Dr Joao Da Silva Filho
- Research Associate (Parasitology)
Publications
2024
Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)
2023
Nyirenda, J. et al. (2023) Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response. bioRxiv, (doi: 10.1101/2023.11.16.566964)
Abdi, A. I. et al. (2023) Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. eLife, 12, e85140. (doi: 10.7554/eLife.85140) (PMID:36916164) (PMCID:PMC10059685)
2022
Sesti-Costa, R., Silva-Filho, J. L. , Barcellini, W., Le Van Kim, C. and Conran, N. (2022) Editorial: inflammatory mechanisms of hemolytic diseases. Frontiers in Immunology, 12, 834527. (doi: 10.3389/fimmu.2021.834527) (PMID:35095935) (PMCID:PMC8791393)
2021
Silva-Filho, J. L. et al. (2021) Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. Brain, Behavior, and Immunity, 97, pp. 260-274. (doi: 10.1016/j.bbi.2021.08.008) (PMID:34390806)
Silva-Filho, J. L. et al. (2021) Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients. eLife, 10, e71351. (doi: 10.7554/eLife.71351) (PMID:34585667) (PMCID:PMC8536259)
2020
Martinelli, L. M. et al. (2020) Malaria in pregnancy regulates P‐glycoprotein (P‐gp/ Abcb1a ) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac. Journal of Cellular and Molecular Medicine, 24(18), pp. 10636-10647. (doi: 10.1111/jcmm.15682) (PMID:32779889) (PMCID:PMC7521277)
Bittencourt, N. C. et al. (2020) Plasmodium vivax AMA1: implications of distinct haplotypes for immune response. PLoS Neglected Tropical Diseases, 14(7), e0008471. (doi: 10.1371/journal.pntd.0008471) (PMID:32639964) (PMCID:PMC7371208)
Dos-Santos, J. C. K. et al. (2020) Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, 14(7), e0007656. (doi: 10.1371/journal.pntd.0007656) (PMID:32687542) (PMCID:PMC7392343)
Silva-Filho, J. L. , Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M. and Costa, F. T.M. (2020) Plasmodium vivax in hematopoietic niches: hidden and dangerous. Trends in Parasitology, 36(5), pp. 447-458. (doi: 10.1016/j.pt.2020.03.002) (PMID:32298632)
2019
Fontes, K. N. et al. (2019) Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor. Scientific Reports, 9, 11488. (doi: 10.1038/s41598-019-47865-3) (PMID:31391498) (PMCID:PMC6685947)
Teixeira, D. E., Peruchetti, D. B., Silva, L. S., Silva-Aguiar, R. P., Oquendo, M. B., Silva-Filho, J. L. , Takiya, C. M., Leal-Cardoso, J. H., Pinheiro, A. A. S. and Caruso-Neves, C. (2019) Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PLoS ONE, 14(4), e0215871. (doi: 10.1371/journal.pone.0215871) (PMID:31002704) (PMCID:PMC6474631)
2018
Bittencourt, N. C. et al. (2018) Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2). Malaria Journal, 17, 401. (doi: 10.1186/s12936-018-2543-7) (PMID:30382855) (PMCID:PMC6208078)
Bastos, M. F. et al. (2018) Inhibition of hypoxia‐associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria. FASEB Journal, 32(8), pp. 4470-4481. (doi: 10.1096/fj.201700844R) (PMID:29558201) (PMCID:PMC6044055)
Ribeiro, M. C., Peruchetti, D. B., Silva, L. S., Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. S. (2018) LPS induces mTORC1 and mTORC2 activation during monocyte adhesion. Frontiers in Molecular Biosciences, 5, 67. (doi: 10.3389/fmolb.2018.00067) (PMID:30073169) (PMCID:PMC6058081)
Pádua, T. A., Torres, N. D., Candéa, A. L. P., Costa, M. F. S., Silva, J. D., Silva‐Filho, J. L. , Costa, F. T. M., Rocco, P. R. M., Souza, M. C. and Henriques, M. G. (2018) Therapeutic effect of lipoxin A4 in malaria‐induced acute lung injury. Journal of Leukocyte Biology, 103(4), pp. 657-670. (doi: 10.1002/JLB.3A1016-435RRR) (PMID:29345368)
2017
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A.S. (2017) Targeting angiotensin II type-1 receptor (AT1R) inhibits the harmful phenotype of plasmodium-specific CD8+ T cells during blood-stage malaria. Frontiers in Cellular and Infection Microbiology, 7, 42. (doi: 10.3389/fcimb.2017.00042) (PMID:28261571) (PMCID:PMC5311040)
2016
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8+ T cells. Scientific Reports, 6, 35997. (doi: 10.1038/srep35997) (PMID:27782175) (PMCID:PMC5080615)
Silva-Filho, J. L. et al. (2016) Group V secretory phospholipase A2 is involved in tubular integrity and sodium handling in the kidney. PLoS ONE, 11(1), e0147785. (doi: 10.1371/journal.pone.0147785) (PMID:26820468) (PMCID:PMC4731149)
Silva, L. S., Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) New concepts in malaria pathogenesis: the role of the renin-angiotensin system. Frontiers in Cellular and Infection Microbiology, 5, 103. (doi: 10.3389/fcimb.2015.00103) (PMID:26779452) (PMCID:PMC4703750)
2015
Silva-Filho, J.L. , Souza, M.C., Henriques, M.G., Morrot, A., Savino, W., Caruso-Neves, C. and Pinheiro, A.A.S. (2015) Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, 573, pp. 1-13. (doi: 10.1016/j.abb.2015.02.035) (PMID:25752953)
2014
Landgraf, S. S. et al. (2014) 5-lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice. PLoS ONE, 9(10), e107549. (doi: 10.1371/journal.pone.0107549) (PMID:25302946) (PMCID:PMC4193734)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2014) IL-4: an important cytokine in determining the fate of T cells. Biophysical Reviews, 6(1), pp. 111-118. (doi: 10.1007/s12551-013-0133-z) (PMID:28509961) (PMCID:PMC5427811)
2013
Nunes, M. P. et al. (2013) Inhibitory effects of Trypanosoma cruzi sialoglycoproteins on CD4+ T cells are associated with increased susceptibility to infection. PLoS ONE, 8(10), e77568. (doi: 10.1371/journal.pone.0077568) (PMID:24204874) (PMCID:PMC3810146)
Nardy, A. F. F.R. et al. (2013) Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes. Microbes and Infection, 15(5), pp. 365-374. (doi: 10.1016/j.micinf.2013.02.003) (PMID:23481510)
Silva-Filho, J. L. et al. (2013) Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS ONE, 8(4), e62999. (doi: 10.1371/journal.pone.0062999) (PMID:23646169) (PMCID:PMC3639972)
Portella, V. G. et al. (2013) Sepsis-surviving mice are more susceptible to a secondary kidney insult. Critical Care Medicine, 41(4), pp. 1056-1068. (doi: 10.1097/CCM.0b013e3182746696) (PMID:23385098)
2011
Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Morrot, A., Savino, W., Nunes, M. P., Caruso-Neves, C. and Pinheiro, A. A. S. (2011) AT1 receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes. Molecular Immunology, 48(15-16), pp. 1835-1843. (doi: 10.1016/j.molimm.2011.05.008) (PMID:21641648)
Saraiva, V. B., Silva, L. d. S., Ferreira-DaSilva, C. T., Silva-Filho, J. L. d. , Teixeira-Ferreira, A., Perales, J., Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. d. S. (2011) Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS ONE, 6(2), e17174. (doi: 10.1371/journal.pone.0017174) (PMID:21364758) (PMCID:PMC3041794)
Articles
Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)
Nyirenda, J. et al. (2023) Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response. bioRxiv, (doi: 10.1101/2023.11.16.566964)
Abdi, A. I. et al. (2023) Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. eLife, 12, e85140. (doi: 10.7554/eLife.85140) (PMID:36916164) (PMCID:PMC10059685)
Sesti-Costa, R., Silva-Filho, J. L. , Barcellini, W., Le Van Kim, C. and Conran, N. (2022) Editorial: inflammatory mechanisms of hemolytic diseases. Frontiers in Immunology, 12, 834527. (doi: 10.3389/fimmu.2021.834527) (PMID:35095935) (PMCID:PMC8791393)
Silva-Filho, J. L. et al. (2021) Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. Brain, Behavior, and Immunity, 97, pp. 260-274. (doi: 10.1016/j.bbi.2021.08.008) (PMID:34390806)
Silva-Filho, J. L. et al. (2021) Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients. eLife, 10, e71351. (doi: 10.7554/eLife.71351) (PMID:34585667) (PMCID:PMC8536259)
Martinelli, L. M. et al. (2020) Malaria in pregnancy regulates P‐glycoprotein (P‐gp/ Abcb1a ) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac. Journal of Cellular and Molecular Medicine, 24(18), pp. 10636-10647. (doi: 10.1111/jcmm.15682) (PMID:32779889) (PMCID:PMC7521277)
Bittencourt, N. C. et al. (2020) Plasmodium vivax AMA1: implications of distinct haplotypes for immune response. PLoS Neglected Tropical Diseases, 14(7), e0008471. (doi: 10.1371/journal.pntd.0008471) (PMID:32639964) (PMCID:PMC7371208)
Dos-Santos, J. C. K. et al. (2020) Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, 14(7), e0007656. (doi: 10.1371/journal.pntd.0007656) (PMID:32687542) (PMCID:PMC7392343)
Silva-Filho, J. L. , Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M. and Costa, F. T.M. (2020) Plasmodium vivax in hematopoietic niches: hidden and dangerous. Trends in Parasitology, 36(5), pp. 447-458. (doi: 10.1016/j.pt.2020.03.002) (PMID:32298632)
Fontes, K. N. et al. (2019) Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor. Scientific Reports, 9, 11488. (doi: 10.1038/s41598-019-47865-3) (PMID:31391498) (PMCID:PMC6685947)
Teixeira, D. E., Peruchetti, D. B., Silva, L. S., Silva-Aguiar, R. P., Oquendo, M. B., Silva-Filho, J. L. , Takiya, C. M., Leal-Cardoso, J. H., Pinheiro, A. A. S. and Caruso-Neves, C. (2019) Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PLoS ONE, 14(4), e0215871. (doi: 10.1371/journal.pone.0215871) (PMID:31002704) (PMCID:PMC6474631)
Bittencourt, N. C. et al. (2018) Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2). Malaria Journal, 17, 401. (doi: 10.1186/s12936-018-2543-7) (PMID:30382855) (PMCID:PMC6208078)
Bastos, M. F. et al. (2018) Inhibition of hypoxia‐associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria. FASEB Journal, 32(8), pp. 4470-4481. (doi: 10.1096/fj.201700844R) (PMID:29558201) (PMCID:PMC6044055)
Ribeiro, M. C., Peruchetti, D. B., Silva, L. S., Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. S. (2018) LPS induces mTORC1 and mTORC2 activation during monocyte adhesion. Frontiers in Molecular Biosciences, 5, 67. (doi: 10.3389/fmolb.2018.00067) (PMID:30073169) (PMCID:PMC6058081)
Pádua, T. A., Torres, N. D., Candéa, A. L. P., Costa, M. F. S., Silva, J. D., Silva‐Filho, J. L. , Costa, F. T. M., Rocco, P. R. M., Souza, M. C. and Henriques, M. G. (2018) Therapeutic effect of lipoxin A4 in malaria‐induced acute lung injury. Journal of Leukocyte Biology, 103(4), pp. 657-670. (doi: 10.1002/JLB.3A1016-435RRR) (PMID:29345368)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A.S. (2017) Targeting angiotensin II type-1 receptor (AT1R) inhibits the harmful phenotype of plasmodium-specific CD8+ T cells during blood-stage malaria. Frontiers in Cellular and Infection Microbiology, 7, 42. (doi: 10.3389/fcimb.2017.00042) (PMID:28261571) (PMCID:PMC5311040)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8+ T cells. Scientific Reports, 6, 35997. (doi: 10.1038/srep35997) (PMID:27782175) (PMCID:PMC5080615)
Silva-Filho, J. L. et al. (2016) Group V secretory phospholipase A2 is involved in tubular integrity and sodium handling in the kidney. PLoS ONE, 11(1), e0147785. (doi: 10.1371/journal.pone.0147785) (PMID:26820468) (PMCID:PMC4731149)
Silva, L. S., Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) New concepts in malaria pathogenesis: the role of the renin-angiotensin system. Frontiers in Cellular and Infection Microbiology, 5, 103. (doi: 10.3389/fcimb.2015.00103) (PMID:26779452) (PMCID:PMC4703750)
Silva-Filho, J.L. , Souza, M.C., Henriques, M.G., Morrot, A., Savino, W., Caruso-Neves, C. and Pinheiro, A.A.S. (2015) Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, 573, pp. 1-13. (doi: 10.1016/j.abb.2015.02.035) (PMID:25752953)
Landgraf, S. S. et al. (2014) 5-lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice. PLoS ONE, 9(10), e107549. (doi: 10.1371/journal.pone.0107549) (PMID:25302946) (PMCID:PMC4193734)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2014) IL-4: an important cytokine in determining the fate of T cells. Biophysical Reviews, 6(1), pp. 111-118. (doi: 10.1007/s12551-013-0133-z) (PMID:28509961) (PMCID:PMC5427811)
Nunes, M. P. et al. (2013) Inhibitory effects of Trypanosoma cruzi sialoglycoproteins on CD4+ T cells are associated with increased susceptibility to infection. PLoS ONE, 8(10), e77568. (doi: 10.1371/journal.pone.0077568) (PMID:24204874) (PMCID:PMC3810146)
Nardy, A. F. F.R. et al. (2013) Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes. Microbes and Infection, 15(5), pp. 365-374. (doi: 10.1016/j.micinf.2013.02.003) (PMID:23481510)
Silva-Filho, J. L. et al. (2013) Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS ONE, 8(4), e62999. (doi: 10.1371/journal.pone.0062999) (PMID:23646169) (PMCID:PMC3639972)
Portella, V. G. et al. (2013) Sepsis-surviving mice are more susceptible to a secondary kidney insult. Critical Care Medicine, 41(4), pp. 1056-1068. (doi: 10.1097/CCM.0b013e3182746696) (PMID:23385098)
Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Morrot, A., Savino, W., Nunes, M. P., Caruso-Neves, C. and Pinheiro, A. A. S. (2011) AT1 receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes. Molecular Immunology, 48(15-16), pp. 1835-1843. (doi: 10.1016/j.molimm.2011.05.008) (PMID:21641648)
Saraiva, V. B., Silva, L. d. S., Ferreira-DaSilva, C. T., Silva-Filho, J. L. d. , Teixeira-Ferreira, A., Perales, J., Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. d. S. (2011) Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS ONE, 6(2), e17174. (doi: 10.1371/journal.pone.0017174) (PMID:21364758) (PMCID:PMC3041794)
Research datasets
2024
Da Silva Filho, J. (2024) Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies. [Data Collection]
2021
Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]