Professor Michael Barrett
- Professor of Biochemical Parasitology (Parasitology)
telephone:
01413306904
email:
Michael.Barrett@glasgow.ac.uk
RB521 Level B5, Iii - Gbrc, University Place, Glasgow G12 8TA
https://orcid.org/0000-0001-9447-3519Biography
Mike Barrett is a Professor in the Wellcome Centre for Integrative Parasitology within the School of Infection & Immunity at the University of Glasgow, and, as of 1 July 2023, Deputy Head of School.
His work focuses on understanding how drugs against pathogens work and how resistance to drugs comes about.
Mike is director of Glasgow Polyomics, a state of the art facility specialising in genomic, proteomic and metabolomic technologies and their application to a range of subjects.
He also directs the Scottish Universities Life Sciences Alliance (SULSA) and advises several international organisations on issues surrounding drug development and resistance issues including the World Health Organisation and the Drugs for Neglected Diseases initiative.
Research interests
Current research :
A focus on understanding how drugs work against parasites and how parasites become resistant to drugs. In the case of African trypanosomiasis, transport related phenomena have been central and a major research area has been associated with understanding drug resistance. This has led to the discovery of new transporters involved in uptake of melaminophenylarsenical and diamidine drugs and eflornithine. In Leishmania changes in drug uptake have also been identified for paromomycin, pentamidine and amphotericin B in selection of drug resistance. Prof Barrett chairs the Kinetoplastids Drug efficacy working group at the World Health Organisation. Since many drugs work at the level of interference with metabolism he has also pioneered work into biochemistry of parasites, identifying several drug targets and also founded the Scottish Metabolomics facility which is now able to report on metabolomics data outputs in any system, and is now part of the Glasgow Polyomics Facility which is involved in collecting metabolomics, genomics and proteomics data and analysing the data within an active bioinformatics hub. Prof Barrett is also interested in developing new screens for drugs, including an in vivo imaging model to determine whether drugs act in stage 2 human African trypanosomiasis, and is Director of New Projects at the Consortium of Parasitic Drug Development. He also is involved in scientific outreach, appearing on radio, television and writing frequently in magazines and newspapers on topics in tropical medicine and application of Omics research.
Publications
2025
Campillo Poveda, M. et al. (2025) Metabolomic and functional analyses of small molecules secreted by intestinal nematodes in the activation of epithelial tuft cells. Metabolomics, (Accepted for Publication)
Richards, S. et al. (2025) Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of african animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania. PLoS Neglected Tropical Diseases, 19(1), e0012541. (doi: 10.1371/journal.pntd.0012541) (PMID:39836697) (PMCID:PMC11785308)
2024
Morrison, L. J., Barrett, M. P. , Steketee, P. C., Cecchi, G., Kijanga, O., Mramba, F. and Auty, H. K. (2024) What is needed to achieve effective and sustainable control of African animal trypanosomosis? Trends in Parasitology, 40(8), pp. 679-686. (doi: 10.1016/j.pt.2024.06.013) (PMID:39048503)
Griffin, D., Despommier, D., Naula, C. and Barrett, M. (2024) This Week in Parasitism - TWiP 238: Eliminating sleeping sickness. [Audio]
Varghese, S. et al. (2024) Novel aroyl guanidine anti-trypanosomal compounds that exert opposing effects on parasite energy metabolism. European Journal of Medicinal Chemistry, 268, 116162. (doi: 10.1016/j.ejmech.2024.116162) (PMID:38394930)
Kovářová, J., Moos, M., Barrett, M. P. , Horn, D. and Zíková, A. (2024) The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis. PLoS Neglected Tropical Diseases, 18(2), e0012007. (doi: 10.1371/journal.pntd.0012007) (PMID:38394337) (PMCID:PMC10917290)
2023
Simwela, N. V. et al. (2023) A conserved metabolic signature associated with response to fast-acting anti-malarial agents. Microbiology Spectrum, 11(6), e0397622. (doi: 10.1128/spectrum.03976-22) (PMID:37800971) (PMCID:PMC10714989)
Năstase, A.-M. et al. (2023) Alignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites. PLoS Neglected Tropical Diseases, 17(7), e0011133. (doi: 10.1371/journal.pntd.0011133) (PMID:37486920) (PMCID:PMC10399774)
Rao, S. P. S. et al. (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380(6652), pp. 1349-1356. (doi: 10.1126/science.adh0614) (PMID:37384702)
Hu, C. , Annese, V. F. , Barrett, M. P. and Cumming, D. R.S. (2023) Point-of-care platform for diagnosis of venous thrombosis by simultaneous detection of thrombin generation and D-dimer in human plasma. Analytical Chemistry, 95(2), pp. 1115-1122. (doi: 10.1021/acs.analchem.2c03819) (PMID:36544272) (PMCID:PMC9850404)
2022
Hu, C. , Annese, V. F. , Giagkoulovits, C. , Barrett, M. P. and Cumming, D. R. S. (2022) Factor VIII companion diagnostic for haemophilia. Frontiers in Bioengineering and Biotechnology, 10, 1006600. (doi: 10.3389/fbioe.2022.1006600) (PMID:36277382) (PMCID:PMC9579283)
Annese, V. F. , Hu, C. , Barrett, M. P. , Jones, R. and Cumming, D. R. S. (2022) A CMOS-based multi-omics detection platform for simultaneous quantification of proteolytically active prostate specific antigen and glutamate in urine. IEEE Sensors Journal, 22(19), pp. 18870-18877. (doi: 10.1109/JSEN.2022.3198282)
Alpizar-Sosa, E. A., Kumordzi, Y., Wei, W., Whitfield, P. D. , Barrett, M. P. and Denny, P. W. (2022) Genome deletions to overcome the directed loss of gene function in Leishmania. Frontiers in Cellular and Infection Microbiology, 12, 988688. (doi: 10.3389/fcimb.2022.988688) (PMID:36211960) (PMCID:PMC9539739)
Koester, D. C. et al. (2022) Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). Journal of Medicinal Chemistry, 65(17), pp. 11776-11787. (doi: 10.1021/acs.jmedchem.2c00791) (PMID:35993839) (PMCID:PMC9469205)
Alpizar-Sosa, E. A. et al. (2022) Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response. PLoS Neglected Tropical Diseases, 16(9), e0010779. (doi: 10.1371/journal.pntd.0010779) (PMID:36170238) (PMCID:PMC9581426)
Sanchez, C. P., Manson, E. D. T., Moliner Cubel, S., Mandel, L., Weidt, S. K., Barrett, M. P. and Lanzer, M. (2022) The knock-down of the chloroquine resistance transporter PfCRT is linked to oligopeptide handling in Plasmodium falciparum. Microbiology Spectrum, 10(4), e0110122. (doi: 10.1128/spectrum.01101-22) (PMID:35867395) (PMCID:PMC9431119)
Jara, M., Barrett, M. , Maes, I., Regnault, C., Imamura, H., Domagalska, M. A. and Dujardin, J.-C. (2022) Transcriptional shift and metabolic adaptations during Leishmania quiescence using stationary phase and drug pressure as models. Microorganisms, 10(1), 97. (doi: 10.3390/microorganisms10010097) (PMID:35056546) (PMCID:PMC8781126)
2021
Steketee, P. C., Giordani, F. , Vincent, I. M. , Crouch, K. , Achcar, F. , Dickens, N. J. , Morrison, L. J., MacLeod, A. and Barrett, M. P. (2021) Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole. PLoS Neglected Tropical Diseases, 15(11), e0009939. (doi: 10.1371/journal.pntd.0009939) (PMID:34752454) (PMCID:PMC8648117)
Richards, S., Morrison, L. J., Torr, S. J., Barrett, M. P. , Manangwa, O., Mramba, F. and Auty, H. (2021) Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis. Trends in Parasitology, 37(9), pp. 831-843. (doi: 10.1016/j.pt.2021.04.007) (PMID:33962879)
Brooke, D. P. et al. (2021) Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype. RSC Medicinal Chemistry, 12(8), pp. 1391-1401. (doi: 10.1039/D1MD00110H)
Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)
Steketee, P. C. et al. (2021) Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition. PLoS Pathogens, 17(7), e1009734. (doi: 10.1371/journal.ppat.1009734) (PMID:34310651) (PMCID:PMC8384185)
Biddau, M. et al. (2021) Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes. International Journal for Parasitology, 51(6), pp. 441-453. (doi: 10.1016/j.ijpara.2020.10.011) (PMID:33713652) (PMCID:PMC8126644)
Annese, V. F. et al. (2021) A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection. Microsystems and Nanoengineering, 7, 21. (doi: 10.1038/s41378-021-00243-4) (PMID:34567735) (PMCID:PMC8433377)
Milne, K. et al. (2021) Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum. eLife, 10, e62800. (doi: 10.7554/elife.62800) (PMID:33648633) (PMCID:PMC7924948)
Villafraz, O. et al. (2021) Procyclic trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in the presence of physiological amounts of proline. PLoS Pathogens, 17(3), e1009204. (doi: 10.1371/journal.ppat.1009204) (PMID:33647053) (PMCID:PMC7951978)
Simwela, N., Hughes, K. R., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2021) Mammalian deubiquitinating enzyme inhibitors display. ACS Infectious Diseases, 7(2), pp. 333-346. (doi: 10.1021/acsinfecdis.0c00580) (PMID:33400499)
Mina, J. G.M. et al. (2021) Antileishmanial chemotherapy through clemastine fumarate mediated inhibition of the Leishmania inositol phosphorylceramide synthase. ACS Infectious Diseases, 7(1), pp. 47-63. (doi: 10.1021/acsinfecdis.0c00546) (PMID:33291887) (PMCID:PMC7802075)
2020
Cockram, P. E., Dickie, E. A., Barrett, M. P. and Smith, T. K. (2020) Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei. PLoS Neglected Tropical Diseases, 14(12), e0008928. (doi: 10.1371/journal.pntd.0008928) (PMID:33275612) (PMCID:PMC7744056)
Giordani, F. et al. (2020) Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs. PLoS Pathogens, 16(11), e1008932. (doi: 10.1371/journal.ppat.1008932) (PMID:33141865) (PMCID:PMC7710103)
Blackburn, G. et al. (2020) Running on empty: a metabolomics approach to investigating changing energy metabolism during fasted exercise and rest. Metabolites, 10(10), 399. (doi: 10.3390/metabo10100399) (PMID:33050077) (PMCID:PMC7600507)
Saldivia, M. et al. (2020) Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature Microbiology, 5(10), pp. 1207-1216. (doi: 10.1038/s41564-020-0745-6) (PMID:32661312) (PMCID:PMC7610364)
Hu, C. , Annese, V. , Velugotla, S. , Al-Rawhani, M. A., Cheah, B. C. , Grant, J. , Barrett, M. P. and Cumming, D. R.S. (2020) Disposable paper-on-CMOS platform for real-time simultaneous detection of metabolites. IEEE Transactions on Biomedical Engineering, 67(9), pp. 2417-2426. (doi: 10.1109/TBME.2019.2962239)
Daly, R. et al. (2020) Changes in plasma itaconate elevation in early rheumatoid arthritis patients elucidates disease activity associated macrophage activation. Metabolites, 10(6), 241. (doi: 10.3390/metabo10060241) (PMID:32531990) (PMCID:PMC7344783)
Doleželová, E., Kunzová, M., Dejung, M., Levin, M., Panicucci, B., Regnault, C., Janzen, C. J., Barrett, M. P. , Butter, F. and Zíková, A. (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei. PLoS Biology, 18(6), e3000741. (doi: 10.1371/journal.pbio.3000741) (PMID:32520929) (PMCID:PMC7307792)
Simwela, N., Hughes, K. R., Roberts, A. B., Rennie, M. T., Barrett, M. P. and Waters, A. P. (2020) Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo susceptibility to artemisinin and chloroquine in Plasmodium berghei. Antimicrobial Agents and Chemotherapy, 64(7), (doi: 10.1128/AAC.02484-19) (PMID:32340987) (PMCID:PMC7318008)
Zoltner, M. et al. (2020) Suramin exposure alters cellular metabolism and mitochondrial energy production in African trypanosomes. Journal of Biological Chemistry, 295(24), pp. 8331-8347. (doi: 10.1074/jbc.ra120.012355) (PMID:32354742) (PMCID:PMC7294092)
Rodgers, L. C., Cole, J., Rattigan, K. M., Barrett, M. P. , Kurian, N., McInnes, I. B. and Goodyear, C. S. (2020) The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion. Rheumatology, 59(4), pp. 869-878. (doi: 10.1093/rheumatology/kez378) (PMID:31497857)
Rao, S. P.S. et al. (2020) Anti-Trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African Trypanosomiasis. Tropical Medicine and Infectious Disease, 5(1), 28. (doi: 10.3390/tropicalmed5010028) (PMID:32079320) (PMCID:PMC7157554)
Ritchie, R., Barrett, M. P. , Mottram, J. C. and Myburgh, E. (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)
Dickie, E. A., Giordani, F. , Gould, M. K., Maeser, P., Burri, C., Mottram, J. C. , Rao, S. P.S. and Barrett, M. P. (2020) New drugs for human African trypanosomiasis:a twenty first century success story. Tropical Medicine and Infectious Disease, 5(1), 29. (doi: 10.3390/tropicalmed5010029) (PMID:32092897) (PMCID:PMC7157223)
Al-Rawhani, M. A. et al. (2020) Multimodal integrated sensor platform for rapid biomarker detection. IEEE Transactions on Biomedical Engineering, 67(2), pp. 614-623. (doi: 10.1109/TBME.2019.2919192) (PMID:31226063)
Lindner, A. K. et al. (2020) New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice. Lancet Infectious Diseases, 20(2), e38-e46. (doi: 10.1016/S1473-3099(19)30612-7) (PMID:31879061)
2019
Lim, A. S. T., Vincent, I. M. , Barrett, M. P. and Gilbert, I. H. (2019) Small polar hits against S. aureus: screening, initial hit optimization, and metabolomic studies. ACS Omega, 4(21), pp. 19199-19215. (doi: 10.1021/acsomega.9b02507) (PMID:31763544) (PMCID:PMC6869403)
Pountain, A. W. and Barrett, M. P. (2019) Untargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant. Wellcome Open Research, 4, 176. (doi: 10.12688/wellcomeopenres.15452.1) (PMID:32133420) (PMCID:PMC7041363)
Johnston, K., Kim, D.-H., Kerkhoven, E. J., Burchmore, R. , Barrett, M. P. and Achcar, F. (2019) Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC-MS. Bioscience Reports, 39(5), BSR2018160. (doi: 10.1042/BSR20181601) (PMID:31028136) (PMCID:PMC6522824)
Giordani, F. , Khalaf, A. I., Gillingwater, K., Munday, J. C. , de Koning, H. P. , Suckling, C. J., Barrett, M. P. and Scott, F. J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62(6), pp. 3021-3035. (doi: 10.1021/acs.jmedchem.8b01847) (PMID:30763102)
Rao, S. P.S. et al. (2019) Drug discovery for kinetoplastid diseases: future directions. ACS Infectious Diseases, 5(2), pp. 152-157. (doi: 10.1021/acsinfecdis.8b00298) (PMID:30543391)
Pountain, A. W. , Weidt, S. K., Regnault, C., Bates, P. A., Donachie, A. M., Dickens, N. J. and Barrett, M. P. (2019) Genomic instability at the locus of sterol C24-methyltransferase promotes amphotericin B resistance in Leishmania parasites. PLoS Neglected Tropical Diseases, 13(2), e0007052. (doi: 10.1371/journal.pntd.0007052) (PMID:30716073) (PMCID:PMC6375703)
2018
Patil, S. B., Dheeman, D. S., Al-Rawhani, M. A., Velugotla, S. , Nagy, B., Cheah, B. C. , Grant, J. P. , Accarino, C., Barrett, M. P. and Cumming, D. R.S. (2018) An integrated portable system for single chip simultaneous measurement of multiple disease associated metabolites. Biosensors and Bioelectronics, 122, pp. 88-94. (doi: 10.1016/j.bios.2018.09.013) (PMID:30245326)
Diaz-Albiter, H. M., Regnault, C., Alpizar-Sosa, E. A., McGuinness, D., Barrett, M. P. and Dillon, R. J. (2018) Non-invasive visualisation and identification of fluorescent. Wellcome Open Research, 3, 160. (doi: 10.12688/wellcomeopenres.14910.1) (PMID:30756095) (PMCID:PMC6367660)
Barrett, M. P. (2018) The elimination of human African trypanosomiasis is in sight: report from the third WHO stakeholders meeting on elimination of gambiense human African trypanosomiasis. PLoS Neglected Tropical Diseases, 12(12), e0006925. (doi: 10.1371/journal.pntd.0006925) (PMID:30521522) (PMCID:PMC6283460)
Kovářová, J., Nagar, R., Faria, J., Ferguson, M. A.J., Barrett, M. P. and Horn, D. (2018) Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei. PLoS Pathogens, 14(12), e1007475. (doi: 10.1371/journal.ppat.1007475) (PMID:30589893) (PMCID:PMC6307712)
Begolo, D. et al. (2018) The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing. PLoS Pathogens, 14(9), e1007315. (doi: 10.1371/journal.ppat.1007315) (PMID:30252911) (PMCID:PMC6173450)
Newton, J., Ramage, G. , Gadegaard, N. , Zachs, W., Rogers, S. , Barrett, M. P. , Carruthers, G. and Burgess, K. (2018) Minimally-destructive atmospheric ionisation mass spectrometry authenticates authorship of historical manuscripts. Scientific Reports, 8, 10944. (doi: 10.1038/s41598-018-28810-2) (PMID:30050048) (PMCID:PMC6062563)
Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi: 10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)
Armitage, E. G. et al. (2018) Complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine. Antimicrobial Agents and Chemotherapy, 62(5), e02095-17. (doi: 10.1128/AAC.02095-17) (PMID:29463533)
Armitage, E. G. et al. (2018) Metabolic clustering analysis as a strategy for compound selection in the drug discovery pipeline for leishmaniasis. ACS Chemical Biology, 13(5), pp. 1361-1369. (doi: 10.1021/acschembio.8b00204) (PMID:29671577)
Nagy, B., Al-Rawhani, M. A., Cheah, B. C., Barrett, M. P. and Cumming, D. R.S. (2018) Immunoassay multiplexing on a complementary metal oxide semiconductor photodiode array. ACS Sensors, 3(5), pp. 953-959. (doi: 10.1021/acssensors.7b00972) (PMID:29652490) (PMCID:PMC5974700)
Kovarova, J., Pountain, A. W. , Wildridge, D., Weidt, S., Bringaud, F., Burchmore, R. J.S. , Achcar, F. and Barrett, M. P. (2018) Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana. PLoS Pathogens, 14(3), e1006953. (doi: 10.1371/journal.ppat.1006953) (PMID:29554142) (PMCID:PMC5882173)
Rattigan, K. M., Pountain, A. W. , Regnault, C., Achcar, F. , Vincent, I. M. , Goodyear, C. S. and Barrett, M. P. (2018) Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli. PLoS ONE, 13(3), e0194126. (doi: 10.1371/journal.pone.0194126) (PMID:29538444) (PMCID:PMC5851634)
Zhang, N. et al. (2018) Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles. PLoS Pathogens, 14(2), e1006850. (doi: 10.1371/journal.ppat.1006850) (PMID:29425238) (PMCID:PMC5823473)
Nayak, A., Akpunarlieva, S., Barrett, M. and Burchmore, R. (2018) A defined medium for Leishmania culture allows definition of essential amino acids. Experimental Parasitology, 185, pp. 39-52. (doi: 10.1016/j.exppara.2018.01.009) (PMID:29326050)
Wandy, J. , Zhu, Y., van der Hooft, J. J.J. , Daly, R. , Barrett, M. P. and Rogers, S. (2018) Ms2lda.org: web-based topic modelling for substructure discovery in mass spectrometry. Bioinformatics, 34(2), pp. 317-318. (doi: 10.1093/bioinformatics/btx582) (PMID:28968802) (PMCID:PMC5860206)
2017
Gloaguen, Y. , Morton, F. , Daly, R. , Gurden, R., Rogers, S. , Wandy, J. , Wilson, D., Barrett, M. and Burgess, K. (2017) PiMP my metabolome: An integrated, web-based tool for LC-MS metabolomics data. Bioinformatics, 33(24), pp. 4007-4009. (doi: 10.1093/bioinformatics/btx499) (PMID:28961954) (PMCID:PMC5860087)
Ponte-Sucre, A., Gamarro, F., Dujardin, J.-C., Barrett, M. P. , López-Vélez, R., García-Hernández, R., Pountain, A. W. and Mwenechanya, R. (2017) Drug resistance and treatment failure in leishmaniasis: A 21st century challenge. PLoS Neglected Tropical Diseases, 11(12), e0006052. (doi: 10.1371/journal.pntd.0006052) (PMID:29240765) (PMCID:PMC5730103)
Barrett, M. P. , Cooper, J. M. , Regnault, C., Holm, S. H., Beech, J. P., Tegenfeldt, J. O. and Hochstetter, A. (2017) Microfluidics-based approaches to the isolation of African trypanosomes. Pathogens, 6(4), 47. (doi: 10.3390/pathogens6040047) (PMID:28981471) (PMCID:PMC5750571)
Barrett, M. P. and Giordani, F. (2017) Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease. Parasitology, 144(12), pp. 1652-1662. (doi: 10.1017/S003118201600202X) (PMID:27928980)
Scott, F. J. et al. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, pp. 561-572. (doi: 10.1016/j.ejmech.2017.05.039)
Alzahrani, K. J.H., Ali, J. A.M., Eze, A. A., Looi, W. L., Tagoe, D. N.A., Creek, D. J., Barrett, M. P. and De Koning, H. P. (2017) Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy. International Journal for Parasitology: Drugs and Drug Resistance, 7(2), pp. 206-226. (doi: 10.1016/j.ijpddr.2017.04.003) (PMID:28453984) (PMCID:PMC5407577)
van der Hooft, J. J.J. , Wandy, J. , Young, F., Padmanabhan, S. , Gerasimidis, K. , Burgess, K. E.V., Barrett, M. P. and Rogers, S. (2017) Unsupervised discovery and comparison of structural families across multiple samples in untargeted metabolomics. Analytical Chemistry, 89(14), pp. 7569-7577. (doi: 10.1021/acs.analchem.7b01391) (PMID:28621528) (PMCID:PMC5524435)
Akpunarlieva, S., Weidt, S., Lamasudin, D., Naula, C. , Henderson, D., Barrett, M. , Burgess, K. and Burchmore, R. (2017) Integration of proteomics and metabolomics to elucidate metabolic adaptation in Leishmania. Journal of Proteomics, 155, pp. 85-98. (doi: 10.1016/j.jprot.2016.12.009) (PMID:28040509)
Al-Rawhani, M. A. et al. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. IEEE Sensors Journal, 17(2), pp. 240-247. (doi: 10.1109/JSEN.2016.2629018)
Cheah, B. C. , MacDonald, A. I., Barrett, M. P. and Cumming, D. R.S. (2017) Metabolomics on integrated circuit. Procedia Technology, 27, pp. 53-54. (doi: 10.1016/j.protcy.2017.04.025)
2016
Srivastava, A., Philip, N., Hughes, K. R., Georgiou, K., MacRae, J. I., Barrett, M. P. , Creek, D. J., McConville, M. J. and Waters, A. P. (2016) Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathogens, 12(12), e1006094. (doi: 10.1371/journal.ppat.1006094) (PMID:28027318) (PMCID:PMC5189940)
Vincent, I. M. , Daly, R. , Courtioux, B., Cattanach, A. M., Biéler, S., Ndung’u, J. M., Bisser, S. and Barrett, M. P. (2016) Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis. PLoS Neglected Tropical Diseases, 10(12), e0005140. (doi: 10.1371/journal.pntd.0005140) (PMID:27941966) (PMCID:PMC5152828)
Biéler, S. et al. (2016) Evaluation of antigens for development of a serological test for human African trypanosomiasis. PLoS ONE, 11(12), e0168074. (doi: 10.1371/journal.pone.0168074) (PMID:27936225) (PMCID:PMC5148118)
Giordani, F. , Morrison, L. J., Rowan, T. G., De Koning, H. P. and Barrett, M. P. (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi: 10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)
van Der Hooft, J. J. J. , Wandy, J. , Barrett, M. P. , Burgess, K. E.V. and Rogers, S. (2016) Topic modeling for untargeted substructure exploration in metabolomics. Proceedings of the National Academy of Sciences of the United States of America, 113(48), pp. 13738-13743. (doi: 10.1073/pnas.1608041113) (PMID:27856765) (PMCID:PMC5137707)
Van Der Hooft, J. , Padmanabhan, S. , Burgess, K. and Barrett, M. (2016) Erratum to: Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. Metabolomics, 12(8), 139. (doi: 10.1007/s11306-016-1078-6)
Holm, S.H., Beech, J.P., Barrett, M.P. and Tegenfeldt, J.O. (2016) Correction: simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(28), p. 5726. (doi: 10.1039/c6ay90099b)
Van Der Hooft, J. J.J. , Padmanabhan, S. , Burgess, K. E.V. and Barrett, M. P. (2016) Urinary antihypertensive drug metabolite screening using molecular networking coupled to high-resolution mass spectrometry fragmentation. Metabolomics, 12, 125. (doi: 10.1007/s11306-016-1064-z) (PMID:27471437) (PMCID:PMC4932139)
Cheah, B. C. , MacDonald, A. I., Martin, C., Streklas, A. J., Campbell, G., Al-Rawhani, M. A., Nemeth, B., Grant, J. P. , Barrett, M. P. and Cumming, D. R.S. (2016) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. IEEE Transactions on Biomedical Circuits and Systems, 10(3), pp. 721-730. (doi: 10.1109/TBCAS.2015.2487603) (PMID:26742138)
Scott, F. J., Khalaf, A. I., Giordani, F. , Wong, P. E., Duffy, S., Barrett, M. , Avery, V. M. and Suckling, C. J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi: 10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)
Holm, S.H., Beech, J.P., Barrett, M.P. and Tegenfeldt, J.O. (2016) Simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(16), pp. 3291-3300. (doi: 10.1039/c6ay00443a)
Vincent, I. M., Ehmann, D. E., Mills, S. D., Perros, M. and Barrett, M. P. (2016) Untargeted metabolomics to ascertain antibiotic modes of action. Antimicrobial Agents and Chemotherapy, 60(4), pp. 2281-2291. (doi: 10.1128/AAC.02109-15) (PMID:26833150) (PMCID:PMC4808186)
Barrett, M. , Sloan, W. , Stark, W. and Watson, I. (2016) New Developments in Synthetic Biology at the University of Glasgow. Industrial Biotechnology Innovation Centre Annual Conference, Glasgow, UK, 28-29 Jan 2016.
2015
Kim, D.-H., Achcar, F. , Breitling, R. , Burgess, K. E. and Barrett, M. P. (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi: 10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)
Baker, N., Hamilton, G., Wilkes, J.M. , Hutchinson, S., Barrett, M.P. and Horn, D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 112(29), pp. 9112-9117. (doi: 10.1073/pnas.1505411112) (PMID:2615048) (PMCID:PMC4517229)
Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P. , McConville, M. J. and Waters, A. P. (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi: 10.1371/journal.ppat.1004882) (PMID:26042734) (PMCID:PMC4456406)
de Macêdo, J. P., Schumann Burkard, G., Niemann, M., Barrett, M. P. , Vial, H., Mäser, P., Roditi, I., Schneider, A. and Bütikofer, P. (2015) An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathogens, 11(5), e1004875. (doi: 10.1371/journal.ppat.1004875) (PMID:25946070) (PMCID:PMC4422618)
Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P. and Robello, C. (2015) Bestatin induces specific changes in trypanosoma cruzi dipeptide pool. Antimicrobial Agents and Chemotherapy, 59(5), pp. 2921-2925. (doi: 10.1128/AAC.05046-14) (PMID:25712359)
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi: 10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)
van der Hooft, J. , Ridder, L., Barrett, M. P. and Burgess, K. V. (2015) Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines. Frontiers in Bioengineering and Biotechnology, 3, p. 26. (doi: 10.3389/fbioe.2015.00026) (PMID:25806366) (PMCID:PMC4353373)
Alkhaldi, A.A.M., Creek, D.J., Ibrahim, H., Kim, D.-H., Quashie, N.B., Burgess, K.E., Changtam, C., Barrett, M.P. , Suksamrarn, A. and De Koning, H.P. (2015) Potent Trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with Trypanothione. Molecular Pharmacology, 87(3), pp. 451-464. (doi: 10.1124/mol.114.096016) (PMID:25527638)
Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)
Hai, Y., Kerkhoven, E. J., Barrett, M. and Christianson, D. W. (2015) Crystal structure of an arginase-like protein fromtrypanosoma bruceithat evolved without a binuclear manganese cluster. Biochemistry, 54(2), pp. 458-471. (doi: 10.1021/bi501366a) (PMID:25536859)
Vincent, I.M. and Barrett, M.B. (2015) Metabolomic-based strategies for anti-parasite drug discovery. Journal of Biomolecular Screening, 20(1), pp. 44-55. (doi: 10.1177/1087057114551519) (PMID:25281738)
2014
Giordani, F. , Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P. , Pellacani, C., Poli, P. and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi: 10.1128/AAC.01449-13)
Achcar, F. , Kerkhoven, E. J. and Barrett, M. P. (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi: 10.1016/j.mib.2014.06.007)
Bourquin, Y., Syed, A., Reboud, J. , Ranford-Cartwright, L. C. , Barrett, M. P. and Cooper, J. M. (2014) Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angewandte Chemie (International Edition), 53(22), pp. 5587-5590. (doi: 10.1002/anie.201310401) (PMID:24677583) (PMCID:PMC4232275)
Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)
Giordani, F. , Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi: 10.1128/AAC.02024-13)
Barrett, M.P. , Nikkhah, D., Gilbert, P. and Dheansa, B. (2014) Why aren’t we doing more to safeguard vulnerable adults from thermal injuries? Burns, 40(2), pp. 360-361. (doi: 10.1016/j.burns.2013.08.018) (PMID:24035041)
Chokkathukalam, A., Kim, D.-H., Barrett, M. P. , Breitling, R. and Creek, D. J. (2014) Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis, 6(4), pp. 511-524. (doi: 10.4155/bio.13.348) (PMID:24568354) (PMCID:PMC4048731)
Kremer, C., Witte, C., Neale, S. L. , Reboud, J. , Barrett, M. P. and Cooper, J. M. (2014) Shape-dependent optoelectronic cell lysis. Angewandte Chemie (International Edition), 53(3), pp. 842-846. (doi: 10.1002/anie.201307751) (PMID:24402800) (PMCID:PMC4441254)
Barrett, M. P. and Croft, S. L. (2014) Emerging paradigms in anti-infective drug design. Parasitology, 141(1), pp. 1-7. (doi: 10.1017/S0031182013001224)
Creek, D. J. and Barrett, M. P. (2014) Determination of antiprotozoal drug mechanisms by metabolomics approaches. Parasitology, 141(1), pp. 83-92. (doi: 10.1017/S0031182013000814)
Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi: 10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)
Giordani, F. , Mwenechanya, R. and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, Sandosh (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi: 10.1016/B978-0-12-386882-4.00039-6)
Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F. , Barrett, M. P. , Wong, P. E., Barrack, K. L. and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi: 10.1021/jm500483b)
Oppenheim, R. D. et al. (2014) BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens, 10(7), e1004263. (doi: 10.1371/journal.ppat.1004263) (PMID:25032958) (PMCID:PMC4102578)
Trochine, A., Creek, D. J., Faral-Tello, P., Barrett, M. P. and Robello, C. (2014) Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics. PLoS Neglected Tropical Diseases, 8(5), e2844. (doi: 10.1371/journal.pntd.0002844)
2013
Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS Computational Biology, 9(12), e1003371. (doi: 10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:PMC3854711)
Munday, J.C. , Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P. , Morrison, L.J. and De Koning, H.P. (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi: 10.1016/j.ijpddr.2013.01.004)
Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi: 10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)
Achcar, F. , Barrett, M.P. and Breitling, R. (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi: 10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)
Barrett, M.P. , Gemmell, C.G. and Suckling, C.J. (2013) Minor groove binders as anti-infective agents. Pharmacology and Therapeutics, 139(1), pp. 12-23. (doi: 10.1016/j.pharmthera.2013.03.002)
Creek, D. J., Nijagal, B., Kim, D.-H., Rojas, F., Matthews, K. R. and Barrett, M. P. (2013) Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy, 57(6), pp. 2768-2779. (doi: 10.1128/AAC.00044-13)
Kim, D.-H. and Barrett, M.P. (2013) Metabolite-dependent regulation of gene expression in trypanosoma brucei. Molecular Microbiology, 88(5), pp. 841-845. (doi: 10.1111/mmi.12243)
Limenitakis, J., Oppenheim, R.D., Creek, D.J., Foth, B.J., Barrett, M.P. and Soldati-Favre, D. (2013) The 2-methylcitrate cycle is implicated in the detoxification of propionate inToxoplasma gondii. Molecular Microbiology, 87(4), pp. 894-908. (doi: 10.1111/mmi.12139)
Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi: 10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)
Creek, D.J., Vincent, I.M. and Barrett, M.P. (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi: 10.1002/9783527670383.ch3)
De Muylder, G. et al. (2013) A trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathogens, 9(10), e1003731. (doi: 10.1371/journal.ppat.1003731)
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
2012
Creek, D.J., Chokkathukalam, A., Jankevics, A., Burgess, K.E.V., Breitling, R. and Barrett, M.P. (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry, 84(20), pp. 8442-8447. (doi: 10.1021/ac3018795) (PMID:22946681) (PMCID:PMC3472505)
Clark, R.L., Clements, C.J., Barrett, M.P. , Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J. and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20(20), pp. 6019-6033. (doi: 10.1016/j.bmc.2012.08.049)
Baker, N., Glover, L., Munday, J. C. , Aguinaga Andres, D., Barrett, M. P. , De Koning, H. P. and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi: 10.1073/pnas.1202885109)
Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R. and Barrett, M.P. (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28(7), pp. 1048-1049. (doi: 10.1093/bioinformatics/bts069) (PMID:22308147)
Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P. and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi: 10.1371/journal.pcbi.1002352) (PMID:22379410) (PMCID:PMC3269904)
Barrett, M.P. and Croft, S.L. (2012) Management of trypanosomiasis and leishmaniasis. British Medical Bulletin, 104(1), pp. 175-196. (doi: 10.1093/bmb/lds031)
Bringaud, F., Barrett, M. and Zilberstein, D. (2012) Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience, 17(1), p. 349. (doi: 10.2741/3931)
Creek, D., Anderson, J. , McConville, M.J. and Barrett, M.P. (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181(2), pp. 73-84. (doi: 10.1016/j.molbiopara.2011.10.003)
Menachery, A., Kremer, C., Wong, P.E., Carlsson, A., Neale, S.L. , Barrett, M.P. and Cooper, J.M. (2012) Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Scientific Reports, 2, 775. (doi: 10.1038/srep00775) (PMID:23105971) (PMCID:PMC3481117)
Vincent, I.M. , Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi: 10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)
Zhang, T., Creek, D.J., Barrett, M.P. , Blackburn, G. and Watson, D.G. (2012) Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry, 84(4), pp. 1994-2001. (doi: 10.1021/ac2030738)
2011
Burgess, K., Creek, D., Dewsbury, P., Cook, K. and Barrett, M.P. (2011) Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3447-3452. (doi: 10.1002/rcm.5247)
Leader, D.P. , Burgess, K., Creek, D. and Barrett, M.P. (2011) Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3422-3426. (doi: 10.1002/rcm.5245)
Barrett, M.P. , Vincent, I.M. , Burchmore, R.J.S. , Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi: 10.2217/fmb.11.88) (PMID:21958143)
Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi: 10.1124/mol.111.071555)
Holm, S. H., Beech, J. P., Barrett, M. P. and Tegenfeldt, J. O. (2011) Separation of parasites from human blood using deterministic lateral displacement. Lab on a Chip, 11(7), pp. 1326-1332. (doi: 10.1039/c0lc00560f)
Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P. and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi: 10.1002/rcm.4939)
Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P. , Wong, P.E., Male, L., Coles, S.J. and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19(5), pp. 1802-1815. (doi: 10.1016/j.bmc.2011.01.010)
Brun, R., Don, R., Jacobs, R.T., Wang, M.Z. and Barrett, M.P. (2011) Development of novel drugs for human African trypanosomiasis. Future Microbiology, 6(6), pp. 677-691. (doi: 10.2217/fmb.11.44)
Creek, D.J., Jankevics, A., Breitling, R. , Watson, D.G., Barrett, M.P. and Burgess, K.E.V. (2011) Toward global metabolomics snalysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry, 83(22), pp. 8703-8710. (doi: 10.1021/ac2021823)
Rodgers, J. , Jones, A., Gibaud, S., Bradley, B., McCabe, C. , Barrett, M. P. , Gettinby, G. and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi: 10.1371/journal.pntd.0001308)
Rogers, S. , Scheltema, R.A., Barrett, M. and Breitling, R. (2011) Bayesian approaches for mass spectrometry-based metabolomics. In: Stumpf, M.P.H., Balding, D.J. and Girolami, M. (eds.) Handbook of Statistical Systems Biology. John Wiley & Sons: Chichester, UK, pp. 467-476. ISBN 9780470710869 (doi: 10.1002/9781119970606.ch24)
Stoffel, S.A., Alibu, V.P., Hubert, J., Ebikeme, C., Portais, J.C., Bringaud, F., Schweingruber, M.E. and Barrett, M. (2011) Transketolase in Trypanosoma brucei. Molecular and Biochemical Parasitology, 179(1), pp. 1-7. (doi: 10.1016/j.molbiopara.2011.04.006)
Ward, C.P., Wong, P.E., Burchmore, R.J.S. , De Koning, H.P. and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi: 10.1128/AAC.01551-10)
2010
Barrett, M. P. (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Current Opinion in Infectious Diseases, 23(6), pp. 603-608. (doi: 10.1097/QCO.0b013e32833f9fd0)
Naula, C.M. , Logan, F.M., Wong, P.E., Barrett, M.P. and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi: 10.1074/jbc.M110.106815)
Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R. and Barrett, M.P. (2010) The silicon trypanosome. Parasitology, 137(9), pp. 1333-1341. (doi: 10.1017/S0031182010000466) (PMID:20444304)
Barrett, M.P., Bakker, B.M. and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137(9), pp. 1285-1290. (doi: 10.1017/S003118201000017X) (PMID:20158937)
Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11(8), pp. 876-883.
Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M.P. , Brenk, R. and Gilbert, I. H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorganic and Medicinal Chemistry, 18(14), pp. 5056-5062. (doi: 10.1016/j.bmc.2010.05.077)
Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343. (doi: 10.1128/EC.00200-09) (PMID:19966032) (PMCID:PMC2823006)
Conti, P., Pinto, A., Wong, P.E., Major, L.L., Tamborini, L., Iannuzzi, M.C., De Micheli, C., Barrett, M.P. and Smith, T.K. (2010) Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor. ChemMedChem, 6(2), pp. 329-333. (doi: 10.1002/cmdc.201000417)
Cottret, L., Wildridge, D., Vinson, F., Barrett, M.P. , Charles, H., Sagot, M.-F. and Jourdan, F. (2010) MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Research, 38(Suppl), W132-W137. (doi: 10.1093/nar/gkq312)
González, D., Pérez, J.L., Serrano, M.L., Igoillo-Esteve, M., Cazzulo, J.J., Barrett, M.P. , Bubis, J. and Mendoza-León, A. (2010) The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction. Journal of Molecular Microbiology and Biotechnology, 19(4), pp. 213-223. (doi: 10.1159/000320697)
Jourdan, F., Cottret, L., Huc, L., Wildridge, D., Scheltema, R., Hillenweck, A., Barrett, M.P., Zalko, D., Watson, D. G. and Debrauwer, L. (2010) Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics, 6(2), pp. 312-321. (doi: 10.1007/s11306-009-0196-9) (PMID:20526351) (PMCID:PMC2874485)
Klee, N., Wong, P. E., Baragana, B., Mazouni, F. E., Phillips, M. A., Barrett, M.P. and Gilbert, I. H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry Letters, 20(15), pp. 4364-4366. (doi: 10.1016/j.bmcl.2010.06.070)
Ruda, G.F., Wong, P.E., Alibu, V.P., Norval, S., Read, K.D., Barrett, M.P. and Gilbert, I.H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds. Journal of Medicinal Chemistry, 53(16), pp. 6071-6078. (doi: 10.1021/jm1004754)
Vincent, I.M. , Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi: 10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)
Ward, C. P., Burgess, K. E.V., Burchmore, R.J.S. , Barrett, M.P. and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi: 10.1016/j.molbiopara.2010.07.002)
2009
Kazibwe, A.J.N., Nerima, B., De Koning, H.P. , Mäser, P., Barrett, M.P. and Matovu, E. (2009) Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases, 3(9), e523. (doi: 10.1371/journal.pntd.0000523)
Mukhopadhyay, A., Chen, C.Y., Doerig, C., Henriquez, F.L., Roberts, C.W. and Barrett, M.P. (2009) The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX. Parasitology, 136(7), pp. 747-755. (doi: 10.1017/S0031182009006027)
Rodgers, J. , Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi: 10.1093/brain/awp074)
Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P. and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164(2), pp. 111-117. (doi: 10.1016/j.molbiopara.2008.12.007)
Wenzel, N., Wong, P.E., Maes, L., Muller, T.J., Krauth-Siegel, R.L., Barrett, M.P. and Davioud-Charvet, E. (2009) Unsaturated mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4(3), pp. 339-351. (doi: 10.1002/cmdc.200800360)
Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M.P. and Gilbert, I.H. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic and Biomolecular Chemistry, 7(6), pp. 1154-1166. (doi: 10.1039/b813394h)
Chollet, C., Baliani, A., Wong, P.E., Barrett, M.P. and Gilbert, I.H. (2009) Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry, 17(6), pp. 2512-2523. (doi: 10.1016/j.bmc.2009.01.058)
Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P. , Wilson, W.D. and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284(49), pp. 34028-34035. (doi: 10.1074/jbc.M109.049726)
2008
Checchi, F., Filipe, J.A.N., Barrett, M.P. and Chandramohan, D. (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS Neglected Tropical Diseases, 2(12), e303. (doi: 10.1371/journal.pntd.0000303) (PMID:19104656) (PMCID:PMC2602732)
Scheltema, R.A., Kamleh, A., Wildridge, D., Ebikeme, C., Watson, D.G., Barrett, M. , Jansen, R.C. and Breitling, R. (2008) Increasing the mass accuracy of high-resolution LC-MS data using background ions - a case study on the LTQ-Orbitrap. Proteomics, 8(22), pp. 4647-4656. (doi: 10.1002/pmic.200800314)
Kamleh, A., Barrett, M.P. , Wildridge, D., Burchmore, R.J.S. , Scheltema, R.A.. and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi: 10.1002/rcm.3564)
Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P. , Franconi, J.M. and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283(24), pp. 16342-16354. (doi: 10.1074/jbc.M709592200)
Ebikeme, C.E., Peacock, L., Coustou, V., Riviere, L., Bringaud, F., Gibson, W.C. and Barrett, M.P. (2008) N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology, 135(5), pp. 585-594. (doi: 10.1017/S0031182008004241)
Checchi, F. and Barrett, M.P. (2008) African sleeping sicknesss - Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored. British Medical Journal, 336(7646), pp. 679-680. (doi: 10.1136/bmj.39505.490544.BE)
Breitling, R. , Vitkup, D. and Barrett, M.P. (2008) New surveyor tools for charting microbial metabolic maps. Nature Reviews Microbiology, 6, pp. 156-161. (doi: 10.1038/nrmicro1797)
Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J. and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18(7), pp. 2455-2458. (doi: 10.1016/j.bmcl.2008.02.037)
Arrighi, R. B. G., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L.C. , Barrett, M.P. , Langel, U. and Faye, I. (2008) Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrobial Agents and Chemotherapy, 52(9), pp. 3414-3417. (doi: 10.1128/AAC.01450-07)
Jourdan, F., Breitling, R., Barrett, M.P. and Gilbert, D. (2008) MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics, 24(1), pp. 143-145. (doi: 10.1093/bioinformatics/btm536)
Reid, C. M., Ebikeme, C., Barrett, M.P. , Patzewitz, E.-M., Muller, S., Robins, D. J. and Sutherland, A. (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi: 10.1016/j.bmcl.2008.09.047)
2007
Sundaramoorthy, R., Iulek, J., Barrett, M. P. , Bidet, O., Ruda, G. F., Gilbert, I. H. and Hunter, W. N. (2007) Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. FEBS Journal, 274(1), pp. 275-286. (doi: 10.1111/j.1742-4658.2006.05585.x)
Barrett, M. (2007) Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology, 152(8), pp. 1155-1171. (doi: 10.1038/sj.bjp.0707354)
Naula, C. , Alibu, V., Brock, J., Veitch, N.J. , Burchmore, R.J.S. and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi: 10.1016/j.jprot.2007.11.002)
Ogbunude, P., Lamour, N. and Barrett, M. (2007) Molecular cloning, expression and characterization of ribokinase of Leishmania major. Acta Biochimica et Biophysica Sinica, 39, pp. 462-466. (doi: 10.1111/j.1745-7270.2007.00298.x)
2006
Anene, B.M., Ezeokonkwo, R.C., Mmesirionye, T.I., Tettey, J.N.A., Brock, J.M., Barrett, M.P. and De Koning, H.P. (2006) A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 132(1), pp. 127-133. (doi: 10.1017/S0031182005008760)
Barrett, M. and Gilbert, I. (2006) Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology, 63, pp. 125-183. (doi: 10.1016/S0065-308X(06)63002-9)
Breitling, R., Ritchie, S., Goodenowe, D., Stewart, M. and Barrett, M. (2006) Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data. Metabolomics, 2, pp. 155-164. (doi: 10.1007/s11306-006-0029-z)
Dardonville, C., Barrett, M. , Brun, R., Kaiser, M., Tanious, F. and Wilson, W. (2006) DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. Journal of Medicinal Chemistry, 49, pp. 3748-3752. (doi: 10.1021/jm060295c)
Lanteri, C.A., Stewart, M.L., Brock, J.M., Alibu, V.P., Meshnick, S.R., Tidwell, R.R. and Barrett, M.P. (2006) Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology, 70(5), pp. 1585-1592. (doi: 10.1124/mol.106.024653)
Mukherjee, A., Padmanabhan, P., Sahani, M., Barrett, M. and Madhubala, R. (2006) Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145, pp. 1-10. (doi: 10.1016/j.molbiopara.2005.08.016)
2005
Baliani, A., Bueno, G., Stewart, M., Yardley, V., Brun, R., Barrett, M. and Gilbert, I. (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. Journal of Medicinal Chemistry, 48, pp. 5570-5579. (doi: 10.1021/jm050177+)
Besteiro, S., Barrett, M. , Riviere, L. and Bringaud, F. (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends in Parasitology, 21, pp. 185-191.
Croft, S., Barrett, M. and Urbina, J. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends in Parasitology, 21, pp. 508-512. (doi: 10.1016/j.pt.2005.08.026)
Lamour, N., Riviere, L., Coustou, V., Coombs, G., Barrett, M. and Bringaud, F. (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280, pp. 11902-11910. (doi: 10.1074/jbc.M414274200)
Stewart, M., Boussard, C., Brun, R., Gilbert, I. and Barrett, M. (2005) Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter. Antimicrobial Agents and Chemotherapy, 49, pp. 5169-5171. (doi: 10.1128/AAC.49.12.5169-5171.2005)
Stewart, M., Krishna, S., Burchmore, R. , Brun, R., de Koning, H. , Boykin, D., Tidwell, R., Hall, J. and Barrett, M. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi: 10.1016/S0140-6736(05)66793-1)
2004
Janssen, C.S., Phillips, R.S., Turner, C. and Barrett, M.P. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32(19), pp. 5712-5720. (doi: 10.1093/nar/gkh907)
Azema, L. et al. (2004) Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochemical Pharmacology, 67, pp. 459-467. (doi: 10.1016/j.bcp.2003.09.005)
Dardonville, C., Rinaldi, E., Barrett, M. , Brun, R., Gilbert, I. and Hanau, S. (2004) Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. Journal of Medicinal Chemistry, 47, pp. 3427-3437. (doi: 10.1021/jm031066i)
de Koning, H. , Anderson, L., Stewart, M., Burchmore, R. , Wallace, L. and Barrett, M. (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi: 10.1128/AAC.48.5.1515-1519.2004)
Hanau, S., Rinaldi, E., Dallocchio, F., Gilbert, I., Dardonville, C., Adams, M., Gover, S. and Barrett, M. (2004) 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes. Current Medicinal Chemistry, 11, pp. 2639-2650.
Janssen, C., Phillips, R., Turner, C. and Barrett, M. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32, pp. 5712-5720. (doi: 10.1093/nar/gkh907)
Stewart, M.L., Bueno, G.J., Baliani, A., Klenke, B., Brun, R., Brock, J.M., Gilbert, I.,H. and Barrett, M.,P., (2004) Trypanocidal activity of melamine-based nitroheterocycles. Antimicrobial Agents and Chemotherapy, 48(5), pp. 1733-1738. (doi: 10.1128/AAC.48.5.1733-1738.2004)
Veitch, N.V. , Maugeri, D.A., Cazzulo, J.J., Lindqvist, Y. and Barrett, M.P. (2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochemical Journal, 382(2), pp. 759-767. (doi: 10.1042/BJ20040459)
2003
Barrett, M. , Burchmore, R. , Stich, A., Lazzari, J., Frasch, A., Cazzulo, J. and Krishna, S. (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi: 10.1016/S0140-6736(03)14694-6)
Bray, P., Barrett, M. , Ward, S. and de Koning, H. (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi: 10.1016/S1471-4922(03)00069-2)
Burchmore, R. , Rodriguez-Contreras, D., McBride, K., Barrett, M. , Modi, G., Sacks, D. and Landfear, S. (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi: 10.1073/pnas.0630165100)
Burchmore, R. , Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M. , Baldwin, S. and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi: 10.1074/jbc.M301252200)
Dardonville, C., Rinaldi, E., Hanau, S., Barrett, M. , Brun, R. and Gilbert, I. (2003) Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 11(14), pp. 3205-3214. (doi: 10.1016/S0968-0896(03)00191-3)
Enanga, B., Ariyanayagam, M., Stewart, M. and Barrett, M. (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47(10), pp. 3368-3370. (doi: 10.1128/AAC.47.10.3368-3370.2003)
Klenke, B., Barrett, M. , Brun, R. and Gilbert, I. (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52(2), pp. 290-293. (doi: 10.1093/jac/dkg307)
Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi: 10.1128/EC.2.5.1003-1008.2003)
Maugeri, D., Cazzulo, J., Burchmore, R. , Barrett, M. and Ogbunude, P. (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi: 10.1016/S0166-6851(03)00173-7)
Stich, A., Barrett, M. and Krishna, S. (2003) Waking up to sleeping sickness. Trends in Parasitology, 19(5), pp. 195-197. (doi: 10.1016/S1471-4922(03)00055-2)
2002
Leslie, G., Barrett, M. and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi: 10.1016/S0014-4894(03)00031-6)
Barrett, M. (2002) Perspectives for new drugs against trypanosomiasis and leishmaniasis. Current Topics in Medicinal Chemistry, 2(5), pp. 471-482. (doi: 10.2174/1568026024607427)
Basselin, M., Denise, H., Coombs, G. and Barrett, M. (2002) Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrobial Agents and Chemotherapy, 46(12), pp. 3731-3738. (doi: 10.1128/AAC.46.12.3731-3788.2002)
Burchmore, R. , Ogbunude, P., Enanga, B. and Barrett, M. (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi: 10.2174/1381612023396159)
Enanga, B., Burchmore, R. , Stewart, M. and Barrett, M. (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi: 10.1007/s00018-002-8472-0)
Greenblatt, C., Schnur, L., Bar-Gal, G., Ermolaev, H., Peleg, N. and Barrett, M. (2002) Polymorphism among alleles of the 6-Phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Molecular and Biochemical Parasitology, 125(1-2), pp. 185-188. (doi: 10.1016/S0166-6851(02)00213-X)
Janssen, C., Barrett, M. , Turner, C. and Phillips, R. (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proceedings of the Royal Society of London Series B: Biological Sciences, 269(1800), pp. 431-436. (doi: 10.1098/rspb.2001.1903)
2001
Bertelli, M., El-Bastawissy, E., Knaggs, M.H., Barrett, M.P. , Hanau, S. and Gilbert, I.H. (2001) Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei. Journal of Computer-Aided Molecular Design, 15(5), pp. 465-475. (doi: 10.1023/A:1011196508214)
Burchmore, R. and Barrett, M. (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi: 10.1016/S0020-7519(01)00259-4)
Denise, H. and Barrett, M.P. (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology, 61(1), pp. 1-5. (doi: 10.1016/S0006-2952(00)00477-9)
Janssen, C., Barrett, M. , Lawson, D., Quail, M., Harris, D., Bowman, S., Phillips, R. and Turner, C. (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113(2), pp. 251-260. (doi: 10.1016/S0166-6851(01)00224-9)
Klenke, B., Stewart, M., Barrett, M. , Brun, R. and Gilbert, I. (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. Journal of Medicinal Chemistry, 44(21), pp. 3440-3452. (doi: 10.1021/jm010854+)
2000
De Koning, H.P. , MacLeod, A. , Barrett, M.P. , Cover, B. and Jarvis, S.M. (2000) Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology, 106(1), pp. 181-185. (doi: 10.1016/S0166-6851(99)00206-6)
1999
Carter, N.S., Barrett, M.P. and De Koning, H.P. (1999) A drug resistance determinant in trypanosoma brucei. Trends in Microbiology, 7(12), pp. 469-471. (doi: 10.1016/S0966-842X(99)01643-1)
Tetaud, E., Hanau, S., Wekks, J. M., Le Page, R. W.F., Adams, M. J., Arkison, S. and Barrett, M. P. (1999) 6-phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme. Biochemical Journal, 338(1), pp. 55-60. (doi: 10.1042/bj3380055) (PMID:9931298) (PMCID:PMC1220024)
1998
Tetaud, E., Hall, D.R., Gourley, D.G., Leonard, G.A., Arkison, S. , Barrett, M.P. and Hunter, W.N. (1998) Crystallization and preliminary X-ray diffraction studies of 6-phosphogluconate dehydrogenase from Lactococcus lactis. Acta Crystallographica Section D: Biological Crystallography, 54(6.2), pp. 1422-1424. (doi: 10.1107/s0907444998004909) (PMID:10089526)
1997
Barrett, M. P. , MacLeod, A. , Tovar, J., Sweetman, J. P., Tait, A., Le Page, R. W.F. and Melville, S. E. (1997) A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates. Molecular and Biochemical Parasitology, 86(1), pp. 95-99. (doi: 10.1016/S0166-6851(97)02832-6) (PMID:9178271)
Articles
Campillo Poveda, M. et al. (2025) Metabolomic and functional analyses of small molecules secreted by intestinal nematodes in the activation of epithelial tuft cells. Metabolomics, (Accepted for Publication)
Richards, S. et al. (2025) Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of african animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania. PLoS Neglected Tropical Diseases, 19(1), e0012541. (doi: 10.1371/journal.pntd.0012541) (PMID:39836697) (PMCID:PMC11785308)
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Scott, F. J., Khalaf, A. I., Giordani, F. , Wong, P. E., Duffy, S., Barrett, M. , Avery, V. M. and Suckling, C. J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi: 10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)
Holm, S.H., Beech, J.P., Barrett, M.P. and Tegenfeldt, J.O. (2016) Simplifying microfluidic separation devices towards field-detection of blood parasites. Analytical Methods, 8(16), pp. 3291-3300. (doi: 10.1039/c6ay00443a)
Vincent, I. M., Ehmann, D. E., Mills, S. D., Perros, M. and Barrett, M. P. (2016) Untargeted metabolomics to ascertain antibiotic modes of action. Antimicrobial Agents and Chemotherapy, 60(4), pp. 2281-2291. (doi: 10.1128/AAC.02109-15) (PMID:26833150) (PMCID:PMC4808186)
Kim, D.-H., Achcar, F. , Breitling, R. , Burgess, K. E. and Barrett, M. P. (2015) LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes. Metabolomics, 11(6), pp. 1721-1732. (doi: 10.1007/s11306-015-0827-2) (PMID:26491423) (PMCID:PMC4605981)
Baker, N., Hamilton, G., Wilkes, J.M. , Hutchinson, S., Barrett, M.P. and Horn, D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 112(29), pp. 9112-9117. (doi: 10.1073/pnas.1505411112) (PMID:2615048) (PMCID:PMC4517229)
Srivastava, A., Creek, D. J., Evans, K. J., De Souza, D., Schofield, L., Muller, S., Barrett, M. P. , McConville, M. J. and Waters, A. P. (2015) Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites. PLoS Pathogens, 11(6), e1004882. (doi: 10.1371/journal.ppat.1004882) (PMID:26042734) (PMCID:PMC4456406)
de Macêdo, J. P., Schumann Burkard, G., Niemann, M., Barrett, M. P. , Vial, H., Mäser, P., Roditi, I., Schneider, A. and Bütikofer, P. (2015) An atypical mitochondrial carrier that mediates drug action in Trypanosoma brucei. PLoS Pathogens, 11(5), e1004875. (doi: 10.1371/journal.ppat.1004875) (PMID:25946070) (PMCID:PMC4422618)
Trochine, A., Creek, D.J., Faral-Tello, P., Barrett, M.P. and Robello, C. (2015) Bestatin induces specific changes in trypanosoma cruzi dipeptide pool. Antimicrobial Agents and Chemotherapy, 59(5), pp. 2921-2925. (doi: 10.1128/AAC.05046-14) (PMID:25712359)
Coles, J. A., Myburgh, E. , Ritchie, R., Hamilton, A., Rodgers, J. , Mottram, J. C. , Barrett, M. P. and Brewer, J. M. (2015) Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes. PLoS Neglected Tropical Diseases, 9(4), e0003714. (doi: 10.1371/journal.pntd.0003714) (PMID:25881126) (PMCID:PMC4400075)
Creek, D. J. et al. (2015) Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose. PLoS Pathogens, 11(3), e1004689. (doi: 10.1371/journal.ppat.1004689) (PMID:25775470) (PMCID:PMC4361558)
van der Hooft, J. , Ridder, L., Barrett, M. P. and Burgess, K. V. (2015) Enhanced acylcarnitine annotation in high-resolution mass spectrometry data: fragmentation analysis for the classification and annotation of acylcarnitines. Frontiers in Bioengineering and Biotechnology, 3, p. 26. (doi: 10.3389/fbioe.2015.00026) (PMID:25806366) (PMCID:PMC4353373)
Alkhaldi, A.A.M., Creek, D.J., Ibrahim, H., Kim, D.-H., Quashie, N.B., Burgess, K.E., Changtam, C., Barrett, M.P. , Suksamrarn, A. and De Koning, H.P. (2015) Potent Trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with Trypanothione. Molecular Pharmacology, 87(3), pp. 451-464. (doi: 10.1124/mol.114.096016) (PMID:25527638)
Shameer, S. et al. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic Acids Research, 43(D1), D637-D644. (doi: 10.1093/nar/gku944) (PMID:25300491) (PMCID:PMC4384016)
Hai, Y., Kerkhoven, E. J., Barrett, M. and Christianson, D. W. (2015) Crystal structure of an arginase-like protein fromtrypanosoma bruceithat evolved without a binuclear manganese cluster. Biochemistry, 54(2), pp. 458-471. (doi: 10.1021/bi501366a) (PMID:25536859)
Vincent, I.M. and Barrett, M.B. (2015) Metabolomic-based strategies for anti-parasite drug discovery. Journal of Biomolecular Screening, 20(1), pp. 44-55. (doi: 10.1177/1087057114551519) (PMID:25281738)
Giordani, F. , Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P. , Pellacani, C., Poli, P. and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi: 10.1128/AAC.01449-13)
Achcar, F. , Kerkhoven, E. J. and Barrett, M. P. (2014) Trypanosoma brucei: meet the system. Current Opinion in Microbiology, 20, pp. 162-169. (doi: 10.1016/j.mib.2014.06.007)
Bourquin, Y., Syed, A., Reboud, J. , Ranford-Cartwright, L. C. , Barrett, M. P. and Cooper, J. M. (2014) Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics. Angewandte Chemie (International Edition), 53(22), pp. 5587-5590. (doi: 10.1002/anie.201310401) (PMID:24677583) (PMCID:PMC4232275)
Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)
Giordani, F. , Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi: 10.1128/AAC.02024-13)
Barrett, M.P. , Nikkhah, D., Gilbert, P. and Dheansa, B. (2014) Why aren’t we doing more to safeguard vulnerable adults from thermal injuries? Burns, 40(2), pp. 360-361. (doi: 10.1016/j.burns.2013.08.018) (PMID:24035041)
Chokkathukalam, A., Kim, D.-H., Barrett, M. P. , Breitling, R. and Creek, D. J. (2014) Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks. Bioanalysis, 6(4), pp. 511-524. (doi: 10.4155/bio.13.348) (PMID:24568354) (PMCID:PMC4048731)
Kremer, C., Witte, C., Neale, S. L. , Reboud, J. , Barrett, M. P. and Cooper, J. M. (2014) Shape-dependent optoelectronic cell lysis. Angewandte Chemie (International Edition), 53(3), pp. 842-846. (doi: 10.1002/anie.201307751) (PMID:24402800) (PMCID:PMC4441254)
Barrett, M. P. and Croft, S. L. (2014) Emerging paradigms in anti-infective drug design. Parasitology, 141(1), pp. 1-7. (doi: 10.1017/S0031182013001224)
Creek, D. J. and Barrett, M. P. (2014) Determination of antiprotozoal drug mechanisms by metabolomics approaches. Parasitology, 141(1), pp. 83-92. (doi: 10.1017/S0031182013000814)
Achcar, F. et al. (2014) The silicon trypanosome: a test case of iterative model extension in systems biology. Advances in Microbial Physiology, 64, pp. 115-143. (doi: 10.1016/B978-0-12-800143-1.00003-8) (PMID:24797926) (PMCID:PMC4773886)
Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F. , Barrett, M. P. , Wong, P. E., Barrack, K. L. and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi: 10.1021/jm500483b)
Oppenheim, R. D. et al. (2014) BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathogens, 10(7), e1004263. (doi: 10.1371/journal.ppat.1004263) (PMID:25032958) (PMCID:PMC4102578)
Trochine, A., Creek, D. J., Faral-Tello, P., Barrett, M. P. and Robello, C. (2014) Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics. PLoS Neglected Tropical Diseases, 8(5), e2844. (doi: 10.1371/journal.pntd.0002844)
Kerkhoven, E. J. et al. (2013) Handling uncertainty in dynamic models: the pentose phosphate pathway in trypanosoma brucei. PLoS Computational Biology, 9(12), e1003371. (doi: 10.1371/journal.pcbi.1003371) (PMID:24339766) (PMCID:PMC3854711)
Munday, J.C. , Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P. , Morrison, L.J. and De Koning, H.P. (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi: 10.1016/j.ijpddr.2013.01.004)
Millerioux, Y. et al. (2013) The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control. Molecular Microbiology, 90(1), pp. 114-129. (doi: 10.1111/mmi.12351) (PMID:23899193) (PMCID:PMC4034587)
Achcar, F. , Barrett, M.P. and Breitling, R. (2013) Explicit consideration of topological and parameter uncertainty gives new insights into a well-established model of glycolysis. FEBS Journal, 280(18), pp. 4640-4651. (doi: 10.1111/febs.12436) (PMID:23865459) (PMCID:PMC4768353)
Barrett, M.P. , Gemmell, C.G. and Suckling, C.J. (2013) Minor groove binders as anti-infective agents. Pharmacology and Therapeutics, 139(1), pp. 12-23. (doi: 10.1016/j.pharmthera.2013.03.002)
Creek, D. J., Nijagal, B., Kim, D.-H., Rojas, F., Matthews, K. R. and Barrett, M. P. (2013) Metabolomics guides rational development of a simplified cell culture medium for drug screening against Trypanosoma brucei. Antimicrobial Agents and Chemotherapy, 57(6), pp. 2768-2779. (doi: 10.1128/AAC.00044-13)
Kim, D.-H. and Barrett, M.P. (2013) Metabolite-dependent regulation of gene expression in trypanosoma brucei. Molecular Microbiology, 88(5), pp. 841-845. (doi: 10.1111/mmi.12243)
Limenitakis, J., Oppenheim, R.D., Creek, D.J., Foth, B.J., Barrett, M.P. and Soldati-Favre, D. (2013) The 2-methylcitrate cycle is implicated in the detoxification of propionate inToxoplasma gondii. Molecular Microbiology, 87(4), pp. 894-908. (doi: 10.1111/mmi.12139)
Chokkathukalam, A., Jankevics, A., Creek, D.J., Achcar, F., Barrett, M.P. and Breitling, R. (2013) mzMatch-ISO: an R tool for the annotation and relative quantification of isotope-labelled mass spectrometry data. Bioinformatics, 29(2), pp. 281-283. (doi: 10.1093/bioinformatics/bts674) (PMID:23162054) (PMCID:PMC3546800)
De Muylder, G. et al. (2013) A trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathogens, 9(10), e1003731. (doi: 10.1371/journal.ppat.1003731)
Myburgh, E. , Coles, J.A., Ritchie, R., Kennedy, P.G.E., McLatchie, A., Rodgers, J. , Taylor, M., Barrett, M. , Brewer, J. and Mottram, J.C. (2013) In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis. PLoS Neglected Tropical Diseases, 7(8), e2384. (doi: 10.1371/journal.pntd.0002384)
Creek, D.J., Chokkathukalam, A., Jankevics, A., Burgess, K.E.V., Breitling, R. and Barrett, M.P. (2012) Stable isotope-assisted metabolomics for network-wide metabolic pathway elucidation. Analytical Chemistry, 84(20), pp. 8442-8447. (doi: 10.1021/ac3018795) (PMID:22946681) (PMCID:PMC3472505)
Clark, R.L., Clements, C.J., Barrett, M.P. , Mackay, S.P., Rathnam, R.P., Owusu-Dapaah, G., Spencer, J. and Huggan, J.K. (2012) Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT. Bioorganic and Medicinal Chemistry, 20(20), pp. 6019-6033. (doi: 10.1016/j.bmc.2012.08.049)
Baker, N., Glover, L., Munday, J. C. , Aguinaga Andres, D., Barrett, M. P. , De Koning, H. P. and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi: 10.1073/pnas.1202885109)
Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R. and Barrett, M.P. (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28(7), pp. 1048-1049. (doi: 10.1093/bioinformatics/bts069) (PMID:22308147)
Achcar, F., Kerkhoven, E.J., SilicoTryp Consortium, , Bakker, B.M., Barrett, M.P. and Breitling, R. (2012) Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism. PLoS Computational Biology, 8(1), e1002352. (doi: 10.1371/journal.pcbi.1002352) (PMID:22379410) (PMCID:PMC3269904)
Barrett, M.P. and Croft, S.L. (2012) Management of trypanosomiasis and leishmaniasis. British Medical Bulletin, 104(1), pp. 175-196. (doi: 10.1093/bmb/lds031)
Bringaud, F., Barrett, M. and Zilberstein, D. (2012) Multiple roles of proline transport and metabolism in trypanosomatids. Frontiers in Bioscience, 17(1), p. 349. (doi: 10.2741/3931)
Creek, D., Anderson, J. , McConville, M.J. and Barrett, M.P. (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181(2), pp. 73-84. (doi: 10.1016/j.molbiopara.2011.10.003)
Menachery, A., Kremer, C., Wong, P.E., Carlsson, A., Neale, S.L. , Barrett, M.P. and Cooper, J.M. (2012) Counterflow dielectrophoresis for trypanosome enrichment and detection in blood. Scientific Reports, 2, 775. (doi: 10.1038/srep00775) (PMID:23105971) (PMCID:PMC3481117)
Vincent, I.M. , Creek, D.J., Burgess, K., Woods, D.J., Burchmore, R.J.S. and Barrett, M.P. (2012) Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei. PLoS Neglected Tropical Diseases, 6(5), e1618. (doi: 10.1371/journal.pntd.0001618) (PMID:22563508) (PMCID:PMC3341325)
Zhang, T., Creek, D.J., Barrett, M.P. , Blackburn, G. and Watson, D.G. (2012) Evaluation of coupling reversed phase, aqueous normal phase, and hydrophilic interaction liquid chromatography with orbitrap mass spectrometry for metabolomic studies of human urine. Analytical Chemistry, 84(4), pp. 1994-2001. (doi: 10.1021/ac2030738)
Burgess, K., Creek, D., Dewsbury, P., Cook, K. and Barrett, M.P. (2011) Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3447-3452. (doi: 10.1002/rcm.5247)
Leader, D.P. , Burgess, K., Creek, D. and Barrett, M.P. (2011) Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry. Rapid Communications in Mass Spectrometry, 25(22), pp. 3422-3426. (doi: 10.1002/rcm.5245)
Barrett, M.P. , Vincent, I.M. , Burchmore, R.J.S. , Kazibwe, A.J.N. and Matovu, E. (2011) Drug resistance in human African trypanosomiasis. Future Microbiology, 6(9), pp. 1037-1047. (doi: 10.2217/fmb.11.88) (PMID:21958143)
Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi: 10.1124/mol.111.071555)
Holm, S. H., Beech, J. P., Barrett, M. P. and Tegenfeldt, J. O. (2011) Separation of parasites from human blood using deterministic lateral displacement. Lab on a Chip, 11(7), pp. 1326-1332. (doi: 10.1039/c0lc00560f)
Goodwin, R.J.A., Pitt, A.R., Harrison, D., Weidt, S.K., Langridge-Smith, P.R.R., Barrett, M.P. and Mackay, C.L. (2011) Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 25(7), pp. 969-972. (doi: 10.1002/rcm.4939)
Spencer, J., Rathnam, R.P., Harvey, A.L., Clements, C.J., Clark, R.L., Barrett, M.P. , Wong, P.E., Male, L., Coles, S.J. and Mackay, S.P. (2011) Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity. Bioorganic and Medicinal Chemistry, 19(5), pp. 1802-1815. (doi: 10.1016/j.bmc.2011.01.010)
Brun, R., Don, R., Jacobs, R.T., Wang, M.Z. and Barrett, M.P. (2011) Development of novel drugs for human African trypanosomiasis. Future Microbiology, 6(6), pp. 677-691. (doi: 10.2217/fmb.11.44)
Creek, D.J., Jankevics, A., Breitling, R. , Watson, D.G., Barrett, M.P. and Burgess, K.E.V. (2011) Toward global metabolomics snalysis with Hydrophilic Interaction Liquid Chromatography–Mass Spectrometry: improved metabolite identification by retention time prediction. Analytical Chemistry, 83(22), pp. 8703-8710. (doi: 10.1021/ac2021823)
Rodgers, J. , Jones, A., Gibaud, S., Bradley, B., McCabe, C. , Barrett, M. P. , Gettinby, G. and Kennedy, P. G.E. (2011) Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Neglected Tropical Diseases, 5(9), e1308. (doi: 10.1371/journal.pntd.0001308)
Stoffel, S.A., Alibu, V.P., Hubert, J., Ebikeme, C., Portais, J.C., Bringaud, F., Schweingruber, M.E. and Barrett, M. (2011) Transketolase in Trypanosoma brucei. Molecular and Biochemical Parasitology, 179(1), pp. 1-7. (doi: 10.1016/j.molbiopara.2011.04.006)
Ward, C.P., Wong, P.E., Burchmore, R.J.S. , De Koning, H.P. and Barrett, M.P. (2011) Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial Agents and Chemotherapy, 55(5), pp. 2352-2361. (doi: 10.1128/AAC.01551-10)
Barrett, M. P. (2010) Potential new drugs for human African trypanosomiasis: some progress at last. Current Opinion in Infectious Diseases, 23(6), pp. 603-608. (doi: 10.1097/QCO.0b013e32833f9fd0)
Naula, C.M. , Logan, F.M., Wong, P.E., Barrett, M.P. and Burchmore, R.J. (2010) A glucose transporter can mediate ribose uptake: definition of residues that confer substrate specificity in a sugar transporter. Journal of Biological Chemistry, 285(39), pp. 29721-29728. (doi: 10.1074/jbc.M110.106815)
Bakker, B., Krauth-Siegel, R.L., Clayton, C., Matthews, K., Girolami, M., Westerhoff, H.V., Michels, P.A.M., Breitling, R. and Barrett, M.P. (2010) The silicon trypanosome. Parasitology, 137(9), pp. 1333-1341. (doi: 10.1017/S0031182010000466) (PMID:20444304)
Barrett, M.P., Bakker, B.M. and Breitling, R. (2010) Metabolomic systems biology of trypanosomes. Parasitology, 137(9), pp. 1285-1290. (doi: 10.1017/S003118201000017X) (PMID:20158937)
Paine, M.F. et al. (2010) Diamidines for human African trypanosomiasis. Current Opinion in Investigational Drugs, 11(8), pp. 876-883.
Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M.P. , Brenk, R. and Gilbert, I. H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorganic and Medicinal Chemistry, 18(14), pp. 5056-5062. (doi: 10.1016/j.bmc.2010.05.077)
Stewart, M.L. et al. (2010) Multiple genetic mechanisms lead to loss of functional TbAT1 expression in drug-resistant trypanosomes. Eukaryotic Cell, 9(2), pp. 336-343. (doi: 10.1128/EC.00200-09) (PMID:19966032) (PMCID:PMC2823006)
Conti, P., Pinto, A., Wong, P.E., Major, L.L., Tamborini, L., Iannuzzi, M.C., De Micheli, C., Barrett, M.P. and Smith, T.K. (2010) Synthesis and in vitro/in vivo Evaluation of the Antitrypanosomal Activity of 3-Bromoacivicin, a Potent CTP Synthetase Inhibitor. ChemMedChem, 6(2), pp. 329-333. (doi: 10.1002/cmdc.201000417)
Cottret, L., Wildridge, D., Vinson, F., Barrett, M.P. , Charles, H., Sagot, M.-F. and Jourdan, F. (2010) MetExplore: a web server to link metabolomic experiments and genome-scale metabolic networks. Nucleic Acids Research, 38(Suppl), W132-W137. (doi: 10.1093/nar/gkq312)
González, D., Pérez, J.L., Serrano, M.L., Igoillo-Esteve, M., Cazzulo, J.J., Barrett, M.P. , Bubis, J. and Mendoza-León, A. (2010) The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction. Journal of Molecular Microbiology and Biotechnology, 19(4), pp. 213-223. (doi: 10.1159/000320697)
Jourdan, F., Cottret, L., Huc, L., Wildridge, D., Scheltema, R., Hillenweck, A., Barrett, M.P., Zalko, D., Watson, D. G. and Debrauwer, L. (2010) Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining. Metabolomics, 6(2), pp. 312-321. (doi: 10.1007/s11306-009-0196-9) (PMID:20526351) (PMCID:PMC2874485)
Klee, N., Wong, P. E., Baragana, B., Mazouni, F. E., Phillips, M. A., Barrett, M.P. and Gilbert, I. H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry Letters, 20(15), pp. 4364-4366. (doi: 10.1016/j.bmcl.2010.06.070)
Ruda, G.F., Wong, P.E., Alibu, V.P., Norval, S., Read, K.D., Barrett, M.P. and Gilbert, I.H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent Trypanocidal compounds. Journal of Medicinal Chemistry, 53(16), pp. 6071-6078. (doi: 10.1021/jm1004754)
Vincent, I.M. , Creek, D., Watson, D.G., Kamleh, M.A., Woods, D.J., Wong, P.E., Burchmore, R.J.S. and Barrett, M.P. (2010) A molecular mechanism for eflornithine resistance in African trypanosomes. PLoS Pathogens, 6(11), e1001204. (doi: 10.1371/journal.ppat.1001204) (PMID:21124824) (PMCID:PMC2991269)
Ward, C. P., Burgess, K. E.V., Burchmore, R.J.S. , Barrett, M.P. and De Koning, H.P. (2010) A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes. Molecular and Biochemical Parasitology, 174(2), pp. 145-149. (doi: 10.1016/j.molbiopara.2010.07.002)
Kazibwe, A.J.N., Nerima, B., De Koning, H.P. , Mäser, P., Barrett, M.P. and Matovu, E. (2009) Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from northwestern Uganda following melarsoprol withdrawal. PLoS Neglected Tropical Diseases, 3(9), e523. (doi: 10.1371/journal.pntd.0000523)
Mukhopadhyay, A., Chen, C.Y., Doerig, C., Henriquez, F.L., Roberts, C.W. and Barrett, M.P. (2009) The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX. Parasitology, 136(7), pp. 747-755. (doi: 10.1017/S0031182009006027)
Rodgers, J. , Stone, T.W., Barrett, M.P., Bradley, B.M. and Kennedy, P.G.E. (2009) Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis. Brain, 132(5), pp. 1259-1267. (doi: 10.1093/brain/awp074)
Jhingran, A., Chawla, B., Saxena, S., Barrett, M.P. and Madhubala, R. (2009) Paromomycin: Uptake and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 164(2), pp. 111-117. (doi: 10.1016/j.molbiopara.2008.12.007)
Wenzel, N., Wong, P.E., Maes, L., Muller, T.J., Krauth-Siegel, R.L., Barrett, M.P. and Davioud-Charvet, E. (2009) Unsaturated mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. ChemMedChem, 4(3), pp. 339-351. (doi: 10.1002/cmdc.200800360)
Baliani, A., Peal, V., Gros, L., Brun, R., Kaiser, M., Barrett, M.P. and Gilbert, I.H. (2009) Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites. Organic and Biomolecular Chemistry, 7(6), pp. 1154-1166. (doi: 10.1039/b813394h)
Chollet, C., Baliani, A., Wong, P.E., Barrett, M.P. and Gilbert, I.H. (2009) Targeted delivery of compounds to Trypanosoma brucei using the melamine motif. Bioorganic and Medicinal Chemistry, 17(6), pp. 2512-2523. (doi: 10.1016/j.bmc.2009.01.058)
Collar, C.J., Al Salabi, M.I., Stewart, M.L., Barrett, M.P. , Wilson, W.D. and de Koning, H.P. (2009) Predictive computational models of substrate binding by a nucleoside transporter. Journal of Biological Chemistry, 284(49), pp. 34028-34035. (doi: 10.1074/jbc.M109.049726)
Checchi, F., Filipe, J.A.N., Barrett, M.P. and Chandramohan, D. (2008) The natural progression of gambiense sleeping sickness: what is the evidence? PLoS Neglected Tropical Diseases, 2(12), e303. (doi: 10.1371/journal.pntd.0000303) (PMID:19104656) (PMCID:PMC2602732)
Scheltema, R.A., Kamleh, A., Wildridge, D., Ebikeme, C., Watson, D.G., Barrett, M. , Jansen, R.C. and Breitling, R. (2008) Increasing the mass accuracy of high-resolution LC-MS data using background ions - a case study on the LTQ-Orbitrap. Proteomics, 8(22), pp. 4647-4656. (doi: 10.1002/pmic.200800314)
Kamleh, A., Barrett, M.P. , Wildridge, D., Burchmore, R.J.S. , Scheltema, R.A.. and Watson, D.G. (2008) Metabolomic profiling using Orbitrap Fourier transform mass spectrometry with hydrophilic interaction chromatography: a method with wide applicability to analysis of biomolecules. Rapid Communications in Mass Spectrometry, 22(12), pp. 1912-1918. (doi: 10.1002/rcm.3564)
Coustou, V., Biran, M., Breton, M., Guegan, F., Riviere, L., Plazolles, N., Nolan, D., Barrett, M.P. , Franconi, J.M. and Bringaud, F. (2008) Glucose-induced remodeling of intermediary and energy metabolism in procyclic Trypanosoma brucei. Journal of Biological Chemistry, 283(24), pp. 16342-16354. (doi: 10.1074/jbc.M709592200)
Ebikeme, C.E., Peacock, L., Coustou, V., Riviere, L., Bringaud, F., Gibson, W.C. and Barrett, M.P. (2008) N-acetyl D-glucosamine stimulates growth in procyclic forms of Trypanosoma brucei by inducing a metabolic shift. Parasitology, 135(5), pp. 585-594. (doi: 10.1017/S0031182008004241)
Checchi, F. and Barrett, M.P. (2008) African sleeping sicknesss - Eflornithine should be the drug of choice for stage 2 disease, but resistance must be monitored. British Medical Journal, 336(7646), pp. 679-680. (doi: 10.1136/bmj.39505.490544.BE)
Breitling, R. , Vitkup, D. and Barrett, M.P. (2008) New surveyor tools for charting microbial metabolic maps. Nature Reviews Microbiology, 6, pp. 156-161. (doi: 10.1038/nrmicro1797)
Reid, C.M., Ebikeme, C., Barrett, M.P., Patzewitz, E.M., Muller, S., Robins, D.J. and Sutherland, A. (2008) Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles. Bioorganic and Medicinal Chemistry Letters, 18(7), pp. 2455-2458. (doi: 10.1016/j.bmcl.2008.02.037)
Arrighi, R. B. G., Ebikeme, C., Jiang, Y., Ranford-Cartwright, L.C. , Barrett, M.P. , Langel, U. and Faye, I. (2008) Cell-Penetrating Peptide TP10 Shows Broad-Spectrum Activity against both Plasmodium falciparum and Trypanosoma brucei brucei. Antimicrobial Agents and Chemotherapy, 52(9), pp. 3414-3417. (doi: 10.1128/AAC.01450-07)
Jourdan, F., Breitling, R., Barrett, M.P. and Gilbert, D. (2008) MetaNetter: inference and visualization of high-resolution metabolomic networks. Bioinformatics, 24(1), pp. 143-145. (doi: 10.1093/bioinformatics/btm536)
Reid, C. M., Ebikeme, C., Barrett, M.P. , Patzewitz, E.-M., Muller, S., Robins, D. J. and Sutherland, A. (2008) Synthesis of novel benzamidine- and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 18(20), pp. 5399-5401. (doi: 10.1016/j.bmcl.2008.09.047)
Sundaramoorthy, R., Iulek, J., Barrett, M. P. , Bidet, O., Ruda, G. F., Gilbert, I. H. and Hunter, W. N. (2007) Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. FEBS Journal, 274(1), pp. 275-286. (doi: 10.1111/j.1742-4658.2006.05585.x)
Barrett, M. (2007) Human African trypanosomiasis: pharmacological re-engagement with a neglected disease. British Journal of Pharmacology, 152(8), pp. 1155-1171. (doi: 10.1038/sj.bjp.0707354)
Naula, C. , Alibu, V., Brock, J., Veitch, N.J. , Burchmore, R.J.S. and Barrett, M. (2007) A new erythrose 4-phosphate dehydrogenase coupled assay for transketolase. Journal of Biochemical and Biophysical Methods, 70(6), pp. 1185-1187. (doi: 10.1016/j.jprot.2007.11.002)
Ogbunude, P., Lamour, N. and Barrett, M. (2007) Molecular cloning, expression and characterization of ribokinase of Leishmania major. Acta Biochimica et Biophysica Sinica, 39, pp. 462-466. (doi: 10.1111/j.1745-7270.2007.00298.x)
Anene, B.M., Ezeokonkwo, R.C., Mmesirionye, T.I., Tettey, J.N.A., Brock, J.M., Barrett, M.P. and De Koning, H.P. (2006) A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 132(1), pp. 127-133. (doi: 10.1017/S0031182005008760)
Barrett, M. and Gilbert, I. (2006) Targeting of toxic compounds to the trypanosome's interior. Advances in Parasitology, 63, pp. 125-183. (doi: 10.1016/S0065-308X(06)63002-9)
Breitling, R., Ritchie, S., Goodenowe, D., Stewart, M. and Barrett, M. (2006) Ab initio prediction of metabolic networks using Fourier transform mass spectrometry data. Metabolomics, 2, pp. 155-164. (doi: 10.1007/s11306-006-0029-z)
Dardonville, C., Barrett, M. , Brun, R., Kaiser, M., Tanious, F. and Wilson, W. (2006) DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity. Journal of Medicinal Chemistry, 49, pp. 3748-3752. (doi: 10.1021/jm060295c)
Lanteri, C.A., Stewart, M.L., Brock, J.M., Alibu, V.P., Meshnick, S.R., Tidwell, R.R. and Barrett, M.P. (2006) Roles for the Trypanosoma brucei P2 transporter in DB75 uptake and resistance. Molecular Pharmacology, 70(5), pp. 1585-1592. (doi: 10.1124/mol.106.024653)
Mukherjee, A., Padmanabhan, P., Sahani, M., Barrett, M. and Madhubala, R. (2006) Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145, pp. 1-10. (doi: 10.1016/j.molbiopara.2005.08.016)
Baliani, A., Bueno, G., Stewart, M., Yardley, V., Brun, R., Barrett, M. and Gilbert, I. (2005) Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites. Journal of Medicinal Chemistry, 48, pp. 5570-5579. (doi: 10.1021/jm050177+)
Besteiro, S., Barrett, M. , Riviere, L. and Bringaud, F. (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends in Parasitology, 21, pp. 185-191.
Croft, S., Barrett, M. and Urbina, J. (2005) Chemotherapy of trypanosomiases and leishmaniasis. Trends in Parasitology, 21, pp. 508-512. (doi: 10.1016/j.pt.2005.08.026)
Lamour, N., Riviere, L., Coustou, V., Coombs, G., Barrett, M. and Bringaud, F. (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. Journal of Biological Chemistry, 280, pp. 11902-11910. (doi: 10.1074/jbc.M414274200)
Stewart, M., Boussard, C., Brun, R., Gilbert, I. and Barrett, M. (2005) Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter. Antimicrobial Agents and Chemotherapy, 49, pp. 5169-5171. (doi: 10.1128/AAC.49.12.5169-5171.2005)
Stewart, M., Krishna, S., Burchmore, R. , Brun, R., de Koning, H. , Boykin, D., Tidwell, R., Hall, J. and Barrett, M. (2005) Detection of arsenical drug resistance in Trypanosoma brucei with a simple fluorescence test. Lancet, 366, pp. 486-487. (doi: 10.1016/S0140-6736(05)66793-1)
Janssen, C.S., Phillips, R.S., Turner, C. and Barrett, M.P. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32(19), pp. 5712-5720. (doi: 10.1093/nar/gkh907)
Azema, L. et al. (2004) Interaction of substituted hexose analogues with the Trypanosoma brucei hexose transporter. Biochemical Pharmacology, 67, pp. 459-467. (doi: 10.1016/j.bcp.2003.09.005)
Dardonville, C., Rinaldi, E., Barrett, M. , Brun, R., Gilbert, I. and Hanau, S. (2004) Selective inhibition of Trypanosoma brucei 6-phosphogluconate dehydrogenase by high-energy intermediate and transition-state analogues. Journal of Medicinal Chemistry, 47, pp. 3427-3437. (doi: 10.1021/jm031066i)
de Koning, H. , Anderson, L., Stewart, M., Burchmore, R. , Wallace, L. and Barrett, M. (2004) The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in African trypanosomes. Antimicrobial Agents and Chemotherapy, 48, pp. 1515-1519. (doi: 10.1128/AAC.48.5.1515-1519.2004)
Hanau, S., Rinaldi, E., Dallocchio, F., Gilbert, I., Dardonville, C., Adams, M., Gover, S. and Barrett, M. (2004) 6-phosphogluconate dehydrogenase: A target for drugs in African trypanosomes. Current Medicinal Chemistry, 11, pp. 2639-2650.
Janssen, C., Phillips, R., Turner, C. and Barrett, M. (2004) Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites. Nucleic Acids Research, 32, pp. 5712-5720. (doi: 10.1093/nar/gkh907)
Stewart, M.L., Bueno, G.J., Baliani, A., Klenke, B., Brun, R., Brock, J.M., Gilbert, I.,H. and Barrett, M.,P., (2004) Trypanocidal activity of melamine-based nitroheterocycles. Antimicrobial Agents and Chemotherapy, 48(5), pp. 1733-1738. (doi: 10.1128/AAC.48.5.1733-1738.2004)
Veitch, N.V. , Maugeri, D.A., Cazzulo, J.J., Lindqvist, Y. and Barrett, M.P. (2004) Transketolase from Leishmania mexicana has a dual subcellular localization. Biochemical Journal, 382(2), pp. 759-767. (doi: 10.1042/BJ20040459)
Barrett, M. , Burchmore, R. , Stich, A., Lazzari, J., Frasch, A., Cazzulo, J. and Krishna, S. (2003) The trypanosomiases. Lancet, 362(9394), pp. 1469-1480. (doi: 10.1016/S0140-6736(03)14694-6)
Bray, P., Barrett, M. , Ward, S. and de Koning, H. (2003) Pentamidine uptake and resistance in pathogenic protozoa: past, present and future. Trends in Parasitology, 19(5), pp. 232-239. (doi: 10.1016/S1471-4922(03)00069-2)
Burchmore, R. , Rodriguez-Contreras, D., McBride, K., Barrett, M. , Modi, G., Sacks, D. and Landfear, S. (2003) Genetic characterization of glucose transporter function in Leishmania mexicana. Proceedings of the National Academy of Sciences of the United States of America, 100(7), pp. 3901-3906. (doi: 10.1073/pnas.0630165100)
Burchmore, R. , Wallace, L., Candlish, D., Al-Salabi, M., Beal, P., Barrett, M. , Baldwin, S. and de Koning, H. (2003) Cloning, heterologous expression, and in situ characterization of the first high affinity nucleobase transporter from a protozoan. Journal of Biological Chemistry, 278(26), pp. 23502-23507. (doi: 10.1074/jbc.M301252200)
Dardonville, C., Rinaldi, E., Hanau, S., Barrett, M. , Brun, R. and Gilbert, I. (2003) Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorganic and Medicinal Chemistry Letters, 11(14), pp. 3205-3214. (doi: 10.1016/S0968-0896(03)00191-3)
Enanga, B., Ariyanayagam, M., Stewart, M. and Barrett, M. (2003) Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage. Antimicrobial Agents and Chemotherapy, 47(10), pp. 3368-3370. (doi: 10.1128/AAC.47.10.3368-3370.2003)
Klenke, B., Barrett, M. , Brun, R. and Gilbert, I. (2003) Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines. Journal of Antimicrobial Chemotherapy, 52(2), pp. 290-293. (doi: 10.1093/jac/dkg307)
Matovu, E. et al. (2003) Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic Cell, 2(5), pp. 1003-1008. (doi: 10.1128/EC.2.5.1003-1008.2003)
Maugeri, D., Cazzulo, J., Burchmore, R. , Barrett, M. and Ogbunude, P. (2003) Pentose phosphate metabolism in Leishmania mexicana. Molecular and Biochemical Parasitology, 130(2), pp. 117-125. (doi: 10.1016/S0166-6851(03)00173-7)
Stich, A., Barrett, M. and Krishna, S. (2003) Waking up to sleeping sickness. Trends in Parasitology, 19(5), pp. 195-197. (doi: 10.1016/S1471-4922(03)00055-2)
Leslie, G., Barrett, M. and Burchmore, R. (2002) Leishmania mexicana: promastigotes migrate through osmotic gradients. Experimental Parasitology, 102(2), pp. 117-120. (doi: 10.1016/S0014-4894(03)00031-6)
Barrett, M. (2002) Perspectives for new drugs against trypanosomiasis and leishmaniasis. Current Topics in Medicinal Chemistry, 2(5), pp. 471-482. (doi: 10.2174/1568026024607427)
Basselin, M., Denise, H., Coombs, G. and Barrett, M. (2002) Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion. Antimicrobial Agents and Chemotherapy, 46(12), pp. 3731-3738. (doi: 10.1128/AAC.46.12.3731-3788.2002)
Burchmore, R. , Ogbunude, P., Enanga, B. and Barrett, M. (2002) Chemotherapy of human African trypanosomiasis. Current Pharmaceutical Design, 8(4), pp. 257-267. (doi: 10.2174/1381612023396159)
Enanga, B., Burchmore, R. , Stewart, M. and Barrett, M. (2002) Sleeping sickness and the brain. Cellular and Molecular Life Sciences, 59(5), pp. 845-858. (doi: 10.1007/s00018-002-8472-0)
Greenblatt, C., Schnur, L., Bar-Gal, G., Ermolaev, H., Peleg, N. and Barrett, M. (2002) Polymorphism among alleles of the 6-Phosphogluconate dehydrogenase gene from Leishmania major and Leishmania tropica. Molecular and Biochemical Parasitology, 125(1-2), pp. 185-188. (doi: 10.1016/S0166-6851(02)00213-X)
Janssen, C., Barrett, M. , Turner, C. and Phillips, R. (2002) A large gene family for putative variant antigens shared by human and rodent malaria parasites. Proceedings of the Royal Society of London Series B: Biological Sciences, 269(1800), pp. 431-436. (doi: 10.1098/rspb.2001.1903)
Bertelli, M., El-Bastawissy, E., Knaggs, M.H., Barrett, M.P. , Hanau, S. and Gilbert, I.H. (2001) Selective inhibition of 6-phosphogluconate dehydrogenase from Trypanosoma brucei. Journal of Computer-Aided Molecular Design, 15(5), pp. 465-475. (doi: 10.1023/A:1011196508214)
Burchmore, R. and Barrett, M. (2001) Life in vacuoles - nutrient acquisition by Leishmania amastigotes. International Journal for Parasitology, 31(12), pp. 1311-1320. (doi: 10.1016/S0020-7519(01)00259-4)
Denise, H. and Barrett, M.P. (2001) Uptake and mode of action of drugs used against sleeping sickness. Biochemical Pharmacology, 61(1), pp. 1-5. (doi: 10.1016/S0006-2952(00)00477-9)
Janssen, C., Barrett, M. , Lawson, D., Quail, M., Harris, D., Bowman, S., Phillips, R. and Turner, C. (2001) Gene discovery in Plasmodium chabaudi by genome survey sequencing. Molecular and Biochemical Parasitology, 113(2), pp. 251-260. (doi: 10.1016/S0166-6851(01)00224-9)
Klenke, B., Stewart, M., Barrett, M. , Brun, R. and Gilbert, I. (2001) Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs. Journal of Medicinal Chemistry, 44(21), pp. 3440-3452. (doi: 10.1021/jm010854+)
De Koning, H.P. , MacLeod, A. , Barrett, M.P. , Cover, B. and Jarvis, S.M. (2000) Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes. Molecular and Biochemical Parasitology, 106(1), pp. 181-185. (doi: 10.1016/S0166-6851(99)00206-6)
Carter, N.S., Barrett, M.P. and De Koning, H.P. (1999) A drug resistance determinant in trypanosoma brucei. Trends in Microbiology, 7(12), pp. 469-471. (doi: 10.1016/S0966-842X(99)01643-1)
Tetaud, E., Hanau, S., Wekks, J. M., Le Page, R. W.F., Adams, M. J., Arkison, S. and Barrett, M. P. (1999) 6-phosphogluconate dehydrogenase from Lactococcus lactis: a role for arginine residues in binding substrate and coenzyme. Biochemical Journal, 338(1), pp. 55-60. (doi: 10.1042/bj3380055) (PMID:9931298) (PMCID:PMC1220024)
Tetaud, E., Hall, D.R., Gourley, D.G., Leonard, G.A., Arkison, S. , Barrett, M.P. and Hunter, W.N. (1998) Crystallization and preliminary X-ray diffraction studies of 6-phosphogluconate dehydrogenase from Lactococcus lactis. Acta Crystallographica Section D: Biological Crystallography, 54(6.2), pp. 1422-1424. (doi: 10.1107/s0907444998004909) (PMID:10089526)
Barrett, M. P. , MacLeod, A. , Tovar, J., Sweetman, J. P., Tait, A., Le Page, R. W.F. and Melville, S. E. (1997) A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates. Molecular and Biochemical Parasitology, 86(1), pp. 95-99. (doi: 10.1016/S0166-6851(97)02832-6) (PMID:9178271)
Book Sections
Ritchie, R., Barrett, M. P. , Mottram, J. C. and Myburgh, E. (2020) In vivo bioluminescence imaging to assess compound efficacy against Trypanosoma brucei. In: Michels, Paul A.M., Ginger, Michael L. and Zilberstein, Dan (eds.) Trypanosomatids: Methods and Protocols. Series: Methods in molecular biology (2116). Humana Press: New York, NY, pp. 801-817. ISBN 9781071602935 (doi: 10.1007/978-1-0716-0294-2_48)
Giordani, F. , Mwenechanya, R. and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, Sandosh (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi: 10.1016/B978-0-12-386882-4.00039-6)
Creek, D.J., Vincent, I.M. and Barrett, M.P. (2013) Pharmacological metabolomics in trypanosomes. In: Jäger, T., Koch, O. and Flohé, L. (eds.) Trypanosomatid Diseases. Series: Drug discovery in infectious diseases (4). John Wiley and Sons, Inc.: Weinheim, pp. 37-56. ISBN 9783527670390 (doi: 10.1002/9783527670383.ch3)
Rogers, S. , Scheltema, R.A., Barrett, M. and Breitling, R. (2011) Bayesian approaches for mass spectrometry-based metabolomics. In: Stumpf, M.P.H., Balding, D.J. and Girolami, M. (eds.) Handbook of Statistical Systems Biology. John Wiley & Sons: Chichester, UK, pp. 467-476. ISBN 9780470710869 (doi: 10.1002/9781119970606.ch24)
Conference or Workshop Item
Barrett, M. , Sloan, W. , Stark, W. and Watson, I. (2016) New Developments in Synthetic Biology at the University of Glasgow. Industrial Biotechnology Innovation Centre Annual Conference, Glasgow, UK, 28-29 Jan 2016.
Audio
Griffin, D., Despommier, D., Naula, C. and Barrett, M. (2024) This Week in Parasitism - TWiP 238: Eliminating sleeping sickness. [Audio]
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Miltefosine - a dual purpose antifungal to mitigate antifungal resistance
Department of Health and Social Care
2025 - 2026
- Research Innovation Scotland - European Engagement Research Fund
Scottish Funding Council
2024 - 2025
- Detecting drug resistance in surra in India.
Biotechnology and Biological Sciences Research Council
2024 - 2027
- Advancing tools and policies to support progressive control of animal trypanosomosis in Africa
Biotechnology and Biological Sciences Research Council
2024 - 2024
- A portable device to detect counterfeit anti-parasitic drugs
Biotechnology and Biological Sciences Research Council
2023 - 2024
- SULSA Next Generation AY 2022 - 2025
University of Edinburgh
2022 - 2025
- Identification and validation of a novel drug target in the Coenzyme A biosynthesis pathway in Leishmania
Engineering and Physical Sciences Research Council
2022 - 2023
- A metabolic analysis of drug uptake, mode of action and mechanism of resistance in Trypanosoma vivax
Biotechnology and Biological Sciences Research Council
2021 - 2024
- A metabolic analysis of drug uptake, mode of action and mechanism of resistance in Trypanosoma Vivax
GALVmed
2021 - 2024
- Parameoba drug development
Biotechnology and Biological Sciences Research Council
2021 - 2024
- Cellular, molecular and functional characterization of quiescence in Leishmania donovani, the etiological agent of visceral leishmaniasis
FWO The Flanders Research Organisation
2021 - 2024
- Biological characterization of kinetoplastid growth inhibitors using metabolomics and animal efficacy studies
Wellcome Trust
2020 - 2022
- 3 Month Continuing Work For GALVMED Animal African Trypanosomiasis project
GALVmed
2020 - 2020
- Mechanism of Amphotericin B resistance and its association with a multi-protein complex: the Leishmania ergosome
The Royal Society
2020 - 2022
- Bridging epigenetic, metabolism and cell cycle in pathogenic trypanosomatids
Medical Research Council
2019 - 2022
- Tracking isometamidium resistance in livestock trypanaosomes
Biotechnology and Biological Sciences Research Council (BBSRC)
2019 - 2021
- An integrated approach to tackling drug resistance in livestock trypanosomes
GALVmed
2019 - 2021
- Leaders Skills Development
Scottish Funding Council (SFC)
2018 - 2021
- InvestigatinggeneticcompositionofOnchocercawormspre- andpost-drug treatment:Improvingtheabilitytotestmacrofilaricidaldrugefficacy
Drugs for Neglected Diseases Initiative
2018 - 2022
- Application of omics technology to improve the industrial ABE fermentation from novel sustainable feedstocks
Scottish Funding Council
2018 - 2020
- Pools Engagement in European Research (PEER) and Postgraduate and Early Career Research Exchanges (PECRE)
Scottish Funding Council
2018 - 2019
- TRIMETHS - A NOVEL URINARY BIOMARKER FOR MINOR STROKE AND TRANSIENT ISCHAEMIC ATTACK
Chief Scientist Office
2018 - 2020
- ScOttish Psoriatic artHritis Observational Study(SOPHOS)
Chief Scientist Office
2017 - 2020
- Continued Development of the Scottish Universities Life Sciences Alliance: SULSA
Scottish Funding Council
2016 - 2021
- Parasite induced changes to the metabolome of insect vectors of disease
The Royal Society
2016 - 2018
- Scottish Universities Life Sciences Alliance (SULSA)
Glasgow Caledonian University
2016 - 2021
- A new drug discovery pipeline for animal African trypanosomiasis.
GALVmed
2016 - 2019
- A new drug discovery pipeline for animal African trypanosomiasis
Biotechnology and Biological Sciences Research Council
2016 - 2019
- Thiol Modification and Redox Signalling
Medical Research Council
2016 - 2018
- Cost-effective community access to integrated information for microbial eukaryotic pathogen research
Wellcome Trust
2016 - 2020
- Discovery of New Drug Candidate(s) for the Treatment of Human African Trypanosomiasis (HAT)
Wellcome Trust
2016 - 2018
- Discovery of New Drug Candidates(s) for the Treatment of Human African Trypanosomiasis (HAT)
Wellcome Trust
2016 - 2019
- Enhanced interpretation of metabolomics data to accelerate microbial engineering
Innovate UK
2015 - 2017
- Glasgow Molecular Pathology (GMP) Node
Medical Research Council
2015 - 2019
- Regulation of stem cell function during tissue homeostasis and transformation
Wellcome Trust
2015 - 2020
- Stability of polyomic signatures in RA to facilitate transition to clinical practice - STABILITY-RA
Chief Scientist Office
2015 - 2018
- Ancestry and biological informative markers for stratification of hypertension - The AIM HY study
Medical Research Council
2015 - 2020
- Identification and analysis of essential proteins involved in Toxoplasma gondii mitochondrial tRNA import (ISSF Fellowship)
Wellcome Trust
2015 - 2015
- In vivo screening resource to support drug development in parasitic disease
Wellcome Trust
2015 - 2016
- Mathematical modelling of the interaction between leishmania and the macrophage using omics data (ISSF Fellowships)
Wellcome Trust
2015 - 2015
- Tracing transmission pathways of endemic canine rabies (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Validation of metabolomics as a technique to identify determinants of treatment response in HCV infection (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Comparing the fitness and patient landscapes of HIV-1 (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Essential or redundant: Dissection of apicomplexan invasion mechanisms
Wellcome Trust
2014 - 2019
- Identification of stage-specific promoter elements in photosynthetic bacteria (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Investigating The Molecular Basis for Stromal Memory Following Influenza Virus Infection (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Microparticles as carriers of genetic material - a new mechanism of intercellular communication that underlies the pathogenesis of rheumatoid arthritis
Tenovus Scotland
2014 - 2015
- The Wellcome Centre for Molecular Parasitology ( Core Support )
Wellcome Trust
2014 - 2021
- Genetic Determinants of Trypanotolerance in Humans (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- Biomarker Discovery 2.0 - Rigorous and Robust Metabolite Characterization using Mass Spectrometry Fragmentation approaches (ISSF Fellowship)
Wellcome Trust
2014 - 2015
- Modes of Action and Mechanisms of Resistance to the Novel Benzoxaborole Class of Drug against Human African Trypanosomiasis
Medical Research Council
2014 - 2017
- Enabling Stratified Medicine in Early Rheumatoid Arthritis - predicting methotrexate (MTX) response and toxicity using an integrated polyomic approach (PROMISERA)
Scottish Funding Council
2014 - 2018
- Drug resistance and cross-resistance in livestock trypanosomes.
Bill and Melinda Gates Foundation
2014 - 2018
- USE OF METABOLOMICS TO DETERMINE MODES OF ACTION OF NOVEL ANTI-LEISHMANIAL COMPOUNDS
Tres Cantos Open Lab Foundation
2014 - 2016
- Systematic analysis of genes and gene networks that modulate differential macrophage response to Toxoplasma gondii and inflammatory stimuli
Wellcome Trust
2014 - 2015
- Molecular epidemiology of Clostridium difficile in Scotland - developing novel, clinically applicable research methods to combine genomic analysis with health informatics
Scottish Government
2014 - 2015
- A new urinary biomarker for stroke
Medical Research Council
2014 - 2015
- Diamidine and oxaborole transporters and resistance in livestock tryponosomes (Gap Period)
Bill and Melinda Gates Foundation
2014 - 2014
- Omics of adaption to changing/novel environments in plants (ISSF STS)
Wellcome Trust
2014 - 2014
- In vivo imaging models of African trypanosomiasis to support drug discovery programmes
Bill and Melinda Gates Foundation
2014 - 2014
- The use of polyomic analyses to direct biologic therapy in biologic-naive people with Rheumatoid Arthritis
Chief Scientist Office
2013 - 2015
- LAPASO
European Commission
2013 - 2017
- A polyomics based approach to identify molecular pathways and genetic modifiers which influence the development of stroke caused by collagen IV mutations (ISSF)
Wellcome Trust
2013 - 2014
- Development of bioinformatic analysis pipelines to integrate transcriptomic and metabolomic data to map the alpha 7 nicotinic receptor... (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- Modulation of the kynurenic pathway following stroke (ISSF STS)
Wellcome Trust
2013 - 2014
- Prenatal programming of adult disease by maternal smoking: the adrenal gland as a key player? (ISSF)
Wellcome Trust
2013 - 2014
- The Urine Microbiome of Livestock and Wildlife as Source of Zoonotic Bacteria in Tanzania (ISSF)
Wellcome Trust
2013 - 2014
- Phylodynamics of Mycobacterium bovis in badgers (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- Characterisation of Mesenchymal Stem Cells in a 3D Niche Mimic via Microarray (ISSF)
Wellcome Trust
2013 - 2013
- Exome Sequencing for the Genetic Diagnosis of Rare Diseases: Fostering a New Working Relationship between the NHS, the University of Glasgow and Glasgow Polyomics (ISSF)
Wellcome Trust
2013 - 2015
- Gene expression and metabolomic phenotype in response to artificial light at night (ISSF STS)
Wellcome Trust
2013 - 2014
- Genetic diversity and population dynamics of Cryptosporidium species and the use of next generation sequencing data to improve diagnostic and outbreak source identification tools. (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- Novel approaches to recreating animal histories: the metabolic signature of hair (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- Wild Immunomics: characterising protective immunity to helminth infection by integrating transcriptomes and metabolomes of wild rodents (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- Detecting population trends for tick-borne pathogens from genomic data: new tools for managing Lyme disease in Scotland (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- Next generation RNA sequencing predicts patient responses to B cell depletion therapy in rheumatoid arthritis (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- An 'Omics Fingerprint of IL-6 Action in Vascular Endothelial Cells (ISSF STS)
Wellcome Trust
2013 - 2013
- Make Mine Metagenomics: An international collaboration to explore the milk microbiome in dairy cattle (ISSF Catalyst)
Wellcome Trust
2013 - 2014
- The Multi-Corder: Poly-Sensor Technology
Engineering and Physical Sciences Research Council
2013 - 2017
- Integron and omics based acceleration of industrial strain development
Biotechnology and Biological Sciences Research Council
2012 - 2015
- Institutional Strategic Support Fund (ISSF)
Wellcome Trust
2012 - 2018
- Integrated bioinformatics resources for kinetoplastid pathogens.
Wellcome Trust
2012 - 2016
- Bayesian Methods for Metabolite Identification and Analysis (ISSF 2012)
Wellcome Trust
2012 - 2013
- ParaMet - A systematic approach to understanding parasite metabolism.
European Commission
2012 - 2016
- Diamidine transporters and resistance in livestock trypanosomes
Department for International Development
2012 - 2013
- Integrated Health - Polyomics and Systems Biomedicine (ISSF Bid)
Wellcome Trust
2011 - 2014
- Using Polyomics for Target Identification on P. falciparum and T. brucei (ISSF 2012)
Wellcome Trust
2011 - 2014
- Adapting cell phone technology for the diagnosis of malaria
Bill and Melinda Gates Foundation
2011 - 2012
- The silicon trypanosome (SilicoTryp)
Biotechnology and Biological Sciences Research Council
2010 - 2014
- Antiparasitic pyrrolopyrimidines
Medical Research Council
2010 - 2013
- In vivo imaging models of African trypanosomiasis to support drug discovery programmes.
Bill and Melinda Gates Foundation
2010 - 2013
- SULSA Chair in Systems Biology - Cathcart Chair
Scottish Funding Council
2010 - 2014
- KTA-EPSRC: Metabolic Diagnostics on a Chip
Engineering and Physical Sciences Research Council
2009 - 2012
- KTA-EPSRC: Metabolomic Diagnostics on a Chip
Engineering and Physical Sciences Research Council
2009 - 2012
- Wellcome VIP award
Wellcome Trust
2009 - 2010
- Metabolomic systems biology analysis of differentiation in trypanosomes
Biotechnology and Biological Sciences Research Council
2008 - 2011
- Drug resistance in African trypanosomes
Medical Research Council
2008 - 2011
- Scottish Universities Life Sciences Alliance (SULSA)- Systems Biology
Scottish Funding Council
2008 - 2015
- Assessment of the probability of developing resistance to novel trypanocides under consideration for late stage HAT
University of North Carolina at Chapel Hill
2006 - 2010
- Design & Synthesis of Potential Agents for the Treatment of African Trypanosomiasis
Drugs for Neglected Diseases Initiative
2006 - 2006
- Use of transporters to selectively deliver agents to trypanosomes
Medical Research Council
2006 - 2009
- Energy metabolism in trypanosomatic parasites - a target for new drugs
British Council
2006 - 2007
- Surveillance of drug resistance in trypanosomiasis
World Health Organization
2005 - 2006
- The molecular basis of functional divergence between structurally similar monosaccharide transporters in Leishmania
Wellcome Trust
2005 - 2009
- Inhibitors of trypanosomal 6-phosphogluconate dehydrogenase - modes of action and drug delivery strategies
Wellcome Trust
2005 - 2008
- Combatting drug resistance in human African trypanosomiasis
UBS Optimus Foundation
2004 - 2007
- Molecular genetics and biochemistry of parasites
Medical Research Council
2004 - 2009
- A diagnostic test for drug resistance in African trypanosomes
Wellcome Trust
2003 - 2005
- Development Novel Drug Candidates Treatment of Human African Trypanosomiasis & Leish
University of North Carolina at Chapel Hill
2002 - 2006
- Molecular and Biochemical mechanisms of pentamidine resistance in Leishmanaia
Wellcome Trust
2002 - 2005
Supervision
- Donald, Marianne
Metabolomic Approaches to Investigate Pathophysiological Biomarkers of Ischaemic Stroke - Tucker, Samantha
N/A
Research datasets
2022
Hu, C. , Annese, V. , Giagkoulovits, C. , Barrett, M. and Cumming, D. (2022) Factor VIII Companion Diagnostic for Haemophilia. [Data Collection]
2018
NAGY, B., Al-Rawhani, M., Cheah, B. C., Barrett, M. and Cumming, D. (2018) Immunoassay Multiplexing on a Complementary Metal Oxide Semiconductor Photodiode Array. [Data Collection]
2017
Al-Rawhani, M., Cheah, B. C., MacDonald, A., Martin, C., Hu, C. , Beeley, J., Gouveia, L., Grant, J. , Campbell, G., Barrett, M. and Cumming, D. (2017) A colorimetric CMOS-based platform for rapid total serum cholesterol quantification. [Data Collection]
2016
Van Der Hooft, J., Rogers, S. , Wandy, J., Barrett, M. and Burgess, K. (2016) Topic Modeling for Untargeted Substructure Exploration in Metabolomics. [Data Collection]
2015
Cheah, B. C., MacDonald, A., Martin, C., Streklas, A.J., Campbell, G., Al-Rawhani, M., Nemeth, B., Grant, J. , Barrett, M. and Cumming, D. (2015) An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification. [Data Collection]
2014
Hai, Y., Kerkhoven, E. J., Barrett, M. and Christianson, D. W. (2014) Crystal structure of an arginase-like protein from trypanosoma brucei that evolved without a binuclear manganese cluster. [Data Collection]
Additional information
Editorial Board
- 2013 - present: Molecular and Biochemical Parasitology
- 2012 - present: International Journal of Parasitology - Drugs and drug resistance
- 1998 - 2004: Letters in Applied Microbiology
- 1996 - 2004: Journal of Applied Microbiology
- 1996 - present: Biochemical Journal
Grant Advisory Board
- 2004 - present: WHO - Chairman of the Drug Resistance working group of the Tripanosomiasis Network
- 2004 - 2008: WHO - Chairman of the Treatment Failure Working Group of Human African Trypanosomiasis Network (HATNET)
- 2004 - present: WHO - Expert Committee on human African trypanosomiasis
- 2004 - present: WHO - Committee, Treatment and Drug Resistance Network for Sleeping Sickness
- 2001 - present: WHO Scientific Working Group - African Trypanosomiasis
- 2000 - 2002: European Commission Framework V - Evaluator, Quality of Life
Invited International Presentations
- 2013: Geneva, Switzerland - World Health Organisation: Drug efficacy in neglected tropical diseases, "Drug efficacy in the Kinetoplastida"
- 2012: Ottawa, Ontario, Canada - Gates Grand Challenges meeting, "In vivo imaging systems for stage 2 human African trypanosomiasis (HAT)"
- 2012: Atlanta, Georgia, USA - American Society of Tropical Medicine and Hygiene, "Drug resistance in human African trypanosomiasis"
- 2012: Paris, France - French trypanosomatids group, "Metabolic analysis of trypanosomes"
- 2012: Brussels, Belgium - Michels/Opperdoes symposium, "The decline in human African trypanosomiasis - metabolism under siege", De Duve Centre
- 2012: Nantes, France - French Network in Metabolomics and Fluxomics, "Identifying drug modes of action using metabolomics"
- 2012: Geneva, Switzerland - World Health Organisation: Drug efficacy in neglected tropical diseases, "Drug efficacy in the Kinetoplastida"
- 2012: Lysen, Switzerland - Swiss Trypanosomiasis group meeting, "Drug induced changes to the T. brucei metabolome"
- 2011: Philadelphia, Pennsylvania, USA - American Society of Tropical Medicine and Hygiene, "Drug induced changes to the T. brucei metabolome"
- 2011: Clearwater, Florida, USA - Consortium of Parasitic Drug Development, "Drug discovery for trypanosomiasis"
- 2011: Geneva, Switzerland - World Health Organisation: Drug efficacy in neglected tropical diseases, "Treatment failures in human African trypanosomiasis"
- 2010: Paris, France - EC Conference on neglected protozoan diseases, "Innovative drug discovery for human African trypanosomiasis"
- 2002: Chapel Hill, North Carolina, USA - Gates Consortium: New drugs for trypanosomiasis and Leishmaniasis, University of North Carolina
Professional Learned Society
- 2013 - present: Royal Society of Edinburgh - Elected Fellow
- 2011 - present: Developing World Health - Scientific Advisor
