Dr Rebecca McHugh

  • Research Associate (Bacteriology)

Publications

List by: Type | Date

Jump to: 2024 | 2022 | 2019
Number of items: 7.

2024

Mark, D. R. , O'Boyle, N., Wale, K. R., Tucker, S. K., McHugh, R. E. and Roe, A. J. (2024) Aurodox inhibits type III secretion in multiple Gram-negative pathogens. Open Biology, 14(11), 240240. (doi: 10.1098/rsob.240240) (PMID:39591989) (PMCID:PMC11597412)

Wale, K. R., O'Boyle, N., McHugh, R. , Serrano, E. , Mark, D. , Douce, G. R. , Connolly, J. P.R. and Roe, A. J. (2024) A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens. PLoS Pathogens, 20(10), e101245. (doi: 10.1371/journal.ppat.1012451) (PMID:39405360) (PMCID:PMC11508082)

Tucker, S. K., McHugh, R. E. and Roe, A. (2024) One problem, multiple potential targets: where are we now in the development of small molecule inhibitors against Shiga toxin? Cellular Signalling, 121, 111253. (doi: 10.1016/j.cellsig.2024.111253) (PMID:38852937)

2022

McHugh, R. E. , Munnoch, J. T., Braes, R. E., McKean, I. J. W., Giard, J., Taladriz-Sender, A., Peschke, F., Burley, G. A., Roe, A. J. and Hoskisson, P. A. (2022) Biosynthesis of aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Applied and Environmental Microbiology, 88(15), e0069222. (doi: 10.1128/aem.00692-22) (PMID:35867559) (PMCID:PMC9361827)

McHugh, R. E. , Munnoch, J. T., Roe, A. J. and Hoskisson, P. A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

2019

McHugh, R. E. , O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

McHugh, R. E. , O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterization of the mode of action of Aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

This list was generated on Thu Dec 19 18:38:59 2024 GMT.
Jump to: Articles
Number of items: 7.

Articles

Mark, D. R. , O'Boyle, N., Wale, K. R., Tucker, S. K., McHugh, R. E. and Roe, A. J. (2024) Aurodox inhibits type III secretion in multiple Gram-negative pathogens. Open Biology, 14(11), 240240. (doi: 10.1098/rsob.240240) (PMID:39591989) (PMCID:PMC11597412)

Wale, K. R., O'Boyle, N., McHugh, R. , Serrano, E. , Mark, D. , Douce, G. R. , Connolly, J. P.R. and Roe, A. J. (2024) A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens. PLoS Pathogens, 20(10), e101245. (doi: 10.1371/journal.ppat.1012451) (PMID:39405360) (PMCID:PMC11508082)

Tucker, S. K., McHugh, R. E. and Roe, A. (2024) One problem, multiple potential targets: where are we now in the development of small molecule inhibitors against Shiga toxin? Cellular Signalling, 121, 111253. (doi: 10.1016/j.cellsig.2024.111253) (PMID:38852937)

McHugh, R. E. , Munnoch, J. T., Braes, R. E., McKean, I. J. W., Giard, J., Taladriz-Sender, A., Peschke, F., Burley, G. A., Roe, A. J. and Hoskisson, P. A. (2022) Biosynthesis of aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Applied and Environmental Microbiology, 88(15), e0069222. (doi: 10.1128/aem.00692-22) (PMID:35867559) (PMCID:PMC9361827)

McHugh, R. E. , Munnoch, J. T., Roe, A. J. and Hoskisson, P. A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

McHugh, R. E. , O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

McHugh, R. E. , O'Boyle, N., Connolly, J. P.R., Hoskisson, P. A. and Roe, A. J. (2019) Characterization of the mode of action of Aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

This list was generated on Thu Dec 19 18:38:59 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Genome mining of the bovine faecal bacterium for novel bioactive compounds
    The Carnegie Trust for the Universities of Scotland
    2023 - 2024
     

Professional activities & recognition

Prizes, awards & distinctions

  • 2023: Research Incentive Grant (Carnegie Trust)
  • 2022: Infection Science Award (Microbiology Society)
  • 2022: Mike Goodfellow Prize (ISBA)
  • 2022: Outstanding Science Prize (Microbiology Society)

Professional & learned societies

  • 2020 - 22: Early Career Executive Forum, Microbiology Society
  • 2022 - 2024: Building Communities Committee, Microbiology Society

Selected international presentations

  • 2023: World Pharmacology Congress (Glasgow)
  • 2022: ISBA (Toronto)