Professor Pasquale Maffia

Professor of Cardiovascular Immunology (Immunology & Infection)
Professor (School of Cardiovascular & Metabolic Health)

telephone: 01413307142
email: Pasquale.Maffia@glasgow.ac.uk
pronouns: He/him/his

RB423 Level B4, Iii - Gbrc, University Place, Glasgow G12 8TA

Biography

I am currently a Professor of Cardiovascular Immunology at the University of Glasgow (UK) within the School of Infection & Immunity. Additionally, I serve as the School’s International Lead and co-lead of the ARUA/Guild Africa-Europe CoRE in Non-Communicable Diseases & Multimorbidity.

I am an elected fellow of the Royal Society of Biology, the British Pharmacological Society, and the European Society of Cardiology.

I am the Vice-President and Chair of the Engagement Committee for the British Pharmacological Society (BPS), Chair of the Immunopharmacology Committee for the International Union of Basic and Clinical Pharmacology (IUPHAR), and Chair of the Translational Research Medical Review Panel for Heart Research UK (HRUK). Additionally, I am a Nucleus Member of the European Society of Cardiology (ESC) Working Group on Atherosclerosis & Vascular Biology and serve on the Executive Committee of the British Atherosclerosis Society (BAS). I am also part of the Fellowship Committee of the British Heart Foundation (BHF) and the Immunotherapy Committee of the International Union of Immunological Societies (IUIS).

I am the Deputy Editor of Cardiovascular Research, Associate Editor of Pharmacological Research, and Editor-in-Chief of the Human Health Section of Frontiers for Young Minds. Additionally, I serve on the editorial boards of several journals, including Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB) and Scientific Reports.

I have a strong interest in the role of the immune response in cardiovascular diseases. My research encompasses both basic and clinical studies, with a focus on understanding and targeting immune and inflammatory mechanisms involved in the pathophysiology of atherosclerosis, hypertension, and heart failure. I have published over 130 scientific papers in peer-reviewed journals including Nature Genetics, Nature Reviews Immunology, Nature Reviews Cardiology, Lancet Global Health, Immunity, European Heart Journal, Circulation, and Circulation Research.

Find out more about my Public Engagement work

Research interests

My primary interest is the immune response in cardiovascular diseases. My current research activities span from basic to clinical research, focusing on the study and targeting of immune and inflammatory mechanisms involved in the pathophysiology of atherosclerosis, hypertension, and heart failure.

Immune responses are crucial in cardiovascular diseases (Nat Rev Cardiol. 2024). Initially, we developed methods to track antigen-presenting cells and their role in vascular immune response development (Arterioscler Thromb Vasc Biol. 2012; Circulation 2014; Cardiovasc Res. 2020). We were among the pioneers in using multiphoton microscopy for experimental atherosclerosis (Circulation 2007) to observe real-time in vivo interactions between T cells and antigen-presenting cells, elucidating the dynamics and location of these interactions (Immunity 2015). Recently, we have shed light on immune mechanisms in hypertension (Circ Res. 2020; Circulation 2020; Nat Genet. 2021; JCI 2022; Eur Heart J. 2023; Nat Rev Cardiol. 2024) and heart failure (Cardiovasc Res. 2022; Eur J Heart Failure 2023), and are currently investigating immunometabolism in atherosclerosis (Nat Rev Cardiol. 2024). Our translational and clinical research aims to understand the relationship between inflammation, infection, and cardiovascular diseases, with a particular emphasis on Africa (Lancet Glob Health. 2024; Circ Res. 2024; Cardiovasc Res. 2024).

My research programme has received substantial external funding from various organizations, including the British Heart Foundation (BHF), the European Commission, the Engineering and Physical Sciences Research Council (EPSRC), the Biotechnology and Biological Sciences Research Council (BBSRC), Erasmus+ International Credit Mobility, the European Society of Cardiology (ESC), Global Challenges Research Funds, Medical Research Scotland (MRS), the Scottish Funding Council (SFC), the Italian Ministry for Universities and Research (MUR), as well as various industry partners.

Publications

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Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1996

Number of items: 124.

2024

Wiejak, J., Murphy, F. A., Barker, G., Maffia, P. and Yarwood, S. J. (2024) Non-cyclic nucleotide EPAC1 activators suppress lipopolysaccharide-regulated gene expression, signalling and intracellular communication in differentiated macrophage-like THP-1 cells. Cellular Signalling, 124, 111444. (doi: 10.1016/j.cellsig.2024.111444) (PMID:39368792)

Maffia, P. , Mauro, C., Case, A. and Kemper, C. (2024) Canonical and non-canonical roles of complement in atherosclerosis. Nature Reviews Cardiology, 21, pp. 743-761. (doi: 10.1038/s41569-024-01016-y) (PMID:38600367)

MacRitchie, N. and Maffia, P. (2024) Blocking interleukin-1β: a double-edged sword in experimental atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(7), pp. 1537-1539. (doi: 10.1161/ATVBAHA.124.321113) (PMID:38813698)

Hudson, J. A., Ferrand, R. A., Gitau, S. N., Mureithi, M. W., Maffia, P. , Alam, S. R. and Shah, A. S.V. (2024) HIV-associated cardiovascular disease pathogenesis: an emerging understanding through imaging and immunology. Circulation Research, 134(11), pp. 1546-1565. (doi: 10.1161/CIRCRESAHA.124.323890) (PMID:38781300)

Sulicka Grodzicka, J. et al. (2024) Sex-specific relationships of inflammatory biomarkers with blood pressure in older adults. GeroScience, (doi: 10.1007/s11357-024-01170-8) (PMID:38720047) (Early Online Publication)

Shoaran, M. and Maffia, P. (2024) Tackling inflammation in atherosclerosis. Nature Reviews Cardiology, 21, 442. (doi: 10.1038/s41569-024-01007-z) (PMID:38472372)

Olowoyo, P. et al. (2024) ACHIEVE conference proceedings: implementing action plans to reduce and control hypertension burden in Africa. Journal of Human Hypertension, 38(3), pp. 193-199. (doi: 10.1038/s41371-024-00903-8) (PMID:38424209)

Olowoyo, P., Maffia, P. , Guzik, T. J. and Owolabi, M. (2024) Understanding and controlling the increasing burden of cardiovascular diseases in Africa. Cardiovascular Research, 120(4), pp. 9-13. (doi: 10.1093/cvr/cvad173) (PMID:38442189)

Olowoyo, P. et al. (2024) Priorities to reduce the burden of hypertension in Africa through ACHIEVE. Lancet Global Health, 12(2), e192-e193. (doi: 10.1016/S2214-109X(23)00540-5) (PMID:38245107)

Guzik, T. J., Nosalski, R., Maffia, P. and Drummond, G. R. (2024) Immune and inflammatory mechanisms in hypertension. Nature Reviews Cardiology, (doi: 10.1038/s41569-023-00964-1) (PMID:38172242) (Early Online Publication)

2023

Caiazzo, E. et al. (2023) Circulating cytokines and risk of developing hypertension: a systematic review and meta-analysis. Pharmacological Research, 200, 107050. (doi: 10.1016/j.phrs.2023.107050) (PMID:38159784)

Peh, H. Y., Gurgone, D. and Maffia, P. (2023) Immunopharmacology sessions at the 19th World Congress of Basic and Clinical Pharmacology 2023. Pharmacological Research, 196, 106911. (doi: 10.1016/j.phrs.2023.106911) (PMID:37696484)

Wiejak, J., Murphy, F. A., Maffia, P. and Yarwood, S. J. (2023) Vascular smooth muscle cells enhance immune/vascular interplay in a 3-cell model of vascular inflammation. Scientific Reports, 13(1), 15889. (doi: 10.1038/s41598-023-43221-8) (PMID:37741880) (PMCID:PMC10517978)

Clément, M. et al. (2023) CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation. eLife, 12, e84752. (doi: 10.7554/eLife.84752) (PMID:37549051) (PMCID:PMC10431918)

Iaconelli, A., Cuthbert, J., Kazmi, S., Maffia, P. , Clark, A. L., Cleland, J. G.F. and Pellicori, P. (2023) Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity. Clinical Research in Cardiology, 112(8), pp. 1077-1086. (doi: 10.1007/s00392-023-02178-4) (PMID:36894788) (PMCID:PMC10359207)

Iaconelli, A., Pellicori, P. , Caiazzo, E., Rezig, A. O. M. , Bruzzese, D., Maffia, P. and Cleland, J. G. F. (2023) Implanted haemodynamic telemonitoring devices to guide management of heart failure: a review and meta-analysis of randomised trials. Clinical Research in Cardiology, 112(8), pp. 1007-1019. (doi: 10.1007/s00392-022-02104-0) (PMID:36241896) (PMCID:PMC9568893)

Caiazzo, E., Sharma, M., Rezig, A. O. , Morsy, M. , Ialenti, A., Pellicori, P. , Bruzzese, D., Maffia, P. and Guzik, T. J. (2023) Inflammatory Cytokines and Risk of Developing Hypertension: A Systematic Review and Meta-Analysis. 19th World Congress of Basic & Clinical Pharmacology (WCP2023), Glasgow, Scotland, 02-07 Jul 2023. (doi: 10.1111/bph.16105)

Iaconelli, A. et al. (2023) Coronary revascularization for heart failure with coronary artery disease: a systematic review and meta-analysis of randomized trials. European Journal of Heart Failure, 25(7), pp. 1170-1175. (doi: 10.1002/ejhf.2911) (PMID:37211964)

Siedlinski, M. et al. (2023) Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure. European Heart Journal, 44(23), pp. 2114-2125. (doi: 10.1093/eurheartj/ehad101) (PMID:36972688) (PMCID:PMC10281555)

2022

Pugliese, N. R., Pellicori, P. , Filidei, F., De Biase, N., Maffia, P. , Guzik, T. J., Masi, S., Taddei, S. and Cleland, J. G.F. (2022) Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions. Cardiovascular Research, 118(18), pp. 3536-3555. (doi: 10.1093/cvr/cvac133) (PMID:36004819) (PMCID:PMC9897694)

Wiejak, J., Luchowska-Stańska, U., Wang, P., Zhou, J., Maffia, P. , Morgan, D., Barker, G. and Yarwood, S. J. (2022) Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs. Scientific Reports, 12, 16505. (doi: 10.1038/s41598-022-20607-8) (PMID:36198739) (PMCID:PMC9534843)

Szczepaniak, P. et al. (2022) Breast cancer chemotherapy induces vascular dysfunction and hypertension through NOX4 dependent mechanism. Journal of Clinical Investigation, 132(13), e149117. (doi: 10.1172/JCI149117) (PMID:35617030) (PMCID:PMC9246378)

Wainwright, C. L. et al. (2022) Future directions for the discovery of natural product-derived immunomodulating drugs. Pharmacological Research, 177, 106076. (doi: 10.1016/j.phrs.2022.106076) (PMID:35074524)

Caiazzo, E., Rezig, A. O.M. , Bruzzese, D., Ialenti, A., Cicala, C., Cleland, J. G.F. , Guzik, T. J., Maffia, P. and Pellicori, P. (2022) Systemic administration of glucocorticoids, cardiovascular complications and mortality in patients hospitalised with COVID-19, SARS, MERS or influenza: a systematic review and meta-analysis of randomised trials. Pharmacological Research, 176, 106053. (doi: 10.1016/j.phrs.2021.106053) (PMID:34979235) (PMCID:PMC8719379)

2021

Murray, E. C. , Nosalski, R., MacRitchie, N., Tomaszewski, M., Maffia, P. , Harrison, D. G. and Guzik, T. J. (2021) Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective. Cardiovascular Research, 117(13), pp. 2589-2609. (doi: 10.1093/cvr/cvab330) (PMID:34698811)

MacRitchie, N., Noonan, J., Guzik, T. J. and Maffia, P. (2021) Molecular imaging of cardiovascular inflammation. British Journal of Pharmacology, 178(21), pp. 4216-4245. (doi: 10.1111/bph.15654) (PMID:34378206)

Maffia, P. , Antoniades, C., Ahluwalia, A. and Cirino, G. (2021) Molecular imaging - the first visual themed issue published in the British Journal of Pharmacology. British Journal of Pharmacology, 178(21), pp. 4213-4215. (doi: 10.1111/bph.15632) (PMID:34664273)

MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P. and Maffia, P. (2021) Nanoparticle theranostics in cardiovascular inflammation. Seminars in Immunology, 56, 101536. (doi: 10.1016/j.smim.2021.101536) (PMID:34862118) (PMCID:PMC8811479)

Olowoyo, P., Popoola, F., Yaria, J., Akinyemi, R., Maffia, P. and Owolabi, M. O. (2021) Strategies for reducing non-communicable diseases in Africa. Pharmacological Research, 170, 105736. (doi: 10.1016/j.phrs.2021.105736) (PMID:34147659) (PMCID:PMC8800856)

Mikolajczyk, T. P., Szczepaniak, P., Vidler, F., Maffia, P. , Graham, G. J. and Guzik, T. J. (2021) Role of inflammatory chemokines in hypertension. Pharmacology and Therapeutics, 223, 107799. (doi: 10.1016/j.pharmthera.2020.107799) (PMID:33359600)

Eales, J. M. et al. (2021) Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. Nature Genetics, 53(5), pp. 630-637. (doi: 10.1038/s41588-021-00835-w) (PMID:33958779)

Maiuri, M. C. and Maffia, P. (2021) Cellular metabolism and diseases. British Journal of Pharmacology, 178(10), pp. 2031-2033. (doi: 10.1111/bph.15355) (PMID:33932230)

Sharma, S. et al. (2021) Periodontal therapy and treatment of hypertension – alternative to the pharmacological approach. A systematic review and meta-analysis. Pharmacological Research, 166, 105511. (doi: 10.1016/j.phrs.2021.105511) (PMID:33617973)

MacRitchie, N. and Maffia, P. (2021) Light sheet fluorescence microscopy for quantitative 3D imaging of vascular remodelling. Cardiovascular Research, 117(2), pp. 348-350. (doi: 10.1093/cvr/cvaa131) (PMID:32386306) (PMCID:PMC7820857)

2020

Charla, E., Mercer, J. , Maffia, P. and Nicklin, S. (2020) Extracellular vesicle signalling in atherosclerosis. Cellular Signalling, 75, 109751. (doi: 10.1016/j.cellsig.2020.109751) (PMID:32860954) (PMCID:PMC7534042)

Nosalski, R., Mikolajczyk, T., Siedlinski, M., Saju, B., Koziol, J., Maffia, P. and Guzik, T.J. (2020) Nox1/4 inhibition exacerbates age dependent perivascular inflammation and fibrosis in a model of spontaneous hypertension. Pharmacological Research, 161, 105235. (doi: 10.1016/j.phrs.2020.105235) (PMID:33131726) (PMCID:PMC8316606)

Henderson, I., Caiazzo, E., McSharry, C., Guzik, T. J. and Maffia, P. (2020) Why do some asthma patients respond poorly to glucocorticoid therapy? Pharmacological Research, 160, 105189. (doi: 10.1016/j.phrs.2020.105189) (PMID:32911071) (PMCID:PMC7672256)

Sabir, S. R., Thomson, E. C. , Guzik, T. J., D’Acquisto, F. and Maffia, P. (2020) COVID-19: the new immune challenge. Frontiers for Young Minds, 8, 582971. (doi: 10.3389/frym.2020.582971)

Di Francesco, V., Gurgone, D. , Palomba, R., Ferreira, M. F. M. M., Catelani, T., Cervadoro, A., Maffia, P. and Decuzzi, P. (2020) Modulating lipoprotein transcellular transport and atherosclerotic plaque formation in apoe-/- mice via nanoformulated lipid-methotrexate conjugates. ACS Applied Materials and Interfaces, 12(34), pp. 37943-37956. (doi: 10.1021/acsami.0c12202) (PMID:32805983) (PMCID:PMC7453397)

Guzik, T. J. et al. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116(10), pp. 1666-1687. (doi: 10.1093/cvr/cvaa106) (PMID:32352535) (PMCID:PMC7197627)

MacRitchie, N., Frleta-Gilchrist, M., Sugiyama, A., Lawton, T., McInnes, I. B. and Maffia, P. (2020) Molecular Imaging of Inflammation - current and emerging technologies for diagnosis and treatment. Pharmacology and Therapeutics, 211, 107550. (doi: 10.1016/j.pharmthera.2020.107550)

Tavares, L. P., Peh, H. Y., Tan, W. S. D., Pahima, H., Maffia, P. , Tiligada, E. and Levi-Schaffer, F. (2020) Granulocyte-targeted therapies for airway diseases. Pharmacological Research, 157, 104881. (doi: 10.1016/j.phrs.2020.104881)

Harding, S. D. et al. (2020) The IUPHAR guide to immunopharmacology: connecting immunology and pharmacology. Immunology, 160(1), pp. 10-23. (doi: 10.1111/imm.13175) (PMID:32020584) (PMCID:PMC7160657)

Milling, S. , Spedding, M. and Maffia, P. (2020) Guide to Immunopharmacology: a database to boost immunology education, research and therapy. Immunology, 160(1), pp. 1-2. (doi: 10.1111/imm.13201)

Siedlinski, M. et al. (2020) White blood cells and blood pressure: a Mendelian randomization study. Circulation, 141(16), pp. 1307-1317. (doi: 10.1161/CIRCULATIONAHA.119.045102) (PMID:32148083) (PMCID:PMC7176352)

Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)

Gurgone, D. , McShane, L. , McSharry, C., Guzik, T. J. and Maffia, P. (2020) Cytokines at the interplay between asthma and atherosclerosis? Frontiers in Pharmacology, 11, 166. (doi: 10.3389/fphar.2020.00166)

MacRitchie, N. et al. (2020) The aorta can act as site of naïve CD4+ T cell priming. Cardiovascular Research, 116(2), pp. 306-316. (doi: 10.1093/cvr/cvz102) (PMID:30980670)

2019

Eales, J. M. et al. (2019) The human Y chromosome exerts pleiotropic effects on susceptibility to atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 39(11), pp. 2386-2401. (doi: 10.1161/ATVBAHA.119.312405) (PMID:31644355) (PMCID:PMC6818981)

Sagan, A. et al. (2019) T cells are dominant population in human abdominal aortic aneurysms and their infiltration in the perivascular tissue correlates with disease severity. Frontiers in Immunology, 10, 1979. (doi: 10.3389/fimmu.2019.01979) (PMID:31552015) (PMCID:PMC6736986)

MacRitchie, N. and Maffia, P. (2019) Resolvin E1 for reducing vascular calcification. Cardiovascular Research, 115(10), pp. 1457-1459. (doi: 10.1093/cvr/cvz101) (PMID:30989192) (PMCID:PMC6648334)

Maffia, P. and Guzik, T. J. (2019) When, where and how to target vascular inflammation in the post-CANTOS era? European Heart Journal, 40(30), pp. 2492-2494. (doi: 10.1093/eurheartj/ehz133) (PMID:30929007) (PMCID:PMC6685316)

McShane, L. , Tabas, I., Lemke, G., Kurowska-Stolarska, M. and Maffia, P. (2019) TAM receptors in cardiovascular disease. Cardiovascular Research, 115(5), pp. 1286-1295. (doi: 10.1093/cvr/cvz100) (PMID:30980657) (PMCID:PMC6587925)

Mikolajczyk, T. P. et al. (2019) 1,2,3,4,6 penta-O -galloyl-β-D-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. British Journal of Pharmacology, 176(12), pp. 1951-1965. (doi: 10.1111/bph.14583) (PMID:30658013) (PMCID:PMC6534792)

Noonan, J., Grassia, G., MacRitchie, N., Garside, P. , Guzik, T. J., Bradshaw, A. C. and Maffia, P. (2019) A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis. Frontiers in Immunology, 10, 849. (doi: 10.3389/fimmu.2019.00849) (PMID:31068936) (PMCID:PMC6491724)

Kritikou, E., van der Heijden, T., Swart, M., van Duijn, J., Slütter, B., Wezel, A., Smeets, H. J., Maffia, P. , Kuiper, J. and Bot, I. (2019) Hypercholesterolemia induces a mast cell–CD4+ T cell interaction in atherosclerosis. Journal of Immunology, 202(5), pp. 1531-1539. (doi: 10.4049/jimmunol.1800648) (PMID:30683705)

Maffia, P. , Mantovani, A. and Spedding, M. (2019) Scientists on the spot: the Guide to Immunopharmacology as a new resource for the cardiovascular community. Cardiovascular Research, 115(1), e5-e6. (doi: 10.1093/cvr/cvy296) (PMID:30576437)

McShane, L. , Sage, A. P. and Maffia, P. (2019) Inflammation and immunity in vascular diseases. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 229-238. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_21)

2018

Harding, S. D., Faccenda, E., Southan, C., Maffia, P. and Davies, J. A. (2018) A new guide to immunopharmacology. Nature Reviews Immunology, 18(12), p. 729. (doi: 10.1038/s41577-018-0079-2) (PMID:30327546)

Cicha, I. et al. (2018) From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research, 114(13), pp. 1714-1727. (doi: 10.1093/cvr/cvy219) (PMID:30165574) (PMCID:PMC6198738)

Guzik, T. J. et al. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114(12), pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

Loperena, R. et al. (2018) Hypertension and increased endothelial mechanical stretch promote monocyte differentiation and activation: roles of STAT3, interleukin 6 and hydrogen peroxide. Cardiovascular Research, 114(11), pp. 1547-1563. (doi: 10.1093/cvr/cvy112) (PMID:29800237) (PMCID:PMC6106108)

Maffia, P. , Nosalski, R. and Guzik, T. J. (2018) Monocytes M(MP)aking way for T cell vascular infiltration. Circulation Research, 123(6), pp. 638-640. (doi: 10.1161/CIRCRESAHA.118.313668) (PMID:30355241)

Cole, J. E., Park, I., Ahern, D., Kassiteridi, C., Danso Abeam, D., Goddard, M., Green, P., Maffia, P. and Monaco, C. (2018) Immune cell census in murine atherosclerosis: cytometry by time of flight illuminates vascular myeloid cell diversity. Cardiovascular Research, 114(10), pp. 1360-1371. (doi: 10.1093/cvr/cvy109) (PMID:29726984) (PMCID:PMC6054192)

MacRitchie, N. and Maffia, P. (2018) "Blow my mind(in)" - Mindin neutralization for the prevention of atherosclerosis? Clinical Science, 132(14), pp. 1509-1512. (doi: 10.1042/CS20180358) (PMID:30037838)

Maffia, P. (2018) Why we should reward peer reviewers. Cardiovascular Research, 114(5), e30-e31. (doi: 10.1093/cvr/cvy050) (PMID:29590390)

Grassia, G., MacRitchie, N. and Maffia, P. (2018) Immune mechanisms in atherosclerosis and potential for immunomodulatory therapies. In: Riccardi, C., Levi-Schaffer, F. and Tiligada, E. (eds.) Immunopharmacology and Inflammation. Springer: Cham, pp. 211-224. ISBN 9783319776576 (doi: 10.1007/978-3-319-77658-3_9)

MacRitchie, N., Grassia, G., Noonan, J., Garside, P. , Graham, D. and Maffia, P. (2018) Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering. Heart, 104(6), pp. 460-467. (doi: 10.1136/heartjnl-2017-311447) (PMID:29061690) (PMCID:PMC5861389)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

2017

Maffia, P. and Cirino, G. (2017) Targeting inflammation to reduce cardiovascular disease risk. British Journal of Pharmacology, 174(22), pp. 3895-3897. (doi: 10.1111/bph.14039) (PMID:29080212) (PMCID:PMC5659995)

Welsh, P. , Grassia, G., Botha, S., Sattar, N. and Maffia, P. (2017) Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology, 174(22), pp. 3898-3913. (doi: 10.1111/bph.13818) (PMID:28409825) (PMCID:PMC5660005)

Yin, C., Mohanta, S., Maffia, P. and Habenicht, A. J.R. (2017) Editorial: tertiary lymphoid organs (TLOs): powerhouses of disease immunity. Frontiers in Immunology, 8, 228. (doi: 10.3389/fimmu.2017.00228) (PMID:28321222) (PMCID:PMC5337484)

Maffia, P. , Döring, Y., Biessen, E. A.L. and Mallat, Z. (2017) Commentary: Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells. Frontiers in Immunology, 10(8), 140. (doi: 10.3389/fimmu.2017.00140) (PMID:28243244) (PMCID:PMC5304905)

2016

Hughes, C. E. , Benson, R. A. , Bedaj, M. and Maffia, P. (2016) Antigen-presenting cells and antigen presentation in tertiary lymphoid organs. Frontiers in Immunology, 7, 481. (doi: 10.3389/fimmu.2016.00481) (PMID:27872626) (PMCID:PMC5097899)

Srikakulapu, P. et al. (2016) Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 36, pp. 1174-1185. (doi: 10.1161/ATVBAHA.115.306983) (PMID:27102965) (PMCID:PMC4894775)

Scales, H. E. , Ierna, M., Smith, K. M., Ross, K., Meiklejohn, G. R., Patterson-Kane, J. C., McInnes, I. B., Brewer, J. M. , Garside, P. and Maffia, P. (2016) Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging. Rheumatology, 55(3), pp. 564-572. (doi: 10.1093/rheumatology/kev361) (PMID:26475798)

2015

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi: 10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Collins, P. E., Grassia, G., Colleran, A., Kiely, P. A., Ialenti, A., Maffia, P. and Carmody, R. J. (2015) Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide. Journal of Biological Chemistry, 290(25), pp. 15687-15696. (doi: 10.1074/jbc.M115.643700) (PMID:25922067) (PMCID:PMC4505479)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

2014

Xiao, Q. et al. (2014) Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(1), pp. 90-98. (doi: 10.1161/ATVBAHA.113.301418) (PMID:24158518)

Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P. , Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi: 10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)

Sage, A. P. et al. (2014) MHC class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity. Circulation, 130(16), pp. 1363-1373. (doi: 10.1161/CIRCULATIONAHA.114.011090) (PMID:25223984) (PMCID:PMC4428652)

2013

Kennedy, S. , Wu, J., Wadsworth, R.M., Lawrence, C.E. and Maffia, P. (2013) Mast cells and vascular diseases. Pharmacology and Therapeutics, 138(1), pp. 53-65. (doi: 10.1016/j.pharmthera.2013.01.001)

Grassia, G., MacRitchie, N., Platt, A., Brewer, J. , Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi: 10.1016/j.pharmthera.2012.10.001) (PMID:23059425)

Maiuri, M.C., Grassia, G., Platt, A., Carnuccio, R., Ialenti, A. and Maffia, P. (2013) Macrophage autophagy in atherosclerosis. Mediators of Inflammation, 2013, Art. 584715. (doi: 10.1155/2013/584715)

2012

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

Blair, P. and Maffia, P. (2012) Revisited role of B cells in atherosclerosis. Pharmaceutica Analytica Acta, 3(8), 1000174. (doi: 10.4172/2153-2435.1000174)

Gibson, V.B. et al. (2012) A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo. Blood, 119(11), pp. 2545-2551. (doi: 10.1182/blood-2011-09-378356) (PMID:22271449) (PMCID:PMC3398133)

Maddaluno, M. et al. (2012) Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. PLoS ONE, 7(10), e47464. (doi: 10.1371/journal.pone.0047464) (PMID:23077623) (PMCID:PMC3471825)

McQueenie, R., Stevenson, R., Benson, R. , MacRitchie, N., McInnes, I. , Maffia, P. , Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi: 10.1021/ac3006445)

2011

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi: 10.1161/ATVBAHA.111.230078) (PMID:21852559)

Patakas, A., Platt, A. M., Butcher, J. P., Maffia, P. , McInnes, I. B. , Brewer, J. M. , Garside, P. and Benson, R. A. (2011) Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunology Letters, 138(1), pp. 38-46. (doi: 10.1016/j.imlet.2011.03.002) (PMID:21419798)

Fumagalli, S. et al. (2011) In vivo real-time multiphoton imaging of t lymphocytes in the mouse brain after experimental stroke. Stroke, 42(5), pp. 1429-1436. (doi: 10.1161/STROKEAHA.110.603704)

2010

Grassia, G. et al. (2010) The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(12), pp. 2458-2466. (doi: 10.1161/ATVBAHA.110.215467) (PMID:20930169)

Ortolano, F., Maffia, P. , Dever, G., Rodolico, G. , Millington, O.R., De Simoni, M.G., Brewer, J.M. , Bushell, T.J., Garside, P. and Carswell, H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain. British Journal of Pharmacology, 159(4), pp. 808-811. (doi: 10.1111/j.1476-5381.2009.00527.x) (PMID:20015295) (PMCID:PMC2829206)

Millington, O. R., Brewer, J. M. , Garside, P. and Maffia, P. (2010) Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy. In: Marelli-Berg, F. M. and Nourshargh, S. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in Molecular Biology, 616 (616). Humana Press Inc, pp. 193-206. ISBN 9781607614609 (doi: 10.1007/978-1-60761-461-6_13)

2009

Grassia, G., Maddaluno, M., Guglielmotti, A., Mangano, G., Biondi, G., Maffia, P. and Ialenti, A. (2009) The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovascular Research, 84(3), pp. 485-493. (doi: 10.1093/cvr/cvp238) (PMID:19592568) (PMCID:PMC2777949)

D'Emmanuele di Villa Bianca, R., Sorrentino, R., Maffia, P. , Mirone, F., Imbimbo, C., Fusco, F., De Palma, R., Ignarro, L.J. and Cirino, G. (2009) Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation. Proceedings of the National Academy of Sciences of the United States of America, 106(11), pp. 4513-4518. (doi: 10.1073/pnas.0807974105)

Ortolano, F. et al. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150 (4). (doi: 10.1111/j.1365-3024.2008.01090.x)

2007

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

2006

Maffia, P. , Grassia, G., Di Meglio, P., Carnuccio, R., Berrino, L., Garside, P. , Ianaro, A. and Ialenti, A. (2006) Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation, 114, pp. 430-437. (doi: 10.1161/CIRCULATIONAHA.105.602714) (PMID:16864728)

Ialenti, A., Di Meglio, P., Grassia, G., Maffia, P. , Di Rosa, M., Lanzetta, R., Molinaro, A., Silipo, A., Grant, W. and Ianaro, A. (2006) A novel lipid A fromHalomonas magadiensis inhibits enteric LPS-induced human monocyte activation. European Journal of Immunology, 36(2), pp. 354-360. (doi: 10.1002/eji.200535305) (PMID:16365914)

2005

Morello, S., Vellecco, V., Roviezzo, F., Maffia, P. , Cuzzocrea, S., Cirino, G. and Cicala, C. (2005) A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats. Biochemical Pharmacology, 71(1-2), pp. 223-230. (doi: 10.1016/j.bcp.2005.10.016) (PMID:16300746)

Corea, G., Fattorusso, E., Lanzotti, V., Di Meglio, P., Maffia, P. , Grassia, G., Ialenti, A. and Ianaro, A. (2005) Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. Journal of Medicinal Chemistry, 48(22), pp. 7055-7062. (doi: 10.1021/jm050321r) (PMID:16250665)

Ialenti, A., Grassia, G., Di Meglio, P., Maffia, P. , Di Rosa, M. and Ianaro, A. (2005) Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway. Molecular Pharmacology, 67(5), pp. 1620-1628. (doi: 10.1124/mol.104.004895) (PMID:15684043)

Ialenti, A., Di Meglio, P., D'Acquisto, F., Pisano, B., Maffia, P. , Grassia, G., Di Rosa, M. and Ianaro, A. (2005) Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages. European Journal of Pharmacology, 509(2-3), pp. 89-96. (doi: 10.1016/j.ejphar.2004.10.052) (PMID:15733543)

2004

Maffia, P. , Brewer, J. M. , Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi: 10.4049/jimmunol.173.1.151) (PMID:15210769)

Cuzzocrea, S. et al. (2004) Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-γ, reduces acute inflammation. European Journal of Pharmacology, 483(1), pp. 79-93. (doi: 10.1016/j.ejphar.2003.10.056) (PMID:14709329)

2003

Lippolis, L., Sorrentino, R., Popolo, A., Maffia, P. , Nasti, C., Villa Bianca, R. d.’E. d., Marzocco, S., Autore, G. and Pinto, A. (2003) Time course of vascular reactivity to contracting and relaxing agents after endothelial denudation by balloon angioplasty in rat carotid artery. Atherosclerosis, 171(2), pp. 171-179. (doi: 10.1016/j.atherosclerosis.2003.07.012) (PMID:14644385)

Ianaro, A., Maffia, P. , Cuzzocrea, S., Mazzon, E., Santoro, M. G., Di Rosa, M. and Ialenti, A. (2003) 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-κB. FEBS Letters, 553(1-2), pp. 21-27. (doi: 10.1016/S0014-5793(03)00873-1) (PMID:14550540)

Ianaro, A., Ialenti, A., Maffia, P. , Di Meglio, P., Di Rosa, M. and Santoro, M. G. (2003) Anti-inflammatory activity of 15-deoxy- 12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response. Molecular Pharmacology, 64(1), pp. 85-93. (doi: 10.1124/mol.64.1.85) (PMID:12815164)

Ianaro, A., Maffia, P. , Rosa, M. and Ialenti, A. (2003) Cyclopentenone prostaglandins as anti-inflammatory agents: A novel therapeutic strategy? Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents, 2(2), pp. 85-93. (doi: 10.2174/1568014033483851)

2002

Mascolo, N., Izzo, A. A., Ligresti, A., Costagliola, A., Pinto, L., Cascio, M. G., Maffia, P. , Cecio, A., Capasso, F. and Di Marzo, V. (2002) The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB Journal, (doi: 10.1096/fj.02-0338fje) (PMID:12397089)

Borrelli, F., Izzo, A.A., Di Carlo, G., Maffia, P. , Russo, A., Maiello, F.M., Capasso, F. and Mascolo, N. (2002) Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon. Fitoterapia, 73(Supl 1), S38-S43. (doi: 10.1016/S0367-326X(02)00189-2) (PMID:12495708)

Borrelli, F., Maffia, P. , Pinto, L., Ianaro, A., Russo, A., Capasso, F. and Ialenti, A. (2002) Phytochemical compounds involved in the anti-inflammatory effect of propolis extract. Fitoterapia, 73(Supl 1), S53-S63. (doi: 10.1016/S0367-326X(02)00191-0) (PMID:12495710)

Maffia, P. , Ianaro, A., Sorrentino, R., Lippolis, L., Maiello, F. M., del Soldato, P., Ialenti, A. and Cirino, G. (2002) Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 22(2), pp. 263-267. (PMID:11834526)

2001

Ianaro, A., Ialenti, A., Maffia, P. , Pisano, B. and Di Rosa, M. (2001) Role of cyclopentenone prostaglandins in rat carrageenin pleurisy. FEBS Letters, 508(1), pp. 61-66. (doi: 10.1016/S0014-5793(01)03035-6) (PMID:11707269)

D'Acquisto, F., Ianaro, A., Ialenti, A., Maffia, P. , Maiuri, M. and Carnuccio, R. (2001) Transcription factor decoy oligodeoxynucleotides to nuclear factor-κB inhibit reverse passive Arthus reaction in rat. Naunyn-Schmiedeberg's Archives of Pharmacology, 364(5), pp. 422-429. (doi: 10.1007/s002100100472) (PMID:11692225)

Ianaro, A., Ialenti, A., Maffia, P. , Pisano, B. and Di Rosa, M. (2001) HSF1/hsp72 pathway as an endogenous anti-inflammatory system. FEBS Letters, 499(3), pp. 239-244. (doi: 10.1016/S0014-5793(01)02569-8) (PMID:11423124)

Ialenti, A. et al. (2001) Synthesis of novel anti-inflammatory peptides derived from the amino-acid sequence of the bioactive protein SV-IV. European Journal of Biochemistry, 268(12), pp. 3399-3406. (doi: 10.1046/j.1432-1327.2001.02236.x) (PMID:11422369)

2000

Ialenti, A., Ianaro, A., Maffia, P. , Sautebin, L. and Di Rosa, M. (2000) Nitric oxide inhibits leucocyte migration in carrageenin-induced rat pleurisy. Inflammation Research, 49(8), pp. 411-417. (doi: 10.1007/s000110050609) (PMID:11028758)

Ianaro, A., Ialenti, A., Maffia, P. , Sautebin, L., Rombolà, L., Carnuccio, R., Iuvone, T., D'Acquisto, F. and Di Rosa, M. (2000) Anti-inflammatory activity of macrolide antibiotics. Journal of Pharmacology and Experimental Therapeutics, 292(1), pp. 156-163. (PMID:10604943)

1996

Costantino, V., Fattorusso, E., Mangoni, A., Rosa, M. D., Ianaro, A. and Maffia, P. (1996) Glycolipids from sponges. IV. Immunomodulating glycosyl ceramides from the marine sponge agelas dispar. Tetrahedron, 52(5), pp. 1573-1578. (doi: 10.1016/0040-4020(95)00986-8)

Caliendo, G., Greco, G., Grieco, P., Perissutti, E., Santagada, V., Ialenti, A., Maffia, P. , Albrizio, S. and Santini, A. (1996) Synthesis and antinociceptive activity of peptides related to interleukin-1β193–195 Lys-Pro-Thr. Biopolymers, 40(5), pp. 479-484. (doi: 10.1002/(SICI)1097-0282(1996)40:5<479::AID-BIP5>3.0.CO;2-T) (PMID:9062070)

This list was generated on Mon Nov 18 12:59:26 2024 GMT.

Jump to: Articles | Book Sections | Conference or Workshop Item

Number of items: 124.

Articles

Shoaran, M. and Maffia, P. (2024) Tackling inflammation in atherosclerosis. Nature Reviews Cardiology, 21, 442. (doi: 10.1038/s41569-024-01007-z) (PMID:38472372)

Olowoyo, P. et al. (2024) Priorities to reduce the burden of hypertension in Africa through ACHIEVE. Lancet Global Health, 12(2), e192-e193. (doi: 10.1016/S2214-109X(23)00540-5) (PMID:38245107)

Maiuri, M. C. and Maffia, P. (2021) Cellular metabolism and diseases. British Journal of Pharmacology, 178(10), pp. 2031-2033. (doi: 10.1111/bph.15355) (PMID:33932230)

Sabir, S. R., Thomson, E. C. , Guzik, T. J., D’Acquisto, F. and Maffia, P. (2020) COVID-19: the new immune challenge. Frontiers for Young Minds, 8, 582971. (doi: 10.3389/frym.2020.582971)

Milling, S. , Spedding, M. and Maffia, P. (2020) Guide to Immunopharmacology: a database to boost immunology education, research and therapy. Immunology, 160(1), pp. 1-2. (doi: 10.1111/imm.13201)

MacRitchie, N. et al. (2020) The aorta can act as site of naïve CD4+ T cell priming. Cardiovascular Research, 116(2), pp. 306-316. (doi: 10.1093/cvr/cvz102) (PMID:30980670)

MacRitchie, N. and Maffia, P. (2019) Resolvin E1 for reducing vascular calcification. Cardiovascular Research, 115(10), pp. 1457-1459. (doi: 10.1093/cvr/cvz101) (PMID:30989192) (PMCID:PMC6648334)

Guzik, T. J. et al. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114(12), pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

Maffia, P. (2018) Why we should reward peer reviewers. Cardiovascular Research, 114(5), e30-e31. (doi: 10.1093/cvr/cvy050) (PMID:29590390)

Blair, P. and Maffia, P. (2012) Revisited role of B cells in atherosclerosis. Pharmaceutica Analytica Acta, 3(8), 1000174. (doi: 10.4172/2153-2435.1000174)

Fumagalli, S. et al. (2011) In vivo real-time multiphoton imaging of t lymphocytes in the mouse brain after experimental stroke. Stroke, 42(5), pp. 1429-1436. (doi: 10.1161/STROKEAHA.110.603704)

Ortolano, F. et al. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150 (4). (doi: 10.1111/j.1365-3024.2008.01090.x)

Book Sections

Conference or Workshop Item

This list was generated on Mon Nov 18 12:59:26 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Correlating Systemic Immunophenotyping to Imaging Characterisartion of Inflammatory Atheroma in Patients Receiving Immunotherapy and Angiogenesis Inhibitors
British Heart Foundation
2024 - 2025
Research collaboration and network building with The Malawi University of Science and Technology (MUST)
Biotechnology and Biological Sciences Research Council
2024 - 2024
NLRP3 Inflammasome Inhibition by EPAC1 in a 3-cell Model of Vascular Inflammation
British Heart Foundation
2024 - 2026
Africa-Europe Cluster of Research Excellence in Non-Communicable Diseases & Multimorbidity
Scottish Funding Council
2023 - 2024
Cross disciplinary capacity building in ultra-high frequency preclinical cardiovascular ultrasound
British Heart Foundation
2022 - 2025
Defining EPAC1 as a therapeutic target for vascular inflammation and atherosclerosis
British Heart Foundation
2021 - 2024
Defining the IL-21/IL-21 receptor axis role(s) in atherosclerosis
British Heart Foundation
2021 - 2023
Defining AXL Role in Atherosclerosis
British Heart Foundation
2021 - 2023
Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosis
British Heart Foundation
2020 - 2023
Single cell sequencing of aortic immune cells from Angiotensis II-induced hypertensive mice
Wellcome Trust
2019 - 2020
Assessment of immune-inflammatory biomarkers
National Centre for the Replacement, Refinement and Reduction of Animals Research
2018 - 2019
Microwave Therapy for Atherosclerotic Lesions
Scottish Funding Council
2017 - 2018
Selective targeting of NF-??B by Bcl-3 in the control of vascular injury
Tenovus Scotland
2016 - 2017
ISSF Catalyst@ The Glasgow FANTOM6 consortium investigation of the role of LncRNAs in specifying tissue macrophage phenotypes
Wellcome Trust
2015 - 2016
NanoMATe
European Commission
2015 - 2017
In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy. Reference: 130479
Engineering and Physical Sciences Research Council
2014 - 2018
BHF centre of excellence
British Heart Foundation
2014 - 2019
Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.
British Heart Foundation
2013 - 2017
Imaging immune cells in lung in order to understand asthma
Asthma UK
2012 - 2012
Transfer of expertise in bioimaging from academia to industry.
Scottish Funding Council
2011 - 2012
Targeting cell contact to reduce autoimmunity and enhance vaccination
Scottish Universities Life Sciences Alliance
2011 - 2012
In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy
Engineering and Physical Sciences Research Council
2010 - 2011
Visualising antigen presentation in mouse models of atherosclerosis
Medical Research Scotland
2010 - 2012
Investigating the role of T cells in vascular pathology
British Heart Foundation
2010 - 2010
Importance of mast cells in vein graft survival
British Heart Foundation
2010 - 2012

Supervision

Booth, Emma
The role of IL15 in angiotensin II-mediated cardiac remodelling
Morsy, Moustafa Ibrahim Mohamed Ahmed
Investigating immune pathways in cardiovascular diseases
Shoaran, Mohsen
Investigating the individual contribution of inflammatory chemokine receptors (iCCRs) to plaque instability

Teaching

Since 2014, I have served as Programme and/or Course Coordinator for the Senior Honours Immunology degree. The BSc (Hons) degree programme in Immunology, which has been running for over forty years, was the first of its kind in Britain. It continues to offer one of the most comprehensive undergraduate educations in immunology in the country.

In addition to teaching 2Y and 3Y Immunology, 1Y Medicine, 3Y Pharmacology, the BMedSci in Inflammation Medicine, MVLS College Research Training courses, and the MSc in Infection Biology and Immunology, I am also a Fellow of the Higher Education Academy and an Adjunct Professor of Pharmacology at the University of Naples Federico II. I actively engage in organizing and delivering national and international teaching and learning activities, including the Spring School in Transferable Skills from the AURORA European University Alliance.

I have served as the External Examiner for the intercalated BMedSci degree course in Molecular Therapeutics at Barts & the London School of Medicine & Dentistry. Additionally, I have been honored with the MVLS College Teaching Excellence Award and received a nomination for Best MVLS College Teacher.

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Professor Pasquale Maffia

Biography

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1996

Articles

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Teaching