2024

Mifsud, J. C.O., Lytras, S., Oliver, M. R. , Toon, K. , Costa, V. A., Holmes, E. C. and Grove, J. (2024) Mapping glycoprotein structure reveals Flaviviridae evolutionary history. Nature, 633(8030), pp. 695-703. (doi: 10.1038/s41586-024-07899-8) (PMID:39232167)

Mifsud, J. C.O., Lytras, S., Oliver, M. R. , Toon, K. , Costa, V. A., Holmes, E. C. and Grove, J. (2024) Mapping glycoprotein structure reveals defining events in the evolution of the Flaviviridae. bioRxiv, (doi: 10.1101/2024.02.06.579159)

Petrone, M. E., Grove, J. , Mifsud, J. C. O., Parry, R. H., Marzinelli, E. M. and Holmes, E. C. (2024) A 39.8kb flavi-like virus uses a novel strategy for overcoming the RNA virus error threshold. bioRxiv, (doi: 10.1101/2024.01.08.574764)

2023

Skeldon, K. et al. (2023) Research Firsts Exhibition. [Exhibitions]

Willett, B. J. et al. (2023) Omicron BA.2.86 cross-neutralising activity in community sera from the UK. Lancet, 402(10417), pp. 2075-2076. (doi: 10.1016/s0140-6736(23)02397-8) (PMID:37952549)

Styles, C. T. et al. (2023) Propylene glycol inactivates respiratory viruses and prevents airborne transmission. EMBO Molecular Medicine, 15(12), e17932. (doi: 10.15252/emmm.202317932) (PMID:37970627) (PMCID:PMC10701621)

Toon, K. , Kalemera, M. D., Palor, M., Rose, N. J., Takeuchi, Y., Grove, J. and Mattiuzzo, G. (2023) GB Virus B and Hepatitis C Virus, distantly related Hepaciviruses, share an entry factor, Claudin-1. Journal of Virology, 97(7), e00469-23. (doi: 10.1128/jvi.00469-23) (PMID:37310242) (PMCID:PMC10373534)

Oliver, M. R. , Toon, K. , Lewis, C. B., Devlin, S., Gifford, R. J. and Grove, J. (2023) Structures of the Hepaci-, Pegi-, and Pestiviruses envelope proteins suggest a novel membrane fusion mechanism. PLoS Biology, 21(7), e3002174. (doi: 10.1371/journal.pbio.3002174) (PMID:37432947) (PMCID:PMC10335668)

Cantoni, D. and Grove, J. (2023) Low hanging fruit for combatting SARS‐CoV‐2? EMBO Reports, 24(4), e56979. (doi: 10.15252/embr.202356979) (PMID:36876512) (PMCID:PMC10074046)

2022

Mersmann, S. F., Johns, E., Yong, T., McEwan, W. A., James, L. C., Cohen, E. A.K. and Grove, J. (2022) A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling. Scientific Reports, 12, 17286. (doi: 10.1038/s41598-022-20506-y) (PMID:36241663) (PMCID:PMC9568568)

Cantoni, D. et al. (2022) Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike. EMBO Reports, 23(10), e54322. (doi: 10.15252/embr.202154322) (PMID:35999696) (PMCID:PMC9535765)

Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)

Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)

Stejskal, L. et al. (2022) An entropic safety catch controls Hepatitis C virus entry and antibody resistance. eLife, 11, e71854. (doi: 10.7554/eLife.71854) (PMID:35796426) (PMCID:PMC9333995)

2021

Schmidt, N. M. et al. (2021) Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nature Communications, 12, 2814. (doi: 10.1038/s41467-021-22967-7) (PMID:33990561) (PMCID:PMC8121939)

Kalemera, M. D., Capella-Pujol, J., Chumbe, A., Underwood, A., Bull, R. A., Schinkel, J., Sliepen, K. and Grove, J. (2021) Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins. Journal of General Virology, 102(1), 001512. (doi: 10.1099/jgv.0.001512) (PMID:33147126) (PMCID:PMC8116788)

2020

Palor, M. et al. (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. Journal of Biological Chemistry, 295(50), pp. 16931-16948. (doi: 10.1074/jbc.RA120.014761) (PMID:32900848) (PMCID:PMC7863897)

Stejskal, L., Lees, W. D., Moss, D. S., Palor, M., Bingham, R. J., Shepherd, A. J. and Grove, J. (2020) Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein. PLoS Computational Biology, 16(2), e1007710. (doi: 10.1371/journal.pcbi.1007710) (PMID:32109245) (PMCID:PMC7065822)

2019

Davies, S. P. et al. (2019) Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process. Cell Reports, 29(6), 1610-1620.e4. (doi: 10.1016/j.celrep.2019.09.068) (PMID:31693899) (PMCID:PMC7057271)

Mazzon, M. et al. (2019) Identification of broad-spectrum antiviral compounds by targeting viral entry. Viruses, 11(2), 176. (doi: 10.3390/v11020176) (PMID:30791609) (PMCID:PMC6410080)

2018

pereira, P. M., Jacobs, C. and Grove, J. (2018) Investigating hepatitis C virus infection using super-resolution microscopy. In: Law, M. (ed.) Hepatitis C Virus Protocols. Series: Methods in molecular biology (1911). Humana Press: New York, NY, pp. 247-261. ISBN 9781493989751 (doi: 10.1007/978-1-4939-8976-8_17)

2017

Grove, J. , Hu, K., Farquhar, M. J., Goodall, M., Walker, L., Jamshad, M., Drummer, H. E., Bill, R. M., Balfe, P. and McKeating, J. A. (2017) A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81. Wellcome Open Research, 2, 82. (doi: 10.12688/wellcomeopenres.12058.1) (PMID:29090272) (PMCID:PMC5657224)

Lythgoe, K. A., Gardner, A., Pybus, O. G. and Grove, J. (2017) Short-sighted virus evolution and a germline hypothesis for chronic viral infections. Trends in Microbiology, 25(5), pp. 336-348. (doi: 10.1016/j.tim.2017.03.003) (PMID:28377208) (PMCID:PMC5405858)

2016

Culley, S., Towers, G. J., Selwood, D. L., Henriques, R. and Grove, J. (2016) Infection counter: automated quantification of in vitro virus replication by fluorescence microscopy. Viruses, 8(7), 201. (doi: 10.3390/v8070201) (PMID:27455304) (PMCID:PMC4974536)

2014

Grove, J. , Metcalf, D. J., Knight, A. E., Wavre-Shapton, S. T., Sun, T., Protonotarios, E. D., Griffin, L. D., Lippincott-Schwartz, J. and Marsh, M. (2014) Flat clathrin lattices: stable features of the plasma membrane. Molecular Biology of the Cell, 25(22), pp. 3581-3594. (doi: 10.1091/mbc.E14-06-1154) (PMID:25165141) (PMCID:PMC4230618)

Grove, J. (2014) Super-resolution microscopy: a virus' eye view of the cell. Viruses, 6(3), pp. 1365-1378. (doi: 10.3390/v6031365) (PMID:24651030) (PMCID:PMC3970155)

2012

Henry, A. G., Hislop, J. N., Grove, J. , Thorn, K., Marsh, M. and von Zastrow, M. (2012) Regulation of endocytic clathrin dynamics by cargo ubiquitination. Developmental Cell, 23(3), pp. 519-532. (doi: 10.1016/j.devcel.2012.08.003) (PMID:22940114) (PMCID:PMC3470869)

2011

Grove, J. and Marsh, M. (2011) The cell biology of receptor-mediated virus entry. Journal of Cell Biology, 195(7), pp. 1071-1082. (doi: 10.1083/jcb.201108131) (PMID:22123832) (PMCID:PMC3246895)

Brimacombe, C. L. et al. (2011) Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. Journal of Virology, 85(1), pp. 596-605. (doi: 10.1128/JVI.01592-10) (PMID:20962076) (PMCID:PMC3014195)

Syder, A. J. et al. (2011) Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. Journal of Hepatology, 54(1), pp. 48-55. (doi: 10.1016/j.jhep.2010.06.024) (PMID:20932595)

2010

Wagoner, J. et al. (2010) Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology, 51(6), pp. 1912-1921. (doi: 10.1002/hep.23587) (PMID:20512985) (PMCID:PMC2909978)

2009

Schwarz, A.K., Grove, J. , Hu, K., Mee, C.J., Balfe, P. and McKeating, J.A. (2009) Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. Journal of Virology, 83(23), pp. 12407-12414. (doi: 10.1128/JVI.01552-09) (PMID:19776133) (PMCID:PMC2786758)

2008

Stamataki, Z., Grove, J. , Balfe, P. and McKeating, J.A. (2008) Hepatitis C virus entry and neutralization. Clinics in Liver Disease, 12(3), pp. 693-712. (doi: 10.1016/j.cld.2008.03.008) (PMID:18625435)

Grove, J. , Nielsen, S., Zhong, J., Bassendine, M.F., Drummer, H.E., Balfe, P. and McKeating, J.A. (2008) Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. Journal of Virology, 82(24), pp. 12020-12029. (doi: 10.1128/JVI.01569-08) (PMID:18829747) (PMCID:PMC2593310)

Mee, C.J., Grove, J. , Harris, H.J., Hu, K., Balfe, P. and McKeating, J.A. (2008) Effect of cell polarization on hepatitis C virus entry. Journal of Virology, 82(1), pp. 461-470. (doi: 10.1128/JVI.01894-07) (PMID:17959672) (PMCID:PMC2224355)

Reynolds, G.M., Harris, H.J., Jennings, A., Hu, K., Grove, J. , Lalor, P.F., Adams, D.H., Balfe, P., Hübscher, S.G. and McKeating, J.A. (2008) Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology, 47(2), pp. 418-427. (doi: 10.1002/hep.22028) (PMID:18085708)

2007

Williams, J.M., Pettitt, T.R., Powell, W., Grove, J. , Savage, C.O.S. and Wakelam, M.J.O. (2007) Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation. Journal of the American Society of Nephrology, 18(4), pp. 1112-1120. (doi: 10.1681/ASN.2006090973) (PMID:17360949)

Articles

Mifsud, J. C.O., Lytras, S., Oliver, M. R. , Toon, K. , Costa, V. A., Holmes, E. C. and Grove, J. (2024) Mapping glycoprotein structure reveals Flaviviridae evolutionary history. Nature, 633(8030), pp. 695-703. (doi: 10.1038/s41586-024-07899-8) (PMID:39232167)

Mifsud, J. C.O., Lytras, S., Oliver, M. R. , Toon, K. , Costa, V. A., Holmes, E. C. and Grove, J. (2024) Mapping glycoprotein structure reveals defining events in the evolution of the Flaviviridae. bioRxiv, (doi: 10.1101/2024.02.06.579159)

Petrone, M. E., Grove, J. , Mifsud, J. C. O., Parry, R. H., Marzinelli, E. M. and Holmes, E. C. (2024) A 39.8kb flavi-like virus uses a novel strategy for overcoming the RNA virus error threshold. bioRxiv, (doi: 10.1101/2024.01.08.574764)

Willett, B. J. et al. (2023) Omicron BA.2.86 cross-neutralising activity in community sera from the UK. Lancet, 402(10417), pp. 2075-2076. (doi: 10.1016/s0140-6736(23)02397-8) (PMID:37952549)

Styles, C. T. et al. (2023) Propylene glycol inactivates respiratory viruses and prevents airborne transmission. EMBO Molecular Medicine, 15(12), e17932. (doi: 10.15252/emmm.202317932) (PMID:37970627) (PMCID:PMC10701621)

Toon, K. , Kalemera, M. D., Palor, M., Rose, N. J., Takeuchi, Y., Grove, J. and Mattiuzzo, G. (2023) GB Virus B and Hepatitis C Virus, distantly related Hepaciviruses, share an entry factor, Claudin-1. Journal of Virology, 97(7), e00469-23. (doi: 10.1128/jvi.00469-23) (PMID:37310242) (PMCID:PMC10373534)

Oliver, M. R. , Toon, K. , Lewis, C. B., Devlin, S., Gifford, R. J. and Grove, J. (2023) Structures of the Hepaci-, Pegi-, and Pestiviruses envelope proteins suggest a novel membrane fusion mechanism. PLoS Biology, 21(7), e3002174. (doi: 10.1371/journal.pbio.3002174) (PMID:37432947) (PMCID:PMC10335668)

Cantoni, D. and Grove, J. (2023) Low hanging fruit for combatting SARS‐CoV‐2? EMBO Reports, 24(4), e56979. (doi: 10.15252/embr.202356979) (PMID:36876512) (PMCID:PMC10074046)

Mersmann, S. F., Johns, E., Yong, T., McEwan, W. A., James, L. C., Cohen, E. A.K. and Grove, J. (2022) A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling. Scientific Reports, 12, 17286. (doi: 10.1038/s41598-022-20506-y) (PMID:36241663) (PMCID:PMC9568568)

Cantoni, D. et al. (2022) Evolutionary remodelling of N-terminal domain loops fine-tunes SARS-CoV-2 spike. EMBO Reports, 23(10), e54322. (doi: 10.15252/embr.202154322) (PMID:35999696) (PMCID:PMC9535765)

Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)

Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)

Stejskal, L. et al. (2022) An entropic safety catch controls Hepatitis C virus entry and antibody resistance. eLife, 11, e71854. (doi: 10.7554/eLife.71854) (PMID:35796426) (PMCID:PMC9333995)

Schmidt, N. M. et al. (2021) Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint. Nature Communications, 12, 2814. (doi: 10.1038/s41467-021-22967-7) (PMID:33990561) (PMCID:PMC8121939)

Kalemera, M. D., Capella-Pujol, J., Chumbe, A., Underwood, A., Bull, R. A., Schinkel, J., Sliepen, K. and Grove, J. (2021) Optimized cell systems for the investigation of hepatitis C virus E1E2 glycoproteins. Journal of General Virology, 102(1), 001512. (doi: 10.1099/jgv.0.001512) (PMID:33147126) (PMCID:PMC8116788)

Palor, M. et al. (2020) Cholesterol sensing by CD81 is important for hepatitis C virus entry. Journal of Biological Chemistry, 295(50), pp. 16931-16948. (doi: 10.1074/jbc.RA120.014761) (PMID:32900848) (PMCID:PMC7863897)

Stejskal, L., Lees, W. D., Moss, D. S., Palor, M., Bingham, R. J., Shepherd, A. J. and Grove, J. (2020) Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein. PLoS Computational Biology, 16(2), e1007710. (doi: 10.1371/journal.pcbi.1007710) (PMID:32109245) (PMCID:PMC7065822)

Davies, S. P. et al. (2019) Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process. Cell Reports, 29(6), 1610-1620.e4. (doi: 10.1016/j.celrep.2019.09.068) (PMID:31693899) (PMCID:PMC7057271)

Mazzon, M. et al. (2019) Identification of broad-spectrum antiviral compounds by targeting viral entry. Viruses, 11(2), 176. (doi: 10.3390/v11020176) (PMID:30791609) (PMCID:PMC6410080)

Grove, J. , Hu, K., Farquhar, M. J., Goodall, M., Walker, L., Jamshad, M., Drummer, H. E., Bill, R. M., Balfe, P. and McKeating, J. A. (2017) A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81. Wellcome Open Research, 2, 82. (doi: 10.12688/wellcomeopenres.12058.1) (PMID:29090272) (PMCID:PMC5657224)

Lythgoe, K. A., Gardner, A., Pybus, O. G. and Grove, J. (2017) Short-sighted virus evolution and a germline hypothesis for chronic viral infections. Trends in Microbiology, 25(5), pp. 336-348. (doi: 10.1016/j.tim.2017.03.003) (PMID:28377208) (PMCID:PMC5405858)

Culley, S., Towers, G. J., Selwood, D. L., Henriques, R. and Grove, J. (2016) Infection counter: automated quantification of in vitro virus replication by fluorescence microscopy. Viruses, 8(7), 201. (doi: 10.3390/v8070201) (PMID:27455304) (PMCID:PMC4974536)

Grove, J. , Metcalf, D. J., Knight, A. E., Wavre-Shapton, S. T., Sun, T., Protonotarios, E. D., Griffin, L. D., Lippincott-Schwartz, J. and Marsh, M. (2014) Flat clathrin lattices: stable features of the plasma membrane. Molecular Biology of the Cell, 25(22), pp. 3581-3594. (doi: 10.1091/mbc.E14-06-1154) (PMID:25165141) (PMCID:PMC4230618)

Grove, J. (2014) Super-resolution microscopy: a virus' eye view of the cell. Viruses, 6(3), pp. 1365-1378. (doi: 10.3390/v6031365) (PMID:24651030) (PMCID:PMC3970155)

Henry, A. G., Hislop, J. N., Grove, J. , Thorn, K., Marsh, M. and von Zastrow, M. (2012) Regulation of endocytic clathrin dynamics by cargo ubiquitination. Developmental Cell, 23(3), pp. 519-532. (doi: 10.1016/j.devcel.2012.08.003) (PMID:22940114) (PMCID:PMC3470869)

Grove, J. and Marsh, M. (2011) The cell biology of receptor-mediated virus entry. Journal of Cell Biology, 195(7), pp. 1071-1082. (doi: 10.1083/jcb.201108131) (PMID:22123832) (PMCID:PMC3246895)

Brimacombe, C. L. et al. (2011) Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission. Journal of Virology, 85(1), pp. 596-605. (doi: 10.1128/JVI.01592-10) (PMID:20962076) (PMCID:PMC3014195)

Syder, A. J. et al. (2011) Small molecule scavenger receptor BI antagonists are potent HCV entry inhibitors. Journal of Hepatology, 54(1), pp. 48-55. (doi: 10.1016/j.jhep.2010.06.024) (PMID:20932595)

Wagoner, J. et al. (2010) Multiple effects of silymarin on the hepatitis C virus lifecycle. Hepatology, 51(6), pp. 1912-1921. (doi: 10.1002/hep.23587) (PMID:20512985) (PMCID:PMC2909978)

Schwarz, A.K., Grove, J. , Hu, K., Mee, C.J., Balfe, P. and McKeating, J.A. (2009) Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. Journal of Virology, 83(23), pp. 12407-12414. (doi: 10.1128/JVI.01552-09) (PMID:19776133) (PMCID:PMC2786758)

Stamataki, Z., Grove, J. , Balfe, P. and McKeating, J.A. (2008) Hepatitis C virus entry and neutralization. Clinics in Liver Disease, 12(3), pp. 693-712. (doi: 10.1016/j.cld.2008.03.008) (PMID:18625435)

Grove, J. , Nielsen, S., Zhong, J., Bassendine, M.F., Drummer, H.E., Balfe, P. and McKeating, J.A. (2008) Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. Journal of Virology, 82(24), pp. 12020-12029. (doi: 10.1128/JVI.01569-08) (PMID:18829747) (PMCID:PMC2593310)

Mee, C.J., Grove, J. , Harris, H.J., Hu, K., Balfe, P. and McKeating, J.A. (2008) Effect of cell polarization on hepatitis C virus entry. Journal of Virology, 82(1), pp. 461-470. (doi: 10.1128/JVI.01894-07) (PMID:17959672) (PMCID:PMC2224355)

Reynolds, G.M., Harris, H.J., Jennings, A., Hu, K., Grove, J. , Lalor, P.F., Adams, D.H., Balfe, P., Hübscher, S.G. and McKeating, J.A. (2008) Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology, 47(2), pp. 418-427. (doi: 10.1002/hep.22028) (PMID:18085708)

Williams, J.M., Pettitt, T.R., Powell, W., Grove, J. , Savage, C.O.S. and Wakelam, M.J.O. (2007) Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation. Journal of the American Society of Nephrology, 18(4), pp. 1112-1120. (doi: 10.1681/ASN.2006090973) (PMID:17360949)

Book Sections

pereira, P. M., Jacobs, C. and Grove, J. (2018) Investigating hepatitis C virus infection using super-resolution microscopy. In: Law, M. (ed.) Hepatitis C Virus Protocols. Series: Methods in molecular biology (1911). Humana Press: New York, NY, pp. 247-261. ISBN 9781493989751 (doi: 10.1007/978-1-4939-8976-8_17)

Exhibitions

Skeldon, K. et al. (2023) Research Firsts Exhibition. [Exhibitions]