Dr Joao Da Silva Filho
- Research Associate (Parasitology)
Publications
2024
Nyirenda, J. et al. (2024) Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population. Nature Medicine, (doi: 10.1038/s41591-024-03354-3) (Early Online Publication)
Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)
Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)
2023
Nyirenda, J. et al. (2023) Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response. bioRxiv, (doi: 10.1101/2023.11.16.566964)
Abdi, A. I. et al. (2023) Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. eLife, 12, e85140. (doi: 10.7554/eLife.85140) (PMID:36916164) (PMCID:PMC10059685)
2022
Sesti-Costa, R., Silva-Filho, J. L. , Barcellini, W., Le Van Kim, C. and Conran, N. (2022) Editorial: inflammatory mechanisms of hemolytic diseases. Frontiers in Immunology, 12, 834527. (doi: 10.3389/fimmu.2021.834527) (PMID:35095935) (PMCID:PMC8791393)
2021
Silva-Filho, J. L. et al. (2021) Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. Brain, Behavior, and Immunity, 97, pp. 260-274. (doi: 10.1016/j.bbi.2021.08.008) (PMID:34390806)
Silva-Filho, J. L. et al. (2021) Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients. eLife, 10, e71351. (doi: 10.7554/eLife.71351) (PMID:34585667) (PMCID:PMC8536259)
2020
Martinelli, L. M. et al. (2020) Malaria in pregnancy regulates P‐glycoprotein (P‐gp/ Abcb1a ) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac. Journal of Cellular and Molecular Medicine, 24(18), pp. 10636-10647. (doi: 10.1111/jcmm.15682) (PMID:32779889) (PMCID:PMC7521277)
Bittencourt, N. C. et al. (2020) Plasmodium vivax AMA1: implications of distinct haplotypes for immune response. PLoS Neglected Tropical Diseases, 14(7), e0008471. (doi: 10.1371/journal.pntd.0008471) (PMID:32639964) (PMCID:PMC7371208)
Dos-Santos, J. C. K. et al. (2020) Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, 14(7), e0007656. (doi: 10.1371/journal.pntd.0007656) (PMID:32687542) (PMCID:PMC7392343)
Silva-Filho, J. L. , Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M. and Costa, F. T.M. (2020) Plasmodium vivax in hematopoietic niches: hidden and dangerous. Trends in Parasitology, 36(5), pp. 447-458. (doi: 10.1016/j.pt.2020.03.002) (PMID:32298632)
2019
Fontes, K. N. et al. (2019) Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor. Scientific Reports, 9, 11488. (doi: 10.1038/s41598-019-47865-3) (PMID:31391498) (PMCID:PMC6685947)
Teixeira, D. E., Peruchetti, D. B., Silva, L. S., Silva-Aguiar, R. P., Oquendo, M. B., Silva-Filho, J. L. , Takiya, C. M., Leal-Cardoso, J. H., Pinheiro, A. A. S. and Caruso-Neves, C. (2019) Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PLoS ONE, 14(4), e0215871. (doi: 10.1371/journal.pone.0215871) (PMID:31002704) (PMCID:PMC6474631)
2018
Bittencourt, N. C. et al. (2018) Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2). Malaria Journal, 17, 401. (doi: 10.1186/s12936-018-2543-7) (PMID:30382855) (PMCID:PMC6208078)
Bastos, M. F. et al. (2018) Inhibition of hypoxia‐associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria. FASEB Journal, 32(8), pp. 4470-4481. (doi: 10.1096/fj.201700844R) (PMID:29558201) (PMCID:PMC6044055)
Ribeiro, M. C., Peruchetti, D. B., Silva, L. S., Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. S. (2018) LPS induces mTORC1 and mTORC2 activation during monocyte adhesion. Frontiers in Molecular Biosciences, 5, 67. (doi: 10.3389/fmolb.2018.00067) (PMID:30073169) (PMCID:PMC6058081)
Pádua, T. A., Torres, N. D., Candéa, A. L. P., Costa, M. F. S., Silva, J. D., Silva‐Filho, J. L. , Costa, F. T. M., Rocco, P. R. M., Souza, M. C. and Henriques, M. G. (2018) Therapeutic effect of lipoxin A4 in malaria‐induced acute lung injury. Journal of Leukocyte Biology, 103(4), pp. 657-670. (doi: 10.1002/JLB.3A1016-435RRR) (PMID:29345368)
2017
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A.S. (2017) Targeting angiotensin II type-1 receptor (AT1R) inhibits the harmful phenotype of plasmodium-specific CD8+ T cells during blood-stage malaria. Frontiers in Cellular and Infection Microbiology, 7, 42. (doi: 10.3389/fcimb.2017.00042) (PMID:28261571) (PMCID:PMC5311040)
2016
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8+ T cells. Scientific Reports, 6, 35997. (doi: 10.1038/srep35997) (PMID:27782175) (PMCID:PMC5080615)
Silva-Filho, J. L. et al. (2016) Group V secretory phospholipase A2 is involved in tubular integrity and sodium handling in the kidney. PLoS ONE, 11(1), e0147785. (doi: 10.1371/journal.pone.0147785) (PMID:26820468) (PMCID:PMC4731149)
Silva, L. S., Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) New concepts in malaria pathogenesis: the role of the renin-angiotensin system. Frontiers in Cellular and Infection Microbiology, 5, 103. (doi: 10.3389/fcimb.2015.00103) (PMID:26779452) (PMCID:PMC4703750)
2015
Silva-Filho, J.L. , Souza, M.C., Henriques, M.G., Morrot, A., Savino, W., Caruso-Neves, C. and Pinheiro, A.A.S. (2015) Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, 573, pp. 1-13. (doi: 10.1016/j.abb.2015.02.035) (PMID:25752953)
2014
Landgraf, S. S. et al. (2014) 5-lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice. PLoS ONE, 9(10), e107549. (doi: 10.1371/journal.pone.0107549) (PMID:25302946) (PMCID:PMC4193734)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2014) IL-4: an important cytokine in determining the fate of T cells. Biophysical Reviews, 6(1), pp. 111-118. (doi: 10.1007/s12551-013-0133-z) (PMID:28509961) (PMCID:PMC5427811)
2013
Nunes, M. P. et al. (2013) Inhibitory effects of Trypanosoma cruzi sialoglycoproteins on CD4+ T cells are associated with increased susceptibility to infection. PLoS ONE, 8(10), e77568. (doi: 10.1371/journal.pone.0077568) (PMID:24204874) (PMCID:PMC3810146)
Nardy, A. F. F.R. et al. (2013) Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes. Microbes and Infection, 15(5), pp. 365-374. (doi: 10.1016/j.micinf.2013.02.003) (PMID:23481510)
Silva-Filho, J. L. et al. (2013) Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS ONE, 8(4), e62999. (doi: 10.1371/journal.pone.0062999) (PMID:23646169) (PMCID:PMC3639972)
Portella, V. G. et al. (2013) Sepsis-surviving mice are more susceptible to a secondary kidney insult. Critical Care Medicine, 41(4), pp. 1056-1068. (doi: 10.1097/CCM.0b013e3182746696) (PMID:23385098)
2011
Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Morrot, A., Savino, W., Nunes, M. P., Caruso-Neves, C. and Pinheiro, A. A. S. (2011) AT1 receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes. Molecular Immunology, 48(15-16), pp. 1835-1843. (doi: 10.1016/j.molimm.2011.05.008) (PMID:21641648)
Saraiva, V. B., Silva, L. d. S., Ferreira-DaSilva, C. T., Silva-Filho, J. L. d. , Teixeira-Ferreira, A., Perales, J., Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. d. S. (2011) Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS ONE, 6(2), e17174. (doi: 10.1371/journal.pone.0017174) (PMID:21364758) (PMCID:PMC3041794)
Articles
Nyirenda, J. et al. (2024) Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population. Nature Medicine, (doi: 10.1038/s41591-024-03354-3) (Early Online Publication)
Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)
Obaldia III, N. et al. (2024) Sterile protection against vivax malaria by repeated blood stage infection in the Aotus monkey model. Life Science Alliance, 7(3), e202302524. (doi: 10.26508/lsa.202302524) (PMID:38158220) (PMCID:PMC10756917)
Nyirenda, J. et al. (2023) Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response. bioRxiv, (doi: 10.1101/2023.11.16.566964)
Abdi, A. I. et al. (2023) Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. eLife, 12, e85140. (doi: 10.7554/eLife.85140) (PMID:36916164) (PMCID:PMC10059685)
Sesti-Costa, R., Silva-Filho, J. L. , Barcellini, W., Le Van Kim, C. and Conran, N. (2022) Editorial: inflammatory mechanisms of hemolytic diseases. Frontiers in Immunology, 12, 834527. (doi: 10.3389/fimmu.2021.834527) (PMID:35095935) (PMCID:PMC8791393)
Silva-Filho, J. L. et al. (2021) Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice. Brain, Behavior, and Immunity, 97, pp. 260-274. (doi: 10.1016/j.bbi.2021.08.008) (PMID:34390806)
Silva-Filho, J. L. et al. (2021) Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients. eLife, 10, e71351. (doi: 10.7554/eLife.71351) (PMID:34585667) (PMCID:PMC8536259)
Martinelli, L. M. et al. (2020) Malaria in pregnancy regulates P‐glycoprotein (P‐gp/ Abcb1a ) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac. Journal of Cellular and Molecular Medicine, 24(18), pp. 10636-10647. (doi: 10.1111/jcmm.15682) (PMID:32779889) (PMCID:PMC7521277)
Bittencourt, N. C. et al. (2020) Plasmodium vivax AMA1: implications of distinct haplotypes for immune response. PLoS Neglected Tropical Diseases, 14(7), e0008471. (doi: 10.1371/journal.pntd.0008471) (PMID:32639964) (PMCID:PMC7371208)
Dos-Santos, J. C. K. et al. (2020) Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, 14(7), e0007656. (doi: 10.1371/journal.pntd.0007656) (PMID:32687542) (PMCID:PMC7392343)
Silva-Filho, J. L. , Lacerda, M. V.G., Recker, M., Wassmer, S. C., Marti, M. and Costa, F. T.M. (2020) Plasmodium vivax in hematopoietic niches: hidden and dangerous. Trends in Parasitology, 36(5), pp. 447-458. (doi: 10.1016/j.pt.2020.03.002) (PMID:32298632)
Fontes, K. N. et al. (2019) Dysregulation of placental ABC transporters in a murine model of malaria-induced preterm labor. Scientific Reports, 9, 11488. (doi: 10.1038/s41598-019-47865-3) (PMID:31391498) (PMCID:PMC6685947)
Teixeira, D. E., Peruchetti, D. B., Silva, L. S., Silva-Aguiar, R. P., Oquendo, M. B., Silva-Filho, J. L. , Takiya, C. M., Leal-Cardoso, J. H., Pinheiro, A. A. S. and Caruso-Neves, C. (2019) Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway. PLoS ONE, 14(4), e0215871. (doi: 10.1371/journal.pone.0215871) (PMID:31002704) (PMCID:PMC6474631)
Bittencourt, N. C. et al. (2018) Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2). Malaria Journal, 17, 401. (doi: 10.1186/s12936-018-2543-7) (PMID:30382855) (PMCID:PMC6208078)
Bastos, M. F. et al. (2018) Inhibition of hypoxia‐associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria. FASEB Journal, 32(8), pp. 4470-4481. (doi: 10.1096/fj.201700844R) (PMID:29558201) (PMCID:PMC6044055)
Ribeiro, M. C., Peruchetti, D. B., Silva, L. S., Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. S. (2018) LPS induces mTORC1 and mTORC2 activation during monocyte adhesion. Frontiers in Molecular Biosciences, 5, 67. (doi: 10.3389/fmolb.2018.00067) (PMID:30073169) (PMCID:PMC6058081)
Pádua, T. A., Torres, N. D., Candéa, A. L. P., Costa, M. F. S., Silva, J. D., Silva‐Filho, J. L. , Costa, F. T. M., Rocco, P. R. M., Souza, M. C. and Henriques, M. G. (2018) Therapeutic effect of lipoxin A4 in malaria‐induced acute lung injury. Journal of Leukocyte Biology, 103(4), pp. 657-670. (doi: 10.1002/JLB.3A1016-435RRR) (PMID:29345368)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A.S. (2017) Targeting angiotensin II type-1 receptor (AT1R) inhibits the harmful phenotype of plasmodium-specific CD8+ T cells during blood-stage malaria. Frontiers in Cellular and Infection Microbiology, 7, 42. (doi: 10.3389/fcimb.2017.00042) (PMID:28261571) (PMCID:PMC5311040)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) Angiotensin II type-1 receptor (AT1R) regulates expansion, differentiation, and functional capacity of antigen-specific CD8+ T cells. Scientific Reports, 6, 35997. (doi: 10.1038/srep35997) (PMID:27782175) (PMCID:PMC5080615)
Silva-Filho, J. L. et al. (2016) Group V secretory phospholipase A2 is involved in tubular integrity and sodium handling in the kidney. PLoS ONE, 11(1), e0147785. (doi: 10.1371/journal.pone.0147785) (PMID:26820468) (PMCID:PMC4731149)
Silva, L. S., Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2016) New concepts in malaria pathogenesis: the role of the renin-angiotensin system. Frontiers in Cellular and Infection Microbiology, 5, 103. (doi: 10.3389/fcimb.2015.00103) (PMID:26779452) (PMCID:PMC4703750)
Silva-Filho, J.L. , Souza, M.C., Henriques, M.G., Morrot, A., Savino, W., Caruso-Neves, C. and Pinheiro, A.A.S. (2015) Renin–angiotensin system contributes to naive T-cell migration in vivo. Archives of Biochemistry and Biophysics, 573, pp. 1-13. (doi: 10.1016/j.abb.2015.02.035) (PMID:25752953)
Landgraf, S. S. et al. (2014) 5-lypoxygenase products are involved in renal tubulointerstitial injury induced by albumin overload in proximal tubules in mice. PLoS ONE, 9(10), e107549. (doi: 10.1371/journal.pone.0107549) (PMID:25302946) (PMCID:PMC4193734)
Silva-Filho, J. L. , Caruso-Neves, C. and Pinheiro, A. A. S. (2014) IL-4: an important cytokine in determining the fate of T cells. Biophysical Reviews, 6(1), pp. 111-118. (doi: 10.1007/s12551-013-0133-z) (PMID:28509961) (PMCID:PMC5427811)
Nunes, M. P. et al. (2013) Inhibitory effects of Trypanosoma cruzi sialoglycoproteins on CD4+ T cells are associated with increased susceptibility to infection. PLoS ONE, 8(10), e77568. (doi: 10.1371/journal.pone.0077568) (PMID:24204874) (PMCID:PMC3810146)
Nardy, A. F. F.R. et al. (2013) Trans-sialidase from Trypanosoma cruzi enhances the adhesion properties and fibronectin-driven migration of thymocytes. Microbes and Infection, 15(5), pp. 365-374. (doi: 10.1016/j.micinf.2013.02.003) (PMID:23481510)
Silva-Filho, J. L. et al. (2013) Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection. PLoS ONE, 8(4), e62999. (doi: 10.1371/journal.pone.0062999) (PMID:23646169) (PMCID:PMC3639972)
Portella, V. G. et al. (2013) Sepsis-surviving mice are more susceptible to a secondary kidney insult. Critical Care Medicine, 41(4), pp. 1056-1068. (doi: 10.1097/CCM.0b013e3182746696) (PMID:23385098)
Silva-Filho, J. L. , Souza, M. C., Henriques, M. d. G., Morrot, A., Savino, W., Nunes, M. P., Caruso-Neves, C. and Pinheiro, A. A. S. (2011) AT1 receptor-mediated angiotensin II activation and chemotaxis of T lymphocytes. Molecular Immunology, 48(15-16), pp. 1835-1843. (doi: 10.1016/j.molimm.2011.05.008) (PMID:21641648)
Saraiva, V. B., Silva, L. d. S., Ferreira-DaSilva, C. T., Silva-Filho, J. L. d. , Teixeira-Ferreira, A., Perales, J., Souza, M. C., Henriques, M. d. G., Caruso-Neves, C. and Pinheiro, A. A. d. S. (2011) Impairment of the Plasmodium falciparum erythrocytic cycle induced by angiotensin peptides. PLoS ONE, 6(2), e17174. (doi: 10.1371/journal.pone.0017174) (PMID:21364758) (PMCID:PMC3041794)
Research datasets
2024
Da Silva Filho, J. (2024) Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies. [Data Collection]
2021
Wickenhagen, A., Sugrue, E. , Lytras, S., Kuchi, S., Noerenberg, M. , Turnbull, M. , Loney, C. , Herder, V., Allan, J., Jarmson, I., Cameron Ruiz, N., Varjak, M. , Pinto, R. , Lee, J. Y., Iselin, L., Palmalux, N., Stewart, D., Swingler, S., Greenwood, E. J. D., Crozier, T. W. M., Gu, Q. , Davies, E., Clohisey, S., Wang, B., Trindade Maranhã Costa, F., Santana, M. F., Carlos de Lima Ferreira, L., Murphy, L., Fawkes, A., Meynert, A., Grimes, G., ISARICC investigators, , Da Silva Filho, J. , Marti, M. , Hughes, J. , Stanton, R. J., Wang, E. C. Y., Ho, A. , Davis, I., Jarrett, R. , Castello, A. , Robertson, D. , Semple, M. G., Openshaw, P. J. M., Palmarini, M. , Lehner, P. J., Baillie, K., Rihn, S. and Wilson, S. (2021) A Prenylated dsRNA Sensor Protects Against Severe COVID-19. [Data Collection]