Ms Lynn Stewart
- Research Associate (Immunology & Infection)
telephone:
0141 330 6267
email:
Lynn.Stewart@glasgow.ac.uk
SGDB B405, 120 University Place, Glasgow, G12 8TA
Biography
I graduated with a 2:1 BSc Hons Degree in Biology from the University of Paisley in 1997, and have since acquired 22 years of experience in immunobiology research, firstly as a Senior Technician in a Canadian allergy and asthma research lab at McMaster University, studying respiratory inflammation, markers of allergic disease and the mechanisms of these diseases to help develop therapeutics.
In 2010, I relocated back to Scotland and for the past 12 years my tenure has been at the University of Glasgow working within the Immunobiology research group with four different investigators. I have worked on basic research, clinical trials and drug discovery themed projects, with a focus on musculoskeletal diseases including rheumatoid arthritis (RA), psoriatic arthritis (PsA), tendinopathies and the role of miRNAs in auto-immune disease.
In 2014, I was appointed as part of a team working in collaboration with a well-known industry partner, working on various projects that were proposed by researchers to help further explore the mechanistic actions of some of the small compound libraries that are available as drug therapies and use bio-banked and clinical samples to study their effect. This utilised my skills in multi-parameter FACS acquisition, cell culture and transfection, qPCR, co-culturing of cells and multiplex protein detection assays.
From August 2018 until February 2023, I worked with Causeway Therapeutics, a small pharma spin-off company based at the University of Glasgow, on various projects related to the discovery and development of therapies to promote healthy ageing. During this time, I was also site lab coordinator for the BioFLARE study, a multi-centre clinical trial cohort that focused on identifying biomarkers of RA remission and flare, helping to inform and predict tailored disease therapies.
At present, I am a Research Associate working with Dr Aurelie Najm on the discovery and validation of new biomarkers and therapeutic targets in rheumatic disease and associated interstitial lung disease. In January 2023, I was awarded a Level 5 Chartered Management Institute qualification in Leadership and Management.
Publications
2023
Barnes, E. et al. (2023) SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29(7), pp. 1760-1774. (doi: 10.1038/s41591-023-02414-4) (PMID:37414897) (PMCID:PMC10353927)
2017
Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)
Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)
2016
Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)
2011
Reece, P., Thanendran, A., Crawford, L., Tulic, M. K., Thabane, L., Prescott, S. L., Sehmi, R. and Denburg, J. A. (2011) Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function. Journal of Allergy and Clinical Immunology, 127(2), pp. 447-453. (doi: 10.1016/j.jaci.2010.11.006)
Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.
2010
Ellis, A. K., Ackerman, S. J., Crawford, L., Du, J., Bedi, R. and Denburg, J. A. (2010) Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5Rα mRNA expression. Pediatric Allergy and Immunology, 21(4p1), pp. 640-648. (doi: 10.1111/j.1399-3038.2010.01003.x)
Ellis, A.K., Fraser, K., Crawford, L. and Denburg, J.A. (2010) Cord blood eosinophil progenitor expression of major basic protein mRNA is associated with maternal atopic sensitization. Journal of Allergy and Clinical Immunology, 125(2), AB231. (doi: 10.1016/j.jaci.2009.12.901)
Reece, P., Crawford, L., Baajtes, A., Cyr, M., Sehmi, R. and Denburg, J.A. (2010) Cord blood hemopoietic progenitor cell toll-like receptor expression and function: a mechanism underlying allergic inflammation in early life. Journal of Allergy and Clinical Immunology, 125(2), AB105. (doi: 10.1016/j.jaci.2009.12.415)
2009
Ellis, A.K., Crawford, L. and Denburg, J.A. (2009) Cord blood CD34 + hemopoietic progenitor eosinophilic lineage commitment assessed by Q-PCR. Journal of Allergy and Clinical Immunology, 123(2), S225. (doi: 10.1016/j.jaci.2008.12.862)
Goronfolah, L.T., Ferrie, P., Schmuck, M., Waserman, S., Denburg, J., Kott, L., Keith, P., Crawford, L. and Fletcher, R. (2009) A double-blind, placebo-controlled, randomized, crossover trial of a mint tea high in rosmarinic acid in adults with nasal polyposis. Journal of Allergy and Clinical Immunology, 123(2), S202-S202. (doi: 10.1016/j.jaci.2008.12.771)
Reece, P., Crawford, L. and Denburg, J.A. (2009) Cord blood (BR) progenitor toll- like receptor (TLR) expression: an alternate innate immune pathway in the development of atopy. Journal of Allergy and Clinical Immunology, 123(2), S50-S50. (doi: 10.1016/j.jaci.2008.12.158)
2008
Cyr, M. M., Baatjes, A. J., Dorman, S. C., Crawford, L., Sehmi, R., Foley, R., Alam, R., O'Byrne, P. and Denburg, J. A. (2008) In Vitro effects of budesonide on eosinophil-basophil lineage commitment. Open Respiratory Medicine Journal, 2(1), pp. 60-66. (doi: 10.2174/1874306400802010060)
2007
Roa, J., Morikawa, H., Crawford, L., Baatjes, A., Duong, M. and Denburg, J. A. (2007) The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiency. Immunology, 122(3), pp. 438-444. (doi: 10.1111/j.1365-2567.2007.02664.x)
Crawford, L., Ellis, A.K. and Denburg, J.A. (2007) Kinetics of cord blood eosinophil lineage biomarker mRNA: co-expression of CysLTR1 with GATA-1. Journal of Allergy and Clinical Immunology, 119(1), S215. (doi: 10.1016/j.jaci.2006.12.213)
Ellis, A.K., Crawford, L. and Denburg, J.A. (2007) Molecular markers of eosinophilopoiesis: multiplex Q-PCR analysis of GATA-1, MBP and IL-5 receptor mRNA expression in peripheral blood. Journal of Allergy and Clinical Immunology, 119(1), S218. (doi: 10.1016/j.jaci.2006.12.225)
2006
Ellis, A.K., Crawford, L. and Denburg, J.A. (2006) Molecular markers of eosinophilopoiesis at birth: kinetics of cord blood GATA-1, MBP and IL-5 receptor expression. Journal of Allergy and Clinical Immunology, 117(2), S60. (doi: 10.1016/j.jaci.2005.12.241)
2005
Cyr, M. M., Hayes, L. M., Crawford, L., Baatjes, A. J., Keith, P. K. and Denburg, J. A. (2005) The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study. International Archives of Allergy and Immunology, 138(3), pp. 209-216. (doi: 10.1159/000088721)
Li, J., Saito, H., Crawford, L., Inman, M. D., Cyr, M. M. and Denburg, J. A. (2005) Haemopoietic mechanisms in murine allergic upper and lower airway inflammation. Immunology, 114(3), pp. 386-396. (doi: 10.1111/j.1365-2567.2005.02109.x)
Cyr, M.M., Crawford, L. and Denburg, J.A. (2005) The effect of lipopolysaccharide (LPS) on cord-blood hemopoietic progenitors. Journal of Allergy and Clinical Immunology, 115(2), S191. (doi: 10.1016/j.jaci.2004.12.776)
Morikawa, H., Howie, K., Crawford, L., Cyr, M.M. and Denburg, J.A. (2005) Interactive effects of a cysteinyl leukotriene receptor (CysLT1R) antagonist, montelukast (ML), and IL-5 deficiency in murine experimental allergic rhinitis. Journal of Allergy and Clinical Immunology, 115(2), S194. (doi: 10.1016/j.jaci.2004.12.786)
2004
Saito, H., Morikawa, H., Howie, K., Crawford, L., Baatjes, A. J., Denburg, E., Cyr, M. M. and Denburg, J. A. (2004) Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Immunology, 113(2), pp. 246-252. (doi: 10.1111/j.1365-2567.2004.01944.x)
Crawford, L., Baatjes, A.J., Cyr, M.M., Hayes, L.M. and Denburg, J.A. (2004) Kinetics of GATA-1 expression in cord blood eosinophil progenitors: effects of Budesonide. Journal of Allergy and Clinical Immunology, 113(2), S169. (doi: 10.1016/j.jaci.2004.01.042)
Li, J., Saito, H., Crawford, L. and Denburg, J.A. (2004) Local and systemic responses in murine experimental allergic airways inflammation: mechanisms linking rhinitis to asthma. Journal of Allergy and Clinical Immunology, 113(2), S186-S187. (doi: 10.1016/j.jaci.2004.01.109)
2003
Li, J., Saito, H., Crawford, L. and Denburg, J.A. (2003) Responses of bone-marrow eosinophil/basophil progenitors in experimental mouse models of upper and/or lower airway inflammation. Journal of Allergy and Clinical Immunology, 111(2), S280. (doi: 10.1016/S0091-6749(03)81005-9)
Saito, H., Crawford, L., Denburg, E. and Denburg, J.A. (2003) The role of cysteinyl leukotrienes (CysLTS) in bone marrow responses in murine experimental allergic rhinitis: blockade of eosinophil production and tissue eosinophilia by a CysLT1 receptor antagonist. Journal of Allergy and Clinical Immunology, 111(2), S266. (doi: 10.1016/S0091-6749(03)80952-1)
2002
Saito, H., Matsumoto, K., Denburg, A. E., Crawford, L., Ellis, R., Inman, M. D., Sehmi, R., Takatsu, K., Matthaei, K. I. and Denburg, J. A. (2002) Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. Journal of Immunology, 168(6), pp. 3017-3023. (doi: 10.4049/jimmunol.168.6.3017)
Baatjes, A. J., Crawford, L., Cyr, M. M., Dorman, S., Foley, R., Hayes, L. M., Sehmi, R. and Denburg, J. A. (2002) The combined effect of all trans retinoic acid and the glucocorticoid, budesonide, on eosinophil differentiation from cord blood-derived CD34+ progenitor cells in vitro. Journal of Allergy and Clinical Immunology, 109(1), S166. (doi: 10.1016/S0091-6749(02)81626-8)
Crawford, L., Saito, H., Inman, M. D. and Denburg, J. A. (2002) Effects of the cysteinyl leukotriene receptor antagonist, montelukast, on eosinophil differentiation in an experimental mouse model of allergic rhinitis. Journal of Allergy and Clinical Immunology, 109(1), S296-S296. (doi: 10.1016/S0091-6749(02)82041-3)
Cyr, M. M., Baatjes, A. J., Hayes, L. M., Crawford, L. and Denburg, J. A. (2002) The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study. Journal of Allergy and Clinical Immunology, 109(1), S117. (doi: 10.1016/S0091-6749(02)81465-8)
Saito, H., Crawford, L., Denburg, A., Inman, M. D. and Denburg, J. A. (2002) Is IL-5 suppression sufficient to control eosinophilic airway allery?: studies of experimental allergic rhinitis in IL-5 deficient mice. Journal of Allergy and Clinical Immunology, 109(1), S255. (doi: 10.1016/S0091-6749(02)81913-3)
Articles
Barnes, E. et al. (2023) SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. Nature Medicine, 29(7), pp. 1760-1774. (doi: 10.1038/s41591-023-02414-4) (PMID:37414897) (PMCID:PMC10353927)
Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)
Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)
Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)
Reece, P., Thanendran, A., Crawford, L., Tulic, M. K., Thabane, L., Prescott, S. L., Sehmi, R. and Denburg, J. A. (2011) Maternal allergy modulates cord blood hematopoietic progenitor Toll-like receptor expression and function. Journal of Allergy and Clinical Immunology, 127(2), pp. 447-453. (doi: 10.1016/j.jaci.2010.11.006)
Ellis, A. K., Ackerman, S. J., Crawford, L., Du, J., Bedi, R. and Denburg, J. A. (2010) Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5Rα mRNA expression. Pediatric Allergy and Immunology, 21(4p1), pp. 640-648. (doi: 10.1111/j.1399-3038.2010.01003.x)
Ellis, A.K., Fraser, K., Crawford, L. and Denburg, J.A. (2010) Cord blood eosinophil progenitor expression of major basic protein mRNA is associated with maternal atopic sensitization. Journal of Allergy and Clinical Immunology, 125(2), AB231. (doi: 10.1016/j.jaci.2009.12.901)
Reece, P., Crawford, L., Baajtes, A., Cyr, M., Sehmi, R. and Denburg, J.A. (2010) Cord blood hemopoietic progenitor cell toll-like receptor expression and function: a mechanism underlying allergic inflammation in early life. Journal of Allergy and Clinical Immunology, 125(2), AB105. (doi: 10.1016/j.jaci.2009.12.415)
Ellis, A.K., Crawford, L. and Denburg, J.A. (2009) Cord blood CD34 + hemopoietic progenitor eosinophilic lineage commitment assessed by Q-PCR. Journal of Allergy and Clinical Immunology, 123(2), S225. (doi: 10.1016/j.jaci.2008.12.862)
Goronfolah, L.T., Ferrie, P., Schmuck, M., Waserman, S., Denburg, J., Kott, L., Keith, P., Crawford, L. and Fletcher, R. (2009) A double-blind, placebo-controlled, randomized, crossover trial of a mint tea high in rosmarinic acid in adults with nasal polyposis. Journal of Allergy and Clinical Immunology, 123(2), S202-S202. (doi: 10.1016/j.jaci.2008.12.771)
Reece, P., Crawford, L. and Denburg, J.A. (2009) Cord blood (BR) progenitor toll- like receptor (TLR) expression: an alternate innate immune pathway in the development of atopy. Journal of Allergy and Clinical Immunology, 123(2), S50-S50. (doi: 10.1016/j.jaci.2008.12.158)
Cyr, M. M., Baatjes, A. J., Dorman, S. C., Crawford, L., Sehmi, R., Foley, R., Alam, R., O'Byrne, P. and Denburg, J. A. (2008) In Vitro effects of budesonide on eosinophil-basophil lineage commitment. Open Respiratory Medicine Journal, 2(1), pp. 60-66. (doi: 10.2174/1874306400802010060)
Roa, J., Morikawa, H., Crawford, L., Baatjes, A., Duong, M. and Denburg, J. A. (2007) The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiency. Immunology, 122(3), pp. 438-444. (doi: 10.1111/j.1365-2567.2007.02664.x)
Crawford, L., Ellis, A.K. and Denburg, J.A. (2007) Kinetics of cord blood eosinophil lineage biomarker mRNA: co-expression of CysLTR1 with GATA-1. Journal of Allergy and Clinical Immunology, 119(1), S215. (doi: 10.1016/j.jaci.2006.12.213)
Ellis, A.K., Crawford, L. and Denburg, J.A. (2007) Molecular markers of eosinophilopoiesis: multiplex Q-PCR analysis of GATA-1, MBP and IL-5 receptor mRNA expression in peripheral blood. Journal of Allergy and Clinical Immunology, 119(1), S218. (doi: 10.1016/j.jaci.2006.12.225)
Ellis, A.K., Crawford, L. and Denburg, J.A. (2006) Molecular markers of eosinophilopoiesis at birth: kinetics of cord blood GATA-1, MBP and IL-5 receptor expression. Journal of Allergy and Clinical Immunology, 117(2), S60. (doi: 10.1016/j.jaci.2005.12.241)
Cyr, M. M., Hayes, L. M., Crawford, L., Baatjes, A. J., Keith, P. K. and Denburg, J. A. (2005) The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study. International Archives of Allergy and Immunology, 138(3), pp. 209-216. (doi: 10.1159/000088721)
Li, J., Saito, H., Crawford, L., Inman, M. D., Cyr, M. M. and Denburg, J. A. (2005) Haemopoietic mechanisms in murine allergic upper and lower airway inflammation. Immunology, 114(3), pp. 386-396. (doi: 10.1111/j.1365-2567.2005.02109.x)
Cyr, M.M., Crawford, L. and Denburg, J.A. (2005) The effect of lipopolysaccharide (LPS) on cord-blood hemopoietic progenitors. Journal of Allergy and Clinical Immunology, 115(2), S191. (doi: 10.1016/j.jaci.2004.12.776)
Morikawa, H., Howie, K., Crawford, L., Cyr, M.M. and Denburg, J.A. (2005) Interactive effects of a cysteinyl leukotriene receptor (CysLT1R) antagonist, montelukast (ML), and IL-5 deficiency in murine experimental allergic rhinitis. Journal of Allergy and Clinical Immunology, 115(2), S194. (doi: 10.1016/j.jaci.2004.12.786)
Saito, H., Morikawa, H., Howie, K., Crawford, L., Baatjes, A. J., Denburg, E., Cyr, M. M. and Denburg, J. A. (2004) Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Immunology, 113(2), pp. 246-252. (doi: 10.1111/j.1365-2567.2004.01944.x)
Crawford, L., Baatjes, A.J., Cyr, M.M., Hayes, L.M. and Denburg, J.A. (2004) Kinetics of GATA-1 expression in cord blood eosinophil progenitors: effects of Budesonide. Journal of Allergy and Clinical Immunology, 113(2), S169. (doi: 10.1016/j.jaci.2004.01.042)
Li, J., Saito, H., Crawford, L. and Denburg, J.A. (2004) Local and systemic responses in murine experimental allergic airways inflammation: mechanisms linking rhinitis to asthma. Journal of Allergy and Clinical Immunology, 113(2), S186-S187. (doi: 10.1016/j.jaci.2004.01.109)
Li, J., Saito, H., Crawford, L. and Denburg, J.A. (2003) Responses of bone-marrow eosinophil/basophil progenitors in experimental mouse models of upper and/or lower airway inflammation. Journal of Allergy and Clinical Immunology, 111(2), S280. (doi: 10.1016/S0091-6749(03)81005-9)
Saito, H., Crawford, L., Denburg, E. and Denburg, J.A. (2003) The role of cysteinyl leukotrienes (CysLTS) in bone marrow responses in murine experimental allergic rhinitis: blockade of eosinophil production and tissue eosinophilia by a CysLT1 receptor antagonist. Journal of Allergy and Clinical Immunology, 111(2), S266. (doi: 10.1016/S0091-6749(03)80952-1)
Saito, H., Matsumoto, K., Denburg, A. E., Crawford, L., Ellis, R., Inman, M. D., Sehmi, R., Takatsu, K., Matthaei, K. I. and Denburg, J. A. (2002) Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. Journal of Immunology, 168(6), pp. 3017-3023. (doi: 10.4049/jimmunol.168.6.3017)
Baatjes, A. J., Crawford, L., Cyr, M. M., Dorman, S., Foley, R., Hayes, L. M., Sehmi, R. and Denburg, J. A. (2002) The combined effect of all trans retinoic acid and the glucocorticoid, budesonide, on eosinophil differentiation from cord blood-derived CD34+ progenitor cells in vitro. Journal of Allergy and Clinical Immunology, 109(1), S166. (doi: 10.1016/S0091-6749(02)81626-8)
Crawford, L., Saito, H., Inman, M. D. and Denburg, J. A. (2002) Effects of the cysteinyl leukotriene receptor antagonist, montelukast, on eosinophil differentiation in an experimental mouse model of allergic rhinitis. Journal of Allergy and Clinical Immunology, 109(1), S296-S296. (doi: 10.1016/S0091-6749(02)82041-3)
Cyr, M. M., Baatjes, A. J., Hayes, L. M., Crawford, L. and Denburg, J. A. (2002) The effect of desloratadine on eosinophil/basophil progenitors and other inflammatory markers in seasonal allergic rhinitis: a placebo-controlled randomized study. Journal of Allergy and Clinical Immunology, 109(1), S117. (doi: 10.1016/S0091-6749(02)81465-8)
Saito, H., Crawford, L., Denburg, A., Inman, M. D. and Denburg, J. A. (2002) Is IL-5 suppression sufficient to control eosinophilic airway allery?: studies of experimental allergic rhinitis in IL-5 deficient mice. Journal of Allergy and Clinical Immunology, 109(1), S255. (doi: 10.1016/S0091-6749(02)81913-3)
Conference Proceedings
Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.
