A. H. et al. (2014) Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity. Nature Communications, 5, 5488. (doi: 10.1038/ncomms6488) (PMID:25421927) (PMCID:PMC4263141)

Sotillo, J. et al. (2014) Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis. Molecular and Cellular Proteomics, 13(10), pp. 2736-2751. (doi: 10.1074/mcp.M114.038950) (PMID:24994561) (PMCID:PMC4188999)

Reynolds, L. A. et al. (2014) MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. Journal of Immunology, 193(6), pp. 2984-2993. (doi: 10.4049/jimmunol.1401056) (PMID:25114104) (PMCID:PMC4157852)

McSorley, H.J., Blair, N.F., Smith, K.A., McKenzie, A.N.J. and Maizels, R.M. (2014) Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunology, 7(5), pp. 1068-1078. (doi: 10.1038/mi.2013.123) (PMID:24496315) (PMCID:PMC4016792)

Maizels, R.M. , McSorley, H.J. and Smyth, D.J. (2014) Helminths in the hygiene hypothesis: sooner or later? Clinical and Experimental Immunology, 177(1), pp. 38-46. (doi: 10.1111/cei.12353) (PMID:24749722) (PMCID:PMC4089153)

Filbey, K. J., Grainger, J. R., Smith, K. A., Boon, L., van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J. P. and Maizels, R. M. (2014) Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection. Immunology and Cell Biology, 92(5), pp. 436-448. (doi: 10.1038/icb.2013.109) (PMID:24492801) (PMCID:PMC4038150)

Lee, S. J. and Maizels, R. M. (2014) Inflammatory bowel disease. Evolution, Medicine, and Public Health, 2014(1), p. 95. (doi: 10.1093/emph/eou017) (PMID:24747119) (PMCID:PMC4204624)

Albers, A., Sartono, E., Wahyuni, S., Yazdanbakhsh, M., Maizels, R. M. , Klarmann-Schulz, U., Pfarr, K. and Hoerauf, A. (2014) Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi infections: a study in Indonesian transmigrants. Parasites and Vectors, 7, 146. (doi: 10.1186/1756-3305-7-146) (PMID:24685183) (PMCID:PMC4021971)

Hewitson, J. and Maizels, R. M. (2014) Vaccination against helminth parasite infections. Expert Review of Vaccines, 13(4), pp. 473-487. (doi: 10.1586/14760584.2014.893195) (PMID:24606541)

Johnston, C. J.C., McSorley, H. J., Anderton, S. M., Wigmore, S. J. and Maizels, R. M. (2014) Helminths and immunological tolerance. Transplantation, 97(2), pp. 127-132. (doi: 10.1097/TP.0b013e3182a53f59) (PMID:24025322) (PMCID:PMC3940291)

Smith, K. A. and Maizels, R. M. (2014) IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo. European Journal of Immunology, 44(1), pp. 150-161. (doi: 10.1002/eji.201343746) (PMID:24185641) (PMCID:PMC3992848)

Hewitson, J. P., Rückerl, D., Harcus, Y., Murray, J., Webb, L. M., Babayan, S. A. , Allen, J. E., Kurniawan, A. and Maizels, R. M. (2014) The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo. PLoS Pathogens, 10(2), e1003930. (doi: 10.1371/journal.ppat.1003930)

Reynolds, L. A., Smith, K. A., Filbey, K. J., Harcus, Y., Hewitson, J. P., Redpath, S. A., Valdez, Y., Yebra, M. J., Finlay, B. B. and Maizels, R. M. (2014) Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites. Gut Microbes, 5(4), pp. 522-532. (doi: 10.4161/gmic.32155) (PMID:25144609) (PMCID:PMC4822684)

2009

Perona-Wright, G. , Jenkins, S. J., O'Connor, R. A., Zienkiewicz, D., McSorley, H. J., Maizels, R. M. , Anderton, S. M. and MacDonald, A. S. (2009) A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. Journal of Immunology, 182(5), pp. 2808-2815. (doi: 10.4049/jimmunol.0803553) (PMID:19234175)

2007

Taylor, M. D., Harris, A., Babayan, S. A. , Bain, O., Culshaw, A., Allen, J. E. and Maizels, R. M. (2007) CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. Journal of Immunology, 179(7), pp. 4626-4634. (doi: 10.4049/jimmunol.179.7.4626) (PMID:17878360)

This list was generated on Mon Nov 18 19:47:02 2024 GMT.

Jump to: Articles | Book Sections | Conference or Workshop Item

Number of items: 103.

Articles

Ndjim, M. et al. (2024) Tuft cell acetylcholine is released into the gut lumen to promote anti-helminth immunity. Immunity, 57(6), 1260-1273.e7. (doi: 10.1016/j.immuni.2024.04.018) (PMID:38744292)

Cunningham, K. T. and Maizels, R. M. (2024) We are what we eat: macrophages and efferocytosis. Trends in Parasitology, 40(6), pp. 446-448. (doi: 10.1016/j.pt.2024.05.004) (PMID:38772757)

Robb, C. T. et al. (2023) Metabolic regulation by prostaglandin E2 impairs lung group 2 innate lymphoid cell responses. Allergy, 78(3), pp. 714-730. (doi: 10.1111/all.15541) (PMID:36181709)

Cook, L. et al. (2021) Induction of stable human FOXP3 + Tregs by a parasite‐derived TGF‐β mimic. Immunology and Cell Biology, 99(8), pp. 833-847. (doi: 10.1111/imcb.12475) (PMID:33929751)

Maizels, R. M. (2020) Regulation of immunity and allergy by helminth parasites. Allergy, 75(3), pp. 524-534. (doi: 10.1111/all.13944) (PMID:31187881)

Löser, S. and Maizels, R. M. (2018) Immunology: the neuronal pathway to mucosal immunity. Current Biology, 28(1), R33-R36. (doi: 10.1016/j.cub.2017.11.025) (PMID:29316420)

Smits, H. H. et al. (2016) Microbes and asthma: opportunities for intervention. Journal of Allergy and Clinical Immunology, 137(3), pp. 690-697. (doi: 10.1016/j.jaci.2016.01.004) (PMID:26947981)

Gerbe, F. et al. (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature, 529(7585), pp. 226-230. (doi: 10.1038/nature16527) (PMID:26762460)

Lee, S. J. and Maizels, R. M. (2014) Inflammatory bowel disease. Evolution, Medicine, and Public Health, 2014(1), p. 95. (doi: 10.1093/emph/eou017) (PMID:24747119) (PMCID:PMC4204624)

Hewitson, J. and Maizels, R. M. (2014) Vaccination against helminth parasite infections. Expert Review of Vaccines, 13(4), pp. 473-487. (doi: 10.1586/14760584.2014.893195) (PMID:24606541)

Book Sections

Conference or Workshop Item

This list was generated on Mon Nov 18 19:47:02 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Redirecting TFG-b signalling inspired by adaptive evolution of parasite mimics
Wellcome Trust
2024 - 2029
Tissue memory: How infections leave an inflammatory imprint that shapes future response
Tenovus Scotland
2022 - 2023
Molecular and Cellular Interactions in Helminth Infections
Wellcome Trust
2020 - 2025
Tuft cells, sensors and effectors in immunity to helminths
Wellcome Trust
2018 - 2022
Asthma Prevention consortium
The Netherlands Lung Foundation
2018 - 2020
Helminths and the Immune System: Regulation, Regulators and Immunity
Wellcome Trust
2016 - 2020
Induction of Therapeutic Regulatory T cells by Parasite Products
The Kenneth Rainin Foundation
2015 - 2018

Supervision

Please visit the Maizels Lab Website for more information.

Teaching

Please visit the Maizels Lab Website for more information.

A head and shoulders shot of Prof Rick Maizels in the lab

Group Members

Caroline Chauche
Claire Ciancia
Anne Donachie
Claire Drurey
Caitlin McManus
Josh Richards
Maddie White

Public Engagement

Some examples of recent activities discussing our research in public and in the media are given below:

Edinburgh Science Festival (March 2016)

Kenneth Rainin Foundation Annual Innovations Symposium

The Kenneth Rainin Foundation supports cutting edge research projects that work on diagnosing, treating and curing Inflammatory Bowl Disease.

In San Francisco in July 2015, Rick Maizels, a Foundation Grantee, spoke at the annual symposium that brings together Influential and Collaborative researchers and Innovative and Creative thinkers to work towards the common goal of curing IBD.

A short video from scientists and researchers, including Rick, on why they attend the annual event

BBC Radio Cambridge 'Naked Scientists' radio programme (8 March 2015) -

Rick Maizels talked about 'Parasites tricking the immune system'
Henry McSorley talked about 'Therapeutic Parasites'

The Academy of Medical Sciences (March 2015)

Chris Johnston talked to Quentin about his Helminth research within the Maizels group.

Cheltenham Science Festival (8 June 2013)

Sold out session on 'Is my immune system normal'.

British Council article (28 June 2012)

Anti Allergy Parasite

Wellcome Trust News (1 September 2011)

Out of Africa: what is an allergen?

Daily Mail article (July 2011)

(download)

Interview with "the Naked Scientist", BBC (May 2011)

Listen to the podcast

Der Spiegel (October 2010)

In English or Deutsch

Guardian article on helminths (May 2010)