Dr Megan Sloan
- Research Fellow (Parasitology)
Publications
2025
Sloan, M. A. , Scott, A., Aghabi, D., Mrvova, L. and Harding, C. R. (2025) Iron-mediated post-transcriptional regulation in Toxoplasma gondii. PLoS Pathogens, 21(2), e1012857. (doi: 10.1371/journal.ppat.1012857) (PMID:39899594) (PMCID:PMC11801735)
2024
Maclean, A. E., Sloan, M. A. , Renaud, E. A., Argyle, B. E., Lewis, W. H., Ovciarikova, J., Demolombe, V., Waller, R. F., Besteiro, S. and Sheiner, L. (2024) The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. mBio, (doi: 10.1128/mbio.00872-24) (PMID:39207139) (Early Online Publication)
2023
Aghabi, D., Sloan, M. , Gill, G., Hartmann, E., Antipova, O., Dou, Z., Guerra, A. J., Carruthers, V. B. and Harding, C. R. (2023) The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii. Nature Communications, 14, 3659. (doi: 10.1038/s41467-023-39436-y) (PMID:37339985) (PMCID:PMC10281983)
2021
Sloan, M. A. , Aghabi, D. and Harding, C. R. (2021) Orchestrating a heist: uptake and storage of metals by apicomplexan parasites. Microbiology, 167(12), 001114. (doi: 10.1099/mic.0.001114) (PMID:34898419) (PMCID:PMC7612242)
Sloan, M. A. , Sadlova, J., Lestinova, T., Sanders, M. J., Cotton, J. A. , Volf, P. and Ligoxygakis, P. (2021) The Phlebotomus papatasi systemic transcriptional response to trypanosomatid-contaminated blood does not differ from the non-infected blood meal. Parasites and Vectors, 14, 15. (doi: 10.1186/s13071-020-04498-0) (PMID:33407867) (PMCID:PMC7789365)
2020
Sloan, M. A. and Ligoxygakis, P. (2020) Tools for the genetic manipulation of Herpetomonas muscarum. G3: Genes, Genomes, Genetics, 10(5), pp. 1613-1616. (doi: 10.1534/g3.120.401048) (PMID:32205316) (PMCID:PMC7202032)
2019
Sloan, M. A. , Brooks, K., Otto, T. D. , Sanders, M. J., Cotton, J. A. and Ligoxygakis, P. (2019) Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania. PLoS Genetics, 15(11), e1008452. (doi: 10.1371/journal.pgen.1008452) (PMID:31710597) (PMCID:PMC6872171)
Wang, L., Sloan, M. A. and Ligoxygakis, P. (2019) Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model. PLoS Genetics, 15(3), e1007931. (doi: 10.1371/journal.pgen.1007931) (PMID:30822306) (PMCID:PMC6415867)
2017
Alharbi, N. K. et al. (2017) ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice. Vaccine, 35(30), pp. 3780-3788. (doi: 10.1016/j.vaccine.2017.05.032) (PMID:28579232) (PMCID:PMC5516308)
Sloan, M. A. and Ligoxygakis, P. (2017) Immunology of insect vectors: midgut interactions of sandflies and tsetse with kinetoplastid parasites as a paradigm for establishing infection. In: Ligoxygakis, Petros (ed.) Insect Immunity. Series: Advances in insect physiology (52). Academic Press: Cambridge, MA, pp. 231-248. ISBN 9780128117750 (doi: 10.1016/bs.aiip.2017.04.003)
2015
Sloan, M. A. , Reaves, B. J., Maclean, M. J., Storey, B. E. and Wolstenholme, A. J. (2015) Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans. Molecular and Biochemical Parasitology, 204(1), pp. 44-50. (doi: 10.1016/j.molbiopara.2015.12.006) (PMID:26747395) (PMCID:PMC4729587)
2014
Thomas, B., Sloan, M. , Wolstenholme, A. and Kner, P. (2014) 120nm resolution in thick samples with structured illumination and adaptive optics. In: MEMS Adaptive Optics VIII, San Francisco, CA, USA, 01-06 Feb 2014, 89780H. ISBN 9780819498915 (doi: 10.1117/12.2040931)
Articles
Sloan, M. A. , Scott, A., Aghabi, D., Mrvova, L. and Harding, C. R. (2025) Iron-mediated post-transcriptional regulation in Toxoplasma gondii. PLoS Pathogens, 21(2), e1012857. (doi: 10.1371/journal.ppat.1012857) (PMID:39899594) (PMCID:PMC11801735)
Maclean, A. E., Sloan, M. A. , Renaud, E. A., Argyle, B. E., Lewis, W. H., Ovciarikova, J., Demolombe, V., Waller, R. F., Besteiro, S. and Sheiner, L. (2024) The Toxoplasma gondii mitochondrial transporter ABCB7L is essential for the biogenesis of cytosolic and nuclear iron-sulfur cluster proteins and cytosolic translation. mBio, (doi: 10.1128/mbio.00872-24) (PMID:39207139) (Early Online Publication)
Aghabi, D., Sloan, M. , Gill, G., Hartmann, E., Antipova, O., Dou, Z., Guerra, A. J., Carruthers, V. B. and Harding, C. R. (2023) The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii. Nature Communications, 14, 3659. (doi: 10.1038/s41467-023-39436-y) (PMID:37339985) (PMCID:PMC10281983)
Sloan, M. A. , Aghabi, D. and Harding, C. R. (2021) Orchestrating a heist: uptake and storage of metals by apicomplexan parasites. Microbiology, 167(12), 001114. (doi: 10.1099/mic.0.001114) (PMID:34898419) (PMCID:PMC7612242)
Sloan, M. A. , Sadlova, J., Lestinova, T., Sanders, M. J., Cotton, J. A. , Volf, P. and Ligoxygakis, P. (2021) The Phlebotomus papatasi systemic transcriptional response to trypanosomatid-contaminated blood does not differ from the non-infected blood meal. Parasites and Vectors, 14, 15. (doi: 10.1186/s13071-020-04498-0) (PMID:33407867) (PMCID:PMC7789365)
Sloan, M. A. and Ligoxygakis, P. (2020) Tools for the genetic manipulation of Herpetomonas muscarum. G3: Genes, Genomes, Genetics, 10(5), pp. 1613-1616. (doi: 10.1534/g3.120.401048) (PMID:32205316) (PMCID:PMC7202032)
Sloan, M. A. , Brooks, K., Otto, T. D. , Sanders, M. J., Cotton, J. A. and Ligoxygakis, P. (2019) Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania. PLoS Genetics, 15(11), e1008452. (doi: 10.1371/journal.pgen.1008452) (PMID:31710597) (PMCID:PMC6872171)
Wang, L., Sloan, M. A. and Ligoxygakis, P. (2019) Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model. PLoS Genetics, 15(3), e1007931. (doi: 10.1371/journal.pgen.1007931) (PMID:30822306) (PMCID:PMC6415867)
Alharbi, N. K. et al. (2017) ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice. Vaccine, 35(30), pp. 3780-3788. (doi: 10.1016/j.vaccine.2017.05.032) (PMID:28579232) (PMCID:PMC5516308)
Sloan, M. A. , Reaves, B. J., Maclean, M. J., Storey, B. E. and Wolstenholme, A. J. (2015) Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans. Molecular and Biochemical Parasitology, 204(1), pp. 44-50. (doi: 10.1016/j.molbiopara.2015.12.006) (PMID:26747395) (PMCID:PMC4729587)
Book Sections
Sloan, M. A. and Ligoxygakis, P. (2017) Immunology of insect vectors: midgut interactions of sandflies and tsetse with kinetoplastid parasites as a paradigm for establishing infection. In: Ligoxygakis, Petros (ed.) Insect Immunity. Series: Advances in insect physiology (52). Academic Press: Cambridge, MA, pp. 231-248. ISBN 9780128117750 (doi: 10.1016/bs.aiip.2017.04.003)
Conference Proceedings
Thomas, B., Sloan, M. , Wolstenholme, A. and Kner, P. (2014) 120nm resolution in thick samples with structured illumination and adaptive optics. In: MEMS Adaptive Optics VIII, San Francisco, CA, USA, 01-06 Feb 2014, 89780H. ISBN 9780819498915 (doi: 10.1117/12.2040931)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- An iron lens for translational regulation in Toxoplasma gondii
Wellcome Trust
2022 - 2027