Dr Laura Medina-Ruiz
- Honorary Senior Lecturer (School of Infection & Immunity)
Publications
2024
Medina-Ruiz, L., Bartolini, R. , Mathie, H., Halawa, H. A., Cunningham, M. and Graham, G. (2024) CCR1 and CCR2 coexpression on monocytes is nonredundant and delineates a distinct monocyte subpopulation. Journal of Immunology, (doi: 10.4049/jimmunol.2400007) (PMID:38829123) (Early Online Publication)
2023
Cuesta-Gomez, N., Medina-Ruiz, L., Graham, G. J. and Campbell, J. D.M. (2023) IL-6 and TGF-β-secreting adoptively-transferred murine mesenchymal stromal cells accelerate healing of psoriasis-like skin inflammation and upregulate IL-17A and TGF-β. International Journal of Molecular Sciences, 24(12), 10132. (doi: 10.3390/ijms241210132) (PMID:37373278) (PMCID:PMC10298958)
Gray, A. L. et al. (2023) Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Reports, 42(1), 111930. (doi: 10.1016/j.celrep.2022.111930) (PMID:36640356)
2022
Bartolini, R. , Medina-Ruiz, L., Hayes, A. J., Kelly, C. J., Halawa, H. A. and Graham, G. J. (2022) Inflammatory chemokine receptors support inflammatory macrophage and dendritic cell maturation. ImmunoHorizons, 6(11), pp. 743-759. (doi: 10.4049/immunohorizons.2200069) (PMID:36426967)
Medina-Ruiz, L. et al. (2022) Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice. eLife, 11, e72418. (doi: 10.7554/eLife.72418) (PMID:35699420) (PMCID:PMC9236609)
2021
Passman, A. M. et al. (2021) Maraviroc prevents HCC development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model. Cancers, 13(19), 4935. (doi: 10.3390/cancers13194935) (PMID:34638423) (PMCID:PMC8508380)
2020
Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)
2019
Lee, K. M., Wilson, G. J. , Pingen, M. , Fukuoka, A. , Hansell, C. A.H., Bartolini, R., Medina-Ruiz, L. and Graham, G. J. (2019) Placental chemokine compartmentalisation: a novel mammalian molecular control mechanism. PLoS Biology, 17(5), e3000287. (doi: 10.1371/journal.pbio.3000287) (PMID:31141500) (PMCID:PMC6557524)
Dyer, D. P. , Nebot, J. B., Kelly, C. J., Medina-Ruiz, L., Schuette, F. and Graham, G. J. (2019) The chemokine receptor CXCR2 contributes to murine adipocyte development. Journal of Leukocyte Biology, 105(3), pp. 497-506. (doi: 10.1002/JLB.1A0618-216RR) (PMID:30517976) (PMCID:PMC6392114)
Dyer, D. P. et al. (2019) Chemokine receptor redundancy and specificity are context dependent. Immunity, 50(2), 378-389.e5. (doi: 10.1016/j.immuni.2019.01.009) (PMID:30784579) (PMCID:PMC6382461)
2018
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
2017
Dyer, D. P. , Pallas, K., Medina Ruiz, L., Schuette, F., Wilson, G. J. and Graham, G. J. (2017) CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses. Scientific Reports, 7, 42681. (doi: 10.1038/srep42681) (PMID:28205614) (PMCID:PMC5311995)
2011
Quesada, V., Sarmiento-Mañús, R., González-Bayón, R., Hricová, A., Pérez-Marcos, R., Graciá-Martínez, E., Medina-Ruiz, L., Leyva-Díaz, E., Ponce, M. R. and Micol, J. L. (2011) Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development. Plant Journal, 68(4), pp. 738-753. (doi: 10.1111/j.1365-313X.2011.04726.x) (PMID:21790815)
2010
Medina-Ruiz, L., Campoy, S., Latasa, C., Cardenas, P., Alonso, J. C. and Barbé, J. (2010) Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica. Infection and Immunity, 78(7), pp. 3217-3225. (doi: 10.1128/IAI.01321-09) (PMID:20457791) (PMCID:PMC2897385)
Articles
Medina-Ruiz, L., Bartolini, R. , Mathie, H., Halawa, H. A., Cunningham, M. and Graham, G. (2024) CCR1 and CCR2 coexpression on monocytes is nonredundant and delineates a distinct monocyte subpopulation. Journal of Immunology, (doi: 10.4049/jimmunol.2400007) (PMID:38829123) (Early Online Publication)
Cuesta-Gomez, N., Medina-Ruiz, L., Graham, G. J. and Campbell, J. D.M. (2023) IL-6 and TGF-β-secreting adoptively-transferred murine mesenchymal stromal cells accelerate healing of psoriasis-like skin inflammation and upregulate IL-17A and TGF-β. International Journal of Molecular Sciences, 24(12), 10132. (doi: 10.3390/ijms241210132) (PMID:37373278) (PMCID:PMC10298958)
Gray, A. L. et al. (2023) Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Reports, 42(1), 111930. (doi: 10.1016/j.celrep.2022.111930) (PMID:36640356)
Bartolini, R. , Medina-Ruiz, L., Hayes, A. J., Kelly, C. J., Halawa, H. A. and Graham, G. J. (2022) Inflammatory chemokine receptors support inflammatory macrophage and dendritic cell maturation. ImmunoHorizons, 6(11), pp. 743-759. (doi: 10.4049/immunohorizons.2200069) (PMID:36426967)
Medina-Ruiz, L. et al. (2022) Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice. eLife, 11, e72418. (doi: 10.7554/eLife.72418) (PMID:35699420) (PMCID:PMC9236609)
Passman, A. M. et al. (2021) Maraviroc prevents HCC development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model. Cancers, 13(19), 4935. (doi: 10.3390/cancers13194935) (PMID:34638423) (PMCID:PMC8508380)
Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)
Lee, K. M., Wilson, G. J. , Pingen, M. , Fukuoka, A. , Hansell, C. A.H., Bartolini, R., Medina-Ruiz, L. and Graham, G. J. (2019) Placental chemokine compartmentalisation: a novel mammalian molecular control mechanism. PLoS Biology, 17(5), e3000287. (doi: 10.1371/journal.pbio.3000287) (PMID:31141500) (PMCID:PMC6557524)
Dyer, D. P. , Nebot, J. B., Kelly, C. J., Medina-Ruiz, L., Schuette, F. and Graham, G. J. (2019) The chemokine receptor CXCR2 contributes to murine adipocyte development. Journal of Leukocyte Biology, 105(3), pp. 497-506. (doi: 10.1002/JLB.1A0618-216RR) (PMID:30517976) (PMCID:PMC6392114)
Dyer, D. P. et al. (2019) Chemokine receptor redundancy and specificity are context dependent. Immunity, 50(2), 378-389.e5. (doi: 10.1016/j.immuni.2019.01.009) (PMID:30784579) (PMCID:PMC6382461)
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
Dyer, D. P. , Pallas, K., Medina Ruiz, L., Schuette, F., Wilson, G. J. and Graham, G. J. (2017) CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses. Scientific Reports, 7, 42681. (doi: 10.1038/srep42681) (PMID:28205614) (PMCID:PMC5311995)
Quesada, V., Sarmiento-Mañús, R., González-Bayón, R., Hricová, A., Pérez-Marcos, R., Graciá-Martínez, E., Medina-Ruiz, L., Leyva-Díaz, E., Ponce, M. R. and Micol, J. L. (2011) Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development. Plant Journal, 68(4), pp. 738-753. (doi: 10.1111/j.1365-313X.2011.04726.x) (PMID:21790815)
Medina-Ruiz, L., Campoy, S., Latasa, C., Cardenas, P., Alonso, J. C. and Barbé, J. (2010) Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica. Infection and Immunity, 78(7), pp. 3217-3225. (doi: 10.1128/IAI.01321-09) (PMID:20457791) (PMCID:PMC2897385)