2024

MacRitchie, N. and Maffia, P. (2024) Blocking interleukin-1β: a double-edged sword in experimental atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(7), pp. 1537-1539. (doi: 10.1161/ATVBAHA.124.321113) (PMID:38813698)

2021

Murray, E. C. , Nosalski, R., MacRitchie, N., Tomaszewski, M., Maffia, P. , Harrison, D. G. and Guzik, T. J. (2021) Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective. Cardiovascular Research, 117(13), pp. 2589-2609. (doi: 10.1093/cvr/cvab330) (PMID:34698811)

MacRitchie, N., Noonan, J., Guzik, T. J. and Maffia, P. (2021) Molecular imaging of cardiovascular inflammation. British Journal of Pharmacology, 178(21), pp. 4216-4245. (doi: 10.1111/bph.15654) (PMID:34378206)

MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P. and Maffia, P. (2021) Nanoparticle theranostics in cardiovascular inflammation. Seminars in Immunology, 56, 101536. (doi: 10.1016/j.smim.2021.101536) (PMID:34862118) (PMCID:PMC8811479)

MacRitchie, N. and Maffia, P. (2021) Light sheet fluorescence microscopy for quantitative 3D imaging of vascular remodelling. Cardiovascular Research, 117(2), pp. 348-350. (doi: 10.1093/cvr/cvaa131) (PMID:32386306) (PMCID:PMC7820857)

2020

MacRitchie, N., Frleta-Gilchrist, M., Sugiyama, A., Lawton, T., McInnes, I. B. and Maffia, P. (2020) Molecular Imaging of Inflammation - current and emerging technologies for diagnosis and treatment. Pharmacology and Therapeutics, 211, 107550. (doi: 10.1016/j.pharmthera.2020.107550)

MacRitchie, N. et al. (2020) The aorta can act as site of naïve CD4+ T cell priming. Cardiovascular Research, 116(2), pp. 306-316. (doi: 10.1093/cvr/cvz102) (PMID:30980670)

2019

Sagan, A. et al. (2019) T cells are dominant population in human abdominal aortic aneurysms and their infiltration in the perivascular tissue correlates with disease severity. Frontiers in Immunology, 10, 1979. (doi: 10.3389/fimmu.2019.01979) (PMID:31552015) (PMCID:PMC6736986)

MacRitchie, N. and Maffia, P. (2019) Resolvin E1 for reducing vascular calcification. Cardiovascular Research, 115(10), pp. 1457-1459. (doi: 10.1093/cvr/cvz101) (PMID:30989192) (PMCID:PMC6648334)

Noonan, J., Grassia, G., MacRitchie, N., Garside, P. , Guzik, T. J., Bradshaw, A. C. and Maffia, P. (2019) A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis. Frontiers in Immunology, 10, 849. (doi: 10.3389/fimmu.2019.00849) (PMID:31068936) (PMCID:PMC6491724)

2018

Cicha, I. et al. (2018) From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research, 114(13), pp. 1714-1727. (doi: 10.1093/cvr/cvy219) (PMID:30165574) (PMCID:PMC6198738)

MacRitchie, N. and Maffia, P. (2018) "Blow my mind(in)" - Mindin neutralization for the prevention of atherosclerosis? Clinical Science, 132(14), pp. 1509-1512. (doi: 10.1042/CS20180358) (PMID:30037838)

Grassia, G., MacRitchie, N. and Maffia, P. (2018) Immune mechanisms in atherosclerosis and potential for immunomodulatory therapies. In: Riccardi, C., Levi-Schaffer, F. and Tiligada, E. (eds.) Immunopharmacology and Inflammation. Springer: Cham, pp. 211-224. ISBN 9783319776576 (doi: 10.1007/978-3-319-77658-3_9)

MacRitchie, N., Grassia, G., Noonan, J., Garside, P. , Graham, D. and Maffia, P. (2018) Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering. Heart, 104(6), pp. 460-467. (doi: 10.1136/heartjnl-2017-311447) (PMID:29061690) (PMCID:PMC5861389)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

2017

Barbour, M., McNaughton, M., Boomkamp, S. D., MacRitchie, N., Jiang, H.-R., Pyne, N. J. and Pyne, S. (2017) Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis. British Journal of Pharmacology, 174(2), pp. 210-222. (doi: 10.1111/bph.13670) (PMID:27864936)

2016

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S. , Pyne, S. and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi: 10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619)

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H.-R., Ubhi, S. and Pyne, S. (2016) Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation. Advances in Biological Regulation, 60, pp. 151-159. (doi: 10.1016/j.jbior.2015.09.001) (PMID:26429117)

2015

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi: 10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

2014

Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P. , Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi: 10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)

2013

Baek, D. J., MacRitchie, N., Anthony, N. G., Mackay, S. P., Pyne, S., Pyne, N. J. and Bittman, R. (2013) Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of Medicinal Chemistry, 56(22), pp. 9310-9327. (doi: 10.1021/jm401399c) (PMID:24164513) (PMCID:PMC3848335)

Byun, H.-S., Pyne, S., MacRitchie, N., Pyne, N. J. and Bittman, R. (2013) Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells. MedChemComm, 4(10), pp. 1394-1399. (doi: 10.1039/C3MD00201B) (PMID:24396570) (PMCID:PMC3880124)

Dempsie, Y., MacRitchie, N.A., White, K., Morecroft, I., Wright, A.F., Nilsen, M., Loughlin, L., Mair, K.M. and MacLean, M.R. (2013) Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular Research, 99(1), pp. 24-34. (doi: 10.1093/cvr/cvt064) (PMID:23519266) (PMCID:PMC3687748)

Liu, Z., MacRitchie, N., Pyne, S., Pyne, N. J. and Bittman, R. (2013) Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators. Bioorganic and Medicinal Chemistry Letters, 21(9), pp. 2503-2510. (doi: 10.1016/j.bmc.2013.02.042) (PMID:23541833) (PMCID:PMC3627827)

Baek, D. J., MacRitchie, N., Pyne, N. J., Pyne, S. and Bittman, R. (2013) Synthesis of selective inhibitors of sphingosine kinase 1. Chemical Communications, 49(21), pp. 2136-2138. (doi: 10.1039/C3CC00181D) (PMID:23388656) (PMCID:PMC3608193)

Grassia, G., MacRitchie, N., Platt, A., Brewer, J. , Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi: 10.1016/j.pharmthera.2012.10.001) (PMID:23059425)

2012

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

McQueenie, R., Stevenson, R., Benson, R. , MacRitchie, N., McInnes, I. , Maffia, P. , Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi: 10.1021/ac3006445)

2008

Dempsie, Y. et al. (2008) Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice. Circulation, 117(22), pp. 2928-2937. (doi: 10.1161/CIRCULATIONAHA.108.767558)

Articles

MacRitchie, N. and Maffia, P. (2024) Blocking interleukin-1β: a double-edged sword in experimental atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 44(7), pp. 1537-1539. (doi: 10.1161/ATVBAHA.124.321113) (PMID:38813698)

Murray, E. C. , Nosalski, R., MacRitchie, N., Tomaszewski, M., Maffia, P. , Harrison, D. G. and Guzik, T. J. (2021) Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective. Cardiovascular Research, 117(13), pp. 2589-2609. (doi: 10.1093/cvr/cvab330) (PMID:34698811)

MacRitchie, N., Noonan, J., Guzik, T. J. and Maffia, P. (2021) Molecular imaging of cardiovascular inflammation. British Journal of Pharmacology, 178(21), pp. 4216-4245. (doi: 10.1111/bph.15654) (PMID:34378206)

MacRitchie, N., Di Francesco, V., Ferreira, M. F. M. M., Guzik, T. J., Decuzzi, P. and Maffia, P. (2021) Nanoparticle theranostics in cardiovascular inflammation. Seminars in Immunology, 56, 101536. (doi: 10.1016/j.smim.2021.101536) (PMID:34862118) (PMCID:PMC8811479)

MacRitchie, N. and Maffia, P. (2021) Light sheet fluorescence microscopy for quantitative 3D imaging of vascular remodelling. Cardiovascular Research, 117(2), pp. 348-350. (doi: 10.1093/cvr/cvaa131) (PMID:32386306) (PMCID:PMC7820857)

MacRitchie, N., Frleta-Gilchrist, M., Sugiyama, A., Lawton, T., McInnes, I. B. and Maffia, P. (2020) Molecular Imaging of Inflammation - current and emerging technologies for diagnosis and treatment. Pharmacology and Therapeutics, 211, 107550. (doi: 10.1016/j.pharmthera.2020.107550)

MacRitchie, N. et al. (2020) The aorta can act as site of naïve CD4+ T cell priming. Cardiovascular Research, 116(2), pp. 306-316. (doi: 10.1093/cvr/cvz102) (PMID:30980670)

Sagan, A. et al. (2019) T cells are dominant population in human abdominal aortic aneurysms and their infiltration in the perivascular tissue correlates with disease severity. Frontiers in Immunology, 10, 1979. (doi: 10.3389/fimmu.2019.01979) (PMID:31552015) (PMCID:PMC6736986)

MacRitchie, N. and Maffia, P. (2019) Resolvin E1 for reducing vascular calcification. Cardiovascular Research, 115(10), pp. 1457-1459. (doi: 10.1093/cvr/cvz101) (PMID:30989192) (PMCID:PMC6648334)

Noonan, J., Grassia, G., MacRitchie, N., Garside, P. , Guzik, T. J., Bradshaw, A. C. and Maffia, P. (2019) A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis. Frontiers in Immunology, 10, 849. (doi: 10.3389/fimmu.2019.00849) (PMID:31068936) (PMCID:PMC6491724)

Cicha, I. et al. (2018) From design to the clinic: practical guidelines for translating cardiovascular nanomedicine. Cardiovascular Research, 114(13), pp. 1714-1727. (doi: 10.1093/cvr/cvy219) (PMID:30165574) (PMCID:PMC6198738)

MacRitchie, N. and Maffia, P. (2018) "Blow my mind(in)" - Mindin neutralization for the prevention of atherosclerosis? Clinical Science, 132(14), pp. 1509-1512. (doi: 10.1042/CS20180358) (PMID:30037838)

MacRitchie, N., Grassia, G., Noonan, J., Garside, P. , Graham, D. and Maffia, P. (2018) Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering. Heart, 104(6), pp. 460-467. (doi: 10.1136/heartjnl-2017-311447) (PMID:29061690) (PMCID:PMC5861389)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

Barbour, M., McNaughton, M., Boomkamp, S. D., MacRitchie, N., Jiang, H.-R., Pyne, N. J. and Pyne, S. (2017) Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis. British Journal of Pharmacology, 174(2), pp. 210-222. (doi: 10.1111/bph.13670) (PMID:27864936)

MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S. , Pyne, S. and Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28(8), pp. 946-955. (doi: 10.1016/j.cellsig.2016.03.014) (PMID:27063355) (PMCID:PMC4913619)

Pyne, N. J., McNaughton, M., Boomkamp, S., MacRitchie, N., Evangelisti, C., Martelli, A. M., Jiang, H.-R., Ubhi, S. and Pyne, S. (2016) Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation. Advances in Biological Regulation, 60, pp. 151-159. (doi: 10.1016/j.jbior.2015.09.001) (PMID:26429117)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S. and Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling. PeerJ, 3, e1192. (doi: 10.7717/peerj.1192) (PMID:26312183) (PMCID:PMC4548472)

Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)

Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P. , Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi: 10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)

Baek, D. J., MacRitchie, N., Anthony, N. G., Mackay, S. P., Pyne, S., Pyne, N. J. and Bittman, R. (2013) Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors. Journal of Medicinal Chemistry, 56(22), pp. 9310-9327. (doi: 10.1021/jm401399c) (PMID:24164513) (PMCID:PMC3848335)

Byun, H.-S., Pyne, S., MacRitchie, N., Pyne, N. J. and Bittman, R. (2013) Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells. MedChemComm, 4(10), pp. 1394-1399. (doi: 10.1039/C3MD00201B) (PMID:24396570) (PMCID:PMC3880124)

Dempsie, Y., MacRitchie, N.A., White, K., Morecroft, I., Wright, A.F., Nilsen, M., Loughlin, L., Mair, K.M. and MacLean, M.R. (2013) Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular Research, 99(1), pp. 24-34. (doi: 10.1093/cvr/cvt064) (PMID:23519266) (PMCID:PMC3687748)

Liu, Z., MacRitchie, N., Pyne, S., Pyne, N. J. and Bittman, R. (2013) Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators. Bioorganic and Medicinal Chemistry Letters, 21(9), pp. 2503-2510. (doi: 10.1016/j.bmc.2013.02.042) (PMID:23541833) (PMCID:PMC3627827)

Baek, D. J., MacRitchie, N., Pyne, N. J., Pyne, S. and Bittman, R. (2013) Synthesis of selective inhibitors of sphingosine kinase 1. Chemical Communications, 49(21), pp. 2136-2138. (doi: 10.1039/C3CC00181D) (PMID:23388656) (PMCID:PMC3608193)

Grassia, G., MacRitchie, N., Platt, A., Brewer, J. , Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi: 10.1016/j.pharmthera.2012.10.001) (PMID:23059425)

MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)

McQueenie, R., Stevenson, R., Benson, R. , MacRitchie, N., McInnes, I. , Maffia, P. , Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi: 10.1021/ac3006445)

Dempsie, Y. et al. (2008) Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice. Circulation, 117(22), pp. 2928-2937. (doi: 10.1161/CIRCULATIONAHA.108.767558)

Book Sections

Grassia, G., MacRitchie, N. and Maffia, P. (2018) Immune mechanisms in atherosclerosis and potential for immunomodulatory therapies. In: Riccardi, C., Levi-Schaffer, F. and Tiligada, E. (eds.) Immunopharmacology and Inflammation. Springer: Cham, pp. 211-224. ISBN 9783319776576 (doi: 10.1007/978-3-319-77658-3_9)