Dr Justine Rudkin
- Lecturer in Bacteriology (Bacteriology)
email:
Justine.Rudkin@glasgow.ac.uk
pronouns:
She/her/hers
Sir Graeme Davies Building, 126 University Place, Glasgow, Glasgow City, Scotland, G12 8TA
Biography
Education:
BSc Tropical Disease Biology, University of Liverpool, 2008
PhD Molecular Microbiology, University of Bath, 2012
PGCert Teaching & Learning in Higher Education, UCC, 2018
Career History:
Lecturer in Bacteriology, University of Glasgow, 2024-present
Senior Postdoctoral Researcher, University of Oxford, 2018-2023
IRC Research Fellow, University College Cork, 2016-2018
Postdoctoral Researcher, APC Microbiome Institute Ireland, 2016
Postdoctoral Researcher, University of Galway, 2012-2015
Publications:
https://orcid.org/0000-0002-3044-0459
Professional Activities:
Editor, Access Microbiology, an Open Research Platform
Committee Member, Impact & Influence Committee, Microbiology Society UK
Research interests
A Bacterium of Two Halves; The Commensal and Pathogenic Lifestyle of Staphylococcus aureus
Staphylococcus aureus is a commensal microbe colonising the nose of some healthy individuals, but it is also an important and potentially lethal pathogen. Within the nose S. aureus colonises as part of the microbiome and my research group is interested in interactions between S. aureus and the other microbes in the nasal niche. We are interested in how microbe-microbe interactions influence colonisation at the host-microbe interface, and how interactions between S. aureus and other skin and respiratory pathogens impacts on virulence and the onset of infection. Are there any other species that help S. aureus to colonise, or indeed any that block it from becoming a resident? What mechanisms underpin these interactions, and can we use this information to modulate the emergence of infections?
My group utilizes a combination of co-culture assays, functional genomics and phenotyping, alongside community analysis (DNA and RNASeq) approaches to investigate how this bacterium adapts to these two different lifestyles, and how conditions within these different niche drive bacterial evolution and pathogenicity.
We are open to collaboration with other teams working on the nasal niche who have an interest in microbe-microbe or host-pathogen interactions, as well as people with an interest in other skin or respiratory infections (bacterial, viral, fungal, phage).
Publications
Prior publications
ORCiD
Hilton B, Wilson DJ, O'Connell AM, Ironmonger D, Rudkin JK, Allen N, Oliver I, Wyllie DH, (2023) Laboratory diagnosed microbial infection in English UK Biobank participants in comparison to the general population. Scientific reports (pmid: 36627297)(pmc: PMC9831014)(doi: 10.1038/s41598-022-20635-4); source: Justine Rudkin
COVID-19 Host Genetics Initiative, (2022) A first update on mapping the human genetic architecture of COVID-19. Nature (pmid: 35922517)(pmc: PMC9352569)(doi: 10.1038/s41586-022-04826-7); source: Justine Rudkin
Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Stuckey A, Odhams CA, susan walker, Russell CD, Tomas Malinauskas, Yang Wu, Millar J, Xia Shen, Katherine Elliott, Griffiths F, Oosthuyzen W, Morrice K, Sean Keating, Bo Wang, Rhodes D, Lucija Klarić, Zechner M, Nicholas Parkinson, Siddiq A, Goddard P, Donovan S, Maslove D, Alistair Nichol, Malcolm Gracie Semple OBE, Zainy T, Maleady-Crowe F, Todd L, Shahla Salehi, Julian Knight, Greg Elgar, Chan G, Arumugam P, Christine Patch, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Aris Baras, Goncalo Abecasis, Manuel Ferreira, Justice A, Mirshahi T, Oetjens M, Daniel Rader, Marylyn D Ritchie, Verma A, Fowler TA, (2022) Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature (pmid: 35255492)(pmc: PMC9259496)(doi: 10.1038/s41586-022-04576-6); source: Justine Rudkin
Alain Townsend, Rijal P, Xiao J, Tiong Kit Tan, Kuan-Ying Huang, Schimanski L, Huo J, Nimesh Gupta, Rolle Rahikainen, Philippa C Matthews, Derrick Crook, Hoosdally S, Susanna Dunachie, Eleanor Barnes, Street T, Christopher Conlon, John Frater, Arancibia-Cárcamo CV, Rudkin J, Nicole Stoesser, Karpe F, Matt Neville, Rutger J Ploeg, Oliveira M, Roberts DJ, Lamikanra AA, Tsang HP, Bown A, Vipond R, Alexander Mentzer, Julian Knight, Andrew Kwok, Gavin Screaton, Juthathip Mongkolsapaya, Dejnirattisai W, Supasa P, paul klenerman, christina dold, John Kenneth Baillie, Shona C Moore, Peter JM Openshaw, Malcolm Gracie Semple OBE, Lance Turtle, Ainsworth M, Alice Allcock, Sally Beer, Sagida Bibi, Donal Skelly, Lizzie Stafford, Katie Jeffery, O'Donnell D, (2021) A haemagglutination test for rapid detection of antibodies to SARS-CoV-2. Nature communications (pmid: 33782398)(pmc: PMC8007702)(doi: 10.1038/s41467-021-22045-y); source: Justine Rudkin
Monique I. Andersson, Carolina V. Arancibia-Carcamo, Kathryn Auckland, J. Kenneth Baillie, Eleanor Barnes, Tom Beneke, Sagida Bibi, Tim Brooks, Miles Carroll, Derrick Crook, Kate Dingle, Christina Dold, Louise O. Downs, Laura Dunn, David W. Eyre, Javier Gilbert Jaramillo, Heli Harvala, Sarah Hoosdally, Samreen Ijaz, Tim James, William James, Katie Jeffery, Anita Justice, Paul Klenerman, Julian C. Knight, Michael Knight, Xu Liu, Sheila F. Lumley, Philippa C. Matthews, Anna L. McNaughton, Alexander J. Mentzer, Juthathip Mongkolsapaya, Sarah Oakley, Marta S. Oliveira, Timothy Peto, Rutger J. Ploeg, Jeremy Ratcliff, Melanie J. Robbins, David J. Roberts, Justine Rudkin, Rebecca A. Russell, Gavin Screaton, Malcolm G. Semple, Donal Skelly, Peter Simmonds, Nicole Stoesser, Lance Turtle, Susan Wareing, Maria Zambon, (2020) SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus [version 2; peer review: 2 approved] (doi: 10.12688/wellcomeopenres.16002.2)(issn: 2398-502X); source: Wellcome Open Research
National SARS-CoV-2 Serology Assay Evaluation Group, (2020) Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison. The Lancet. Infectious diseases (pmid: 32979318)(pmc: PMC7511171)(doi: 10.1016/s1473-3099(20)30634-4); source: Justine Rudkin
Severe Covid-19 GWAS Group, David Ellinghaus, Frauke Degenhardt, Luis Bujanda, Buti M, Albillos A, Invernizzi P, Fernández J, Daniele Prati, Guido Alessandro Baselli, Rosanna Asselta, Grimsrud MM, Milani C, Jan Christian Kässens, Kässens J, May S, Mareike Wendorff, Lars Wienbrandt, Uellendahl-Werth F, Zheng T, Yi X, Raúl de Pablo Sánchez, Chercoles AG, Palom A, Alba Estela García-Fernández, Rodriguez-Frias F, ALESSANDRA BANDERA, Bandera A, Alessandro Protti, Aghemo A, Lleo A, Andrea Biondi, Caballero-Garralda A, Gori A, Tanck A, Carreras Nolla A, Anna Latiano, Fracanzani AL, Peschuck A, Julià A, Pesenti A, Voza A, Jiménez D, Mateos B, Nafria Jimenez B, Quereda C, Paccapelo C, Christoph Gassner, Angelini C, Cea C, Solier A, (2020) Genomewide Association Study of Severe Covid-19 with Respiratory Failure. The New England journal of medicine (pmid: 32558485)(pmc: PMC7315890)(doi: 10.1056/nejmoa2020283); source: Justine Rudkin
Emily R. Adams, Mark Ainsworth, Rekha Anand, Monique I. Andersson, Kathryn Auckland, J. Kenneth Baillie, Eleanor Barnes, Sally Beer, John I. Bell, Tamsin Berry, Sagida Bibi, Miles Carroll, Senthil K. Chinnakannan, Elizabeth Clutterbuck, Richard J. Cornall, Derrick W. Crook, Thushan de Silva, Wanwisa Dejnirattisai, Kate E. Dingle, Christina Dold, Alexis Espinosa, David W. Eyre, Helen Farmer, Maria Fernandez Mendoza, Dominique Georgiou, Sarah J. Hoosdally, Alastair Hunter, Katie Jefferey, Dominic F. Kelly, Paul Klenerman, Julian Knight, Clarice Knowles, Andrew J. Kwok, Ullrich Leuschner, Robert Levin, Chang Liu, César López-Camacho, Jose Martinez, Philippa C. Matthews, Hannah McGivern, Alexander J. Mentzer, Jonathan Milton, Juthathip Mongkolsapaya, Shona C. Moore, Marta S. Oliveira, Fiona Pereira, Elena Perez, Timothy Peto, Rutger J. Ploeg, Andrew Pollard, Tessa Prince, David J. Roberts, Justine K. Rudkin, Veronica Sanchez, Gavin R. Screaton, Malcolm G. Semple, Jose Slon-Campos, Donal T. Skelly, Elliot Nathan Smith, Alberto Sobrinodiaz, Julie Staves, David I. Stuart, Piyada Supasa, Tomas Surik, Hannah Thraves, Pat Tsang, Lance Turtle, A. Sarah Walker, Beibei Wang, Charlotte Washington, Nicholas Watkins, James Whitehouse, National COVID Testing Scientific Advisory Panel, (2020) Antibody testing for COVID-19: A report from the National COVID Scientific Advisory Panel [version 1; peer review: 2 approved] (doi: 10.12688/wellcomeopenres.15927.1)(issn: 2398-502X); source: Wellcome Open Research
Armstrong J, Rudkin JK, Allen N, Crook DW, Wilson DJ, Wyllie DH, O'Connell AM, (2020) Dynamic linkage of COVID-19 test results between Public Health England's Second Generation Surveillance System and UK Biobank. Microbial genomics (pmid: 32553051)(doi: 10.1099/mgen.0.000397); source: Europe PubMed Central
Bridget Hilton, Daniel Wilson, Anne-Marie O’Connell, Dean Ironmonger, Justine K Rudkin, Naomi Allen, Isabel Oliver, David Wyllie, (2020) Incidence of Microbial Infections in English UK Biobank Participants: Comparison with the General Population (doi: 10.1101/2020.03.18.20038281); source: Crossref
Las Heras V, Clooney AG, Ryan FJ, Cabrera-Rubio R, Casey PG, Hueston CM, Pinheiro J, Rudkin JK, Melgar S, Cotter PD, Hill C, Gahan CGM, (2019) Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection. Microbiome (pmid: 30658700)(pmc: PMC6339339)(doi: 10.1186/s40168-019-0621-x); source: Europe PubMed Central
(2018) Environmental Selection of Avirulence in Food-Borne Pathogen Listeria monocytogenes Microbiology Society Conference, Birmingham, UK. ; source: Justine Rudkin
Rudkin JK, McLoughlin RM, Preston A, Massey RC, (2017) Bacterial toxins: Offensive, defensive, or something else altogether? PLoS pathogens (pmid: 28934339)(pmc: PMC5608399)(doi: 10.1371/journal.ppat.1006452); source: Europe PubMed Central
(2017) Evading Decontamination Strategies; Genetic basis of the persistence of Listeria monocytogenes in food processing plants and the knock-on effects on virulence. FEMs congress 2017, Valencia, Spain. ; source: Justine Rudkin
(2017) Redeploying β-Lactam Antibiotics as a Novel Antivirulence Strategy for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections Journal of Infectious Diseases (pmid: 28077586); source: Justine Rudkin
(2015) An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections. Journal of Infectious Diseases (pmid: 26044292); source: Justine Rudkin
(2015) Turning strength into weakness; Using antibiotic resistance to attenuate highly virulent CA-MRSA infections SGM Irish Division meeting, June 2015. Galway. ; source: Justine Rudkin
(2015) Turning strength into weakness; Using antibiotic resistance to attenuate highly virulent CA-MRSA infections. SGM spring conference, March 2015. Birmingham. ; source: Justine Rudkin
(2015) Methicillin resistance and the biofilm phenotype in Staphylococcus aureus. Frontiers in Infection and Cellular Microbiology (pmid: 25674541); source: Justine Rudkin
(2015) Resistance is futile; MRSA sacrifices virulence for resistance. NUIG MicroSoc Postgraduate Seminar Series, January 2015. Galway. ; source: Justine Rudkin
(2014) Predicting the virulence of MRSA from its genome sequence. Genome Research (pmid: 24717264); source: Justine Rudkin
(2014) A novel use for an old antibiotic; Oxacillin as an attenuator of toxicity in highly virulent CA-MRSA strains. SGM spring conference, April 2014. Liverpool. ; source: Justine Rudkin
(2014) Oxacillin alters the toxin expression profile of community-associated methicillin-resistant Staphylococcus aureus Antimicrobial Agents and Chemotherapy (pmid: 24295979); source: Justine Rudkin
(2013) Oxacillin as an anti-virulence strategy against CA-MRSA; a novel use for an old antibiotic. Staph GBI conference, September 2013. Dublin. ; source: Justine Rudkin
(2012) From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence? Nature Reviews Microbiology (pmid: 23070558); source: Justine Rudkin
(2012) Oxacillin reduces the toxicity and virulence of CA-MRSA; A potential new use for a redundant antibiotic? International Symposium on Staphylococci and Staphylococcal Infections, August 2012. Lyon. ; source: Justine Rudkin
(2012) Oxacillin reduces the toxicity and virulence of CA-MRSA; A potential new use for a redundant antibiotic? Bristol and South West Microbiology Microforum, July 2012. Bristol. ; source: Justine Rudkin
(2012) Hospital superbug MRSA; Why is it so prolific in healthcare settings and not yet in the wider community. Meeting of Minds, June 2012. Bath. ; source: Justine Rudkin
(2012) Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections. PLoS Pathogens (pmid: 22496652); source: Justine Rudkin
(2012) Why HA-MRSA is restricted to the hospital environment. SGM spring conference, March 2012. Dublin. ; source: Justine Rudkin
(2012) Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system. Journal of Infectious Disease (pmid: 22301683); source: Justine Rudkin
(2011) Antibiotic resistance reduces the virulence of HA-MRSA via quorum sensing inhibition. Staph GBI conference, September 2011. Edinburgh. ; source: Justine Rudkin
(2011) Antibiotic resistance reduces the virulence of HA-MRSA via quorum sensing inhibition. International Symposium on Staphylococci and Staphylococcal Infections, September 2011. Bath. ; source: Justine Rudkin
(2011) Antibiotic resistance reduces the virulence of HA-MRSA. An explanation for their environmental restriction. University of Bath Postgraduate Forum, May 2011. Bath. ; source: Justine Rudkin
(2010) Can you have it all? The trade-off of toxin production for antibiotic resistance in MRSA. Bristol and South West Microbiology Microforum, June 2010. ; source: Justine Rudkin
(2010) Is MRSA really a ‘superbug’? The cost of antibiotic resistance in S. aureus. University of Bath Postgraduate Forum, February 2010. Bath. ; source: Justine Rudkin
(2010) Offsetting virulence and antibiotic resistance costs by MRSA. ISME (pmid: 20072161); source: Justine Rudkin
Supervision
Open to Undergraduate Students who wish apply for the Microbiology Society Vacation Studentship to spend a summer gaining research experience