Professor Jonathan Cavanagh
- Professor of Psychiatry (Immunology & Infection)
telephone:
01413307769
email:
Jonathan.Cavanagh@glasgow.ac.uk
centre for immunobiology, sir graeme davies building, 120 university place, Glasgow, G12 8TA
Publications
2024
Lombardo, G. et al. (2024) Disturbed sex hormones milieu in males and females with major depressive disorder and low-grade inflammation. Journal of Affective Disorders, 356, pp. 167-176. (doi: 10.1016/j.jad.2024.03.018) (PMID:38494137)
Queirazza, F., Cavanagh, J. , Philiastides, M. G. and Krishnadas, R. (2024) Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants. Brain, Behavior, and Immunity, 119, pp. 197-210. (doi: 10.1016/j.bbi.2024.03.044) (PMID:38555987)
Cavanagh, J. , Spiller, J. and Taylor, D. R. (2024) Assisted dying, moral distress, and conscientious objection. Lancet, 403(10435), pp. 1443-1444. (doi: 10.1016/S0140-6736(23)01910-4) (PMID:38614475)
Michael, B. D. et al. (2024) Author correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15, 2918. (doi: 10.1038/s41467-024-47320-6) (PMID:38575615) (PMCID:PMC10995197)
Dehsarvi, A. et al. (2024) Characterizing the neurobiological mechanisms of action of exercise and cognitive–behavioral interventions for rheumatoid arthritis fatigue: a magnetic resonance imaging brain study. Arthritis and Rheumatology, 76(4), pp. 522-530. (doi: 10.1002/art.42755) (PMID:37975154)
2023
Michael, B. D. et al. (2023) Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14, 8487. (doi: 10.1038/s41467-023-42320-4) (PMID:38135686) (PMCID:PMC10746705)
Brock, J., Basu, N. , Schlachetzki, J. C. M., Schett, G., McInnes, I. B. and Cavanagh, J. (2023) Immune mechanisms of depression in rheumatoid arthritis. Nature Reviews Rheumatology, 19(12), pp. 790-804. (doi: 10.1038/s41584-023-01037-w) (PMID:37923863)
Queirazza, F., Steele, J. D., Krishnadas, R. , Cavanagh, J. and Philiastides, M. G. (2023) Functional magnetic resonance imaging signatures of Pavlovian and instrumental valuation systems during a modified orthogonalized go/no-go task. Journal of Cognitive Neuroscience, 35(12), pp. 2089-2109. (doi: 10.1162/jocn_a_02062) (PMID:37788326)
Sijtsma, M., Marjoram, D., Gallagher, H. L., Grealy, M. A., Brennan, D., Mathias, C., Cavanagh, J. and Pollick, F. E. (2023) Major depression and the perception of affective instrumental and expressive gestures: an fMRI investigation. Psychiatry Research: Neuroimaging, 336, 111728. (doi: 10.1016/j.pscychresns.2023.111728) (PMID:37939431)
Gamble, A., Suessmilch, M., Bonestroo, A., Merits, A., Graham, G. J. , Cavanagh, J. , Edgar, J. M. and Pingen, M. (2023) Establishing mixed neuronal and glial cell cultures from embryonic mouse brains to study infection and innate immunity. Journal of Visualized Experiments(196), 65331. (doi: 10.3791/65331) (PMID:37458443)
Sforzini, L. et al. (2023) Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study. Translational Psychiatry, 13, 185. (doi: 10.1038/s41398-023-02438-x) (PMID:37264010) (PMCID:PMC10235092)
Cullen, B. et al. (2023) Cognitive function in people with familial risk of depression. JAMA Psychiatry, 80(6), pp. 610-620. (doi: 10.1001/jamapsychiatry.2023.0716) (PMID:37074691) (PMCID:PMC10116387)
Mumuni, A. N., Krishnadas, R. and Cavanagh, J. (2023) Peripheral inflammation is associated with alterations in brain biochemistry and mood: evidence from in vivo proton magnetic resonance spectroscopy study. Pure and Applied Chemistry, 95(3), pp. 289-300. (doi: 10.1515/pac-2022-1119)
Stefanov, K. , Al-Wasity, S., Parkinson, J. T. , Waiter, G. D., Cavanagh, J. and Basu, N. (2023) Brain mapping inflammatory arthritis related fatigue in the pursuit of novel therapeutics. Lancet Rheumatology, 5(2), e99-e109. (doi: 10.1016/S2665-9913(23)00007-3)
2022
Kwon, J., Arsenis, C., Suessmilch, M., McColl, A., Cavanagh, J. and Morris, B. J. (2022) Differential effects of toll-like receptor activation and differential mediation by MAP kinases of immune responses in microglial cells. Cellular and Molecular Neurobiology, 42(8), pp. 2655-2671. (doi: 10.1007/s10571-021-01127-x) (PMID:34297254) (PMCID:PMC9560989)
Needham, E. J. et al. (2022) Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses. Brain, 145(11), pp. 4097-4107. (doi: 10.1093/brain/awac321) (PMID:36065116) (PMCID:PMC9494359)
Leighton, S. P. , Herron, J. W. , Jackson, E., Sheridan, M., Deligianni, F. and Cavanagh, J. (2022) Delirium and the risk of developing dementia: a cohort study of 12 949 patients. Journal of Neurology, Neurosurgery and Psychiatry, 93(8), pp. 822-827. (doi: 10.1136/jnnp-2022-328903) (PMID:35606105) (PMCID:PMC9304115)
Lee, R., Leighton, S. P. , Thomas, L., Gkoutos, G. V., Wood, S. J., Fenton, S.-J. H., Deligianni, F. , Cavanagh, J. and Mallikarjun, P. K. (2022) Prediction models in first-episode psychosis: systematic review and critical appraisal. British Journal of Psychiatry, 220(SI4), pp. 179-191. (doi: 10.1192/bjp.2021.219) (PMID:35067242)
Tank, R., Ward, J. , Flegal, K. E. , Smith, D. J. , Bailey, M. E.S. , Cavanagh, J. and Lyall, D. M. (2022) Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology, 47(2), pp. 564-569. (doi: 10.1038/s41386-021-01190-4) (PMID:34621014) (PMCID:PMC8674313)
2021
Kwon, J., Suessmilch, M., McColl, A., Cavanagh, J. and Morris, B. J. (2021) Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk. Scientific Reports, 11, 23841. (doi: 10.1038/s41598-021-03216-9) (PMID:34903784) (PMCID:PMC8668921)
Kitzbichler, M. G. et al. (2021) Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks. Molecular Psychiatry, 26(12), pp. 7346-7354. (doi: 10.1038/s41380-021-01272-1) (PMID:34535766) (PMCID:PMC8872995)
Aruldass, A. R. et al. (2021) Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression. Brain, Behavior, and Immunity, 98, pp. 299-309. (doi: 10.1016/j.bbi.2021.08.226) (PMID:34450247)
Cole, J. J. et al. (2021) No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing. Translational Psychiatry, 11, 404. (doi: 10.1038/s41398-021-01506-4) (PMID:34294682) (PMCID:PMC8298604)
Bourgognon, J.-M. , McColl, A., Suessmilch, M., Krishnadas, R. and Cavanagh, J. (2021) Stress, immune system and the brain. In: Textbook of Immunopsychiatry. Cambridge University Press: Cambridge, pp. 51-72. ISBN 9781108539623 (doi: 10.1017/9781108539623.004)
Leighton, S. P. et al. (2021) Development and validation of a non-remission risk prediction model in first episode psychosis: an analysis of two longitudinal studies. Schizophrenia Bulletin Open, 2(1), sgab041. (doi: 10.1093/schizbullopen/sgab041) (PMID:34568827) (PMCID:PMC8458108)
2020
Ferguson, A. C. et al. (2020) Association of SBP and BMI with cognitive and structural brain phenotypes in UK Biobank. Journal of Hypertension, 38(12), pp. 2482-2489. (doi: 10.1097/HJH.0000000000002579) (PMID:32665523)
Fragoulis, G. E., Cavanagh, J. , Tindell, A., Derakhshan, M., Paterson, C., Porter, D., McInnes, I. B. and Siebert, S. (2020) Depression and anxiety in an Early Rheumatoid Arthritis inception cohort. Associations with demographic, socioeconomic and disease features. RMD Open, 6, e001376. (doi: 10.1136/rmdopen-2020-001376) (PMID:33127857)
Lyall, D. M. et al. (2020) Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity. Brain Imaging and Behavior, 14(5), pp. 1468-1476. (doi: 10.1007/s11682-019-00069-9) (PMID:30903549) (PMCID:PMC7572345)
Stefanov, K. , McLean, J., McColl, A., Basu, N. , Cavanagh, J. and Krishnadas, R. (2020) Mild inflammation in healthy males induces fatigue mediated by changes in effective connectivity within the insula. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(9), pp. 865-874. (doi: 10.1016/j.bpsc.2020.04.005) (PMID:32532687)
Ferguson, A. C. et al. (2020) Alzheimer’s disease susceptibility gene apolipoprotein e (APOE) and blood biomarkers in UK Biobank (N=395,769). Journal of Alzheimer's Disease, 76(4), pp. 1541-1551. (doi: 10.3233/JAD-200338) (PMID:32651323)
Cattaneo, A. et al. (2020) Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study. Translational Psychiatry, 10(1), 232. (doi: 10.1038/s41398-020-00874-7) (PMID:32699209) (PMCID:PMC7376244)
Lynall, M.-E. et al. (2020) Peripheral blood cell-stratified subgroups of inflamed depression. Biological Psychiatry, 88(2), pp. 185-196. (doi: 10.1016/j.biopsych.2019.11.017) (PMID:32000983)
Nikkheslat, N. et al. (2020) Childhood trauma, HPA axis activity and antidepressant response in patients with depression. Brain, Behavior, and Immunity, 87, pp. 229-237. (doi: 10.1016/j.bbi.2019.11.024) (PMID:31794798) (PMCID:PMC7327513)
Smith, C. R., Cullen, B. , Sheridan, M. P., Cavanagh, J. , Grosset, K. and Grosset, D. G. (2020) Cognitive impairment in Parkinson’s disease is multifactorial: a neuropsychological study. Acta Neurologica Scandinavica, 141(6), pp. 500-508. (doi: 10.1111/ane.13226) (PMID:32002988)
Thomson, C., McColl, A., Graham, G. and Cavanagh, J. (2020) Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes. Journal of Neuroinflammation, 17, 94. (doi: 10.1186/s12974-020-01759-8) (PMID:32213184) (PMCID:PMC7098135)
Smith, C., Cavanagh, J. , Sheridan, M., Grosset, K., Cullen, B. and Grosset, D. (2020) Factor structure of the Montreal Cognitive Assessment in Parkinson’s disease. International Journal of Geriatric Psychiatry, 35(2), pp. 188-194. (doi: 10.1002/gps.5234) (PMID:31736141)
Bain, K.A. et al. (2020) Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity. British Journal of Dermatology, 182(1), pp. 130-137. (doi: 10.1111/bjd.18008) (PMID:30980732)
Bourgognon, J.-M. and Cavanagh, J. (2020) The role of cytokines in modulating learning and memory and brain plasticity. Brain and Neuroscience Advances, 4, pp. 1-13. (doi: 10.1177/2398212820979802) (PMID:33415308) (PMCID:PMC7750764)
Stefanov, K. , McLean, J., Allan, B., Cavanagh, J. and Krishnadas, R. (2020) Mild inflammation causes a reduction in resting-state amplitude of low-frequency fluctuation in healthy adult males. Brain and Neuroscience Advances, 4, pp. 1-5. (doi: 10.1177/2398212820949353)
2019
Leighton, S. P. et al. (2019) Development and validation of multivariable prediction models of remission, recovery, and quality of life outcomes in people with first episode psychosis: a machine learning approach. Lancet Digital Health, 1(6), e261-e270. (doi: 10.1016/S2589-7500(19)30121-9)
Mancuso, R. et al. (2019) CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain, 142(10), pp. 3243-3264. (doi: 10.1093/brain/awz241) (PMID:31504240) (PMCID:PMC6794948)
Graham, N. A., Ward, J. , Mackay, D. , Pell, J. , Cavanagh, J. , Padmanabhan, S. and Smith, D. J. (2019) Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank. BMJ Open, 9(9), e024433. (doi: 10.1136/bmjopen-2018-024433) (PMID:31575565) (PMCID:PMC6797415)
Lyall, L. M., Cullen, B. , Lyall, D. M. , Leighton, S. P. , Siebert, S. , Smith, D. J. and Cavanagh, J. (2019) The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank. European Psychiatry, 60, pp. 63-70. (doi: 10.1016/j.eurpsy.2019.05.007) (PMID:31158611) (PMCID:PMC6669333)
Queirazza, F., Fouragnan, E., Steele, J. D., Cavanagh, J. and Philiastides, M. G. (2019) Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression. Science Advances, 5(7), eaav4962. (doi: 10.1126/sciadv.aav4962) (PMID:31392266) (PMCID:PMC6669013)
Lyall, D. M. et al. (2019) Assessing for interaction between APOE ε4, sex and lifestyle on cognitive abilities. Neurology, 92, e2691-e2698. (doi: 10.1212/WNL.0000000000007551) (PMID:31028125) (PMCID:PMC6556094)
Nevado-Holgado, A. J., Ribe, E., Thei, L., Furlong, L., Angel-Mayer, M., Quan, J., Richardson, J. C., Cavanagh, J. and Lovestone, S. (2019) Genetic and real-world clinical data, combined with empirical validation, nominate JAK-STAT signaling as a target for Alzheimer’s Disease therapeutic development. Cells, 8(5), 425. (doi: 10.3390/cells8050425) (PMID:31072055)
Leighton, S. P. , Krishnadas, R. , Chung, K., Blair, A., Brown, S., Clark, S., Sowerbutts, K., Schwannauer, M., Cavanagh, J. and Gumley, A. (2019) Predicting one-year outcome in first episode psychosis using machine learning. PLoS ONE, 14(3), e0212846. (doi: 10.1371/journal.pone.0212846) (PMID:30845268) (PMCID:PMC6405084)
Herron, J. W. , Nerurkar, L. and Cavanagh, J. (2019) Neuroimmune biomarkers in mental illness. In: Pratt, J. and Hall, J. (eds.) Current Topics in Behavioural Neurosciences. Series: Current topics in behavioral neurosciences (40). Springer: Cham, Switzerland, pp. 45-78. ISBN 9783319996417 (doi: 10.1007/7854_2018_45)
Nerurkar, L., Siebert, S. , McInnes, I. B. and Cavanagh, J. (2019) Rheumatoid arthritis and depression: an inflammatory perspective. Lancet Psychiatry, 6(2), pp. 164-173. (doi: 10.1016/S2215-0366(18)30255-4) (PMID:30366684)
Openshaw, R. L. , Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J. , Pratt, J. A. and Morris, B. J. (2019) JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. Journal of Neuroinflammation, 16(1), 18. (doi: 10.1186/s12974-019-1408-5) (PMID:30691477) (PMCID:PMC6350402)
Chamberlain, S. R. et al. (2019) Treatment-resistant depression and peripheral C-reactive protein. British Journal of Psychiatry, 214(1), pp. 11-19. (doi: 10.1192/bjp.2018.66) (PMID:29764522) (PMCID:PMC6124647)
2018
Strawbridge, R. et al. (2018) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. Translational Psychiatry, 8, 178. (doi: 10.1038/s41398-018-0236-1) (PMID:30181555) (PMCID:PMC6123450)
Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)
Cullen, B. , Newby, D., Lee, D. , Lyall, D. M. , Nevado-Holgado, A. J., Evans, J. J. , Pell, J. P. , Lovestone, S. and Cavanagh, J. (2018) Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Scientific Reports, 8, 12089. (doi: 10.1038/s41598-018-30568-6) (PMID:30108252) (PMCID:PMC6092329)
Strawbridge, R. J. et al. (2018) Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort. Translational Psychiatry, 8, 39. (doi: 10.1038/s41398-017-0079-1) (PMID:29391395) (PMCID:PMC5804026)
Krishnadas, R. , Cooper, S.-A. , Nicol, A., Pimlott, S., Soni, S., Holland, A., McArthur, L. and Cavanagh, J. (2018) Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader–Willi syndrome. British Journal of Psychiatry, 212(1), pp. 57-58. (doi: 10.1192/bjp.2017.7)
Leighton, S.P. , Nerurkar, L., Krishnadas, R. , Johnman, C., Graham, G.J. and Cavanagh, J. (2018) Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Molecular Psychiatry, 23(1), pp. 48-58. (doi: 10.1038/mp.2017.205) (PMID:29133955) (PMCID:PMC5754468)
2017
Ward, J. et al. (2017) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. Translational Psychiatry, 7, 1264. (doi: 10.1038/s41398-017-0012-7) (PMID:29187730) (PMCID:PMC5802589)
Nerurkar, L., McColl, A., Graham, G. and Cavanagh, J. (2017) The systemic response to topical Aldara treatment is mediated through direct TLR7 stimulation as Imiquimod enters the circulation. Scientific Reports, 7, 16570. (doi: 10.1038/s41598-017-16707-5) (PMID:29185473) (PMCID:PMC5707416)
Mackay, G. A., Campbell, S., Jampana, R. and Cavanagh, J. (2017) A 50 year old with a rapid neuropsychiatric deterioration and choreaform movements. Practical Neurology, (doi: 10.1136/practneurol-2016-001481) (PMID:28119377) (PMCID:PMC5520242)
Kalk, N.J. et al. (2017) Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. Translational Psychiatry, 7(1), e996. (doi: 10.1038/tp.2016.264) (PMID:28072413)
Jani, B. D. , Boachie, C., McCowan, C. , Barry, S. J.E. , Cavanagh, J. and Mair, F. S. (2017) Relationship of depression screening in cardiometabolic disease with vascular events and mortality: findings from a large primary care cohort with 4 years follow-up. European Heart Journal: Quality of Care and Clinical Outcomes, 3(1), pp. 61-73. (doi: 10.1093/ehjqcco/qcw045) (PMID:28927181)
2016
Jani, B. D. , Cavanagh, J. , Barry, S. J.E. , Der, G. , Sattar, N. and Mair, F. S. (2016) Relationship between blood pressure values, depressive symptoms and cardiovascular outcomes in patients with cardiometabolic disease. Journal of Clinical Hypertension, 18(10), pp. 1027-1035. (doi: 10.1111/jch.12813) (PMID:27040355)
Mccoll, A., Thomson, C. A., Nerurkar, L., Graham, G. J. and Cavanagh, J. (2016) TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain. Journal of Neuroinflammation, 13, 102. (doi: 10.1186/s12974-016-0562-2) (PMID:27160148)
Krishnadas, R. et al. (2016) Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans. Brain, Behavior, and Immunity, 51, pp. 29-38. (doi: 10.1016/j.bbi.2015.08.005) (PMID:26255693)
2015
Krishnadas, R. , Nicol, A., Sassarini, J., Puri, N.,, Pimlott, S. , Hadley, D., McInnnes, I. and Cavanagh, J. (2015) SPECT Scanning of Brainstem Serotonin Transporter Availability Reveals Association with Circulating Inflammatory Tumour Necrosis Factor. 28th Annual EANM Congress of the European Association of Nuclear Medicine 2015, Hamburg, Germany, 10-14 Oct 2015. S557-S558. (doi: 10.1007/s00259-015-3198-z)
Arnone, D., Mumuni, A. N., Jauhar, S., Condon, B. and Cavanagh, J. (2015) Indirect evidence of selective glial involvement in glutamate-based mechanisms of mood regulation in depression: Meta-analysis of absolute prefrontal neuro-metabolic concentrations. European Neuropsychopharmacology, 25(8), pp. 1109-1117. (doi: 10.1016/j.euroneuro.2015.04.016) (PMID:26028038)
Jani, B. D. , Purves, D., Barry, S. J.E. , Mccowan, C. , Cavanagh, J. and Mair, F. S. (2015) The effects of anti-depressants on depression symptom scores at 12 months follow-up in patients with cardiometabolic disease: results from a large primary care cohort. Journal of Family Medicine and Primary Care, 4(3), pp. 373-379. (doi: 10.4103/2249-4863.161324)
Carson, A. J., Stone, J., Hansen, C. H., Duncan, R., Cavanagh, J. , Matthews, K., Murray, G. and Sharpe, M. (2015) Somatic symptom count scores do not identify patients with symptoms unexplained by disease: a prospective cohort study of neurology outpatients. Journal of Neurology, Neurosurgery and Psychiatry, 86(3), pp. 295-301. (doi: 10.1136/jnnp-2014-308234)
Jani, B. D. , McLean, G., Nicholl, B. I. , Barry, S. J.E. , Sattar, N. , Mair, F. S. and Cavanagh, J. (2015) Risk assessment and predicting outcomes in patients with depressive symptoms: a review of potential role of peripheral blood based biomarkers. Frontiers in Human Neuroscience, 9(Art 18), (doi: 10.3389/fnhum.2015.00018)
Gale, C. R., Batty, G. D., Cooper, S.-A. , Deary, I. J., Der, G. , McEwan, B. S. and Cavanagh, J. (2015) Reaction time in adolescence, cumulative allostatic load and symptoms of anxiety and depression in adulthood: the West of Scotland Twenty-07 Study. Psychosomatic Medicine, 7(5), pp. 493-505. (doi: 10.1097/PSY.0000000000000189) (PMID:25984823) (PMCID:PMC4459883)
2014
van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J. , Donnan, P.T., Padmanabhan, S. , Porteous, D.J., Hocking, L. and Smith, B.H. (2014) Does a history of depressionactuallymediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18(9), pp. 1223-1230. (doi: 10.1002/j.1532-2149.2014.00470.x)
Queirazza, F. and Cavanagh, J. (2014) Poststroke depression and 5-HTTLPR. Journal of Neurology, Neurosurgery and Psychiatry, 85(3), pp. 241-243. (doi: 10.1136/jnnp-2012-304149)
Sassarini, J., Krishnadas, R. , Cavanagh, J. , Nicol, A., Pimlott, S. L. , Ferrell, W. and Lumsden, M. A. (2014) Venlafaxine alters microvascular perfusion, [123I]-beta-CIT binding and BDI scores in flushing postmenopausal women. Maturitas, 77(3), pp. 267-273. (doi: 10.1016/j.maturitas.2013.12.003)
Queirazza, F., Krishnadas, R. , McLean, J. and Cavanagh, J. (2014) Neighbourhood-level deprivation and morphological changes within the limbic stress circuit: results from a prospective, population-based, cohort study. Lancet, 383(s1), s85. (doi: 10.1016/S0140-6736(14)60348-2)
Jani, B. , Cavanagh, J. , Barry, S. J.E. , Der, G. , Sattar, N. and Mair, F. S. (2014) Revisiting the J shaped curve, exploring the association between cardiovascular risk factors and concurrent depressive symptoms in patients with cardiometabolic disease: findings from a large cross-sectional study. BMC Cardiovascular Disorders, 14, p. 139. (doi: 10.1186/1471-2261-14-139)
Jani, B. D. , Boachie, C., McCowan, C., Barry, S. , Cavanagh, J. and Mair, F. S. (2014) Association of depression screening in cardiometabolic disease with future vascular events and mortality: a cohort study. In: Public Health Science, Glasgow, UK, 19 Nov 2014, S41. (doi: 10.1016/S0140-6736(14)62167-X)
Jani, B. D. , Cavanagh, J. , Barry, S. , Der, G. , Sattar, N. and Mair, F. S. (2014) Association between cardiovascular risk factors and concurrent depressive symptoms in cardiometabolic disease: a cross-sectional study. In: Public Health Science, Glasgow, UK, 19 Nov 2014, S40. (doi: 10.1016/S0140-6736(14)62166-8)
Thomson, C. A., McColl, A., Cavanagh, J. and Graham, G. J. (2014) Peripheral inflammation is associated with remote global gene expression changes in the brain. Journal of Neuroinflammation, 11(73), (doi: 10.1186/1742-2094-11-73)
2013
Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi: 10.1007/s12311-013-0497-4)
Krishnadas, R. , Kim, J., Mclean, J., Batty, D., Mclean, J., Millar, K., Packard, C. and Cavanagh, J. (2013) The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation. Frontiers in Human Neuroscience, 7(722), (doi: 10.3389/fnhum.2013.00722)
Krishnadas, R. , Palaniyappan, L., Lang, J., Mclean, J. and Cavanagh, J. (2013) Psychoticism and salience network morphology. Personality and Individual Differences, 57, pp. 37-42. (doi: 10.1016/j.paid.2013.09.016)
Bourne, C. et al. (2013) Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatrica Scandinavica, 128(3), pp. 149-162. (doi: 10.1111/acps.12133)
Jani, B. , Purves, D., Barry, S. , Cavanagh, J. , McLean, G. and Mair, F. (2013) Challenges and implications of routine depression screening for depression in chronic disease and multimorbidity: a cross sectional study. PLoS ONE, 8(9), e74610. (doi: 10.1371/journal.pone.0074610) (PMID:24058602) (PMCID:PMC3772931)
Kalk, N., Cherian, R., Naveed, M., McInnes, I.B., Cavanagh, J. and Lingford-Hughes, A. (2013) The peripheral cytokine profile in alcohol detoxification: relationship to cognitive function. Alcohol and Alcoholism, 48(Sup. 1), p. 60. (doi: 10.1093/alcalc/agt117)
Krishnadas, R. et al. (2013) Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. Psychosomatic Medicine, 75(7), pp. 616-623. (doi: 10.1097/PSY.0b013e3182a151a7)
Wong, E.K.O., Krishnadas, R. and Cavanagh, J. (2013) The interface between neurology and psychiatry: the case of multiple sclerosis. Advances in Psychiatric Treatment, 19(5), pp. 370-377. (doi: 10.1192/apt.bp.112.010710)
Tillmann, T., Krishnadas, R. , Cavanagh, J. and Petrides, K.V. (2013) Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study. Arthritis Research and Therapy, 15(2), R45. (doi: 10.1186/ar4204)
Jauhar, S. and Cavanagh, J. (2013) The classification and epidemiology of bipolar disorders. In: Power, M. (ed.) The Wiley Blackwell Handbook of Mood Disorders, 2nd Edition. Wiley Blackwell: Chichester. ISBN 9781119978923
Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. NeuroImage: Clinical, 2(2013), pp. 646-657. (doi: 10.1016/j.nicl.2013.04.012)
Millar, K. et al. (2013) Personality, socio-economic status and inflammation: cross-sectional, population-based study. PLoS ONE, 8(3), e58256. (doi: 10.1371/journal.pone.0058256) (PMID:23516457) (PMCID:PMC3596406)
2012
McLean, J. et al. (2012) Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations. Behavioural Brain Research, 235(2), pp. 225-230. (doi: 10.1016/j.bbr.2012.08.013)
Packard, C. et al. (2012) Interaction of personality traits with social deprivation in determining mental wellbeing and health behaviours. Journal of Public Health, 34(4), pp. 615-624. (doi: 10.1093/pubmed/fds030)
Miller, A. M. et al. (2012) Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? PLoS ONE, 7(10), e47830. (doi: 10.1371/journal.pone.0047830) (PMID:23112853) (PMCID:PMC3480428)
Knox, S. et al. (2012) 25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid. Atherosclerosis, 223(2), pp. 437-441. (doi: 10.1016/j.atherosclerosis.2012.05.001) (PMID:22632919)
Taylor, M., Cavanagh, J. , Hodgson, R. and Tiihonen, J. (2012) Examining the effectiveness of antipsychotic medication in first episode psychosis. Journal of Psychopharmacology, 26(5), pp. 27-32. (doi: 10.1177/0269881112439252)
Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J. , Pimlott, S. , Grosset, K.A. and Grosset, D.G. (2012) Serotonergic Function in Early Parkinson's Disease With and Without Depression: A Pilot Study. Association of British Neurologists Annual Meeting 2011, Newcastle, UK, 2011. (doi: 10.1136/jnnp-2011-301993.158)
McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi: 10.1093/ije/dyr215)
Krishnadas, R. and Cavanagh, J. (2012) Depression: an inflammatory illness? Journal of Neurology, Neurosurgery and Psychiatry, 83(5), pp. 495-502. (doi: 10.1136/jnnp-2011-301779)
Stone, J. et al. (2012) Which neurological diseases are most likely to be associated with "symptoms unexplained by organic disease". Journal of Neurology, 259(1), pp. 33-38. (doi: 10.1007/s00415-011-6111-0)
2011
Williams, C. , Carson, A., Smith, S., Sharpe, M., Cavanagh, J. and Kent, C. (2011) Overcoming Functional Neurological Symptoms: A Five Areas Approach. Series: Overcoming. CRC Press: London. ISBN 9781444138344
Sharpe, M., Walker, J., Williams, C. , Stone, J., Cavanagh, J. , Murray, G., Butcher, I., Duncan, R., Smith, S. and Carson, A. (2011) Guided self-help for functional (psychogenic) symptoms: a randomized controlled efficacy trial. Neurology, 77(6), pp. 564-572. (doi: 10.1212/WNL.0b013e318228c0c7)
Cavanagh, J. (2011) Understanding the biological mechanisms underlying symptoms might help us cross the brain-body divide to the benefit of both. Journal of Neurology, Neurosurgery and Psychiatry, 82(7), p. 709. (doi: 10.1136/jnnp.2011.240507)
Krishnadas, R. , Mallon, V., McInnes, I. and Cavanagh, J. (2011) Correlates of depression and quality of life in patients with inflammatory arthritides. European Psychiatry, 26, p. 383. (doi: 10.1016/S0924-9338(11)72091-0)
Krishnadas, R. , Krishnadas, R. and Cavanagh, J. (2011) Sustained remission of rheumatoid arthritis with a specific serotonin reuptake inhibitor antidepressant: a case report and review of the literature. Journal of Medical Case Reports, 5, 112. (doi: 10.1186/1752-1947-5-112) (PMID:21418592) (PMCID:PMC3072330)
Carson, A. et al. (2011) Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by organic disease'. Journal of Neurology, Neurosurgery and Psychiatry, 82(7), pp. 810-813. (doi: 10.1136/jnnp.2010.220640)
Packard, C.J. et al. (2011) Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health, 11, p. 42. (doi: 10.1186/1471-2458-11-42)
Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi: 10.1371/journal.pone.0022521) (PMID:21818333) (PMCID:PMC3144896)
2010
Gradin, V. et al. (2010) Between- and within-scanner variability in the CaliBrain study n-back cognitive task. Psychiatry Research: Neuroimaging, 184(2), pp. 86-95. (doi: 10.1016/j.pscychresns.2010.08.010)
Cavanagh, J. , Patterson, J., Pimlott, S. , Wyper, D. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: In vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi: 10.1002/syn.20705) (PMID:19771591)
Gountouna, V.-E. et al. (2010) Functional magnetic resonance imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. NeuroImage, 49(1), pp. 552-560. (doi: 10.1016/j.neuroimage.2009.07.026) (PMID:19631757)
Cavanagh, J. , Paterson, C., McLean, J., Pimlott, S. , McDonald, M., Patterson, J., Wyper, D. and McInnes, I. (2010) Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study. Annals of the Rheumatic Diseases, 69(6), 1251-U367. (doi: 10.1136/ard.2009.107912)
Cavanagh, J. and Smyth, R. (2010) Suicide and self harm. In: Johnstone, E.C., Lawrie, S., Owens, D.G.C., Sharpe, M. and McIntosh, A. (eds.) Companion to Psychiatric Studies [8th edition]. Churchill Livingstone: London. ISBN 9780702031373
Stone, J. et al. (2010) Who is referred to neurology clinics?—The diagnoses made in 3781 new patients. Clinical Neurology and Neurosurgery, 112(9), pp. 747-751. (doi: 10.1016/j.clineuro.2010.05.011)
2009
Stone, J. et al. (2009) Symptoms 'unexplained by organic disease' in 1144 new neurology out-patients: how often does the diagnosis change at follow-up? Brain, 132(10), pp. 2878-2888. (doi: 10.1093/brain/awp220)
Goodwin, G.M. and Cavanagh, J. (2009) Evidence-based guidelines for treating bipolar disorder: revised second edition - recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology, 23(4), pp. 346-388. (doi: 10.1177/0269881109102919)
Moorhead, T. W. J. et al. (2009) Prospective multi-centre Voxel Based Morphometry study employing scanner specific segmentations: Procedure development using CaliBrain structural MRI data. BMC Medical Imaging, 9(8), (doi: 10.1186/1471-2342-9-8)
Arnone, D., Cavanagh, J., Gerber, D., Lawrie, S., Ebmeier, K. and McIntosh, A. (2009) Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. British Journal of Psychiatry, 195(3), pp. 194-201. (doi: 10.1192/bjp.bp.108.059717)
Cavanagh, J., Schwannauer, M., Power, M. and Goodwin, G.M. (2009) A novel scale for measuring mixed states in bipolar disorder. Clinical Psychology and Psychotherapy, 16(6), pp. 497-509. (doi: 10.1002/cpp.633)
Deans, K.A. et al. (2009) Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study. British Medical Journal, 339, b4170. (doi: 10.1136/bmj.b4170)
McLean, J., Brennan, D., Wyper, D.J., Condon, B., Hadley, D.M. and Cavanagh, J. (2009) Localisation of regions of intense pleasure response evoked by soccer goals. Psychiatry Research: Neuroimaging, 171(1), pp. 33-43. (doi: 10.1016/j.pscychresns.2008.02.005)
Sharpe, M. et al. (2009) Neurology out-patients with symptoms unexplained by disease: illness beliefs and financial benefits predict 1-year outcome. Psychological Medicine, 40(4), pp. 689-698. (doi: 10.1017/S0033291709990717)
2008
Cavanagh, J. and Mathias, C. (2008) Inflammation and its relevance to psychiatry. Advances in Psychiatric Treatment, 14(4), pp. 248-255.
Smith, F.W., Muckli, L., Brennan, D., Pernet, C., Smith, M., Belin, P., Gosselin, F., Hadley, D.M., Cavanagh, J. and Schyns, P.G. (2008) Classification images reveal the information sensitivity of brain voxels in fMRI. NeuroImage, 40(4), pp. 1643-1654. (doi: 10.1016/j.neuroimage.2008.01.029)
Velupillai, Y.N. et al. (2008) Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health, 8(126), (doi: 10.1186/1471-2458-8-126)
2007
Pimlott, S. L. , Piggott, M., Patterson, J., Cavanagh, J. and Wyper, D. J. (2007) SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380. Journal of Labelled Compounds and Radiopharmaceuticals, 50(5-6), pp. 350-353. (doi: 10.1002/jlcr.1192)
2006
Cannon, M., Cavanagh, J., McNeill, Y., Murray, R. and Scott, J. (2006) Exposure to obstetric complications and subsequent development of bipolar disorder - Systematic review. British Journal of Psychiatry, 189, pp. 3-11.
Cavanagh, J. (2006) The classification and epidemiology of bipolar disorders. In: Power, M.J. (ed.) Mood Disorders : A Handbook of Science and Practice. John Wiley & Sons. ISBN 9780470092767
Cavanagh, J. , Patterson, J., Pimlott, S., Dewar, D., Eersels, J., Dempsey, M. and Wyper, D. (2006) Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Biological Psychiatry, 59, pp. 301-308. (doi: 10.1016/j.biopsych.2005.06.029)
Scott, J., McNeill, Y., Cavanagh, J., Cannon, M. and Murray, R. (2006) Exposure to obstetric complications and subsequent development of bipolar disorder. British Journal of Psychiatry, 189, pp. 3-11. (doi: 10.1192/bjp.bp.105.010579)
2005
Cavanagh, J. T.O. and Smith, D. J. (2005) The use of single photon emission computed tomography in depressive disorders. Nuclear Medicine Communications, 26(3), pp. 197-203.
Smith, D.J. and Cavanagh, J.T.O. (2005) The use of single photon emission computed tomography in depressive disorders. Nuclear Medicine Communications, 26(3), pp. 197-203.
2004
Cavanagh, J., Goodwin, G. and Smyth, R. (2004) Relapse into mania or depression following lithium discontinuation: a 7-year follow-up. Acta Psychiatrica Scandinavica, 109, pp. 91-95.
Cavanagh, J. (2004) The classification and epidemiology of bipolar disorders. In: Power, M. J. (ed.) Mood Disorders: A handbook of science and practice. John Wiley & Sons Ltd.: West Sussex. ISBN 047084390X
Cavanagh, J. and Masterton, G. (2004) Suicide and deliberate self harm. In: Johnstone, E.C., Lawrie, S., Owens, D.G.C., Sharpe, M. and Freeman, C. (eds.) Companion to Psychiatric Studies [7th edition]. Churchill Livingstone: London. ISBN 9780443072635
2003
Jackson, A., Cavanagh, J. and Scott, J. (2003) A systematic review of manic and depressive prodromes. Journal of Affective Disorders, 74(3), pp. 209-217. (doi: 10.1016/S0165-0327(02)00266-5)
Carson, A., Cavanagh, J., Lawrie, S. and Sharpe, M. (2003) Psychological autopsy studies of suicide: a systematic review. Psychological Medicine, 33, pp. 395-405. (doi: 10.1017/S0033291702006943)
2002
Cavanagh, J.T.O. , Van Beck, M., Muir, W. and Blackwood, D.H.R. (2002) Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania. British Journal of Psychiatry, 180, pp. 320-326. (doi: 10.1192/bjp.180.4.320)
2000
Lawrie, S.M., MacHale, S.M., Cavanagh, J.T.O. , O'Carroll, R.E. and Goodwin, G.M. (2000) The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness. Psychological Medicine, 30(2), pp. 433-442. (doi: 10.1017/S0033291799001816)
Cavanagh, J. (2000) Genetics. In: Lawrie, S. M., Sharpe, M. and Johnstone, E. C. (eds.) MCQs for the Companion to Psychiatric Studies. Churchill Livingstone: London. ISBN 9780443064333
Cavanagh, J. (2000) Mood disorders. In: Lawrie, S. M., Sharpe, M. and Johnstone, E. C. (eds.) MCQs for the Companion to Psychiatric Studies. Churchill Livingstone: London. ISBN 9780443064333
Cavanagh, J. (2000) Neuroanatomy. In: Lawrie, S. M., Sharpe, M. and Johnstone, E. C. (eds.) MCQs for the Companion to Psychiatric Studies. Churchill Livingstone: London. ISBN 9780443064333
MacHale, S.M., Lawrie, S.M., Cavanagh, J.T.O. , Glabus, M.F., Murray, C.M. and Goodwin, G.M. (2000) Cerebral perfusion in chronic fatigue syndrome and depression. British Journal of Psychiatry, 176(6), pp. 550-556. (doi: 10.1192/bjp.176.6.550)
Shajahan, P. M., MacIntosh, A. M. and Cavanagh, J. T.O. (2000) Admission patterns by psychiatric trainees. Are women patients as likely as men to be admitted for major mental illness? Psychiatric Bulletin, 24(2), pp. 59-61. (doi: 10.1192/pb.24.2.59)
1999
Cavanagh, J.T.O. , Owens, D.G.C. and Johnstone, E.C. (1999) Life events in suicide and undetermined death in south-east Scotland: a case-control study using the method of psychological autopsy. Social Psychiatry and Psychiatric Epidemiology, 34(12), pp. 645-650. (doi: 10.1007/s001270050187)
Cavanagh, J.T.O. , Owens, D.G. and Johnstone, E.C. (1999) Suicide and undetermined death in south east Scotland. A case-control study using the psychological autopsy method. Psychological Medicine, 29(5), pp. 1141-9.
Cavanagh, J.T.O. and Shajahan, P.M. (1999) Increasing rates of hospital admission for men with major mental illnesses: data from Scottish mental health units, 1980–1995. Acta Psychiatrica Scandinavica, 99(5), pp. 353-359. (doi: 10.1111/j.1600-0447.1999.tb07241.x)
Buckley, L., MacHale, S. M., Cavanagh, J. T.O. , Sharpe, M., Deary, I. J. and Lawrie, S. M. (1999) Personality dimensions in chronic fatigue syndrome and depression. Journal of Psychosomatic Research, 46(4), pp. 395-400. (doi: 10.1016/S0022-3999(98)00120-2)
1998
MacHale, S.M., Cavanagh, J.T.O. , Bennie, J., Carroll, S., Goodwin, G.M. and Lawrie, S.M. (1998) Diurnal variation of adrenocortical activity in chronic fatigue syndrome. Neuropsychobiology, 38(4), pp. 213-217. (doi: 10.1159/000026543)
Shajahan, P.M. and Cavanagh, J.T. (1998) Admission for depression among men in Scotland, 1980-95: retrospective study. British Medical Journal, 316(7143), pp. 1496-1497. (doi: 10.1136/bmj.316.7143.1496)
Cavanagh, J. and Masterton, G. (1998) Suicide and deliberate self harm. In: Johnstone, E.C., Freeman, C. and Zealley, A.K. (eds.) Companion to Psychiatric Studies, 6th Edition. Churchill Livingstone: London, pp. 751-783.
1997
Ebmeier, K.P., Cavanagh, J.T. , Moffoot, A.P., Glabus, M.F., O'Carroll, R.E. and Goodwin, G.M. (1997) Cerebral perfusion correlates of depressed mood. British Journal of Psychiatry, 170(1), pp. 77-81. (doi: 10.1192/bjp.170.1.77)
Goodwin, G.M., Cavanagh, J.T.O. , Glabus, M.F., Kehoe, R.F., O'Carroll, R.E. and Ebmeier, K.P. (1997) Uptake of 99mTc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: associations with mania. British Journal of Psychiatry, 170(5), pp. 426-430. (doi: 10.1192/bjp.170.5.426)
Articles
Lombardo, G. et al. (2024) Disturbed sex hormones milieu in males and females with major depressive disorder and low-grade inflammation. Journal of Affective Disorders, 356, pp. 167-176. (doi: 10.1016/j.jad.2024.03.018) (PMID:38494137)
Queirazza, F., Cavanagh, J. , Philiastides, M. G. and Krishnadas, R. (2024) Mild exogenous inflammation blunts neural signatures of bounded evidence accumulation and reward prediction error processing in healthy male participants. Brain, Behavior, and Immunity, 119, pp. 197-210. (doi: 10.1016/j.bbi.2024.03.044) (PMID:38555987)
Cavanagh, J. , Spiller, J. and Taylor, D. R. (2024) Assisted dying, moral distress, and conscientious objection. Lancet, 403(10435), pp. 1443-1444. (doi: 10.1016/S0140-6736(23)01910-4) (PMID:38614475)
Michael, B. D. et al. (2024) Author correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15, 2918. (doi: 10.1038/s41467-024-47320-6) (PMID:38575615) (PMCID:PMC10995197)
Dehsarvi, A. et al. (2024) Characterizing the neurobiological mechanisms of action of exercise and cognitive–behavioral interventions for rheumatoid arthritis fatigue: a magnetic resonance imaging brain study. Arthritis and Rheumatology, 76(4), pp. 522-530. (doi: 10.1002/art.42755) (PMID:37975154)
Michael, B. D. et al. (2023) Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14, 8487. (doi: 10.1038/s41467-023-42320-4) (PMID:38135686) (PMCID:PMC10746705)
Brock, J., Basu, N. , Schlachetzki, J. C. M., Schett, G., McInnes, I. B. and Cavanagh, J. (2023) Immune mechanisms of depression in rheumatoid arthritis. Nature Reviews Rheumatology, 19(12), pp. 790-804. (doi: 10.1038/s41584-023-01037-w) (PMID:37923863)
Queirazza, F., Steele, J. D., Krishnadas, R. , Cavanagh, J. and Philiastides, M. G. (2023) Functional magnetic resonance imaging signatures of Pavlovian and instrumental valuation systems during a modified orthogonalized go/no-go task. Journal of Cognitive Neuroscience, 35(12), pp. 2089-2109. (doi: 10.1162/jocn_a_02062) (PMID:37788326)
Sijtsma, M., Marjoram, D., Gallagher, H. L., Grealy, M. A., Brennan, D., Mathias, C., Cavanagh, J. and Pollick, F. E. (2023) Major depression and the perception of affective instrumental and expressive gestures: an fMRI investigation. Psychiatry Research: Neuroimaging, 336, 111728. (doi: 10.1016/j.pscychresns.2023.111728) (PMID:37939431)
Gamble, A., Suessmilch, M., Bonestroo, A., Merits, A., Graham, G. J. , Cavanagh, J. , Edgar, J. M. and Pingen, M. (2023) Establishing mixed neuronal and glial cell cultures from embryonic mouse brains to study infection and innate immunity. Journal of Visualized Experiments(196), 65331. (doi: 10.3791/65331) (PMID:37458443)
Sforzini, L. et al. (2023) Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study. Translational Psychiatry, 13, 185. (doi: 10.1038/s41398-023-02438-x) (PMID:37264010) (PMCID:PMC10235092)
Cullen, B. et al. (2023) Cognitive function in people with familial risk of depression. JAMA Psychiatry, 80(6), pp. 610-620. (doi: 10.1001/jamapsychiatry.2023.0716) (PMID:37074691) (PMCID:PMC10116387)
Mumuni, A. N., Krishnadas, R. and Cavanagh, J. (2023) Peripheral inflammation is associated with alterations in brain biochemistry and mood: evidence from in vivo proton magnetic resonance spectroscopy study. Pure and Applied Chemistry, 95(3), pp. 289-300. (doi: 10.1515/pac-2022-1119)
Stefanov, K. , Al-Wasity, S., Parkinson, J. T. , Waiter, G. D., Cavanagh, J. and Basu, N. (2023) Brain mapping inflammatory arthritis related fatigue in the pursuit of novel therapeutics. Lancet Rheumatology, 5(2), e99-e109. (doi: 10.1016/S2665-9913(23)00007-3)
Kwon, J., Arsenis, C., Suessmilch, M., McColl, A., Cavanagh, J. and Morris, B. J. (2022) Differential effects of toll-like receptor activation and differential mediation by MAP kinases of immune responses in microglial cells. Cellular and Molecular Neurobiology, 42(8), pp. 2655-2671. (doi: 10.1007/s10571-021-01127-x) (PMID:34297254) (PMCID:PMC9560989)
Needham, E. J. et al. (2022) Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses. Brain, 145(11), pp. 4097-4107. (doi: 10.1093/brain/awac321) (PMID:36065116) (PMCID:PMC9494359)
Leighton, S. P. , Herron, J. W. , Jackson, E., Sheridan, M., Deligianni, F. and Cavanagh, J. (2022) Delirium and the risk of developing dementia: a cohort study of 12 949 patients. Journal of Neurology, Neurosurgery and Psychiatry, 93(8), pp. 822-827. (doi: 10.1136/jnnp-2022-328903) (PMID:35606105) (PMCID:PMC9304115)
Lee, R., Leighton, S. P. , Thomas, L., Gkoutos, G. V., Wood, S. J., Fenton, S.-J. H., Deligianni, F. , Cavanagh, J. and Mallikarjun, P. K. (2022) Prediction models in first-episode psychosis: systematic review and critical appraisal. British Journal of Psychiatry, 220(SI4), pp. 179-191. (doi: 10.1192/bjp.2021.219) (PMID:35067242)
Tank, R., Ward, J. , Flegal, K. E. , Smith, D. J. , Bailey, M. E.S. , Cavanagh, J. and Lyall, D. M. (2022) Association between polygenic risk for Alzheimer’s disease, brain structure and cognitive abilities in UK Biobank. Neuropsychopharmacology, 47(2), pp. 564-569. (doi: 10.1038/s41386-021-01190-4) (PMID:34621014) (PMCID:PMC8674313)
Kwon, J., Suessmilch, M., McColl, A., Cavanagh, J. and Morris, B. J. (2021) Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk. Scientific Reports, 11, 23841. (doi: 10.1038/s41598-021-03216-9) (PMID:34903784) (PMCID:PMC8668921)
Kitzbichler, M. G. et al. (2021) Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks. Molecular Psychiatry, 26(12), pp. 7346-7354. (doi: 10.1038/s41380-021-01272-1) (PMID:34535766) (PMCID:PMC8872995)
Aruldass, A. R. et al. (2021) Dysconnectivity of a brain functional network was associated with blood inflammatory markers in depression. Brain, Behavior, and Immunity, 98, pp. 299-309. (doi: 10.1016/j.bbi.2021.08.226) (PMID:34450247)
Cole, J. J. et al. (2021) No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing. Translational Psychiatry, 11, 404. (doi: 10.1038/s41398-021-01506-4) (PMID:34294682) (PMCID:PMC8298604)
Leighton, S. P. et al. (2021) Development and validation of a non-remission risk prediction model in first episode psychosis: an analysis of two longitudinal studies. Schizophrenia Bulletin Open, 2(1), sgab041. (doi: 10.1093/schizbullopen/sgab041) (PMID:34568827) (PMCID:PMC8458108)
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Fragoulis, G. E., Cavanagh, J. , Tindell, A., Derakhshan, M., Paterson, C., Porter, D., McInnes, I. B. and Siebert, S. (2020) Depression and anxiety in an Early Rheumatoid Arthritis inception cohort. Associations with demographic, socioeconomic and disease features. RMD Open, 6, e001376. (doi: 10.1136/rmdopen-2020-001376) (PMID:33127857)
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Stefanov, K. , McLean, J., McColl, A., Basu, N. , Cavanagh, J. and Krishnadas, R. (2020) Mild inflammation in healthy males induces fatigue mediated by changes in effective connectivity within the insula. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(9), pp. 865-874. (doi: 10.1016/j.bpsc.2020.04.005) (PMID:32532687)
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Smith, C. R., Cullen, B. , Sheridan, M. P., Cavanagh, J. , Grosset, K. and Grosset, D. G. (2020) Cognitive impairment in Parkinson’s disease is multifactorial: a neuropsychological study. Acta Neurologica Scandinavica, 141(6), pp. 500-508. (doi: 10.1111/ane.13226) (PMID:32002988)
Thomson, C., McColl, A., Graham, G. and Cavanagh, J. (2020) Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes. Journal of Neuroinflammation, 17, 94. (doi: 10.1186/s12974-020-01759-8) (PMID:32213184) (PMCID:PMC7098135)
Smith, C., Cavanagh, J. , Sheridan, M., Grosset, K., Cullen, B. and Grosset, D. (2020) Factor structure of the Montreal Cognitive Assessment in Parkinson’s disease. International Journal of Geriatric Psychiatry, 35(2), pp. 188-194. (doi: 10.1002/gps.5234) (PMID:31736141)
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Bourgognon, J.-M. and Cavanagh, J. (2020) The role of cytokines in modulating learning and memory and brain plasticity. Brain and Neuroscience Advances, 4, pp. 1-13. (doi: 10.1177/2398212820979802) (PMID:33415308) (PMCID:PMC7750764)
Stefanov, K. , McLean, J., Allan, B., Cavanagh, J. and Krishnadas, R. (2020) Mild inflammation causes a reduction in resting-state amplitude of low-frequency fluctuation in healthy adult males. Brain and Neuroscience Advances, 4, pp. 1-5. (doi: 10.1177/2398212820949353)
Leighton, S. P. et al. (2019) Development and validation of multivariable prediction models of remission, recovery, and quality of life outcomes in people with first episode psychosis: a machine learning approach. Lancet Digital Health, 1(6), e261-e270. (doi: 10.1016/S2589-7500(19)30121-9)
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Graham, N. A., Ward, J. , Mackay, D. , Pell, J. , Cavanagh, J. , Padmanabhan, S. and Smith, D. J. (2019) Impact of major depression on cardiovascular outcomes for individuals with hypertension: prospective survival analysis in UK Biobank. BMJ Open, 9(9), e024433. (doi: 10.1136/bmjopen-2018-024433) (PMID:31575565) (PMCID:PMC6797415)
Lyall, L. M., Cullen, B. , Lyall, D. M. , Leighton, S. P. , Siebert, S. , Smith, D. J. and Cavanagh, J. (2019) The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank. European Psychiatry, 60, pp. 63-70. (doi: 10.1016/j.eurpsy.2019.05.007) (PMID:31158611) (PMCID:PMC6669333)
Queirazza, F., Fouragnan, E., Steele, J. D., Cavanagh, J. and Philiastides, M. G. (2019) Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression. Science Advances, 5(7), eaav4962. (doi: 10.1126/sciadv.aav4962) (PMID:31392266) (PMCID:PMC6669013)
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Nevado-Holgado, A. J., Ribe, E., Thei, L., Furlong, L., Angel-Mayer, M., Quan, J., Richardson, J. C., Cavanagh, J. and Lovestone, S. (2019) Genetic and real-world clinical data, combined with empirical validation, nominate JAK-STAT signaling as a target for Alzheimer’s Disease therapeutic development. Cells, 8(5), 425. (doi: 10.3390/cells8050425) (PMID:31072055)
Leighton, S. P. , Krishnadas, R. , Chung, K., Blair, A., Brown, S., Clark, S., Sowerbutts, K., Schwannauer, M., Cavanagh, J. and Gumley, A. (2019) Predicting one-year outcome in first episode psychosis using machine learning. PLoS ONE, 14(3), e0212846. (doi: 10.1371/journal.pone.0212846) (PMID:30845268) (PMCID:PMC6405084)
Nerurkar, L., Siebert, S. , McInnes, I. B. and Cavanagh, J. (2019) Rheumatoid arthritis and depression: an inflammatory perspective. Lancet Psychiatry, 6(2), pp. 164-173. (doi: 10.1016/S2215-0366(18)30255-4) (PMID:30366684)
Openshaw, R. L. , Kwon, J., McColl, A., Penninger, J. M., Cavanagh, J. , Pratt, J. A. and Morris, B. J. (2019) JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. Journal of Neuroinflammation, 16(1), 18. (doi: 10.1186/s12974-019-1408-5) (PMID:30691477) (PMCID:PMC6350402)
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Ferguson, A. et al. (2018) Genome-wide association study of circadian rhythmicity in 71,500 UK Biobank participants and polygenic association with mood instability. EBioMedicine, 35, pp. 279-287. (doi: 10.1016/j.ebiom.2018.08.004) (PMID:30120083) (PMCID:PMC6154782)
Cullen, B. , Newby, D., Lee, D. , Lyall, D. M. , Nevado-Holgado, A. J., Evans, J. J. , Pell, J. P. , Lovestone, S. and Cavanagh, J. (2018) Cross-sectional and longitudinal analyses of outdoor air pollution exposure and cognitive function in UK Biobank. Scientific Reports, 8, 12089. (doi: 10.1038/s41598-018-30568-6) (PMID:30108252) (PMCID:PMC6092329)
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Krishnadas, R. , Cooper, S.-A. , Nicol, A., Pimlott, S., Soni, S., Holland, A., McArthur, L. and Cavanagh, J. (2018) Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader–Willi syndrome. British Journal of Psychiatry, 212(1), pp. 57-58. (doi: 10.1192/bjp.2017.7)
Leighton, S.P. , Nerurkar, L., Krishnadas, R. , Johnman, C., Graham, G.J. and Cavanagh, J. (2018) Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Molecular Psychiatry, 23(1), pp. 48-58. (doi: 10.1038/mp.2017.205) (PMID:29133955) (PMCID:PMC5754468)
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Nerurkar, L., McColl, A., Graham, G. and Cavanagh, J. (2017) The systemic response to topical Aldara treatment is mediated through direct TLR7 stimulation as Imiquimod enters the circulation. Scientific Reports, 7, 16570. (doi: 10.1038/s41598-017-16707-5) (PMID:29185473) (PMCID:PMC5707416)
Mackay, G. A., Campbell, S., Jampana, R. and Cavanagh, J. (2017) A 50 year old with a rapid neuropsychiatric deterioration and choreaform movements. Practical Neurology, (doi: 10.1136/practneurol-2016-001481) (PMID:28119377) (PMCID:PMC5520242)
Kalk, N.J. et al. (2017) Decreased hippocampal translocator protein (18 kDa) expression in alcohol dependence: a [(11)C]PBR28 PET study. Translational Psychiatry, 7(1), e996. (doi: 10.1038/tp.2016.264) (PMID:28072413)
Jani, B. D. , Boachie, C., McCowan, C. , Barry, S. J.E. , Cavanagh, J. and Mair, F. S. (2017) Relationship of depression screening in cardiometabolic disease with vascular events and mortality: findings from a large primary care cohort with 4 years follow-up. European Heart Journal: Quality of Care and Clinical Outcomes, 3(1), pp. 61-73. (doi: 10.1093/ehjqcco/qcw045) (PMID:28927181)
Jani, B. D. , Cavanagh, J. , Barry, S. J.E. , Der, G. , Sattar, N. and Mair, F. S. (2016) Relationship between blood pressure values, depressive symptoms and cardiovascular outcomes in patients with cardiometabolic disease. Journal of Clinical Hypertension, 18(10), pp. 1027-1035. (doi: 10.1111/jch.12813) (PMID:27040355)
Mccoll, A., Thomson, C. A., Nerurkar, L., Graham, G. J. and Cavanagh, J. (2016) TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain. Journal of Neuroinflammation, 13, 102. (doi: 10.1186/s12974-016-0562-2) (PMID:27160148)
Krishnadas, R. et al. (2016) Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans. Brain, Behavior, and Immunity, 51, pp. 29-38. (doi: 10.1016/j.bbi.2015.08.005) (PMID:26255693)
Arnone, D., Mumuni, A. N., Jauhar, S., Condon, B. and Cavanagh, J. (2015) Indirect evidence of selective glial involvement in glutamate-based mechanisms of mood regulation in depression: Meta-analysis of absolute prefrontal neuro-metabolic concentrations. European Neuropsychopharmacology, 25(8), pp. 1109-1117. (doi: 10.1016/j.euroneuro.2015.04.016) (PMID:26028038)
Jani, B. D. , Purves, D., Barry, S. J.E. , Mccowan, C. , Cavanagh, J. and Mair, F. S. (2015) The effects of anti-depressants on depression symptom scores at 12 months follow-up in patients with cardiometabolic disease: results from a large primary care cohort. Journal of Family Medicine and Primary Care, 4(3), pp. 373-379. (doi: 10.4103/2249-4863.161324)
Carson, A. J., Stone, J., Hansen, C. H., Duncan, R., Cavanagh, J. , Matthews, K., Murray, G. and Sharpe, M. (2015) Somatic symptom count scores do not identify patients with symptoms unexplained by disease: a prospective cohort study of neurology outpatients. Journal of Neurology, Neurosurgery and Psychiatry, 86(3), pp. 295-301. (doi: 10.1136/jnnp-2014-308234)
Jani, B. D. , McLean, G., Nicholl, B. I. , Barry, S. J.E. , Sattar, N. , Mair, F. S. and Cavanagh, J. (2015) Risk assessment and predicting outcomes in patients with depressive symptoms: a review of potential role of peripheral blood based biomarkers. Frontiers in Human Neuroscience, 9(Art 18), (doi: 10.3389/fnhum.2015.00018)
Gale, C. R., Batty, G. D., Cooper, S.-A. , Deary, I. J., Der, G. , McEwan, B. S. and Cavanagh, J. (2015) Reaction time in adolescence, cumulative allostatic load and symptoms of anxiety and depression in adulthood: the West of Scotland Twenty-07 Study. Psychosomatic Medicine, 7(5), pp. 493-505. (doi: 10.1097/PSY.0000000000000189) (PMID:25984823) (PMCID:PMC4459883)
van Hecke, O., Torrance, N., Cochrane, L., Cavanagh, J. , Donnan, P.T., Padmanabhan, S. , Porteous, D.J., Hocking, L. and Smith, B.H. (2014) Does a history of depressionactuallymediate smoking-related pain? Findings from a cross-sectional general population-based study. European Journal of Pain, 18(9), pp. 1223-1230. (doi: 10.1002/j.1532-2149.2014.00470.x)
Queirazza, F. and Cavanagh, J. (2014) Poststroke depression and 5-HTTLPR. Journal of Neurology, Neurosurgery and Psychiatry, 85(3), pp. 241-243. (doi: 10.1136/jnnp-2012-304149)
Sassarini, J., Krishnadas, R. , Cavanagh, J. , Nicol, A., Pimlott, S. L. , Ferrell, W. and Lumsden, M. A. (2014) Venlafaxine alters microvascular perfusion, [123I]-beta-CIT binding and BDI scores in flushing postmenopausal women. Maturitas, 77(3), pp. 267-273. (doi: 10.1016/j.maturitas.2013.12.003)
Queirazza, F., Krishnadas, R. , McLean, J. and Cavanagh, J. (2014) Neighbourhood-level deprivation and morphological changes within the limbic stress circuit: results from a prospective, population-based, cohort study. Lancet, 383(s1), s85. (doi: 10.1016/S0140-6736(14)60348-2)
Jani, B. , Cavanagh, J. , Barry, S. J.E. , Der, G. , Sattar, N. and Mair, F. S. (2014) Revisiting the J shaped curve, exploring the association between cardiovascular risk factors and concurrent depressive symptoms in patients with cardiometabolic disease: findings from a large cross-sectional study. BMC Cardiovascular Disorders, 14, p. 139. (doi: 10.1186/1471-2261-14-139)
Thomson, C. A., McColl, A., Cavanagh, J. and Graham, G. J. (2014) Peripheral inflammation is associated with remote global gene expression changes in the brain. Journal of Neuroinflammation, 11(73), (doi: 10.1186/1742-2094-11-73)
Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi: 10.1007/s12311-013-0497-4)
Krishnadas, R. , Kim, J., Mclean, J., Batty, D., Mclean, J., Millar, K., Packard, C. and Cavanagh, J. (2013) The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation. Frontiers in Human Neuroscience, 7(722), (doi: 10.3389/fnhum.2013.00722)
Krishnadas, R. , Palaniyappan, L., Lang, J., Mclean, J. and Cavanagh, J. (2013) Psychoticism and salience network morphology. Personality and Individual Differences, 57, pp. 37-42. (doi: 10.1016/j.paid.2013.09.016)
Bourne, C. et al. (2013) Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis. Acta Psychiatrica Scandinavica, 128(3), pp. 149-162. (doi: 10.1111/acps.12133)
Jani, B. , Purves, D., Barry, S. , Cavanagh, J. , McLean, G. and Mair, F. (2013) Challenges and implications of routine depression screening for depression in chronic disease and multimorbidity: a cross sectional study. PLoS ONE, 8(9), e74610. (doi: 10.1371/journal.pone.0074610) (PMID:24058602) (PMCID:PMC3772931)
Kalk, N., Cherian, R., Naveed, M., McInnes, I.B., Cavanagh, J. and Lingford-Hughes, A. (2013) The peripheral cytokine profile in alcohol detoxification: relationship to cognitive function. Alcohol and Alcoholism, 48(Sup. 1), p. 60. (doi: 10.1093/alcalc/agt117)
Krishnadas, R. et al. (2013) Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. Psychosomatic Medicine, 75(7), pp. 616-623. (doi: 10.1097/PSY.0b013e3182a151a7)
Wong, E.K.O., Krishnadas, R. and Cavanagh, J. (2013) The interface between neurology and psychiatry: the case of multiple sclerosis. Advances in Psychiatric Treatment, 19(5), pp. 370-377. (doi: 10.1192/apt.bp.112.010710)
Tillmann, T., Krishnadas, R. , Cavanagh, J. and Petrides, K.V. (2013) Possible rheumatoid arthritis subtypes in terms of rheumatoid factor, depression, diagnostic delay and emotional expression: an exploratory case-control study. Arthritis Research and Therapy, 15(2), R45. (doi: 10.1186/ar4204)
Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. NeuroImage: Clinical, 2(2013), pp. 646-657. (doi: 10.1016/j.nicl.2013.04.012)
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Taylor, M., Cavanagh, J. , Hodgson, R. and Tiihonen, J. (2012) Examining the effectiveness of antipsychotic medication in first episode psychosis. Journal of Psychopharmacology, 26(5), pp. 27-32. (doi: 10.1177/0269881112439252)
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Krishnadas, R. and Cavanagh, J. (2012) Depression: an inflammatory illness? Journal of Neurology, Neurosurgery and Psychiatry, 83(5), pp. 495-502. (doi: 10.1136/jnnp-2011-301779)
Stone, J. et al. (2012) Which neurological diseases are most likely to be associated with "symptoms unexplained by organic disease". Journal of Neurology, 259(1), pp. 33-38. (doi: 10.1007/s00415-011-6111-0)
Sharpe, M., Walker, J., Williams, C. , Stone, J., Cavanagh, J. , Murray, G., Butcher, I., Duncan, R., Smith, S. and Carson, A. (2011) Guided self-help for functional (psychogenic) symptoms: a randomized controlled efficacy trial. Neurology, 77(6), pp. 564-572. (doi: 10.1212/WNL.0b013e318228c0c7)
Cavanagh, J. (2011) Understanding the biological mechanisms underlying symptoms might help us cross the brain-body divide to the benefit of both. Journal of Neurology, Neurosurgery and Psychiatry, 82(7), p. 709. (doi: 10.1136/jnnp.2011.240507)
Krishnadas, R. , Mallon, V., McInnes, I. and Cavanagh, J. (2011) Correlates of depression and quality of life in patients with inflammatory arthritides. European Psychiatry, 26, p. 383. (doi: 10.1016/S0924-9338(11)72091-0)
Krishnadas, R. , Krishnadas, R. and Cavanagh, J. (2011) Sustained remission of rheumatoid arthritis with a specific serotonin reuptake inhibitor antidepressant: a case report and review of the literature. Journal of Medical Case Reports, 5, 112. (doi: 10.1186/1752-1947-5-112) (PMID:21418592) (PMCID:PMC3072330)
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Cavanagh, J. , Patterson, J., Pimlott, S. , Wyper, D. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: In vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi: 10.1002/syn.20705) (PMID:19771591)
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Cavanagh, J. , Paterson, C., McLean, J., Pimlott, S. , McDonald, M., Patterson, J., Wyper, D. and McInnes, I. (2010) Tumour necrosis factor blockade mediates altered serotonin transporter availability in rheumatoid arthritis: a clinical, proof-of-concept study. Annals of the Rheumatic Diseases, 69(6), 1251-U367. (doi: 10.1136/ard.2009.107912)
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Goodwin, G.M. and Cavanagh, J. (2009) Evidence-based guidelines for treating bipolar disorder: revised second edition - recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology, 23(4), pp. 346-388. (doi: 10.1177/0269881109102919)
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Arnone, D., Cavanagh, J., Gerber, D., Lawrie, S., Ebmeier, K. and McIntosh, A. (2009) Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. British Journal of Psychiatry, 195(3), pp. 194-201. (doi: 10.1192/bjp.bp.108.059717)
Cavanagh, J., Schwannauer, M., Power, M. and Goodwin, G.M. (2009) A novel scale for measuring mixed states in bipolar disorder. Clinical Psychology and Psychotherapy, 16(6), pp. 497-509. (doi: 10.1002/cpp.633)
Deans, K.A. et al. (2009) Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study. British Medical Journal, 339, b4170. (doi: 10.1136/bmj.b4170)
McLean, J., Brennan, D., Wyper, D.J., Condon, B., Hadley, D.M. and Cavanagh, J. (2009) Localisation of regions of intense pleasure response evoked by soccer goals. Psychiatry Research: Neuroimaging, 171(1), pp. 33-43. (doi: 10.1016/j.pscychresns.2008.02.005)
Sharpe, M. et al. (2009) Neurology out-patients with symptoms unexplained by disease: illness beliefs and financial benefits predict 1-year outcome. Psychological Medicine, 40(4), pp. 689-698. (doi: 10.1017/S0033291709990717)
Cavanagh, J. and Mathias, C. (2008) Inflammation and its relevance to psychiatry. Advances in Psychiatric Treatment, 14(4), pp. 248-255.
Smith, F.W., Muckli, L., Brennan, D., Pernet, C., Smith, M., Belin, P., Gosselin, F., Hadley, D.M., Cavanagh, J. and Schyns, P.G. (2008) Classification images reveal the information sensitivity of brain voxels in fMRI. NeuroImage, 40(4), pp. 1643-1654. (doi: 10.1016/j.neuroimage.2008.01.029)
Velupillai, Y.N. et al. (2008) Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health, 8(126), (doi: 10.1186/1471-2458-8-126)
Pimlott, S. L. , Piggott, M., Patterson, J., Cavanagh, J. and Wyper, D. J. (2007) SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380. Journal of Labelled Compounds and Radiopharmaceuticals, 50(5-6), pp. 350-353. (doi: 10.1002/jlcr.1192)
Cannon, M., Cavanagh, J., McNeill, Y., Murray, R. and Scott, J. (2006) Exposure to obstetric complications and subsequent development of bipolar disorder - Systematic review. British Journal of Psychiatry, 189, pp. 3-11.
Cavanagh, J. , Patterson, J., Pimlott, S., Dewar, D., Eersels, J., Dempsey, M. and Wyper, D. (2006) Serotonin transporter residual availability during long-term antidepressant therapy does not differentiate responder and nonresponder unipolar patients. Biological Psychiatry, 59, pp. 301-308. (doi: 10.1016/j.biopsych.2005.06.029)
Scott, J., McNeill, Y., Cavanagh, J., Cannon, M. and Murray, R. (2006) Exposure to obstetric complications and subsequent development of bipolar disorder. British Journal of Psychiatry, 189, pp. 3-11. (doi: 10.1192/bjp.bp.105.010579)
Cavanagh, J. T.O. and Smith, D. J. (2005) The use of single photon emission computed tomography in depressive disorders. Nuclear Medicine Communications, 26(3), pp. 197-203.
Smith, D.J. and Cavanagh, J.T.O. (2005) The use of single photon emission computed tomography in depressive disorders. Nuclear Medicine Communications, 26(3), pp. 197-203.
Cavanagh, J., Goodwin, G. and Smyth, R. (2004) Relapse into mania or depression following lithium discontinuation: a 7-year follow-up. Acta Psychiatrica Scandinavica, 109, pp. 91-95.
Jackson, A., Cavanagh, J. and Scott, J. (2003) A systematic review of manic and depressive prodromes. Journal of Affective Disorders, 74(3), pp. 209-217. (doi: 10.1016/S0165-0327(02)00266-5)
Carson, A., Cavanagh, J., Lawrie, S. and Sharpe, M. (2003) Psychological autopsy studies of suicide: a systematic review. Psychological Medicine, 33, pp. 395-405. (doi: 10.1017/S0033291702006943)
Cavanagh, J.T.O. , Van Beck, M., Muir, W. and Blackwood, D.H.R. (2002) Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania. British Journal of Psychiatry, 180, pp. 320-326. (doi: 10.1192/bjp.180.4.320)
Lawrie, S.M., MacHale, S.M., Cavanagh, J.T.O. , O'Carroll, R.E. and Goodwin, G.M. (2000) The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness. Psychological Medicine, 30(2), pp. 433-442. (doi: 10.1017/S0033291799001816)
MacHale, S.M., Lawrie, S.M., Cavanagh, J.T.O. , Glabus, M.F., Murray, C.M. and Goodwin, G.M. (2000) Cerebral perfusion in chronic fatigue syndrome and depression. British Journal of Psychiatry, 176(6), pp. 550-556. (doi: 10.1192/bjp.176.6.550)
Shajahan, P. M., MacIntosh, A. M. and Cavanagh, J. T.O. (2000) Admission patterns by psychiatric trainees. Are women patients as likely as men to be admitted for major mental illness? Psychiatric Bulletin, 24(2), pp. 59-61. (doi: 10.1192/pb.24.2.59)
Cavanagh, J.T.O. , Owens, D.G.C. and Johnstone, E.C. (1999) Life events in suicide and undetermined death in south-east Scotland: a case-control study using the method of psychological autopsy. Social Psychiatry and Psychiatric Epidemiology, 34(12), pp. 645-650. (doi: 10.1007/s001270050187)
Cavanagh, J.T.O. , Owens, D.G. and Johnstone, E.C. (1999) Suicide and undetermined death in south east Scotland. A case-control study using the psychological autopsy method. Psychological Medicine, 29(5), pp. 1141-9.
Cavanagh, J.T.O. and Shajahan, P.M. (1999) Increasing rates of hospital admission for men with major mental illnesses: data from Scottish mental health units, 1980–1995. Acta Psychiatrica Scandinavica, 99(5), pp. 353-359. (doi: 10.1111/j.1600-0447.1999.tb07241.x)
Buckley, L., MacHale, S. M., Cavanagh, J. T.O. , Sharpe, M., Deary, I. J. and Lawrie, S. M. (1999) Personality dimensions in chronic fatigue syndrome and depression. Journal of Psychosomatic Research, 46(4), pp. 395-400. (doi: 10.1016/S0022-3999(98)00120-2)
MacHale, S.M., Cavanagh, J.T.O. , Bennie, J., Carroll, S., Goodwin, G.M. and Lawrie, S.M. (1998) Diurnal variation of adrenocortical activity in chronic fatigue syndrome. Neuropsychobiology, 38(4), pp. 213-217. (doi: 10.1159/000026543)
Shajahan, P.M. and Cavanagh, J.T. (1998) Admission for depression among men in Scotland, 1980-95: retrospective study. British Medical Journal, 316(7143), pp. 1496-1497. (doi: 10.1136/bmj.316.7143.1496)
Ebmeier, K.P., Cavanagh, J.T. , Moffoot, A.P., Glabus, M.F., O'Carroll, R.E. and Goodwin, G.M. (1997) Cerebral perfusion correlates of depressed mood. British Journal of Psychiatry, 170(1), pp. 77-81. (doi: 10.1192/bjp.170.1.77)
Goodwin, G.M., Cavanagh, J.T.O. , Glabus, M.F., Kehoe, R.F., O'Carroll, R.E. and Ebmeier, K.P. (1997) Uptake of 99mTc-exametazime shown by single photon emission computed tomography before and after lithium withdrawal in bipolar patients: associations with mania. British Journal of Psychiatry, 170(5), pp. 426-430. (doi: 10.1192/bjp.170.5.426)
Books
Williams, C. , Carson, A., Smith, S., Sharpe, M., Cavanagh, J. and Kent, C. (2011) Overcoming Functional Neurological Symptoms: A Five Areas Approach. Series: Overcoming. CRC Press: London. ISBN 9781444138344
Book Sections
Bourgognon, J.-M. , McColl, A., Suessmilch, M., Krishnadas, R. and Cavanagh, J. (2021) Stress, immune system and the brain. In: Textbook of Immunopsychiatry. Cambridge University Press: Cambridge, pp. 51-72. ISBN 9781108539623 (doi: 10.1017/9781108539623.004)
Herron, J. W. , Nerurkar, L. and Cavanagh, J. (2019) Neuroimmune biomarkers in mental illness. In: Pratt, J. and Hall, J. (eds.) Current Topics in Behavioural Neurosciences. Series: Current topics in behavioral neurosciences (40). Springer: Cham, Switzerland, pp. 45-78. ISBN 9783319996417 (doi: 10.1007/7854_2018_45)
Jauhar, S. and Cavanagh, J. (2013) The classification and epidemiology of bipolar disorders. In: Power, M. (ed.) The Wiley Blackwell Handbook of Mood Disorders, 2nd Edition. Wiley Blackwell: Chichester. ISBN 9781119978923
Cavanagh, J. and Smyth, R. (2010) Suicide and self harm. In: Johnstone, E.C., Lawrie, S., Owens, D.G.C., Sharpe, M. and McIntosh, A. (eds.) Companion to Psychiatric Studies [8th edition]. Churchill Livingstone: London. ISBN 9780702031373
Cavanagh, J. (2006) The classification and epidemiology of bipolar disorders. In: Power, M.J. (ed.) Mood Disorders : A Handbook of Science and Practice. John Wiley & Sons. ISBN 9780470092767
Cavanagh, J. (2004) The classification and epidemiology of bipolar disorders. In: Power, M. J. (ed.) Mood Disorders: A handbook of science and practice. John Wiley & Sons Ltd.: West Sussex. ISBN 047084390X
Cavanagh, J. and Masterton, G. (2004) Suicide and deliberate self harm. In: Johnstone, E.C., Lawrie, S., Owens, D.G.C., Sharpe, M. and Freeman, C. (eds.) Companion to Psychiatric Studies [7th edition]. Churchill Livingstone: London. ISBN 9780443072635
Cavanagh, J. (2000) Genetics. In: Lawrie, S. M., Sharpe, M. and Johnstone, E. C. (eds.) MCQs for the Companion to Psychiatric Studies. Churchill Livingstone: London. ISBN 9780443064333
Cavanagh, J. (2000) Mood disorders. In: Lawrie, S. M., Sharpe, M. and Johnstone, E. C. (eds.) MCQs for the Companion to Psychiatric Studies. Churchill Livingstone: London. ISBN 9780443064333
Cavanagh, J. (2000) Neuroanatomy. In: Lawrie, S. M., Sharpe, M. and Johnstone, E. C. (eds.) MCQs for the Companion to Psychiatric Studies. Churchill Livingstone: London. ISBN 9780443064333
Cavanagh, J. and Masterton, G. (1998) Suicide and deliberate self harm. In: Johnstone, E.C., Freeman, C. and Zealley, A.K. (eds.) Companion to Psychiatric Studies, 6th Edition. Churchill Livingstone: London, pp. 751-783.
Conference or Workshop Item
Krishnadas, R. , Nicol, A., Sassarini, J., Puri, N.,, Pimlott, S. , Hadley, D., McInnnes, I. and Cavanagh, J. (2015) SPECT Scanning of Brainstem Serotonin Transporter Availability Reveals Association with Circulating Inflammatory Tumour Necrosis Factor. 28th Annual EANM Congress of the European Association of Nuclear Medicine 2015, Hamburg, Germany, 10-14 Oct 2015. S557-S558. (doi: 10.1007/s00259-015-3198-z)
Newman, E., Khoo, T.C., Patterson, J., Cavanagh, J. , Pimlott, S. , Grosset, K.A. and Grosset, D.G. (2012) Serotonergic Function in Early Parkinson's Disease With and Without Depression: A Pilot Study. Association of British Neurologists Annual Meeting 2011, Newcastle, UK, 2011. (doi: 10.1136/jnnp-2011-301993.158)
Conference Proceedings
Jani, B. D. , Boachie, C., McCowan, C., Barry, S. , Cavanagh, J. and Mair, F. S. (2014) Association of depression screening in cardiometabolic disease with future vascular events and mortality: a cohort study. In: Public Health Science, Glasgow, UK, 19 Nov 2014, S41. (doi: 10.1016/S0140-6736(14)62167-X)
Jani, B. D. , Cavanagh, J. , Barry, S. , Der, G. , Sattar, N. and Mair, F. S. (2014) Association between cardiovascular risk factors and concurrent depressive symptoms in cardiometabolic disease: a cross-sectional study. In: Public Health Science, Glasgow, UK, 19 Nov 2014, S40. (doi: 10.1016/S0140-6736(14)62166-8)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Translating Cutting-Edge Discovery Science into Patient Benefit
Medical Research Council
2023 - 2030
- Probing the Rheumatoid Arthritis Brain to Expose Central Pain Pathways
Versus Arthritis
2020 - 2022
- Exploiting leading edge 7 Tesla MRI brain imaging to decipher Olumiant's mode of analgesic action in rheumatoid arthritis
Eli Lilly and Company (UK)
2020 - 2023
- TNF antagonism and brain monocyte recruitment in sickness behaviour in rheumatoid arthritis
Medical Research Council
2019 - 2022
- CSO clinical training grant - psychotic disorders
Chief Scientist Office
2019 - 2022
- Consortium of Neuroimmunology of Mood Disorders and Alzheimer's Disease
Wellcome Trust
2015 - 2021
- Sackler Research Fellowships
The Dr Mortimer and Theresa Sackler Foundation
2013 - 2018
- Comparing biomarkers of stress and allostatic load in medically ill populations with and without major depressive disorder
Scottish Mental Health Research Network
2013 - 2017
- Investigating the neural basis for checking, selective attention and working memory in obsessive compulsive disorder, through MEG and TMS.
Medical Research Council
2013 - 2015
- Exploring the potential role for allostatic load markers in risk assessment of patients presenting with depressive symptoms
Chief Scientist Office
2012 - 2015
- The allostatic load model as a predictor of outcome following head injury
Chief Scientist Office
2012 - 2015
- Prevalence of Depression in Diabetes, Cardiovascular disease and Stroke in Community based population.
BUPA Medical Foundation
2011 - 2014
- Functional MRI markers associated with initial and sustained response to CBT
Greater Glasgow & Clyde Primary Care Trust
2009 - 2010
- [123I]B-CIT midbrain uptake correlates with depressive symptoms in patients newly diagnosed with Parkinson's Disease
Neurosciences Foundation
2009 - 2010
- From genotype to psychiatric phenotype - serotonergic function in adults with Prader-Willi syndrome
Baily Thomas Charitable Fund
2008 - 2009
- Brain Mechanisms of Emotional Processing in Depression
The Carnegie Trust for the Universities of Scotland
2007 - 2008
- CaliBrain - multicentre structural and functional MRI in Scotland
Scottish Executive Health Department
2006 - 2007
- Factors determining physical and mental well being in affluent and deprived communities in Glasgow
Glasgow Centre for Population Health
2005 - 2007
- A complex intervention for patients with medically unexplained neurological symptoms - trial platform
Medical Research Council
2004 - 2006
- A SPECT study of the ratio of Dopamine Transporter to Seretonic Transporter in Treatment Resistant compared with Treatment Responsive.....
Greater Glasgow Primary Care NHS Trust
2004 - 2005
- A pilot study of the effects of antidepressants on nicotinic acetylcholine receptors
West of Scotland Research and Development
2003 - 2009
- The outcome of medically unexplained neurological symptoms - a Scottish national study
Scottish Executive Health Department
2002 - 2006
Research datasets
2020
Ward, J., Strawbridge, R. , Bailey, M. , Graham, N., Ferguson, A., Lyall, D. , Cullen, B. , Pidgeon, L., Cavanagh, J., Mackay, D. , Pell, J. , O'Donovan, M., Escott-Price, V. and Smith, D. (2020) Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia. [Data Collection]
2019
Ferguson, A., Lyall, L., Ward, J., Strawbridge, R. , Cullen, B. , Graham, N., Niedzwiedz, C. , Johnston, K., Mackay, D. , Biello, S. , Pell, J. , Cavanagh, J., McIntosh, A. M., Doherty, A., Bailey, M. , Lyall, D. , Wyse, C. and Smith, D. (2019) Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability. [Data Collection]
Strawbridge, R. , Ward, J., Lyall, L., Tunbridge, E. M., Cullen, B. , Graham, N., Ferguson, A., Johnston, K., Lyall, D. , Mackay, D. , Cavanagh, J., Howard, D. M., Adams, M. J., Deary, I., Escott-Price, V., O’Donovan, M., McIntosh, A. M., Bailey, M. , Pell, J. , Harrison, P. and Smith, D. (2019) Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression. [Data Collection]
Additional information
Invited International Presentations
- 2015: University of Cambridge - Department of Psychiatry
- 2014: King's College London - Institute of Psychiatry, Centre for Affective Disorders
- 2014: India - Wellcome Trust Liverpool Glasgow Centre for Global Health, joint meeting with NIMHANS
- 2014: University of New South Wales, Australia - Plenary Speaker Brain Health Complexity: molecules to systems
- 2014: European Behavioural Pharmacology Society - “Immune Influences on Brain & Behaviour: from Psychoneuroimmunology to Immunopsychiatry”
- 2014: Columbia University, NY, USA - Sackler Centre for Neuroscience
- 2014: Rockefeller University, NY, USA - “Integrative Medicine” Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology
- 2014: University of Cardiff - Neuroscience and Mental Health Research Institute Seminar Series
- 2014: University of Dundee - Division of Neuroscience Seminar Programme
- 2014: University of Edinburgh - Special Lecture Series in Psychiatry
- 2013: Royal College of Physicians, Edinburgh - Annual Scientific Meeting of Scottish Mental Health Research Network, “Mind and Body in the 21st Century”
- 2013: King's College London - Stress, Psychiatry and Immunology Laboratory Seminar Series
- 2013: Brighton & Sussex Medical School - Clinical Imaging Sciences Centre
- 2013: University of Glasgow - Glasgow Psychosis Research Network Inaugural Conference
- 2013: University of Strathclyde - Conference on Challenges and Opportunities in Mental Health Research
- 2011: King's College London - Immune – Neurobiology : Future Research Conference
- 2010: Columbia University, NY, USA - Grand Round, Department of Psychiatry
- 2010: University of Strathclyde - CENSUS-Psychology Interface Conference
- 2009: Rockefeller University, NY, USA - McArthur Foundation Network Meeting
- 2009: University of Edinburgh - Department of Psychiatry Special Lecture Series
- 2009: University of Oxford - Department of Psychiatry Post-Graduate Lecture
- 2009: University of Cambridge - Prader-Willi Research Conference
- 2005: New York, NY, USA - United States-United Kingdom Joint Sackler Institutes Conference